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Genomes and GenesSpecies | Ulrike Nowak-GottlSummaryCountry: Germany Publications
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Publications
Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: a multicentre cohort studyGili Kenet
Israel National Haemophilia Centre, Sheba Medical Centre, Tel Hashomer, Israel
Lancet Neurol 6:595-603. 2007....- The plasminogen activator inhibitor (PAI)-1 promoter 4G/4G genotype is not associated with ischemic stroke in a population of German children. Childhood Stroke Study GroupU Nowak-Gottl
Paediatric Haematology and Oncology, University Hospital Munster, Germany
Eur J Haematol 66:57-62. 2001..To investigate the relationship between an insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor (PAI)-1 gene and childhood patients with a past history of ischemic stroke... - Arterial ischemic stroke in neonates, infants, and children: an overview of underlying conditions, imaging methods, and treatment modalitiesUlrike Nowak-Gottl
Department of Haematology Oncology, University of Münster Münster, Germany
Semin Thromb Hemost 29:405-14. 2003.... - Neonatal thromboembolismUlrike Nowak-Gottl
Pediatric Hematology Oncology, University Children s Hospital, Munster, Germany
Semin Thromb Hemost 29:227-34. 2003..Secondary long-term anticoagulation should be administered on an individual basis... - Interaction of fibrinolysis and prothrombotic risk factors in neonates, infants and children with and without thromboembolism and underlying cardiac disease. a prospective studyU Nowak-Gottl
Pediatric Hematology and Oncology, University Hospital Munster, D 48149 Munster, Germany
Thromb Res 103:93-101. 2001.... - Haemophilia and thrombophilia. What do we learn about combined inheritance of both genetic variations?U Nowak-Gottl
Pediatric Hematology Oncology, University of Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
Hamostaseologie 23:36-40. 2003..Conclusion: The data of this multicentre cohort study demonstrate that the clinical phenotype of severe haemophilia A in childhood is clearly influenced by the coinheritance of prothrombotic risk factors... - Thromboembolism in newborns, infants and childrenU Nowak-Gottl
Department of Paediatric Haematology Oncology, University of Munster, Germany
Thromb Haemost 86:464-74. 2001..Thus, recommendations from small-scale studies in paediatric patients and guidelines adapted from adult patient protocols may be helpful in the management of paediatric patients on an individual patient basis... - Thrombotic events revisited in children with acute lymphoblastic leukemia: impact of concomitant Escherichia coli asparaginase/prednisone administrationU Nowak-Gottl
Department of Pediatric Hematology Oncology, University of Münster Children s Hospital, Albert Schweitzerstrasse 33, Munster D 48149, Germany
Thromb Res 103:165-72. 2001..coli asparaginase concomitantly administered in a leukemic patient suffering from a prothrombotic risk factor to be responsible for the onset of venous thrombosis in the majority of cases... - Thromboembolic diseases in neonates and childrenUlrike Nowak-Gottl
Paediatric Haematology Oncology Univ children s hospital Münster, Germany
Pathophysiol Haemost Thromb 33:269-74. 2003..Data interpretation is based on age-dependent reference ranges or the identification of causative gene mutations/polymorphisms with respect to individual ethnic backgrounds... - Thromboembolism in childrenUlrike Nowak-Gottl
Department of Pediatric Hematology Oncology, University of Munster, Germany
Curr Opin Hematol 9:448-53. 2002..Pediatric treatment protocols for acute thromboembolism, including thrombolytic and anticoagulant therapy, are mainly adapted from adult patient protocols... - Thrombolysis in newborns and infantsU Nowak-Gottl
Department of Paediatrics, University Children Hospital Münster, Germany
Thromb Haemost 82:112-6. 1999..Controlled prospective multicentre studies on thrombolytic therapy in neonates and infants are recommended to evaluate patency rates and adverse effects for the different thrombolytic agents used... - Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studiesGili Kenet
Pediatric Hematology and Oncology, University Hospital of Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
Circulation 121:1838-47. 2010..The aim of this study was to estimate the impact of thrombophilia on risk of first childhood stroke through a meta-analysis of published observational studies... - Genetics of hemostasis: differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke familiesUlrike Nowak-Gottl
