Hannelore Ehrenreich

Summary

Affiliation: Max Planck Institute for Experimental Medicine
Country: Germany

Publications

  1. ncbi Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients
    Hannelore Ehrenreich
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 17:1306-10. 2011
  2. ncbi Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    Kamilla W Miskowiak
    Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Trials 11:97. 2010
  3. ncbi Recombinant human erythropoietin in the treatment of acute ischemic stroke
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Stroke 40:e647-56. 2009
  4. ncbi Erythropoietin therapy for acute stroke is both safe and beneficial
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Departments of Neurology and Psychiatry, Georg August University, Goettingen, Germany
    Mol Med 8:495-505. 2002
  5. ncbi A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
    Hannelore Ehrenreich
    Max Planck Institute of Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 102:862-7. 2005
  6. ncbi Does disulfiram have a role in alcoholism treatment today? Not to forget about disulfiram's psychological effects
    Hannelore Ehrenreich
    Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str 3, , Germany
    Addiction 99:26-7; author reply 27-8. 2004
  7. ncbi Erythropoietin: novel approaches to neuroprotection in human brain disease
    Hannelore Ehrenreich
    Clinical Neuroscience Laboratory, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Metab Brain Dis 19:195-206. 2004
  8. ncbi A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Transfus Apher Sci 31:39-44. 2004
  9. ncbi Recombinant human erythropoietin in the treatment of human brain disease: focus on cognition
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Ren Nutr 18:146-53. 2008
  10. ncbi Medicine. A boost for translational neuroscience
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max-Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
    Science 305:184-5. 2004

Detail Information

Publications83

  1. ncbi Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients
    Hannelore Ehrenreich
    Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 17:1306-10. 2011
    ..To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke. In particular, reduction in the neuronal damage marker UCH-L1 may reflect neuroprotection by EPO...
  2. ncbi Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    Kamilla W Miskowiak
    Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Trials 11:97. 2010
    ..TRIAL REGISTRATION: The trial is approved by the Local Ethics Committee: H-C-2008-092, Danish Medicines Agency: 2612-4020, EudraCT: 2008-04857-14, Danish Data Agency: 2008-41-2711 and ClinicalTrials.gov: NCT 00916552...
  3. ncbi Recombinant human erythropoietin in the treatment of acute ischemic stroke
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Stroke 40:e647-56. 2009
    ..Accordingly, the double-blind, placebo-controlled, randomized German Multicenter EPO Stroke Trial (Phase II/III; ClinicalTrials.gov Identifier: NCT00604630) was designed to evaluate efficacy and safety of EPO in stroke...
  4. ncbi Erythropoietin therapy for acute stroke is both safe and beneficial
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Departments of Neurology and Psychiatry, Georg August University, Goettingen, Germany
    Mol Med 8:495-505. 2002
    ..EPO protects neurons from hypoxic/ ischemic injury. The objective of this trial is to study the safety and efficacy of recombinant human EPO (rhEPO) for treatment of ischemic stroke in man...
  5. ncbi A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
    Hannelore Ehrenreich
    Max Planck Institute of Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 102:862-7. 2005
    ..This effect is not only inhibited by EPO but also by neurotrophins. We suggest that the proapoptotic function of TPO helps to select for neurons that have acquired target-derived neurotrophic support...
  6. ncbi Does disulfiram have a role in alcoholism treatment today? Not to forget about disulfiram's psychological effects
    Hannelore Ehrenreich
    Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str 3, , Germany
    Addiction 99:26-7; author reply 27-8. 2004
  7. ncbi Erythropoietin: novel approaches to neuroprotection in human brain disease
    Hannelore Ehrenreich
    Clinical Neuroscience Laboratory, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Metab Brain Dis 19:195-206. 2004
    ....
  8. ncbi A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Transfus Apher Sci 31:39-44. 2004
    ..At the moment a multicenter study is being carried out in Germany...
