Research Topics
Species | E KirchesSummaryAffiliation: Otto-von-Guericke University Country: Germany Publications
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Detail Information
Publications
Mitochondrial tRNA(Cys) mutation A5823G in a patient with motor neuron disease and temporal lobe epilepsyE Kirches
Institut for Neuropathologie, Universität Magdeburg, Magdeburg, Deutschland
Pathobiology 67:214-8. 1999..Since this rare mutation affected a nonconserved base position and was not observed in MND or TLE materials, its relation to disease remains unclear...- Expression of matrix metalloproteinases in a series of 12 meningiomasE Kirches
Institute for Neuropathology of the University of Magdeburg, Germany
Clin Neuropathol 20:26-30. 2001..Therefore, other mechanisms must be responsible for extracellular matrix degradation at least in a fraction of meningiomas... - Heterogeneous tissue distribution of a mitochondrial DNA polymorphism in heteroplasmic subjects without mitochondrial disordersE Kirches
Institute of Neuropathology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
J Med Genet 38:312-7. 2001..The same mutation may cause various diseases, probably because of a different tissue distribution... - High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samplesE Kirches
Department of Neuropathology, University of Magdeburg, Magdeburg, Germany
Int J Cancer 93:534-8. 2001..Our data suggest that the same mechanisms that generate inherited mtDNA polymorphisms are strongly enhanced in gliomas and produce somatic mutations... - Comparison between mitochondrial DNA sequences in low grade astrocytomas and corresponding blood samplesE Kirches
Department of Neuropathology, University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Mol Pathol 55:204-6. 2002..This study was extended by sequencing 10 DNA samples of diffuse astrocytomas (World Health Organisation grade II) and corresponding blood samples... - 2-methoxyestradiol as a potential cytostatic drug in gliomas?E Kirches
Institute of Neuropathology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
Anticancer Agents Med Chem 9:55-65. 2009..They were found to be superior in some animal models of tumor growth and vascularization, following oral application... - Short incubation with 2-methoxyestradiol kills malignant glioma cells independent of death receptor 5 upregulationS Braeuninger
Institute of Neuropathology, Otto von Guericke University, Magdeburg, Germany
Clin Neuropathol 24:175-83. 2005.... - Glutathione depletion in antioxidant defense of differentiated NT2-LHON cybridsS Schoeler
Department of Neuropathology, Leipziger Str 44, 39120 Magdeburg, Germany
Neurobiol Dis 25:536-44. 2007..The activity of the H(2)O(2) degrading enzyme glutathione peroxidase (GPx) and the activities of glutathione reductase (GR) and superoxide dismutase (SOD) were unaffected... - Gliomatosis cerebri: post-mortem molecular and immunohistochemical analyses in a case treated with thalidomideC Mawrin
Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
J Neurooncol 55:11-7. 2001..No mutations in the p53 and PTEN tumor suppressor genes were found; immunoreactivities for p53, PTEN, and EGFR could not be detected... - Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeletonK Chamaon
Department of Neuropathology, University of Magdeburg, Magdeburg, Germany
J Neurooncol 72:11-6. 2005..A round cell morphology occurred in most treated cells, which was not accompanied by a complete destruction of the microtubule network, as it can be observed with other microtubule targeting drugs... - Increased human polo-like kinase-1 expression in gliomasK Dietzmann
Institute of Neuropathology, Otto von Guericke University of Magdeburg, Germany
J Neurooncol 53:1-11. 2001..While all inhibitors minimized the cell density, only the PLCy inhibitor clearly lead to a reduced PLK-1 expression in the three cell lines U87MG, U118MG, U138MG... - Absence of major accumulation of mitochondrial ND5 mutations in Parkinson patient muscleS Schoeler
Institute of Neuropathology, Otto von Guericke University, Magdeburg, Germany
Clin Neuropathol 26:164-8. 2007..Recently, somatic point mutations in a narrow region of the complex I polypeptide ND5 (codons 120 - 150) were suggested to separate PD patients from age-matched controls, using frontal cortex homogenates... - Re-evaluation of the dysfunction of mitochondrial respiratory chain in skeletal muscle of patients with Parkinson's diseaseK Winkler-Stuck
, , Leipziger Strasse 44, D-39120 Magdeburg, Germany
J Neural Transm 112:499-518. 2005..Our data confirm the previously debated presence of a mild mitochondrial defect in skeletal muscle of patients with PD which is accompanied with an about 1.5 to 2-fold increase of point mutated mtDNA... - Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeletonA Dietzmann
