Research Topics
Genomes and GenesSpecies | Frank W PfriegerSummaryCountry: Germany Publications
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Detail Information
Publications
Role of cholesterol in synapse formation and functionFrank W Pfrieger
Max Planck CNRS Group, UPR 2356, Centre de Neurochimie 5, rue Blaise Pascal F 67084 Cedex, Strasbourg, France
Biochim Biophys Acta 1610:271-80. 2003....
Glia-induced neuronal differentiation by transcriptional regulationChristian Goritz
Department of Neurotransmission Neuroendocrine Secretion, Institute of Cellular and Integrative Neurosciences INCI UMR7168 LC2 CNRS ULP, Strasbourg, France
Glia 55:1108-22. 2007..Together, our results suggest that glial cells promote different aspects of neuronal differentiation by regulating transcription of distinct classes of genes...
Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuronChristian Goritz
Max-Planck/CNRS Group, UPR 2356, Centre de Neurochimie, 5, rue Blaise Pascal, F-67084 Strasbourg, France
Mol Cell Neurosci 29:190-201. 2005..These results reveal new roles of cholesterol in neuronal differentiation and underline the importance of neuron-glia interactions during brain development...
Synaptic plasticity, astrocytes and morphological homeostasisMichal Slezak
Max-Planck/CNRS Group, UPR 2356, Centre de Neurochimie, 5, rue Blaise Pascal, 67084 Strasbourg Cedex, France
J Physiol Paris 99:84-91. 2006..We argue that astrocytes control neuronal morphology locally and across long-ranging assemblies of neurons and that on the other hand, astrocytes are part of the engram with plasticity-related changes affecting their morphology...
Marked differences in cholesterol synthesis between neurons and glial cells from postnatal ratsKatja Nieweg
Department of Neurotransmission, Institute of Cellular and Integrative Neurosciences, CNRS UPR 3212, Strasbourg, France
J Neurochem 109:125-34. 2009..Our results support the idea that neurons cannot produce cholesterol efficiently and that they depend on an external source of this lipid...
[New aspects of cholesterol in the central nervous system]Thomas Claudepierre
Atip Cnrs/Max-Planck, UPR 2356, Centre de Neurochimie, 5, rue Blaise Pascal, 67084 Strasbourg, France
Med Sci (Paris) 19:601-5. 2003..This provokes new ideas about the role of astrocytes as cholesterol producers and about the function of cholesterol in the CNS and its involvement in neurodegenerative diseases...
New roles for astrocytes: regulation of CNS synaptogenesisMichal Slezak
Max Planck CNRS Group, UPR 2356, Centre de Neurochimie, 5 rue Blaise Pascal, F 67084 Strasbourg, France
Trends Neurosci 26:531-5. 2003..Further progress on this issue requires new experimental models to identify signaling pathways and to scrutinize the relevance of glia-synapse interactions in vivo...
Transgenic mice for conditional gene manipulation in astroglial cellsMichal Slezak
Department of Neurotransmission Neuroendocrine Secretion, Institute of Cellular and Integrative Neuroscience INCI, UMR 7168 LC2 CNRS Université Louis Pasteur, Strasbourg, France
Glia 55:1565-76. 2007..These new mouse lines should help to further explore the relevance of astrocytes for brain function, as well as their contribution to pathological conditions because of aging, disease or injury...
Roles of glial cells in synapse developmentFrank W Pfrieger
Institute of Cellular and Integrative Neurosciences, CNRS UPR 3212, University of Strasbourg, 5, rue Louis Pasteur, 67084, Strasbourg, France
Cell Mol Life Sci 66:2037-47. 2009..Peeking at the future, I will highlight recent technical advances that are likely to revolutionize our views on synapse-glia interactions in the developing, adult and diseased brain...
Role of glial cells in the formation and maintenance of synapsesFrank W Pfrieger
CNRS UPR 3212, University of Strasbourg, Institute of Cellular and Integrative Neurosciences INCI, 67084 Strasbourg Cedex, France
Brain Res Rev 63:39-46. 2010..Our understanding of synapse-glia interactions in the developing, adult and diseased brain is likely to advance more rapidly as new experimental approaches to identify, visualize and manipulate glial cells in vivo become available...
Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?Frank W Pfrieger
Max Planck CNRS Group, UPR2356, Centre de Neurochimie, Strasbourg, France
Bioessays 25:72-8. 2003..Testing these hypotheses will help to improve our still insufficient understanding of brain cholesterol metabolism and its role in neurodegeneration...
Role of glia in synapse developmentFrank W Pfrieger
Max Planck CNRS Group, UPR 2356, Centre de Neurochimie, 5 rue Blaise Pascal, Strasbourg, France
Curr Opin Neurobiol 12:486-90. 2002..Scrutinizing the molecular mechanisms underlying this new function of glia and testing its relevance in vivo may help to understand how synapses develop and why they degenerate under pathological conditions...
