Wolfgang G Kreyling

Summary

Country: Germany

Publications

  1. ncbi The procoagulant effects of fine particulate matter in vivo
    Evren Kilinc
    Department of Internal Medicine, Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, P, O, Box 616, Uns 50 Box 8, 6200 MD, Maastricht, The Netherlands
    Part Fibre Toxicol 8:12. 2011
  2. ncbi Deposition and biokinetics of inhaled nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 7:2. 2010
  3. ncbi Soluble iron modulates iron oxide particle-induced inflammatory responses via prostaglandin E(2 )synthesis: In vitro and in vivo studies
    Ingrid Beck-Speier
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    Part Fibre Toxicol 6:34. 2009
  4. ncbi Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging
    Sonu Bhaskar
    Comprehensive Pneumology Centre, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Part Fibre Toxicol 7:3. 2010
  5. ncbi Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
    Wolfgang G Kreyling
    Helmholtz Center Munich, Neuherberg Munich, Germany
    Inhal Toxicol 21:55-60. 2009
  6. ncbi Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium
    Manuela Semmler-Behnke
    GSF National Research Center for Environment and Health, Institute of Inhalation Biology, Neuherberg Munich, Germany
    Environ Health Perspect 115:728-33. 2007
  7. ncbi Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration
    Stephanie Hirn
    Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Munich, Germany
    Eur J Pharm Biopharm 77:407-16. 2011
  8. ncbi Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection
    Jens Lipka
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease and Focus Network Nanoparticles and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Biomaterials 31:6574-81. 2010
  9. ncbi Binding of polystyrene and carbon black nanoparticles to blood serum proteins
    Stefanie Fertsch-Gapp
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease and Focus Network Nanoparticles and Health, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg Munich, Germany
    Inhal Toxicol 23:468-75. 2011
  10. ncbi Left-to-right asymmetry of aerosol deposition after shallow bolus inhalation depends on lung ventilation
    Winfried Möller
    Helmholtz Center Munich, German Research Center for Environmental Health, Clinical Cooperation Group Inflammatory Lung Diseases, Institute for Lung Biology and Disease, and Focus Network Nanoparticles and Health, Gauting and Neuherberg, Germany
    J Aerosol Med Pulm Drug Deliv 22:333-9. 2009

Collaborators

Detail Information

Publications16

  1. ncbi The procoagulant effects of fine particulate matter in vivo
    Evren Kilinc
    Department of Internal Medicine, Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, P, O, Box 616, Uns 50 Box 8, 6200 MD, Maastricht, The Netherlands
    Part Fibre Toxicol 8:12. 2011
    ....
  2. ncbi Deposition and biokinetics of inhaled nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 7:2. 2010
    ..We emphasize the importance for quantitative analyses and the use of particle doses derived from real world exposures...
  3. ncbi Soluble iron modulates iron oxide particle-induced inflammatory responses via prostaglandin E(2 )synthesis: In vitro and in vivo studies
    Ingrid Beck-Speier
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    Part Fibre Toxicol 6:34. 2009
    ..In addition, we exposed male WKY rats to monodispersed Fe(2)O(3 )particles by intratracheal instillation (1.3 or 4.0 mg/kg body weight) to examine in vivo inflammation...
  4. ncbi Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging
    Sonu Bhaskar
    Comprehensive Pneumology Centre, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Part Fibre Toxicol 7:3. 2010
    ....
  5. ncbi Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
    Wolfgang G Kreyling
    Helmholtz Center Munich, Neuherberg Munich, Germany
    Inhal Toxicol 21:55-60. 2009
    ..These studies show that both NP characteristics--the material and the size of the chain-type aggregates--determine translocation and accumulation in STOs, skeleton, and soft tissue...
  6. ncbi Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium
    Manuela Semmler-Behnke
    GSF National Research Center for Environment and Health, Institute of Inhalation Biology, Neuherberg Munich, Germany
    Environ Health Perspect 115:728-33. 2007
    ..There is ongoing discussion that inhaled nanoparticles (NPs, < 100 nm) may translocate from epithelial deposition sites of the lungs to systemic circulation...
  7. ncbi Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration
    Stephanie Hirn
    Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Munich, Germany
    Eur J Pharm Biopharm 77:407-16. 2011
    ..A better understanding of these mechanisms will improve drug delivery and dose estimates used in risk assessment...
  8. ncbi Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection
    Jens Lipka
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease and Focus Network Nanoparticles and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Biomaterials 31:6574-81. 2010
    ..However, a prolonged retention time in the circulation was detected for the small fraction of translocated 10 kDa PEG Au NPs, too...
  9. ncbi Binding of polystyrene and carbon black nanoparticles to blood serum proteins
    Stefanie Fertsch-Gapp
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease and Focus Network Nanoparticles and Health, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg Munich, Germany
    Inhal Toxicol 23:468-75. 2011
    ..Once inhaled, nanoparticles (NP) deposit on the lung surface and have first contact with the epithelial lung lining fluid (ELF) rich in proteins, which may bind to NP...
  10. ncbi Left-to-right asymmetry of aerosol deposition after shallow bolus inhalation depends on lung ventilation
    Winfried Möller
    Helmholtz Center Munich, German Research Center for Environmental Health, Clinical Cooperation Group Inflammatory Lung Diseases, Institute for Lung Biology and Disease, and Focus Network Nanoparticles and Health, Gauting and Neuherberg, Germany
    J Aerosol Med Pulm Drug Deliv 22:333-9. 2009
    ..It was not clear, however, whether this phenomenon was an effect of asymmetry in lung ventilation or aerosol deposition efficiency...
  11. ncbi The influence of pulmonary surfactant on nanoparticulate drug delivery systems
    Carsten Schleh
    Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Neuherberg Munich, Germany
    Eur J Pharm Biopharm 77:350-2. 2011
    ..In the present comment, we discuss the potential interactions of nanoparticulate drug delivery systems with pulmonary surfactant as well as the potential consequences of this interaction...
  12. ncbi Ultrafine particle-lung interactions: does size matter?
    Wolfgang G Kreyling
    Institute of Inhalation Biology, GSF Focus Aerosols and Health, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
    J Aerosol Med 19:74-83. 2006
    ..This paper reviews the current concept of interactions between insoluble ultrafine particles and biological systems...
  13. ncbi Nanoparticle delivery in infant lungs
    Manuela Semmler-Behnke
    Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, D 85764 Neuherberg Munich, Germany
    Proc Natl Acad Sci U S A 109:5092-7. 2012
    ..This finding has significant implications for the application of nanoparticle-based inhalation therapeutics in young children with immature lungs from birth to 2 y of age...
  14. ncbi Postnatal lung function in the developing rat
    Ines Bolle
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute for Inhalation Biology, Neuherberg Munich, Germany
    J Appl Physiol 104:1167-76. 2008
    ..The pivotal step for improvement of gas exchange occurs with the transition from bulk alveolarization to the phase of expansion of air spaces with septal reconstruction and microvascular maturation...
  15. ncbi Corrections in dose assessment of 99mTc radiolabeled aerosol particles targeted to central human airways using planar gamma camera imaging
    Winfried Möller
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Clinical Cooperation Group Inflammatory Lung Diseases, Gauting and Neuherberg, Germany
    J Aerosol Med Pulm Drug Deliv 22:45-54. 2009
    ..The aerosol distribution index C/P may provide one suitable indicator for corrections, which should be confirmed in future studies by individual attenuation analysis based on radiotracer transmission measurements...
  16. ncbi Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs)
    Swapna Upadhyay
    Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg Munich, Germany
    Part Fibre Toxicol 7:27. 2010
    ....