  9. ncbi Recombinant human erythropoietin in the treatment of human brain disease: focus on cognition
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    J Ren Nutr 18:146-53. 2008
    ..These promising results are just the beginning and will hopefully stimulate further work along these lines...
  10. ncbi Medicine. A boost for translational neuroscience
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max-Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
    Science 305:184-5. 2004
  11. ncbi Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin
    H Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Psychiatry 12:206-20. 2007
    ..The fact that rhEPO is the first compound to exert a selective and lasting beneficial effect on cognition should encourage new treatment strategies for schizophrenia...
  12. ncbi Erythropoietin: a candidate compound for neuroprotection in schizophrenia
    H Ehrenreich
    Max Planck Institute for Experimental Medicine and Department of Psychiatry, Georg August University, Goettingen, Germany
    Mol Psychiatry 9:42-54. 2004
    ....
  13. ncbi Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice
    Derya Sargin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Biol 9:27. 2011
    ..However, the critical EPO targets in brain are unknown, and separation of direct and indirect effects has remained difficult, given the role of EPO in hematopoiesis and brain oxygen supply...
  14. ncbi Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms
    Martin Begemann
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Arch Gen Psychiatry 67:879-88. 2010
    ..In particular, the specific contribution of risk or candidate gene variants to the complex schizophrenic phenotype is largely unknown...
  15. ncbi Practice effects in healthy adults: a longitudinal study on frequent repetitive cognitive testing
    Claudia Bartels
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Neurosci 11:118. 2010
    ....
  16. ncbi Hypoxia inducible factor stabilization leads to lasting improvement of hippocampal memory in healthy mice
    Bartosz Adamcio
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Behav Brain Res 208:80-4. 2010
    ..FG-4497 application for 3 weeks leads to delayed but lasting enhancement of hippocampal memory, making HIF stabilization an attractive target for pharmacological manipulation of cognition...
  17. ncbi Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion
    Derya Sargin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Glia 57:693-702. 2009
    ..Although the detailed mechanisms remain to be defined, these profound EPO effects open new ways for prophylaxis and therapy of neuropsychiatric diseases, e.g. schizophrenia...
  18. ncbi Recovery of hippocampus-related functions in chronic alcoholics during monitored long-term abstinence
    Claudia Bartels
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine Hermann Rein Str 3, 37075 Gottingen, Germany
    Alcohol Alcohol 42:92-102. 2007
    ....
  19. ncbi Development of an outcome prediction measure for alcoholism therapy by multimodal monitoring of treatment processes
    Henning Krampe
    Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, 37075 Goettingen, Germany
    J Psychiatr Res 43:30-47. 2008
    ..001). The results suggest to validate the item combination described in the TOPPS in addiction therapy as a treatment guideline of individual relapse prevention strategies...
  20. ncbi Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain
    Magdalena M Brzózka
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Biol Psychiatry 68:33-40. 2010
    ..Tcf4 null mutant mice die perinatally, and haploinsufficiency of TCF4 in humans causes severe mental retardation...
  21. ncbi A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia
    Sabrina Grube
    Divison of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    EMBO Mol Med 3:309-19. 2011
    ..Reduction of SK3 function may constitute a pharmacological target to improve cognition in schizophrenia and other conditions with cognitive impairment...
  22. ncbi Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Arch Gen Psychiatry 68:1247-56. 2011
    ..Prediction of persons at risk for AUD is crucial for future preventive and therapeutic strategies...
  23. ncbi Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Georg August University, Gottingen, Germany
    Brain 130:2577-88. 2007
    ..There were no adverse events, no safety concerns and a surprisingly low need of blood-lettings. This first pilot study demonstrates the necessity and feasibility of controlled trials using high-dose rhEPO in chronic progressive MS...
  24. ncbi Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome
    Henning Krampe
    Department of Psychiatry and Psychotherapy, Georg-August-University, and Max-Planck-Institute of Experimental Medicine, Goettingen, Germany
    Alcohol Clin Exp Res 30:86-95. 2006
    ..Supervised, guided intake of AD, also over extended periods, can be used as a predominantly psychologically acting ingredient of successful alcoholism therapy...