Department of Pediatric Hematology Oncology, University of Munster, Munster, Germany
Environ Health Perspect 116:839-43. 2008..Such epidemiologic approaches in families with a first acute ischemic stroke during early childhood are lacking... - Thrombophilia in the youngU Nowak-Gottl
Univ Children Hospital, Pediatric Hematology and Oncology, Albert Schweitzer Str 33, 48149 Munster, Germany
Hamostaseologie 28:16-20. 2008..Based on these data treatment algorithms have to be discussed... - Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhoodU Nowak-Gottl
Department of Paediatrics, Institute of Clinical Chemistry and Laboratory Medicine and Institute of Arteriosclerosis Research, Westphalian Wilhelms University Münster, Germany
Blood 94:3678-82. 1999..75/4.7 to 272; P <. 0001). Increased Lp (a) levels, the FV G1691A mutation, protein C deficiency, the prothrombin G20210A variant, and the MTHFR TT677 are important risk factors for spontaneous ischemic stroke in childhood... - Pharmacokinetics, efficacy, and safety of LMWHs in venous thrombosis and stroke in neonates, infants and childrenU Nowak-Gottl
Department of Paediatric Haematology and Oncology, University of Munster, Munster, Germany
Br J Pharmacol 153:1120-7. 2008..Further randomized controlled trials are recommended to evaluate the optimum duration and application for different LMWH indications in children... - Antithrombotic drug treatment of pediatric patients with ischemic strokeUlrike Nowak-Gottl
Department of Paediatric Haematology and Oncology, University Paediatric Hospital, University of Munster, Albert Schweitzer Strasse 3, 48149 Munster, Germany
Paediatr Drugs 5:167-75. 2003..Alteplase has been used in a few patients within 3 hours of the onset of symptoms. In each patient treated the benefit of anticoagulation has to be weighed up against the individual bleeding risk... - Recurrent pulmonary embolism in a 13-year-old male homozygous for the prothrombin G20210A mutation combined with protein S deficiency and increased lipoprotein (a)Andrea Kosch
Department of Pediatric Hematology and Oncology, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
Thromb Res 105:49-53. 2002.... - Role of endogenous testosterone concentration in pediatric strokeSandra Normann
Department of Pediatric Hematology, University Children s Hospital, University of Munster, Munster, Germany
Ann Neurol 66:754-8. 2009..98 [1.38-11.45]; AIS = 3.88 [1.13-13.35]; CSVT = 5.50 [1.65-18.32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3-fold... - Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-upAndrea Kosch
Department of Pediatric Hematology Oncology, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
Blood 104:1356-60. 2004..In conclusion, the present study demonstrates the significance of genetic PR-especially the FV mutation and elevated Lp(a)-for the etiology of neonatal RVT... - Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in childrenAndrea Kosch
Department of Pediatric Hematology Oncology, University Children s Hospital Munster, Germany
Thromb Haemost 91:308-14. 2004..Therefore, screening for elevated fasting tHcy levels of patients with thromboembolism is recommended to stratify the risk of thromboembolism... - Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. For the Childhood Thrombophilia Study GroupC Heller
Department of Paediatrics, University of Frankfurt, Germany
Br J Haematol 111:534-9. 2000..1; P < 0.0001), PVT (5.47/1.7-17.6; P < 0.0007) and HVT (3.3/0.58-18.7; P = 0.18). The data presented here suggest that genetic prothrombotic risk factors also play an important role in abdominal venous thrombosis during infancy... - Role of genetic prothrombotic risk factors in childhood caval vein thrombosisN Münchow
Paediatric Haematology and Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Eur J Pediatr 158:S109-12. 1999..Remarkably, during puberty and adolescence the predominant defect diagnosed was the PT G20210A variant, whereas the FV G1691A mutation had a higher incidence during infancy... - Outcome of kidney transplantation in patients with inherited thrombophilia: data of a prospective studyStefan Heidenreich
Department of Medicine, University of Munster, Germany
J Am Soc Nephrol 14:234-9. 2003..Screening for hypercoagulable states pretransplant is recommended to intensify anticoagulatory treatment posttransplant... - Symptomatic ischemic stroke in full-term neonates : role of acquired and genetic prothrombotic risk factorsG Gunther
Department of Paediatrics, University of Magdeburg, Magdeburg, Germany
