Research Topics
| Utz J PapeSummaryAffiliation: Max Planck Institute for Molecular Genetics Country: Germany Publications
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Detail Information
Publications
A new statistical model to select target sequences bound by transcription factorsUtz J Pape
Computational Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
Genome Inform 17:134-40. 2006..Two examples show the necessity of such a model as well as the superiority of the proposed method compared to standard approaches...
Natural similarity measures between position frequency matrices with an application to clusteringUtz J Pape
Computational Biology, Max Planck Institute f Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
Bioinformatics 24:350-7. 2008..Furthermore, we introduce a second measure based on the same idea to cluster a set of the Jaspar PFMs...
Compound poisson approximation of the number of occurrences of a position frequency matrix (PFM) on both strandsUtz J Pape
Computational Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
J Comput Biol 15:547-64. 2008..In general, our approach outperforms these approximations or is equally good but significantly faster. An implementation of our approach is available at http://mosta.molgen.mpg.de...
Statistical detection of cooperative transcription factors with similarity adjustmentUtz J Pape
Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestr 73 and Mathematics and Computer Science, Free University of Berlin, Takustr 9, 14195 Berlin, Germany
Bioinformatics 25:2103-9. 2009..However, similar DNA motifs tend to co-occur in random sequences due to high probability of overlapping occurrences. Therefore, it is important to consider similarity of DNA motifs in the statistical assessment...
Prediction of cardiac transcription networks based on molecular data and complex clinical phenotypesMartje Toenjes
Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
Mol Biosyst 4:589-98. 2008..Several of the found interactions have been previously described in literature, demonstrating that the approach is a versatile tool to predict regulatory networks...