  25. ncbi A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia
    Sergi Papiol
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:340-5. 2011
    ..The GRAS Data Collection as a prerequisite for PGAS has enabled us to associate protective NRG1 genotypes with later onset and milder course of schizophrenia...
  26. ncbi Erythropoietin enhances hippocampal long-term potentiation and memory
    Bartosz Adamcio
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Biol 6:37. 2008
    ..We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of how EPO influences cognition, and how it may act on hippocampal neurons to modulate plasticity...
  27. ncbi Endothelin B receptor deficiency augments neuronal damage upon exposure to hypoxia-ischemia in vivo
    ANNA LEENA SIREN
    Department of Neurology, Georg August University, and Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Brain Res 945:144-9. 2002
    ..n=5, P=0.0560). To conclude, absence of functional ETB receptors is associated with an increased susceptibility to HI in-vivo, which is not intrinsic to neurons. Antagonism of ETB receptors seems not to be desirable in ischemic stroke...
  28. ncbi Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: a neuroprotective substitution effect?
    Christian Unzicker
    Division of Clinical Neuroscience, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Neurochem Res 30:1305-9. 2005
    ..We suggest that CB1-receptor upregulation in the ETB-mutant hippocampus reflects an attempt to compensate for the lack of ETB-receptors...
  29. ncbi Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches
    Martin Begemann
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 14:546-52. 2008
    ..This case suggests that rapid cycling is a systemic disease, resembling hibernation, with prostaglandins playing a mediator role...
  30. ncbi Erythropoietin augments survival of glioma cells after radiation and temozolomide
    Imam Hassouna
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Int J Radiat Oncol Biol Phys 72:927-34. 2008
    ..For prophylactic neuroprotection, erythropoietin (EPO) is a promising candidate, provided that concerns regarding potential tumor promoting effects are alleviated...
  31. ncbi Expression patterns of erythropoietin and its receptor in the developing spinal cord and dorsal root ganglia
    Wolfgang Knabe
    Department of Anatomy Embryology, Georg August University Gottingen, Kreuzbergring 36, 37075 Gottingen, Germany
    Anat Embryol (Berl) 210:209-19. 2005
    ....
  32. ncbi The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Psychiatry 10:91. 2010
    ..This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia...
  33. ncbi Erythropoietin improves operant conditioning and stability of cognitive performance in mice
    Ahmed El-Kordi
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    BMC Biol 7:37. 2009
    ..This procedure allows the study of the effects of erythropoietin on discrete processes of learning and attention in a sequential fashion...
  34. ncbi Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics
    Martin Hasselblatt
    Division of Clinical Neuroscience, Max-Planck-Institute of Experimental Medicine, , Germany
    Alcohol Alcohol 41:372-8. 2006
    ..The common denominator of many of these changes may be an acquired irreversible deficiency in cellular energy regulation...
  35. ncbi Cell type specific signalling by hematopoietic growth factors in neural cells
    Nadiya Byts
    Division of Clinical Neuroscience, Max-Planck-Institute of Experimental Medicine, Hermann-Rein-Str. 3, , D-37075, Germany
    Neurochem Res 31:1219-30. 2006
    ..This effect was accompanied by activation of ERK1/2 and inhibition of STAT3 activity. A balance between growth factors, their receptors and signalling proteins may play an important role in regulation of neural cell survival...
  36. ncbi The approximate planimetric method: a simple, rapid and reliable method for estimation of lesion size in acute ischemic stroke
    Martin Hasselblatt
    Department of Neurology and Psychiatry, Georg August University, , Germany
    Neuroradiology 45:164-5. 2003
    ..966, FLAIR: r = 0.979, p < 0.001). To conclude, the APM is simple, rapid and reliable for the estimation of lesion size in acute ischemic stroke. It can be recommended for broader application in clinical trials...
