Adrian W Briggs

Summary

Affiliation: Max Planck Institute for Evolutionary Anthropology
Country: Germany

Publications

  1. ncbi Patterns of damage in genomic DNA sequences from a Neandertal
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 104:14616-21. 2007
  2. ncbi Targeted retrieval and analysis of five Neandertal mtDNA genomes
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 325:318-21. 2009
  3. ncbi Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e87. 2010
  4. ncbi Targeted investigation of the Neandertal genome by array-based sequence capture
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:723-5. 2010
  5. ncbi A draft sequence of the Neandertal genome
    Richard E Green
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:710-22. 2010
  6. ncbi The Neandertal genome and ancient DNA authenticity
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    EMBO J 28:2494-502. 2009
  7. ncbi A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Cell 134:416-26. 2008
  8. ncbi A complete mtDNA genome of an early modern human from Kostenki, Russia
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 20:231-6. 2010
  9. ncbi Road blocks on paleogenomes--polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA
    Patricia Heyn
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e161. 2010
  10. ncbi From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 36:e5. 2008

Detail Information

Publications12

  1. ncbi Patterns of damage in genomic DNA sequences from a Neandertal
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 104:14616-21. 2007
    ..The results suggest that reliable genome sequences can be obtained from Pleistocene organisms...
  2. ncbi Targeted retrieval and analysis of five Neandertal mtDNA genomes
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 325:318-21. 2009
    ..Together with analyses of mtDNA protein evolution, these data suggest that the long-term effective population size of Neandertals was smaller than that of modern humans and extant great apes...
  3. ncbi Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e87. 2010
    ..In addition, our results demonstrate that Neandertal DNA retains in vivo patterns of CpG methylation, potentially allowing future studies of gene inactivation and imprinting in ancient organisms...
  4. ncbi Targeted investigation of the Neandertal genome by array-based sequence capture
    Hernán A Burbano
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:723-5. 2010
    ..By generating the sequence of one Neandertal and 50 present-day humans at these positions, we have identified 88 amino acid substitutions that have become fixed in humans since our divergence from the Neandertals...
  5. ncbi A draft sequence of the Neandertal genome
    Richard E Green
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:710-22. 2010
    ....
  6. ncbi The Neandertal genome and ancient DNA authenticity
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    EMBO J 28:2494-502. 2009
    ..For analyses of other fossil hominins, which may become possible in the future, we suggest a similar 'boot-strap' approach in which interim approaches are applied until sufficient data for more definitive direct assays are acquired...
  7. ncbi A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Cell 134:416-26. 2008
    ..There is evidence that purifying selection in the Neandertal mtDNA was reduced compared with other primate lineages, suggesting that the effective population size of Neandertals was small...
  8. ncbi A complete mtDNA genome of an early modern human from Kostenki, Russia
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 20:231-6. 2010
    ..We use these features to determine a complete mtDNA sequence from a approximately 30,000-year-old EMH from the Kostenki 14 site in Russia...
  9. ncbi Road blocks on paleogenomes--polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA
    Patricia Heyn
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 38:e161. 2010
    ....
  10. ncbi From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing
    Matthias Meyer
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nucleic Acids Res 36:e5. 2008
    ..The method should also apply to Illumina/Solexa and ABI/SOLiD sequencing, and should therefore help to widen the accessibility of all three platforms...
  11. ncbi Analysis of one million base pairs of Neanderthal DNA
    Richard E Green
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Nature 444:330-6. 2006
    ..Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort...
  12. ncbi Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary
    Johannes Krause
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    BMC Evol Biol 8:220. 2008
    ..Widely divergent topologies have been suggested based on various data sets and methods...