C L Will

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi Protein functions in pre-mRNA splicing
    C L Will
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Emil Mannkopff Strasse 2, 35037, Marburg, Germany
    Curr Opin Cell Biol 9:320-8. 1997
  2. ncbi The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase
    S Fetzer
    Institut fur Molekularbiologie und Tumorforschung, Marburg, Germany
    RNA 3:344-55. 1997
  3. ncbi The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p
    S Teigelkamp
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Germany
    RNA 3:1313-26. 1997
  4. ncbi The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p
    J Lauber
    Institut fur Molekularbiologie und Tumorforschung, Marburg, Germany
    RNA 3:926-41. 1997
  5. ncbi In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes
    C L Will
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Germany
    Nucleic Acids Res 24:4614-23. 1996
  6. ncbi Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors
    A Woppmann
    Institut fur Molekularbiologie und Tumorforschung, Marburg, Germany
    Nucleic Acids Res 21:2815-22. 1993

Collaborators

  • J L Manley
  • R Luhrmann
  • J Lauber
  • S Teigelkamp
  • S Fetzer
  • G Plessel
  • T Achsel
  • W S Lane
  • K Gröning
  • C Mundt
  • S Prehn
  • P Fabrizio
  • A Woppmann
  • U Kornstädt
  • P Zuo

Detail Information

Publications6

  1. ncbi Protein functions in pre-mRNA splicing
    C L Will
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Emil Mannkopff Strasse 2, 35037, Marburg, Germany
    Curr Opin Cell Biol 9:320-8. 1997
    ..Finally, growing evidence suggests that proteins may contribute directly to the spliceosome's active sites...
  2. ncbi The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase
    S Fetzer
    Institut fur Molekularbiologie und Tumorforschung, Marburg, Germany
    RNA 3:344-55. 1997
    ..Thus, the tri-snRNP-specific 27K protein could potentially be involved in SR protein-mediated protein/protein interactions and, additionally, its phosphorylation state could modulate pre-mRNA splicing...
  3. ncbi The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p
    S Teigelkamp
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Germany
    RNA 3:1313-26. 1997
    ....
  4. ncbi The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p
    J Lauber
    Institut fur Molekularbiologie und Tumorforschung, Marburg, Germany
    RNA 3:926-41. 1997
    ..Based on their structural similarity with essential splicing factors in yeast, the human U4/U6-60kD and 90kD proteins are likely also to play important roles in the mammalian splicing process...
  5. ncbi In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes
    C L Will
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Germany
    Nucleic Acids Res 24:4614-23. 1996
    ..Studies with recombinant U1-C protein mutants indicated that the N-terminal domain of U1-C is necessary and sufficient for the stimulation of E complex formation...
  6. ncbi Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors
    A Woppmann
    Institut fur Molekularbiologie und Tumorforschung, Marburg, Germany
    Nucleic Acids Res 21:2815-22. 1993
    ..A potential general role for this enzyme in the phosphorylation of splicing factors and its consequences for pre-mRNA splicing regulation are discussed...