  37. ncbi In vitro gender differences in neuronal survival on hypoxia and in 17beta-estradiol-mediated neuroprotection
    Andrea Heyer
    Max-Planck-Institute for Experimental Medicine, , Germany
    J Cereb Blood Flow Metab 25:427-30. 2005
    ..Estrogens, acting via membrane receptors, had a higher neuroprotective power in male neurons, explained at least in part by the pronounced increase in estrogen receptor beta/alpha ratio during hypoxia in male cells only...
  38. ncbi Callosal dysfunction in amyotrophic lateral sclerosis correlates with diffusion tensor imaging of the central motor system
    Claudia Bartels
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Neuromuscul Disord 18:398-407. 2008
    ..The Contralateral Co-Movement Test delivers simple means of symptom quantification, independent of ALS Functional Rating Scale, for future neuroprotective trials...
  39. ncbi Therapist rotation--a new element in the outpatient treatment of alcoholism
    Henning Krampe
    Department of Psychiatry, Georg-August-University, Max-Planck-Institute for Experimental Medicine, , Germany
    Subst Use Misuse 39:135-78. 2004
    ..Finally, the implementation of therapist rotation into OLITA is described, including the theoretical background of the program itself and the treatment procedure. New areas of application for the therapist rotation are discussed...
  40. ncbi Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4
    Kerstin Reim
    Department of Molecular Neurobiology and Center for the Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Sci 122:1352-61. 2009
    ....
  41. ncbi Reduced oxidative damage in ALS by high-dose enteral melatonin treatment
    Jochen H Weishaupt
    Department of Neurology, Georg August University, , Germany
    J Pineal Res 41:313-23. 2006
    ..This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS...
  42. ncbi Outpatient Long-term Intensive Therapy for Alcoholics (OLITA): a successful biopsychosocial approach to the treatment of alcoholism
    Henning Krampe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Dialogues Clin Neurosci 9:399-412. 2007
    ..Thus, process-outcome research on OLITA can serve for the development of new therapeutic guidelines on adapting individual relapse prevention strategies...
  43. ncbi Expression patterns of erythropoietin and its receptor in the developing midbrain
    W Knabe
    Department of Anatomy and Embryology, Georg August University, 37075 Gottingen, Germany
    Anat Embryol (Berl) 207:503-12. 2004
    ..Whether the observed expression patterns of EPO and EPOR may reflect EPO-mediated trophic and/or antiapoptotic effects on neurons is discussed...
  44. ncbi Chronic psychosocial stress in the absence of social support induces pathological pre-pulse inhibition in mice
    Bartosz Adamcio
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Street 3, 37075 Gottingen, Germany
    Behav Brain Res 204:246-9. 2009
    ..Thus, social support in situations of severe psychosocial stress may prevent lasting impairment in basic information processing...
  45. ncbi Erythropoietin--a novel concept for neuroprotection
    A L Siren
    Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 251:179-84. 2001
    ....
  46. ncbi Differential glial and vascular expression of endothelins and their receptors in rat brain after neurotrauma
    A L Siren
    Department of Psychiatry, Georg August University, and Max Planck Institute for Experimental Medicine, Goettingen, Germany
    Neurochem Res 25:957-69. 2000
    ..These changes seem to be posttranscriptional and cell type specific. They favor vasoconstriction increasing the risk of late vasospasm and ischemia...
  47. ncbi Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain
    A L Siren
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Acta Neuropathol 101:271-6. 2001
    ....
  48. ncbi Erythropoietin as neuroprotective and neuroregenerative treatment strategy: comprehensive overview of 12 years of preclinical and clinical research
    Derya Sargin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, 37075 Gottingen, Germany
    Best Pract Res Clin Anaesthesiol 24:573-94. 2010
    ....
  49. ncbi The influence of personality factors on disease progression and health-related quality of life in people with ALS
    Henning Krampe
    Max Planck Institute of Experimental Medicine, Division of Clinical Neuroscience, Goettingen, Germany
    Amyotroph Lateral Scler 9:99-107. 2008
    ..These findings suggest that being less agreeable might serve as a protective factor with respect to QOL and disease progression in ALS...
