Research Topics
Genomes and Genes | Edgar MeinlSummaryAffiliation: Max-Planck-Institute of Neurobiology Country: Germany Publications
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Publications
Concepts of viral pathogenesis of multiple sclerosisE Meinl
Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Germany
Curr Opin Neurol 12:303-7. 1999..If human herpesvirus-6 does play a role as an initiator or amplifier of inflammatory lesions in some multiple sclerosis patients, these individuals might benefit from antiviral therapy...- Humoral autoimmunity in multiple sclerosisEdgar Meinl
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
J Neurol Sci 306:180-2. 2011..Testing the functional relevance of such an autoimmune response in animal models revealed that antibodies to neurofascin may induce axonal injury and that T cells specific for contactin-2/TAG-1 mediate preferentially gray matter injury... - Compartmentalization of inflammation in the CNS: a major mechanism driving progressive multiple sclerosisEdgar Meinl
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
J Neurol Sci 274:42-4. 2008.... - B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulationEdgar Meinl
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Munich, Germany
Ann Neurol 59:880-92. 2006..Finally, we outline the possibly double-edged effects of B cells and immunoglobulin in the CNS and discuss various therapeutic strategies for targeting the B-cell response... - Differential requirement of ZAP-70 for CD2-mediated activation pathways of mature human T cellsE Meinl
Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Germany
J Immunol 165:3578-83. 2000..Deletion of ZAP-70 affected CD2- and CD3-mediated proliferation and cytokine production in a similar way, suggesting that one of the different CD2 pathways converges with a CD3 pathway at or upstream of the activation of ZAP-70... - T cell transformation with Herpesvirus saimiri: a tool for neuroimmunological researchE Meinl
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
J Neuroimmunol 103:1-7. 2000..In contrast, H. saimiri-transformed T cells are activated by a single crosslinked anti-CD2 mAb and also by interaction with CD58-bearing cells... - Herpesvirus saimiri replaces ZAP-70 for CD3- and CD2-mediated T cell activationE Meinl
Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
J Biol Chem 276:36902-8. 2001..In conclusion, wild type H. saimiri can restore CD2- and CD3-mediated activation in signaling-deficient human T cells. It extends our understanding of interactions between the oncogenic H. saimiri and the infected host cells... - Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitmentMarkus Krumbholz
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
Brain 129:200-11. 2006..Therefore, both CXCL13 and CXCR5 may be promising therapeutic targets in multiple sclerosis... - Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cellsHema Mohan
Institute for Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany
Brain Pathol 20:966-75. 2010..Induced fibrillar collagens may contribute to limiting enlargement of MS lesions by inhibiting the production of CCL2 by monocytes... - Preferential expression and function of Toll-like receptor 3 in human astrocytesCinthia Farina
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
J Neuroimmunol 159:12-9. 2005..These data indicate that astrocytes function as sentinels for viral infections in the CNS... - Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cellsVivian Vargas-Leal
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
J Immunol 175:2301-8. 2005..Together, this suggests that immune cells communicate with each other via NTN. Production of NTN by immune cells might also contribute to the neuroprotective immunity in the CNS observed in different model systems... - MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47Andreas Junker
Institute for Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany
Brain 132:3342-52. 2009..This mechanism may have broad implications for microRNA-regulated macrophage activation in inflammatory diseases... - BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphomaMarkus Krumbholz
Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, D-82152 Martinsried, Germany
J Exp Med 201:195-200. 2005..This paper identifies astrocytes as a nonimmune source of BAFF. CNS-produced BAFF may support B cell survival in inflammatory diseases and primary B cell lymphoma... - Novel approaches for identifying target antigens of autoreactive human B and T cellsKlaus Dornmair
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152, Martinsried, Germany
Semin Immunopathol 31:467-77. 2009..The first method detects Ig antigens directly, whereas the latter two methods allow reconstruction of Ig molecules, which can be used for antigen searches... - Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal gangliaTobias Derfuss
Institute of Clinical Neuroimmunology, University Clinic, Munich, Germany
Brain Pathol 17:389-98. 2007..Thus, HSV-1 IE genes are expressed in human TG and the infiltrating T-cells bear several characteristics that suggest viral antigenic stimulation... - Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B-cell responseTobias Derfuss