Stroke 31:2437-41. 2000..The present multicenter case-control study was prospectively designed to assess the extent to which single and combined clotting factor abnormalities influence the onset of symptomatic ischemic stroke in full-term neonates... - Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studiesUlrike Nowak-Gottl
Pediatric Hematology Oncology, University of Muenster, Muenster, Germany
Blood 114:1947-53. 2009..The observed negative correlation of genetic VT risk with the plasma levels of the fibrinogen gamma' variant suggests that FGG-H2 and -H3 haplotypes modify thrombosis risk by controlling the level of this FGG splice isoform... - Association of the protein Z ATG haplotype with symptomatic nonvascular stroke or thromboembolism in white children: a family-based cohort studyUlrike Nowak-Gottl
Pediatric Hematology Oncology, University Clinics Münster, Munster, Germany
Blood 113:2336-41. 2009..4; 95% confidence interval [95% CI] 1.08-1.93). Our results suggest that the ATG haplotype of the PZ gene is a genetic marker for symptomatic TE in white German children... - Thromboembolic events in children with acute lymphoblastic leukemia (BFM protocols): prednisone versus dexamethasone administrationUlrike Nowak-Gottl
Pediatric Hematology Oncology, University Hospital Munster, Germany
Blood 101:2529-33. 2003..In conclusion, the use of dexamethasone instead of prednisone, administered with CASP, significantly reduced the onset of venous thromboembolism... - In pediatric patients, age has more impact on dosing of vitamin K antagonists than VKORC1 or CYP2C9 genotypesUlrike Nowak-Gottl
Pediatric Hematology Oncology, University Children s Hospital, University of Munster, Munster, Germany
Blood 116:6101-5. 2010..3% of VKA dose variations; VKORC1 and CYP2C9 explained only 3.7% and 0.4%, respectively. In children, the most critical factor in determining VKA dose is age. VKORC1/CYP2C9 genotypes only marginally explain dose variations... - Role of elevated alpha2-macroglobulin revisited: results of a case-control study in children with symptomatic thromboembolismA Beheiri
Department of Paediatric Haematology Oncology, Univ Children s Hospital, Munster, Germany
J Thromb Haemost 5:1179-84. 2007..The present study was conducted to evaluate the role of alpha2MG in children with venous thromboembolism [VTE: paradoxical embolism causing ischemic stroke (IS) or deep-vein thrombosis (DVT)]... - Safety and efficacy of low molecular weight heparins in children: a systematic review of the literature and meta-analysis of single-arm studiesChristoph Bidlingmaier
Department of Thrombosis and Hemostasis, Dr von Hauner s Children s Hospital, University Children s Hospital, Munich, Germany
Semin Thromb Hemost 37:814-25. 2011..The present systematic review suggests that use of LMWH in children as primary prophylaxis and in treatment of symptomatic thrombosis is effective and safe. However, properly designed randomized controlled trials are needed... - Thrombosis in childhood acute lymphoblastic leukaemia: epidemiology, aetiology, diagnosis, prevention and treatmentUlrike Nowak-Gottl
Paediatric Haematology and Oncology, University Hospital Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
Best Pract Res Clin Haematol 22:103-14. 2009..External CVLs are affected more often than internal CVLs. Evidence-based guidelines on prevention and treatment guidelines for ALL-related VTE are lacking, and carefully designed clinical trials are needed urgently... - Spectrum of molecular defects and mutation detection rate in patients with severe hemophilia ANadja Bogdanova
Institut fur Humangenetik, UKM, Munster, Germany
Hum Mutat 26:249-54. 2005..The newly detected amino acid substitutions were scored for potential gross or local conformational changes and influence on molecular stability for every single F8 domain with available structures, using homology modeling... - The factor V G1691A mutation is a risk for porencephaly: A case-control studyOtfried M Debus
University Children s Hospital Munster, Department of Neuropediatrics, Germany
Ann Neurol 56:287-90. 2004..003) were significantly associated with porencephaly. These data give evidence that the FV G1691A mutation and a combination of prothromboic factors play a major role in the development of childhood porencephaly... - Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart diseaseR Junker
Institute of Clinical Chemistry and Laboratory Medicine and Institute of Atherosclerosis Research, University Hospital Munster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
Cardiovasc Res 51:251-4. 2001..However, no data are available so far with respect to the MTHFR 677TT genotype in children with underlying structural congenital heart disease (CHD)... - Population pharmacokinetics of enoxaparin in infants, children and adolescents during secondary thromboembolic prophylaxis: a cohort studyM N Trame