  50. ncbi Role of the astrocytic ET(B) receptor in the regulation of extracellular endothelin-1 during hypoxia
    M Hasselblatt
    Department of Neurology, Georg-August-University, , Germany
    Glia 34:18-26. 2001
    ..This stimulation is (over)compensated for by increased ET-1 binding to functional ET(B) receptors. ET(B) deficiency, whether genetic or experimentally induced, impairs elimination of extracellular ET-1...
  51. ncbi Endothelin converting enzyme activity in primary rat astrocytes is modulated by endothelin B receptors
    H Ehrenreich
    Departments of Neurology, Georg August University, Gottingen, Germany
    Biochem Biophys Res Commun 261:149-55. 1999
    ..ECE-1 from sl/sl revealed a glycosylation pattern different from +/+ astrocytes. In conclusion, the ET(B) receptor may, via ECE-1 glycosylation, exert a negative feedback on ECE activity in the astrocytic endothelin system...
  52. ncbi Stromal endothelin B receptor-deficiency inhibits breast cancer growth and metastasis
    Claudia Binder
    Department of Hematology Oncology, Georg August University, D 37099 Goettingen, Germany
    Mol Cancer Ther 8:2452-60. 2009
    ..This shows that tumor growth and metastasis are critically dependent on ET(B)R function in cells of the microenvironment and suggests that successful ETR antagonist therapy should also target the stromal component of ET signaling..
  53. ncbi Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism
    Stephane Jamain
    Abteilung Molekulare Neurobiologie and Division für Klinische Neurowissenschaften, Max Planck Institut fur experimentelle Medizin, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 105:1710-5. 2008
    ....
  54. ncbi Recombinant Human Erythropoietin: Novel Strategies for Neuroprotective/Neuro-regenerative Treatment of Multiple Sclerosis
    Claudia Bartels
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Ther Adv Neurol Disord 1:193-206. 2008
    ..An exploratory study on chronic progressive MS yielded lasting improvement in motor and cognitive performance upon high-dose long-term EPO treatment...
  55. ncbi Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
    ..Thus, NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ErbB-independent mechanism of myelination control...
  56. ncbi Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    A L Siren
    Max Planck Institute for Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 98:4044-9. 2001
    ..The neurotrophic actions suggest there may be longer-latency effects as well. Evaluation of EPO, a compound established as clinically safe, as neuroprotective therapy in acute brain injury is further supported...
  57. ncbi Supervised disulfiram in the treatment of alcohol use disorder: a commentary
    Henning Krampe
    From the Department of Anaesthesiology and Intensive Care Medicine HK, CDS, Charite Universitatsmedizin Berlin, Berlin, Germany and Division of Clinical Neuroscience HE, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Alcohol Clin Exp Res 35:1732-6. 2011
    ..Future randomized controlled trials are needed that investigate psychological actions and long-term outcomes of this alcohol deterrent...
  58. ncbi Mechanisms of disease: inherited demyelinating neuropathies--from basic to clinical research
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Nat Clin Pract Neurol 3:453-64. 2007
    ..Transgenic animal models have become essential for dissecting CMT disease mechanisms and exploring novel therapies...
  59. ncbi Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis
    M B Sättler
    Neurologische Universitatsklinik, Robert Koch Str 40, 37075 Gottingen, Germany
    Cell Death Differ 11:S181-92. 2004
    ..We conclude that in MOG-EAE the PI3-K/Akt pathway has an important influence on RGC survival under systemic treatment with Epo...
  60. ncbi Endothelin b receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus
    H Ehrenreich
    Max Planck Institute for Experimental Medicine and Department of Neurology, Gottingen, Germany
    Neuroscience 95:993-1001. 2000
    ..In conclusion, endothelin B receptors appear to act as neuronal survival factors in the dentate gyrus in rodents and man, both during postnatal development and under pathological conditions...