Dept. of Neuroimmunology, Max-Planck-Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
J Neurol 252:968-71. 2005..In the other 20% the intrathecal Ig production to HHV-6 might reflect reactivation of HHV-6 or could be part of a polyspecific B cell activation... - B- and T-cell responses in multiple sclerosis: novel approaches offer new insightsReinhard Hohlfeld
Department of Neuroimmunology, Max Planck Institute for Neurobiology, Am Klopferspitz, D 82152 Martinsried, Germany
J Neurol Sci 274:5-8. 2008.... - Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animalsTobias Derfuss
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
Proc Natl Acad Sci U S A 106:8302-7. 2009..This study identifies contactin-2 as an autoantigen targeted by T cells and autoantibodies in MS. Our findings suggest that a contactin-2-specific T-cell response contributes to the development of gray matter pathology... - Glatiramer acetate in multiple sclerosis: update on potential mechanisms of actionCinthia Farina
Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, Martinsried, Germany
Lancet Neurol 4:567-75. 2005..Finally, we will think about how a better understanding of glatiramer acetate might help the development of new immunomodulatory agents for MS... - Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivoMartin S Weber
Institute for Clinical Neuroimmunology, Marchioninistrasse 15, D 81377 Munich, Germany
Brain 127:1370-8. 2004..These results demonstrate for the first time that GA inhibits monocyte reactivity in vitro and in vivo, significantly extending the current concept of the mechanism of action of GA... - Distinct responses of monocytes to Toll-like receptor ligands and inflammatory cytokinesCinthia Farina
Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, D-82152 Martinsried, Germany
Int Immunol 16:799-809. 2004..SLAM+ monocytes and macrophages were identified for the first time in vivo. Their presence might be a sign of innate immune activation... - BAFF is elevated in serum of patients with Wegener's granulomatosisMarkus Krumbholz
Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
J Autoimmun 25:298-302. 2005..We propose that BAFF might be a pathogenic factor in WG and that targeting BAFF may represent a new therapeutic strategy in a subset of chronically relapsing WG patients with elevated BAFF levels... - Latent herpesvirus infection in human trigeminal ganglia causes chronic immune responseDiethilde Theil
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Am J Pathol 163:2179-84. 2003..The chronic immune response seems to maintain viral latency and influence viral reactivation... - Dual role of inflammation in CNS diseaseReinhard Hohlfeld
Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
Neurology 68:S58-63; discussion S91-6. 2007..This might explain why inflammatory reactions may contribute to both injury and protection of neurons. The dual role of CNS inflammation also has important therapeutic implications that are only beginning to be explored... - Antibodies to MOG are transient in childhood acute disseminated encephalomyelitisA K Pröbstel
Max Planck Institute of Neurobiology, Department of Neuroimmunology, Martinsried, Germany
Neurology 77:580-8. 2011..To study the longitudinal dynamics of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in childhood demyelinating diseases... - Multiple sclerosis: T-cell receptor expression in distinct brain regionsAndreas Junker
Institute for Clinical Neuroimmunology, Ludwig Maximilians University, D 81377 Munich, Germany
Brain 130:2789-99. 2007..These experiments revealed that at least some of the pervasive T-cell clones belonged to the CD8+ compartment, supporting the pathogenic relevance of this T-cell subset... - Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoterSabine Kirchhoff
Tumor Immunology Program, Tumorvirus-Immunology, German Cancer Research Center, D-16920 Heidelberg, Germany
J Immunol 168:1226-34. 2002..Thus, these results demonstrate an important mechanism of HHV8 to modulate the immune response by down-regulation of CD95L expression. Inhibition of CD95-dependent T cell function might contribute to the immune escape of HHV8... - BDNF and its receptors in human myasthenic thymus: implications for cell fate in thymic pathologyAngela Berzi
Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy
J Neuroimmunol 197:128-39. 2008..In thymomas both BDNF production and receptor expression in TEC were strongly hindered. This may represent an attempt of tumour escape from cell death... - Neurofascin as a novel target for autoantibody-mediated axonal injuryEmily K Mathey
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
J Exp Med 204:2363-72. 2007..Collectively, these results identify a novel mechanism of immune-mediated axonal injury that can contribute to axonal pathology in MS... - Astrocytes are active players in cerebral innate immunityCinthia Farina
Neuroimmunology and Neuromuscular Disorders Unit, National Neurological Institute Carlo Besta, 20133 Milan, Italy
Trends Immunol 28:138-45. 2007..The role of astrocytes in inflammation and tissue repair is elaborated by recent in vivo studies employing cell-type specific gene targeting...