Research Topics
Species | T KalinskiSummaryAffiliation: Otto-von-Guericke University Country: Germany Publications
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Detail Information
Publications
Digital workflow management for quality assessment in pathologyThomas Kalinski
Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
Pathol Res Pract 204:17-21. 2008..Moreover, digital workflow management provides the basis for the integration of diagnostic virtual microscopy...- Heterogeneity of angiogenesis and blood vessel maturation in cartilage tumorsThomas Kalinski
Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
Pathol Res Pract 205:339-45. 2009..Altogether, cartilage tumors exhibit a heterogeneous but predominantly mature angiogenic phenotype with differential proliferative activity... - Lossy compression in diagnostic virtual 3-dimensional microscopy--where is the limit?Thomas Kalinski
Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
Hum Pathol 40:998-1005. 2009..We conclude that compression ratios higher than those commonly used can be applied in virtual microscopy, even in diagnostic applications... - Improvements in education in pathology: virtual 3D specimensThomas Kalinski
Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
Pathol Res Pract 205:811-4. 2009..Virtual 3D specimens expand the application of digital techniques in pathology, and will contribute significantly to the successful introduction of knowledge databases and electronic learning platforms... - Hepatocellular carcinoma: pathology and liver biopsyThomas Kalinski
Department of Pathology, Otto von Guericke University, Magdeburg, Germany
Dig Dis 27:102-8. 2009..We further specify problems and pitfalls in the differential diagnosis and discuss limitations of liver biopsies in the diagnosis of HCC... - Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcomaThomas Kalinski
Department of Pathology, Otto von Guericke University, Magdeburg, Germany
Hum Pathol 40:1679-85. 2009.... - [Angiogenesis in cartilage tumors]T Kalinski
Institut fur Pathologie, Otto von Guericke Universitat, Leipziger Str 44, 39120 Magdeburg
Pathologe 31:177-82. 2010..Furthermore, we describe the effects of hypoxia and interleukin-1? on angiogenic signaling in chondrosarcoma cells... - ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcomaThomas Kalinski
Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
Hum Pathol 38:86-94. 2007..We believe that IL-1beta has a stronger impact on vascularization in chondrosarcomas than hypoxia, as both factors, ADAMTS1 and VEGF-A, are regulated in a way that favors angiogenesis... - Virtual 3D microscopy using multiplane whole slide images in diagnostic pathologyThomas Kalinski
Department of Pathology, Otto von Guericke University, Magdeburg, Germany
Am J Clin Pathol 130:259-64. 2008..95 each, which was approximately the same as in conventional microscopy. We consider virtual 3D microscopy appropriate for primary diagnosis of H pylori gastritis and equivalent to conventional microscopy... - [Rare neuroendocrine carcinoma of the gall bladder. Coincidental occurrence of an endometrioid ovarian adenocarcinoma]M Petersen
Klinik fUr Allgemein, Viszeral und Gefässchirurgie, Universitatsklinikum, Magdeburg, Germany
Dtsch Med Wochenschr 134:19-22. 2009..The histological investigation of a surgical specimen (after cholecystectomy) from a 73-year-old woman revealed a poorly differentiated carcinoma with glandular structures and a lymph node metastasis... - Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cellsAtanas Ignatov
Department of Obstetrics and Gynecology, Otto von Guericke University, G Hauptmann Str 35, 39108 Magdeburg, Germany
Breast Cancer Res Treat 123:87-96. 2010..This data suggests the important role of GPR30/EGFR receptor signaling in the development of tamoxifen resistance. The inhibition of this pathway is a valid option to improve anti-hormone response in breast cancer... - Self-renewal of the human gastric epithelium: new insights from expression profiling using laser microdissectionIrina Kouznetsova
Institute of Molecular Biology and Medicinal Chemistry, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
Mol Biosyst 7:1105-12. 2011.... - [Virtual microscopy and digital pathology]T Kalinski
Institut fur Pathologie, Otto von Guericke Universitat Magdeburg, Germany
Pathologe 27:222-7. 2006..In the long term, digital archives and networks will be established that will allow for a worldwide access to virtual specimens... - Establishment and characterization of the permanent human cell line C3842 derived from a secondary chondrosarcoma in Ollier's diseaseThomas Kalinski
Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
Virchows Arch 446:287-99. 2005..In conclusion, the cell line C3842 provides the first model of a secondary chondrosarcoma in Ollier's disease in vitro, which is characterized by distinct features of such malignant cartilage tumors... - Digital imaging and electronic patient records in pathology using an integrated department information system with PACSThomas Kalinski
