Research Topics
Genomes and Genes
Species | Daniel Martins-de-SouzaSummaryAffiliation: Max Planck Institute of Psychiatry Country: Germany Publications
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Detail Information
Publications
Proteome analyses of cultured astrocytes treated with MK-801 and clozapine: similarities with schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 261:217-28. 2011..Interestingly, clozapine reversed protein changes induced by MK-801. The treatment of cell cultures with neural transmission agonists and antagonists might provide useful insights about psychiatric disorders...- Different apolipoprotein E, apolipoprotein A1 and prostaglandin-H2 D-isomerase levels in cerebrospinal fluid of schizophrenia patients and healthy controlsDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Munich, Germany
World J Biol Psychiatry 11:719-28. 2010..To identify proteins differentially expressed in schizophrenia patients, we collected 50 microl cerebrospinal fluid from 17 first-episode schizophrenia patients and 10 healthy controls... - Proteome and transcriptome analysis suggests oligodendrocyte dysfunction in schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
J Psychiatr Res 44:149-56. 2010..The presented data contribute to the composition of a scenario that may lead to a better understanding of schizophrenia pathogenesis... - Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulationDaniel Martins-de-Souza
Laboratorio de Neurociencias, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr, Ovídio Pires de Campos, no 785, Sao Paulo, SP, CEP 05403 010, Brazil
BMC Psychiatry 9:17. 2009..The superior temporal gyrus is implicated in schizophrenia and executes functions such as the processing of speech, language skills and sound processing... - Shotgun mass spectrometry analysis of the human thalamus proteomeDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Munich, Germany
J Sep Sci 32:1231-6. 2009..The thalamus proteome contributes to the knowledge of the human brain proteome and future applications in basic and clinical research... - Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophreniaDaniel Martins-de-Souza
Laboratorio de Neurociencias, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr Ovidio Pires de Campos, SP, Brazil
J Psychiatr Res 43:978-86. 2009..Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease... - Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophreniaDaniel Martins-de-Souza
Laboratorio de Neurociencias, Instituto de Psiquiatria, Universidade de Sao Paulo, Rua Dr Ovidio Pires de Campos, no 785, Consolação, Sao Paulo, SP 05403 010, Brazil
Eur Arch Psychiatry Clin Neurosci 259:151-63. 2009..In addition a number of new potential markers were found that may contribute to the understanding of the pathogenesis of this complex disease... - Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
J Psychiatr Res 44:1176-89. 2010.... - Proteome analysis of schizophrenia brain tissueDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Munich, Germany
World J Biol Psychiatry 11:110-20. 2010..Reviewing the results of 13 proteome studies in SCZ brain tissue, we aimed to provide information regarding potential proteins biomarkers as well as information about the pathophysiology of the disease... - Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysisDaniel Martins-de-Souza
Laboratorio de Neurociencias, Faculdade de Medicina da USP, Instituto de Psiquiatria, Universidade de Sao Paulo, Rua Dr Ovidio Pires de Campos, no 785, s n Consolação, Sao Paulo, SP, CEP 05403 010, Brazil
J Neural Transm 116:275-89. 2009.... - Sex-specific proteome differences in the anterior cingulate cortex of schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstr 2, 80804 Munich, Germany
J Psychiatr Res 44:989-91. 2010..Our findings not only support previous findings but also indicate areas that warrant further study in schizophrenia... - Proteome analysis of human dorsolateral prefrontal cortex using shotgun mass spectrometryDaniel Martins-de-Souza
Laboratorio de Neurociencias, Instituto de Psiquiatria, Facultdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
J Sep Sci 31:3122-6. 2008..It will also aid comparative studies of different brain areas and medical conditions, with future applications in basic and clinical research... - Structural and pharmacological characterization of the crotamine isoforms III-4 (MYX4_CROCu) and III-7 (MYX7_CROCu) isolated from the Crotalus durissus cumanensis venomLuis Alberto Ponce-Soto
Department of Biochemistry, Institute of Biology IB, State University of Campinas UNICAMP, P O Box 6109, 13083 970 Campinas, SP, Brazil
Toxicon 55:1443-52. 2010..Edema-forming activity was also analyzed by injection of the crotamine isoforms into the right paw, since both crotamine isoforms exert a strong pro-inflammatory effect... - Shotgun mass spectrometry workflow combining IEF and LC-MALDI-TOF/TOFGiuseppina Maccarrone
Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstrasse 2, 80804, Munich, Germany
Protein J 29:99-102. 2010..Such workflow was successfully applied to a comparative proteome analysis of schizophrenia versus healthy control brain tissues and can be an alternative to proteome researches... - Quantitative proteomics for investigating psychiatric disordersMichaela D Filiou
Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, Germany
