Research Topics
Genomes and GenesSpecies | Thomas PapSummaryCountry: Germany Publications
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Publications
Cyclophilins in rheumatoid arthritis--stepping into an undiscovered country?Thomas Pap
Division of Molecular Medicine of Musculoskeletal Tissue, Department of Orthopaedic Surgery, University Hospital of Munster, Domagkstrasse 3, D-48129 Munster, Germany
Clin Immunol 116:199-201. 2005- Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis?Thomas Pap
Division of Molecular Medicine of Musculoskeletal Tissue, , Germany
Arthritis Res Ther 7:44-6. 2005 - The role of synovial fibroblasts in mediating joint destruction in rheumatoid arthritisIngmar Meinecke
Division of Experimental Rheumatology, University Hospital Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany
Curr Pharm Des 11:563-8. 2005..This article will review current data and hypotheses on disease mechanisms by which fibroblasts are involved in the destruction of joints in RA... - Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblastsAndreas Drynda
Division of Experimental Rheumatology and Orthopedics, Institute of Microbiology, Otto von Guericke University, Magdeburg, Germany
J Immunol 174:6524-31. 2005..Thus, our findings may stimulate further studies on the therapeutic potential of gene transfer strategies with TIMP-3... - Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblastsEdita Rutkauskaite
Otto-von-Guericke-University, Magdeburg, Germany
Arthritis Rheum 52:2010-4. 2005..05). CONCLUSION: The data demonstrate that an antisense RNA expression construct against MT1-MMP can be generated and expressed in RASFs for at least 60 days. Inhibition of MT1-MMP significantly reduces the cartilage degradation by RASFs... - MAPK signalling in rheumatoid joint destruction: can we unravel the puzzle?Lars-Henrik Meyer
Division of Molecular Medicine of Musculoskeletal Tissue, Department of Orthopaedics, University Hospital of Munster, Munster, Germany
Arthritis Res Ther 7:177-8. 2005..These data highlight the complexity of MAPK signalling in arthritis and provide a basis for the design of novel strategies to treat human RA... - The role of mesenchymal cells in the pathophysiology of inflammatory arthritisLars-Henrik Meyer
Division of Molecular Medicine of Musculoskeletal Tissue, Department of Orthopedics, University Hospital Muenster, Domagkstrasse 3, D-48149 Munster, Germany
Best Pract Res Clin Rheumatol 20:969-81. 2006.... - Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblastsMaik Hoberg
Department of Orthopedic Surgery, CRONA University Hospital, Tuebingen, Germany
Ann Rheum Dis 66:446-51. 2007.... - Hepatocyte growth factor induction of macrophage chemoattractant protein-1 and osteophyte-inducing factors in osteoarthritisBerno Dankbar
Department of Orthopaedics, University Hospital of Muenster, Domagkstrasse 3, D 48149 Muenster, Germany
J Orthop Res 25:569-77. 2007..The results indicate that HGF may facilitate osteophyte development by promoting MCP-1-mediated entry of monocytes/macrophages into the OA-affected joint and/or by stimulating macrophage-derived growth factors... - Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblastsIngmar Meinecke
Department of Traumatology and Reconstructive Surgery, University Hospital Munster, D 48149 Munster, Germany
Proc Natl Acad Sci U S A 104:5073-8. 2007..Accumulation of DAXX in PML NBs by SUMO-1 may, therefore, contribute to the pathogenesis of inflammatory disorders... - Gene transfer to synovial fibroblast: methods and evaluation in the SCID mouse modelIngmar Meinecke
Methods Mol Med 135:393-412. 2007..Finally, the SCID mouse in vivo model of rheumatoid joint destruction is described as a means of evaluating the effects of gene transfer on the invasiveness of synovial fibroblasts... - Ex vivo gene transfer in the years to comeThomas Pap
Division of Experimental Rheumatology, Center of Internal Medicine, University Hospital Magdeburg, Germany
Arthritis Res 4:10-2. 2002..Recent progress in this field will lead to the achievement of high transgene expression, and will facilitate the use of gene transfer in human trials... - Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritisThomas Pap
Center of Internal Medicine, University Hospital Magdeburg, Magdeburg, Germany
Arthritis Rheum 50:2794-802. 2004..To study the specific contribution of MAP kinase activator c-Raf-1 and one of its downstream transcription factors, c-Myc, to the growth and invasive behavior of rheumatoid arthritis synovial fibroblasts (RASFs)... - Cells of the synovium in rheumatoid arthritis. Synovial fibroblastsUlf Müller-Ladner
Justus Liebig University Giessen, Department of Rheumatology and Clinical Immunology, Kerckhoff Clinic Bad Nauheim, Benekestrasse, D 61231 Bad Nauheim, Germany
Arthritis Res Ther 9:223. 2007.... - Apoptosis in rheumatoid arthritisAnja Baier
Division of Experimental Rheumatology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
