Research Topics
Species | T KochSummaryAffiliation: Otto-von-Guericke University Country: Germany Publications
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Publications
Role of phospholipase D2 in the agonist-induced and constitutive endocytosis of G-protein coupled receptorsThomas Koch
Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
J Neurochem 97:365-72. 2006..These data indicate the generally important role for PLD2 in the regulation of agonist-dependent and agonist-independent G protein-coupled receptor (GPCR) endocytosis...- Role of receptor internalization in opioid tolerance and dependenceThomas Koch
Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
Pharmacol Ther 117:199-206. 2008..Thus, clearer understanding of the role of opioid receptor trafficking in the regulation of opioid tolerance and dependence will help in the treatment of patients suffering from chronic pain or drug dependence... - Receptor endocytosis counteracts the development of opioid toleranceThomas Koch
Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Leipziger Strasse 44, Germany
Mol Pharmacol 67:280-7. 2005..Our findings suggest that opioids with high endocytotic efficacies might cause reduced opioid tolerance but can facilitate compensatory mechanisms, resulting in an enhanced opioid dependence... - Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitizationThomas Koch
Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
J Neurochem 88:680-8. 2004..In summary, our data strongly suggest that PLD2 is a modulator of agonist-induced endocytosis, desensitization and resensitization of the mu-opioid receptor... - ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosisThomas Koch
Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
J Biol Chem 278:9979-85. 2003..Together, these data suggest that PLD2 play a key role in the regulation of agonist-induced endocytosis of the mu-opioid receptor... - C-terminal splice variants of the mouse mu-opioid receptor differ in morphine-induced internalization and receptor resensitizationT Koch
Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
J Biol Chem 276:31408-14. 2001..Our findings also suggest a mechanism by which cell- and tissue-specific C-terminal splicing of the mu-opioid receptor may significantly modulate the development of tolerance to the various effects of morphine... - Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the micro-opioid receptorH Schroder
Dept of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
Neuropharmacology 56:768-78. 2009..In addition, co-immunoprecipitation experiments revealed evidence for an interaction between MOR and mGluR5 which is facilitated by MPEP treatment... - Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A)M Pfeiffer
, , 39120 Magdeburg, Germany
J Biol Chem 276:14027-36. 2001..Thus, inactivation of sst(3) receptor function by heterodimerization with sst(2A) or possibly other G protein-coupled receptors may explain some of the difficulties in detecting sst(3)-specific binding and signaling in mammalian tissues... - Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitizationManuela Pfeiffer
Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany
J Biol Chem 277:19762-72. 2002..Heterodimerization may thus represent a novel regulatory mechanism that could either restrict or enhance phosphorylation and desensitization of G protein-coupled receptors... - Interaction of the mu-opioid receptor with synaptophysin influences receptor trafficking and signalingYing Jian Liang
Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
Mol Pharmacol 71:123-31. 2007..Taken together, our findings strongly suggest that synaptophysin plays an important role in the regulation of micro-opioid receptor trafficking and signaling... - ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2Marija Rankovic
Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
Cell Signal 21:1784-93. 2009..Together, these results provide evidence that ARF6 protein regulates MOPr trafficking and signaling via PLD2 activation and hence affects the development of opioid receptor desensitization and tolerance... - mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2Thomas Koch
Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
J Neurochem 110:1288-96. 2009..These findings indicate that the agonist-selective PLD2 activation plays a key role in the regulation of NADH/NADPH-mediated ROS formation by opioids... - Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375Stefan Schulz
Institut fur Pharmakologie und Toxikologie, Otto von Guericke Universitat, Magdeburg, Germany
EMBO J 23:3282-9. 2004..Thus, morphine promotes terminal MOR desensitization by inducing a persistent modification of Ser(375)... - Development of tolerance and sensitization to different opioid agonists in ratsGisela Grecksch
Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Psychopharmacology (Berl) 186:177-84. 2006.... - Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptorsDai Fei Wu
Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
J Neurochem 104:1132-43. 2008.... - Role of phospholipase D2/phosphatidic acid signal transduction in micro- and delta-opioid receptor endocytosisLiquan Yang
Institute of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Leipziger Str 44, Germany
Mol Pharmacol 78:105-13. 2010..Taken together, our results revealed that the regulation of opioid receptor endocytosis by PLD2 involves the conversion of its product PA to DAG resulting in an activation of the p38 MAPK pathway... - Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptorAndrea Beyer
Department of Pharmacology and Toxicology, Otto-von-Guericke University, Magdeburg, Germany
J Neurochem 89:553-60. 2004..After prolonged treatment with morphine, morphine-6-glucuronide or beta-endorphin both receptors showed similiar desensitization time courses. In addition, the receptor resensitization rates were nearly identical for both receptor types... - Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitizationManuela Pfeiffer
Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
J Biol Chem 278:51630-7. 2003..Together, our findings indicate that MOR1 by virtue of its physical interaction with NK1 is sequestered via an endocytotic pathway with delayed recycling and resensitization kinetics... - Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recyclingDai Fei Wu
Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
J Biol Chem 282:22239-47. 2007..Taken together, these data provide evidence that M6a may act as a scaffolding molecule in the regulation of GPCR endocytosis and intracellular trafficking... - Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathwayYing Jian Liang
Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
Cell Res 18:768-79. 2008..In conclusion, our results strongly indicate that M6a modulates MOPr endocytosis and post-endocytotic sorting and has an important role in receptor regulation... - Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitizationT Koch
Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
J Neurochem 69:1767-70. 1997..These results suggest that phosphorylation of Ser261 and Ser266 by CaM kinase II is involved in the desensitization of the mu-opioid receptor... - Internalization of PrP106-126 by the formyl-peptide-receptor-like-1 in glial cellsLars Ove Brandenburg
Department of Anatomy, University of Kiel, Kiel, Germany
J Neurochem 101:718-28. 2007.... - Herbivore-induced volatiles induce the emission of ethylene in neighboring lima bean plantsGen-ichiro Arimura
Bio-oriented Technology Research Advancement Institution, Tokyo 105-0001, Japan
Plant J 29:87-98. 2002..They also suggest that ethylene biosynthesis might be regulated by signaling pathways involving JA, SA and ethylene in T. urticae-infested leaves...