Research Topics
Genomes and GenesSpecies | F WinauSummaryAffiliation: Max-Planck-Institute for Infection Biology Country: Germany Publications
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Detail Information
Publications
Emil von Behring and serum therapyFlorian Winau
Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrabetae 21 22, 10117, Berlin, Germany
Microbes Infect 4:185-8. 2002..We present an overview of the development of this important tool in the treatment of diphtheria. In a historical context Behring's work reflects the scientific spirit of fin de siècle Berlin...
Starring stellate cells in liver immunologyFlorian Winau
Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, 10117 Berlin, Germany
Curr Opin Immunol 20:68-74. 2008..Finally, future studies will show whether in the firmament of immunology stellate cells will represent fixed or falling stars...
Ito cells are liver-resident antigen-presenting cells for activating T cell responsesFlorian Winau
Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
Immunity 26:117-29. 2007....
Paul Ehrlich--in search of the magic bulletFlorian Winau
Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
Microbes Infect 6:786-9. 2004..Paul Ehrlich can be perceived as a man whose success was not the consequence of a will to power, but of his substantial interest in science...
No life without death--apoptosis as prerequisite for T cell activationF Winau
Max Planck Institute for Infection Biology, Department of Immunology, Schumannstr 21 22, D 10117 Berlin, Germany
Apoptosis 10:707-15. 2005....
Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosisFlorian Winau
Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
Immunity 24:105-17. 2006..tuberculosis infection. Taken together, we propose the detour pathway to represent a genuine immunological mechanism mediating crosspriming of CD8 T cells in vivo and protection against tuberculosis...
Saposin C is required for lipid presentation by human CD1bFlorian Winau
Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
Nat Immunol 5:169-74. 2004..We propose a model in which SAP-C exposes lipid antigens from intralysosomal membranes for loading onto CD1b. Thus, SAP-C represents a missing link in antigen presentation of lipids through CD1b to human T cells...
From bacteriology to immunology: the dualism of specificityStefan H E Kaufmann
Max-Planck-Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany
Nat Immunol 6:1063-6. 2005
Apoptosis paves the detour path for CD8 T cell activation against intracellular bacteriaFlorian Winau
Max-Planck-Institute for Infection Biology, Department of Immunology, Schumannstr. 21-22, D-10117 Berlin, Germany
Cell Microbiol 6:599-607. 2004..This important new function of cell death in antibacterial immunity requires consideration for rational vaccine design...
Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosisUlrich E Schaible
Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
Nat Med 9:1039-46. 2003....
Viral danger signals control CD1d de novo synthesis and NKT cell activationMartin J Raftery
Institute of Virology, Charite Universitatsmedizin Berlin, Berlin, Germany
Eur J Immunol 38:668-79. 2008..In conclusion, our data indicate that viral danger signals trigger NKT cell activation by enhancing CD1d de novo synthesis through increasing the abundance of CD1D mRNA in human myeloid DC...
Inhibition of CD1 antigen presentation by human cytomegalovirusMartin J Raftery
Institute of Virology, Charite Medical School, Chariteplatz 1, D 10117 Berlin, Germany
J Virol 82:4308-19. 2008..HCMV present in antigen-presenting cells thus blunts the immune response by the blockage of CD1 molecules...
Cholesterol glucosylation promotes immune evasion by Helicobacter pyloriChristian Wunder
Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany
Nat Med 12:1030-8. 2006..Thus, we propose a mechanism regulating the host-pathogen interaction whereby glucosylation of a lipid tips the scales towards immune evasion or response...
CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasionMartin J Raftery
Institute of Virology, , Humboldt University Berlin, Schumannstrasse 20/21, D-10117 Berlin, Germany
J Immunol 177:6207-14. 2006..Thus, we demonstrate both the existence of a CD1 pathway allowing human DC to react to viral infection, as well as its blockage by a human herpesvirus...
Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defenseThomas Kolter
, D-53121 Bonn, Germany
J Biol Chem 280:41125-8. 2005