  61. ncbi Effects of cerebrovascular challenges on plasma endothelin
    Wolfgang Jordan
    Psychiatrische Klinik, Department of Psychiatry and Psychotherapy, University of Gottingen, von Sieboldstr 5, 37075, Gottingen, Germany
    Neurosci Res 43:127-34. 2002
    ..No alterations in plasma ET-1 levels were found upon any of the cerebrovascular stimuli. We conclude that massive cerebrovascular challenges in healthy individuals do not lead to high circulating ET-1 levels...
  62. ncbi Endothelin-1 concentration in plasma is increased after jogging but decreased after cycling in healthy men
    P Lewczuk
    Departments of Neurology and Psychiatry, Georg-August-University, and Max-Planck-Institute for Experimental Medicine, Goettingen, Germany
    Clin Exp Med 2:166-70. 2003
    ..In contrast, similarly enhanced lung perfusion together with a relatively lower stimulation of endothelin-1 compared with jogging, may explain the net decrease in plasma after cycling...
  63. ncbi Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia
    K Radyushkin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Genes Brain Behav 9:592-602. 2010
    ..These findings provide suggestive evidence for the 'second hit' hypothesis of schizophrenia and may offer new tools for the development of advanced treatment strategies...
  64. ncbi The brain erythropoietin system and its potential for therapeutic exploitation in brain disease
    Martin Hasselblatt
    Institute of Neuropathology, , , Germany
    J Neurosurg Anesthesiol 18:132-8. 2006
    ..The safety profile and effectiveness of EPO in a wide variety of neurologic disease models make EPO a candidate compound for a potential first-line therapeutic for neurologic emergencies...
  65. ncbi Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients
    Sonja Jacob
    J Pineal Res 33:186-7. 2002
  66. ncbi Erythropoietin in the cerebrospinal fluid in neurodegenerative diseases
    Johannes Brettschneider
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neurosci Lett 404:347-51. 2006
    ..This may be due to a relative deficiency of endogenous CNS EPO in these conditions and/or to a more efficient extraction of free EPO molecules from brain intercellular fluid by increased numbers of EPOR...
  67. ncbi Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells
    Jochen H Weishaupt
    Department of Neurology, , , Germany
    Invest Ophthalmol Vis Sci 45:1514-22. 2004
    ....
  68. ncbi Personality disorder and chronicity of addiction as independent outcome predictors in alcoholism treatment
    Henning Krampe
    Division of Clinical Neuroscience at the Max-Planck-Institute of Experimental Medicine in Goettingen, Germany
    Psychiatr Serv 57:708-12. 2006
    ..CONCLUSIONS: Their high predictive values suggest that chronicity and personality disorder rank among the most important characteristics of addiction severity...
  69. ncbi ETB receptor deficiency causes salt-sensitive hypertension
    Berthold Hocher
    J Mol Med 80:747-9; author reply 750-2. 2002
  70. ncbi Preserved vasopressin response to osmostimulation despite decreased basal vasopressin levels in long-term abstinent alcoholics
    Henriette Jahn
    Department of Psychiatry and Psychotherapy, Georg-August University, and Max-Planck Institute for Experimental Medicine, Hermann-Rein Str. 3, , Germany
    Alcohol Clin Exp Res 28:1925-30. 2004
    ..This finding indicates a peripheral suppression of AVP levels that is most likely due to a regulatory set-point shift toward hypotonic hyperhydration, rather than to a reduced central capacity of AVP secretion...
  71. ncbi Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling
    Anatoly Samoylenko
    University of Wurzburg, Section of Experimental Neurosurgery, Department of Neurosurgery, Josef Schneider St 11, 97080 Wurzburg, Germany
    Cell Signal 20:154-62. 2008
    ..Our data indicate that TPO via activation of its receptor-bound JAK2 delays the NGF-dependent acquisition of neuronal phenotype and decreases neuronal survival by suppressing NGF-induced ERK activity...
