Research Topics
Species | Peter HemmerichSummaryAffiliation: Leibniz Institute for Age Research Country: Germany Publications
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Detail Information
Publications
Assembly dynamics of PML nuclear bodies in living cellsPeter Brand
Leibniz Institute of Age Research, Fritz Lipman Institute, Beutenbergstr, 11, 07745 Jena, Germany
PMC Biophys 3:3. 2010..MCS code: 92C37...
DNA damage-induced translocation of S100A11 into the nucleus regulates cell proliferationTheresa Gorsler
Institute of Human Genetics and Anthropology, University Hospital Jena, Germany
BMC Cell Biol 11:100. 2010..To gain further insight into the underlying mechanism subcellular trafficking of S100A11 in response to DNA damage was analyzed...
Dynamic as well as stable protein interactions contribute to genome function and maintenancePeter Hemmerich
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstr 11, 07745, Jena, Germany
Chromosome Res 19:131-51. 2011..Our new "induced stability" model suggests that self-organization, self-assembly, and assisted assembly contribute to nuclear architecture and function...
Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-BDaniela Hellwig
Leibniz Institute for Age Research Fritz Lipmann Institute, Dept of Molecular Biology, Beutenbergstr 11, D 07745 Jena, Germany
J Biophotonics 1:245-54. 2008..These properties make CENP-T one of the basic inner kinetochore proteins with most further proteins binding downstream, suggesting a fundamental role of CENP-T in kinetochore function...
Dynamics of inner kinetochore assembly and maintenance in living cellsPeter Hemmerich
Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany i leibniz de
J Cell Biol 180:1101-14. 2008..Our data reveal a wide range of cell cycle-specific assembly plasticity of the centromere that provides both stability through sustained binding of some components and flexibility through dynamic exchange of other components...
Dynamics of component exchange at PML nuclear bodiesStefanie Weidtkamp-Peters
Leibniz Institute of Age Research, Fritz Lipman Institute, Beutenbergstr 11, 07745 Jena, Germany
J Cell Sci 121:2731-43. 2008..These findings provide a kinetics model for factor exchange at PML NBs and highlight potential mechanisms to regulate intranuclear trafficking of specific factors at these domains...
Fluorescence correlation spectroscopy to assess the mobility of nuclear proteinsStefanie Weidtkamp-Peters
Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany
Methods Mol Biol 464:321-41. 2009..Here we describe how FCS can be applied to retrieve biophysical parameters of nuclear proteins in living cells...
Replication of centromeric heterochromatin in mouse fibroblasts takes place in early, middle, and late S phaseStefanie Weidtkamp-Peters
Institute of Molecular Biotechnology, Beutenbergstr. 11, 07745, Jena, Germany
Histochem Cell Biol 125:91-102. 2006..Thus, in contrast to expectation, late replication is not an obligatory feature of centromeric heterochromatin in murine cells and it does not determine their 'heterochromatic state'...
Cell cycle-dependent association of PML bodies with sites of active transcription in nuclei of mammalian cellsAlmut Kiesslich
Institute of Molecular Biotechnology, Beutenbergstrasse 11, Jena, Germany
J Struct Biol 140:167-79. 2002..Our observations suggest that PML bodies may be recruited to nuclear sites of induced or up-regulated mRNA transcription where it may serve as a scaffold for factors involved in expression of specific genes...
Centrosomal localization of DNA damage checkpoint proteinsSuisheng Zhang
Leibniz Institute for Age Research, Jena, Germany
J Cell Biochem 101:451-65. 2007..Taken together, these results indicate that DNA damage checkpoint proteins may control the formation of gamma-tubulin and/or the kinetics of microtubule formation at the centrosomes, and thereby couple them to the DNA damage response...