Curr Opin Rheumatol 15:274-9. 2003..Current efforts are aimed at elucidating the specific role of these molecules in regulating the apoptosis of rheumatoid fibroblasts and at identifying molecular targets to interfere with altered apoptosis... - The SCID mouse model: novel therapeutic targets - lessons from gene transferMatthias Pierer
WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, Department of Rheumatology, University Hospital, Gloriastrasse 25, 8091, Zurich, Switzerland
Springer Semin Immunopathol 25:65-78. 2003..Modulation of both pathways by gene transfer approaches in the SCID mouse model is a feasible method aimed at identifying novel targets for the prevention of cartilage destruction in RA... - Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritisAndreas Wunder
Department of Radiochemistry and Radiopharmacology, German Cancer Research Center, Heidelberg, Germany
J Immunol 170:4793-801. 2003..In conclusion, albumin appears to be a suitable drug carrier in RA, most likely due to effects on synovial fibroblasts, which might increase therapeutic efficacy and reduce side effects of MTX... - Modulation of pathways regulating both the invasiveness and apoptosis in rheumatoid arthritis synovial fibroblastsThomas Pap
Division of Experimental Rheumatology, University Hospital Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany
Joint Bone Spine 70:477-9. 2003 - Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblastsEdita Rutkauskaite
Otto-von-Guericke-University, University Hospital Magdeburg, Leipziger-Strasse 44, D-39120 Magdeburg, Germany
Arthritis Rheum 50:1448-56. 2004..CONCLUSION: Intracellular expression of ribozymes constitutes a feasible tool for inhibiting the production of matrix-degrading enzymes. Inhibition of MMP-1 alone results in a significant reduction of cartilage invasion by RASFs... - Synovial fibroblasts from rheumatoid arthritis patients differ in their regulation of IL-16 gene activity in comparison to osteoarthritis fibroblastsMichaela Weis-Klemm
Center for Orthopedic Surgery, , Germany
Cell Physiol Biochem 14:293-300. 2004..The enhanced expression of IL-16 in the synovial membrane early in RA vs OA may be associated in part with these distinct signaling responses... - New insights into integrin signalling: implications for rheumatoid arthritis synovial fibroblastsThomas Pap
Division of Experimental Rheumatology, University Hospital Magdeburg, Germany, and Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland
Arthritis Res Ther 5:154-5. 2003 - TNF-induced structural joint damage is mediated by IL-1Jochen Zwerina
Department of Internal Medicine III, Medical University of Vienna, A 1090 Vienna, Austria
Proc Natl Acad Sci U S A 104:11742-7. 2007..These data show that TNF-mediated cartilage damage is completely and TNF-mediated bone damage is partially dependent on IL-1, suggesting that IL-1 is a crucial mediator for inflammatory cartilage and bone degradation... - Osteoclast-independent bone resorption by fibroblast-like cellsThomas Pap
Division of Experimental Rheumatology, Otto von Guericke University, Magdeburg, Germany
Arthritis Res Ther 5:R163-73. 2003..These cells should therefore be considered novel therapeutic targets in the treatment of bone destructive disorders... - Gene transfer as a future therapy for rheumatoid arthritisUlf Müller-Ladner
Department of Internal Medicine I, University of Regensburg, FJS Allee 11, D 93042 Regensburg, Germany
Expert Opin Biol Ther 3:587-98. 2003..Future strategies will also examine the potential of novel long-term expression vectors such as lentiviruses and cytomegalovirus (CMV)-based viruses as a basis for future clinical trials in RA... - Differential effects of PDGF-BB on matrix metalloproteases and cytokine release in fibroblasts of Type 2 diabetic patients and normal controls in vitroRalf Lobmann
Department of Endocrinology and Metabolism, Magdeburg University Medical School, Magdeburg 39120, Germany
J Diabetes Complications 20:105-12. 2006..In this study, the in vitro effects of platelet-derived growth factor (PDGF)-BB on the expression of cytokines and matrix metalloproteases (MMPs) in fibroblasts of Type 2 diabetic patients and healthy controls were investigated... - Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor-alpha in periarticular tenocytes from patients with knee joint osteoarthritisAndreas Machner
Department of Orthopedic Surgery, Otto-von-Guericke-University, Magdeburg, Germany
Arthritis Res Ther 5:R253-61. 2003..The antiapoptotic effects of TNF-alpha in OA tenocytes most likely reflect regenerative attempts and must be taken into account when anti-TNF strategies are considered for OA... - Linking angiogenesis to bone destruction in arthritisThomas Pap
Arthritis Rheum 52:1346-8. 2005 - Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosisFrank Buhling
Institute of Immunology, Otto von Guericke University, Magdeburg, Germany
Respir Res 6:37. 2005..We also analysed the effects of tumor necrosis factor-beta on FasL-induced cell death... - Gene targeting: roadmap to future therapiesLars C Huber
WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies, Department of Rheumatology, University Hospital, Gloriastrasse 25, CH-8091 Zurich, Switzerland
Curr Rheumatol Rep 6:323-5. 2004