Institute of Pathology, Otto von Guericke University, Magdeburg, Germany
Pathol Res Pract 198:679-84. 2002..Moreover, we evaluate the current situation and future prospects for PACS in pathology... - Digital pathology: DICOM-conform draft, testbed, and first resultsRalf Zwönitzer
Department of Biometry and Medical Informatics, Otto von Guericke University, Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Comput Methods Programs Biomed 87:181-8. 2007..The results showed that digital pathology is feasible but strong efforts by users and vendors are still necessary to integrate Digital Pathology into existing information systems... - Helicobacter pylori alters the distribution of ZO-1 and p120ctn in primary human gastric epithelial cellsSabine Krueger
Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
Pathol Res Pract 203:433-44. 2007..These alterations, triggered by H. pylori infection, are associated with an elongation phenotype and increased migration... - Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancerSabine Krueger
Department of Pathology, Otto von Guericke University, Magdeburg, Germany
J Pathol 207:32-42. 2005..Although no correlation of cathepsin X expression and TNM stage was found, our study demonstrates that cathepsin X plays a role not only in the chronic inflammation of gastric mucosa but also in the tumourigenesis of gastric cancer... - Differential expression of VEGF-A and angiopoietins in cartilage tumors and regulation by interleukin-1betaThomas Kalinski
Department of Pathology, Otto von Guericke University, Magdeburg, Germany
Cancer 106:2028-38. 2006..As interleukin (IL)-1beta has been found to be an indispensable factor in angiogenic signaling, we further analyzed the effect of IL-1beta on the expression of VEGF-A, Ang-1, and Ang-2 using a previously established cell culture model... - Distribution of sex chromosomes in dysgenetic gonads of mixed typeA Röpke
Institute of Human Genetics, Otto von Guericke University Magdeburg, Magdeburg, Germany
Cytogenet Genome Res 116:146-51. 2007..The proportion of XY/X cells in theca-like cells and Leydig cells was similar to that of the whole dysgenetic gonad. In contrast to these findings, spermatogonia exclusively contained an XY constellation... - Biosynthesis of gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucinsIrina Kouznetsova
IInstitut fur Molekularbiologie und Medizinische Chemie, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
Cell Physiol Biochem 20:899-908. 2007..This points to different physiological functions of TFF1 and TFF2, the latter maybe acting as a 'link peptide' for stabilization of the gastric mucus... - Liver cirrhosis and membranoproliferative glomerulonephritis caused by inapparent hepatitis C virus infectionThomas Kalinski
Department of Pathology, Otto von Guericke University, Magdeburg, Germany
Pathol Res Pract 202:891-4. 2006..Specimens of FFPE liver tissue may be used for the diagnosis of HCV infection, even if the tissue was obtained in a postmortem examination... - Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERKSabine Krueger
Institute of Pathology, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
J Biol Chem 281:2868-75. 2006..Induction of MMP-1 is further implicated in complex processes induced by H. pylori, resulting in tissue degradation and remodeling of the gastric mucosa... - Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia: differentiation of two types of gastric pit cells along the rostro-caudal axisIrina Kouznetsova
Institut für Molekularbiologie und Medizinische Chemie, Universitatsklinikum, Otto von Guericke Universitat Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
Cell Tissue Res 328:365-74. 2007..This indicates the special requirement, particularly of the esophagogastric junction, for TFF3-triggered protection and repair... - Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfideTimo K Albert
Institute of Molecular Biology and Medicinal Chemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany
J Proteome Res 9:3108-17. 2010..Also proteolytic processing of FCGBP was observed which is in line with multiple autocatalytic cleavages as proposed earlier by Johansson et al. (J. Proteome Res. 2009 , 8 , 3549 - 3557)... - Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasivenessSabine Krueger
Department of Pathology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Cancer Lett 223:313-22. 2005..This is dependent on the functional activity of cathepsin B as shown by specific siRNA's and seems to be regulated by activation of ERK1/2 and p38 signal transduction pathways... - A randomized study of docetaxel and dexamethasone with low- or high-dose estramustine for patients with advanced hormone-refractory prostate cancerThomas Nelius
Department of Urology, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
BJU Int 98:580-5. 2006....