Department of Pharmaceutical and Medical Chemistry Clinical Pharmacy, University of Munster, Munster, Germany
J Thromb Haemost 8:1950-8. 2010..In children, it is still used off-label and little is known about the pharmacokinetics in children... - Plasminogen activator inhibitor-1 4G/5G-polymorphism and factor V Q506 mutation are not associated with myocardial infarction in young menR Junker
Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
Blood Coagul Fibrinolysis 9:597-602. 1998..In conclusion, in the present study neither homozygosity for the 4G allele of the PAI-1 4G/5G-polymorphism nor the FV:Q506 mutation led to an increased risk of myocardial infarction in young men... - The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosisH G Koch
Department of Paediatrics, University Hospital, Munster, Germany
Eur J Pediatr 158:S113-6. 1999..3 micromol/l and the CT genotype of the MTHFR C677T variant are significant risk factors for venous vascular occlusion in children... - Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic systemR Junker
Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, Germany
Thromb Haemost 85:280-6. 2001..Therefore, the clinical significance of the present findings remains to be evaluated... - Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED surveyR Sträter
Paediatric Haematology and Oncology, University Hospital, Munster
Eur J Pediatr 158:S122-5. 1999.... - [Thrombocytic alpha-delta-storage-pool-disease: shortening of bleeding time after infusion of 1-desamino-8-D-arginine vasopressin]A Kosch
Klinik und Poliklinik für Kinderheilkunde, Westfälischen Wilhelms Universität Münster
Klin Padiatr 211:198-200. 1999..In addition to substitution of platelets, vasopressin is therefore used to prevent bleeding complications... - Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophiliaR Junker
Institute of Clinical Chemistry and Laboratory Medicine, Westfalische Wilhelms Universitat Munster, Germany
Arterioscler Thromb Vasc Biol 19:2568-72. 1999..In conclusion, the prothrombin G20210A and the FV G1691A mutation, deficiencies of protein C, protein S, and antithrombin are important risk factors for venous thrombosis during childhood and adolescence... - Health-related quality of life in children and adolescents with stroke, self-reports, and parent/proxies reports: cross-sectional investigationBruno Neuner
Department of Clinical Epidemiology and Social Medicine, University of Munster, Munster, Germany
Ann Neurol 70:70-8. 2011..The aim of the present study was to assess HR-QoL by self-assessment and parent/proxy-assessment in children and adolescents who survived a first stroke episode... - Interferences in coagulation tests--evaluation of the 570-nm method on the Dade Behring BCS analyserRalf Junker
Institute of Arteriosclerosis Research, University of Munster, Munster, Germany
Clin Chem Lab Med 43:244-52. 2005..Limitations have to be taken into account regarding lipaemic plasma... - Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in menG Benze
Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Munster, Germany
Eur Heart J 23:325-30. 2002..The T807 allele of the GPIa gene alone or in combination with the PlA2 allele had no major effect on premature myocardial infarction risk... - Testing for lipoprotein(a) concentration and apolipoprotein(a) phenotypes: method standardization and pediatric reference valuesClaus Langer
Department of Thrombosis and Hemostasis Research, Institute of Clinical Chemistry and Laboratory Medicine, Germany
Semin Thromb Hemost 37:810-3. 2011..The latter will help to harmonize international pediatric studies and to further evaluate the role of elevated Lp(a) in childhood vascular disease... - Post-trauma coagulation and fibrinolysis in children suffering from severe cerebro-cranial traumaS Becker
Department of Paediatrics, University Hospital Frankfurt am Main, Germany
Eur J Pediatr 158:S197-202. 1999..CONCLUSION: Our data underline the significance of post-trauma disturbances of the haemostatic system for the clinical course and outcome in children with severe cranio-cerebral injuries... - Resistance to activated protein C (APCR) in children with venous or arterial thromboembolismU Nowak-Gottl
Department of Paediatrics, University Hospital Kiel, Germany
Br J Haematol 92:992-8. 1996..These data are evidence that APCR combined with exogenous reasons may play an important role in the early manifestation of thromboembolism during infancy and childhood...