  72. ncbi Persistent disturbance of the hypothalamic-pituitary-gonadal axis in abstinent alcoholic men
    Martin Hasselblatt
    Department of Psychiatry, Georg-August-University, and Max-Planck-Institute for Experimental Medicine, , Germany
    Alcohol Alcohol 38:239-42. 2003
    ....
  73. ncbi Soccer, neurotrauma and amyotrophic lateral sclerosis: is there a connection?
    Ornella Piazza
    Max-Planck-Institute for Experimental Medicine Goettingen, Germany
    Curr Med Res Opin 20:505-8. 2004
    ..To further clarify this issue, extensive prospective epidemiological investigations on ALS following neurotrauma as well as carefully designed animal studies will have to be conducted...
  74. ncbi Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients
    Claudia D Spies
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, 10098 Berlin, Germany
    Anesthesiology 100:1088-100. 2004
    ..The aim of this study was to evaluate perioperative T cell-mediated immune parameters as well as cytokine release from whole blood cells after lipopolysaccharide stimulation and its association with postoperative infections...
  75. ncbi [Oral condition of abstaining alcoholics. A case-control study]
    Else Hornecker
    Abt. Zahnerhaltung, , Zentrum Zahn, Mund- und Kieferheilkunde, ,
    Schweiz Monatsschr Zahnmed 113:1281-8. 2003
    ..They also support the assumption that excessive consumption of alcohol may promote the progression of chronic periodontal disease...
  76. ncbi Pre-embedding immunogold labeling of TUNEL stain enables evaluation of DNA strand breaks and ultrastructural alterations in individual cells of neuronal tissue
    Martin Barth
    Department of Neurosurgery, Division of Neurosurgical Research, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Acta Neuropathol 104:621-36. 2002
    ..These results suggest that under pathological conditions apoptosis and necrosis are not mutually exclusive mechanisms but rather may occur concurrently along a continuum in which cell death occurs...
  77. ncbi Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis
    Ricarda Diem
    Neurologische Universitatsklinik, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Brain 128:375-85. 2005
    ..In contrast, isolated neuronal or axonal protection without clinical benefit was achieved under monotherapy with erythropoietin or methylprednisolone, respectively...
  78. ncbi Brain derived proteins as markers of acute stroke: their relation to pathophysiology, outcome prediction and neuroprotective drug monitoring
    Manfred Herrmann
    Center for Advanced Imaging and Department of Neuropsychology and Behavioral Neurobiology, Bremen University, Germany
    Restor Neurol Neurosci 21:177-90. 2003
    ..Neurone-specific enolase (NSE), protein S100B and glial fibrillary acidic protein (GFAP) are those proteins investigated most often as peripheral surrogate markers of brain damage after stroke in humans...
  79. ncbi A pilot study on the oral conditions of severely alcohol addicted persons
    Else Hornecker
    Division of Periodontology in the Department of Operative Dentistry, Preventive Dentistry and Periodontology at the University of Goettingen, Germany
    J Contemp Dent Pract 4:51-9. 2003
    ..Our results indicate severe alcoholics have a high risk of periodontal break down and tooth loss. To what extent these findings were caused by general/oral neglect alone (in combination with nicotine abuse) is at present unknown...
  80. ncbi Substantial decrease of psychiatric comorbidity in chronic alcoholics upon integrated outpatient treatment - results of a prospective study
    Thilo Wagner
    Department of Psychiatry and Psychotherapy, Georg-August-University, and Max-Planck-Institute for Experimental Medicine, , Germany
    J Psychiatr Res 38:619-35. 2004
    ..The presence of an Axis II rather than an Axis I disorder on admission strongly predicts drinking outcome over a four-year follow-up...
  81. ncbi Effect of endothelin-1 on astrocytic protein content
    Martin Hasselblatt
    , , Germany
    Glia 42:390-7. 2003
    ..This hypertrophic response involves uncoupling of the astrocytic gap junctional network and is not dependent on DNA synthesis...