Ingo Klein

Summary

Country: Germany

Publications

  1. ncbi Complete differentiation of CD8+ T cells activated locally within the transplanted liver
    Ingo Klein
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Research, University of Rochester, Rochester, NY 14642, USA
    J Exp Med 203:437-47. 2006
  2. ncbi A microsurgical approach to hepatic and extrahepatic antigen presentation and its effects on the migration pattern of activated CD8(+) T cells
    Ingo Klein
    David H Smith Center for Vaccine Biology and Immunology Aab Institute of Biomedical Sciences, University of Rochester School of Medicine, Rochester, NY, USA
    Microsurgery 27:289-94. 2007
  3. ncbi Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages
    Ingo Klein
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, NY, USA
    Blood 110:4077-85. 2007
  4. ncbi Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses
    Noelle K Polakos
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 179:201-10. 2007
  5. ncbi Immune role of hepatic TLR-4 revealed by orthotopic mouse liver transplantation
    Beena John
    The David H Smith Center for Vaccine Biology and Immunology, The Aab Institute for Biomedical Research, University of Rochester, Rochester, NY 14642, USA
    Hepatology 45:178-86. 2007
  6. ncbi Cellular and molecular mechanisms of liver tolerance
    Ian N Crispe
    The Liver Immunobiology Program, David H Smith Center for Vaccine Biology and Immunology, The University of Rochester, Rochester, NY 14642, USA
    Immunol Rev 213:101-18. 2006

Detail Information

Publications6

  1. ncbi Complete differentiation of CD8+ T cells activated locally within the transplanted liver
    Ingo Klein
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Research, University of Rochester, Rochester, NY 14642, USA
    J Exp Med 203:437-47. 2006
    ..We conclude that local antigen presentation cannot explain liver tolerance. On the contrary, the liver may be an excellent priming site for naive CD8+ T cells...
  2. ncbi A microsurgical approach to hepatic and extrahepatic antigen presentation and its effects on the migration pattern of activated CD8(+) T cells
    Ingo Klein
    David H Smith Center for Vaccine Biology and Immunology Aab Institute of Biomedical Sciences, University of Rochester School of Medicine, Rochester, NY, USA
    Microsurgery 27:289-94. 2007
    ..This illustrates that orthotopic liver transplantation is a powerful technique for addressing issues of antigen presentation...
  3. ncbi Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages
    Ingo Klein
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, NY, USA
    Blood 110:4077-85. 2007
    ..Our conclusions resolve a long-standing controversy and explain how different experimental approaches may reveal one or both of these subsets...
  4. ncbi Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses
    Noelle K Polakos
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 179:201-10. 2007
    ..Instead, it constitutes a substantial reservoir of usable Ag-specific effector CD8+ T cells involved in both acute and recall immune responses...
  5. ncbi Immune role of hepatic TLR-4 revealed by orthotopic mouse liver transplantation
    Beena John
    The David H Smith Center for Vaccine Biology and Immunology, The Aab Institute for Biomedical Research, University of Rochester, Rochester, NY 14642, USA
    Hepatology 45:178-86. 2007
    ..CONCLUSION: These studies reveal a new function for the liver, which is to regulate the magnitude of T cell memory responses through a Toll-like receptor-4-dependent mechanism...
  6. ncbi Cellular and molecular mechanisms of liver tolerance
    Ian N Crispe
    The Liver Immunobiology Program, David H Smith Center for Vaccine Biology and Immunology, The University of Rochester, Rochester, NY 14642, USA
    Immunol Rev 213:101-18. 2006
    ..The evidence favors clonal deletion mechanisms and is consistent with a role for regulatory T cells but does not support either anergy or immune deviation as important factors in liver tolerance...