Department of Neuropathology, University of Magdeburg, Magdeburg, Germany
J Neurooncol 65:99-106. 2003..These results prove that EPOs have antiproliferative effects in glioma cells and affect their tubulin cytoskeleton, as it was previously observed in several types of carcinoma cells... - The G11778A LHON mutation does not enhance ethambutol cytotoxicity in a cybrid modelR Pommer
Institute of Neuropathology, Otto von Guericke University Magdeburg, Germany
Clin Neuropathol 27:414-23. 2008..Moreover, LHON was reported to be elicited by ethambutol in some mutation carriers... - Transcripts of PTTG and growth factors bFGF and IGF-1 are correlated in pituitary adenomasK Chamaon
Department of Neuropathology, Otto von Guericke University of Magdeburg, Magdeburg, Germany
Exp Clin Endocrinol Diabetes 118:121-6. 2010..This result was obtained, when all pituitary adenoma samples were included in the statistical calculations, irrespective of their subclassification. Our study suggests a connection between PTTG and IGF-1 in pituitary adenomas... - Mitochondrial DNA as a clonal tumor cell marker: gliomatosis cerebriE Kirches
Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
J Neurooncol 61:1-5. 2003..Taken together, these results support that even distant tumors in a patient with GC can share a common clonal origin. They demonstrate the extraordinary mobility and infiltrative power of these tumor cells... - Pineal epidermoid coinciding with pineocytomaC Mawrin
Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
Acta Neurochir (Wien) 145:783-7. 2003..The unique finding of two different types of tumours in the pineal region is evaluated with regard to the histogenesis of epidermoid cysts and pineocytomas... - PTEN is not altered in sporadic vestibular schwannomasChristian Mawrin
Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
Histopathology 40:526-30. 2002.... - Preliminary results of active specific immunization with modified tumor cell vaccine in glioblastoma multiformeT Schneider
Department of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany
J Neurooncol 53:39-46. 2001..As there were no side effects, however, active specific immunization may be considered an alternative in the management of glioblastoma... - Mitochondrial DNA deletions sensitize cells to apoptosis at low heteroplasmy levelsS Schoeler
Institute of Neuropathology of the Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
Biochem Biophys Res Commun 332:43-9. 2005..Mitochondrial deletions confer enhanced susceptibility against proapoptotic signals to proliferating cells, which might explain the elimination of deletions from hematopoietic stem cells... - Promoter mutations are no major cause of PTTG overexpression in pituitary adenomasD Kanakis
Department of Neuropathology, University of Magdeburg, Magdeburg, Germany
Clin Endocrinol (Oxf) 58:151-5. 2003..PTTG is overexpressed in about 90% of pituitary adenomas. The reason for its overexpression is still unclear... - Uterine leiomyosarcoma metastatic to the brain stemC Mawrin
Institute of Neuropathology, Otto von Guericke University, Magdeburg, Germany
Arch Gynecol Obstet 266:119-21. 2002..Despite whole-brain irradiation, the patient died due to respiratory arrest. This case illustrates that brain stem metastasis may occur as a rare complication in uterine leiomyosarcoma... - Effects of phospholipase Cgamma on Polo-like kinase 1 expression in human glioma cellsK Dietzmann
Institute of Neuropathology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
J Cancer Res Clin Oncol 128:265-70. 2002..Therefore, we studied the correlation between PLCgamma activity and PLK-1 expression and determined cell size and proliferation after PLCgamma inhibition in two glioma cell lines and a primary culture of a glioblastoma... - Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the CNS and brain injuries following dramatic circulatory arrests: an immunohistochemical studyK Dietzmann
Department of Neuropathology, Medical School, Otto von Guericke University Magdeburg, Germany
Pathol Res Pract 196:15-21. 2000.... - Spatial and temporal disease progression of adult-onset subacute sclerosing panencephalitisC Mawrin
Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
Neurology 58:1568-71. 2002..This case underlines the importance of measles virus migration for the progression of this fatal disorder... - Quantification of total mitochondrial DNA and mitochondrial common deletion in the frontal cortex of patients with schizophrenia and bipolar disorderS Sabunciyan
Department of Pediatrics, Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, MD, USA
J Neural Transm 114:665-74. 2007..The effect of premortem agonal factors and medication on mitochondrial dysfunction still needs further elucidation...