Proteomics Clin Appl 5:38-49. 2011..Finally, we explore the applicability of implementing proteomic methods as a routine diagnostic tool in the clinical laboratory... - Biochemical and pharmacological characterization of PhTX-I a new myotoxic phospholipase A2 isolated from Porthidium hyoprora snake venomSalomón Huancahuire-Vega
Department of Biochemistry, Institute of Biology, State University of Campinas, SP, Brazil
Comp Biochem Physiol C Toxicol Pharmacol 154:108-19. 2011..In vitro, both induced low cytotoxicity in skeletal muscle myoblasts, however PhTX-I PLA(2) was able to lyse myotubes... - Biological and biochemical characterization of two new PLA2 isoforms Cdc-9 and Cdc-10 from Crotalus durissus cumanensis snake venomFrey Francisco Romero-Vargas
Department of Biochemistry, Institute Biology CP 6109, State University of Campinas, Campinas, SP, Brazil
Comp Biochem Physiol C Toxicol Pharmacol 151:66-74. 2010..However, p-BPB strongly diminishes the local and systemic myotoxic effects... - Purification and inflammatory edema induced by two PLA2 (Anch TX-I and Anch TX-II) from sea anemone Anthothoe chilensis (Actiniaria: Sagartiidae)Elen Cristina Teizem Landucci
Departamento de Farmacologia, Faculdade de Ciencias Medicas, CEP 13083 970, Campinas, SP, Brazil
Comp Biochem Physiol B Biochem Mol Biol 161:170-7. 2012..We also investigated the in vivo edematogenic activity of Anch TX-I and Anch TX-II in a model of paw and skin edema in rats and observed that both are able to induce dose-dependent edema... - To label or not to label: applications of quantitative proteomics in neuroscience researchMichaela D Filiou
Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Munich, Germany
Proteomics 12:736-47. 2012.... - The role of proteomics in depression researchDaniel Martins-de-Souza
Max Planck Institute for Psychiatry, Kraepelinstr 2, 80804, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 260:499-506. 2010..Here, we will show the potential of proteome analyses as a tool to elucidate the pathophysiological mechanisms of depression as well as the discovery of potential diagnostic, therapeutic and disease course biomarkers... - Functional and structural characterization of a new serine protease with thrombin-like activity TLBan from Bothrops andianus (Andean Lancehead) snake venomJosé Antonio Valeriano-Zapana
Department of Biochemistry, Institute of Biology IB, State University of Campinas UNICAMP, P O Box 6109, Zip Code 13083 970, Campinas, SP, Brazil
Toxicon 59:231-40. 2012..TLBan showed a potential medical-scientific interest to understand the pathophysiological mechanism of the snake venom action and identification of new blood coagulation cascade acting enzymes of natural sources... - Differential expression of HINT1 in schizophrenia brain tissueJeeva Varadarajulu
Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 262:167-72. 2012..Our results combined to previous studies in human samples and preclinical models support the notion that HINT1 must be more explored as a potential target for psychiatric disorders... - Proteomic Technologies for Biomarker Studies in Psychiatry: Advances and needsDaniel Martins-de-Souza
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom Lab de Neurociências LIM 27, Inst Psiquiatria, Fac de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
Int Rev Neurobiol 101:65-94. 2011..The future development of such technologies may put proteomics closer to clinical applications in psychiatry... - The use of ASB-14 in combination with CHAPS is the best for solubilization of human brain proteins for two-dimensional gel electrophoresisDaniel Martins-de-Souza
Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, 13083 970 Campinas, SP, Brazil
Brief Funct Genomic Proteomic 6:70-5. 2007..Our results confirm that the most efficient solubilizing solution for 2-DE analysis of cytosolic and membrane Human Brain Proteins is SB combined with 4% CHAPS and 2% ASB-14... - Characterization of the C-terminal half of human juvenile myoclonic epilepsy protein EFHC1: dimer formation blocks Ca2+ and Mg2+ binding to its functional EF-handMarcelo J Murai
Department of Medical Genetics, Faculty of Medical Sciences, Tessalia Vieira de Camargo, 126, CEP 13083 970, University of Campinas, UNICAMP, Campinas, SP, Brazil
Arch Biochem Biophys 477:131-8. 2008..It was also found that under reducing condition Ca(2+) or Mg(2+) ions bind to EFHC1C in a 1/1 molar ratio, while under oxidizing condition this ratio is reduced, showing that EFHC1C dimerization blocks Ca(2+) and Mg(2+) binding... - Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolismAlana Knapman
Research Group of Psychoneuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
Eur J Neurosci 35:412-22. 2012..Thus, our results provide further support for the involvement of a dysregulated HPA axis and mitochondrial dysfunction in the etiology and pathophysiology of affective disorders... - Xylella fastidiosa disturbs nitrogen metabolism and causes a stress response in sweet orange Citrus sinensis cv. PeraRúbia P Purcino
Departamento de Fisiologia Vegetal, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, 13083 970, Campinas, SP, Brazil
J Exp Bot 58:2733-44. 2007..These results showed that significant changes take place in the nitrogen metabolism of DP, probably as a response to the alterations in the absorption, assimilation and distribution of N in the plant...