Research Topics
| Barbara C KahlSummaryCountry: Germany Publications
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Publications
Thymidine-dependent small-colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separationBarbara C Kahl
Institute of Medical Microbiology, University of Muenster Hospital and Clinics, Muenster, Germany
J Clin Microbiol 41:410-3. 2003..Electron microscopy revealed enlarged cocci with incomplete or multiple cross walls consistent with impaired cell separation. Fried-egg SCV phenotypes could be reversed by thymidine supplementation...- Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profilesBarbara C Kahl
Institute of Medical Microbiology, University Clinics of Muenster, Domagkstr 10, 48149 Muenster, Germany
Infect Immun 73:4119-26. 2005.... - Non-spa-typeable clinical Staphylococcus aureus strains are naturally occurring protein A mutantsCathrin Baum
Institute of Medical Microbiology, University Hospital Muenster, Domagkstr 10, 48149 Munster, Germany
J Clin Microbiol 47:3624-9. 2009..This is the first report demonstrating that nontypeability of S. aureus by spa sequencing is due either to mutation or to a true deficiency of spa... - Variation of the polymorphic region X of the protein A gene during persistent airway infection of cystic fibrosis patients reflects two independent mechanisms of genetic change in Staphylococcus aureusBarbara C Kahl
Institute of Medical Microbiology, University of Muenster, Domagkstr 10, 48149 Muenster, Germany
J Clin Microbiol 43:502-5. 2005..Independent mutational events were observed eight times in 142 isolates: four deletions, two duplications of repeats, and two point mutations... - Impact of Staphylococcus aureus on the pathogenesis of chronic cystic fibrosis lung diseaseBarbara C Kahl
Institute of Medical Microbiology, University Hospital Munster, Germany
Int J Med Microbiol 300:514-9. 2010..aureus in the background of CF. In this review, recent data and studies will be reported and discussed to give an overview of the latest research... - agr-dependent bacterial interference has no impact on long-term colonization of Staphylococcus aureus during persistent airway infection of cystic fibrosis patientsBarbara C Kahl
Institute of Medical of Microbiology Institute for Hygiene, University of Muenster, Muenster 48149, Germany
J Clin Microbiol 41:5199-201. 2003..The success of CF clones in terms of cocolonization and/or infection with S. aureus, prevalence of clones, or persistence appeared to be independent of agr group specificity... - Population dynamics of persistent Staphylococcus aureus isolated from the airways of cystic fibrosis patients during a 6-year prospective studyBarbara C Kahl
Institute of Medical Microbiology Department of Pediatrics, University of Muenster Hospital and Clinics, Muenster, Germany
J Clin Microbiol 41:4424-7. 2003..Most patients (33 of 52, 63.46%) harbored single clones. This study provides a basis for improved understanding of S. aureus colonization and infection dynamics in CF patients... - Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophilsBettina Löffler
Institute of Medical Microbiology, University Hospital of Munster, Germany
PLoS Pathog 6:e1000715. 2010.... - Evaluation of two chromogenic agar media for recovery and identification of Staphylococcus aureus small-colony variantsFrank Kipp
Institute of Medical Microbiology, , Domagkstrasse 10, , Germany
J Clin Microbiol 43:1956-9. 2005..In conclusion, the most accurate and rapid method to detect both the species S. aureus and the SCV phenotype is to inoculate specimens onto both Columbia blood agar and SAID... - Comparative in vitro activity of finafloxacin against staphylococci displaying normal and small colony variant phenotypesEvgeny A Idelevich
Institute of Medical Microbiology, University Hospital Munster, Munster, Germany
J Antimicrob Chemother 66:2809-13. 2011.... - Microbiology. Mayhem in the lungBarbara C Kahl
Institute of Medical Microbiology, , Domagkstrasse 10, , Germany
Science 315:1082-3. 2007 - Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patientsSabine Ridder Schaphorn
Institute of Medical Microbiology, University of Muenster Hospital, Domagkstr 10, 48149 Muenster, Germany
J Clin Microbiol 45:2979-84. 2007..In CF patients, the oropharynx, and not the nose, was the predominant site of S. aureus infection and persistence. Hence, it is unlikely that CF patients will benefit from topical treatment strategies to eradicate nasal carriage... - In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureusIndranil Chatterjee
Institute of Medical Microbiology and Hygiene, Institutes of Infectious Disease Medicine, University of Saarland, Homburg Saar, Germany
J Bacteriol 190:834-42. 2008..Complementation of TD-SCVs with thyA revealed that a functional ThyA protein is necessary and sufficient to change the SCV phenotype and behavior back to normal... - High phenotypic diversity in infecting but not in colonizing Staphylococcus aureus populationsChristiane Goerke
Institute for Medical Microbiology and Hygiene, University Hospital Tubingen, Tubingen, Germany
Environ Microbiol 9:3134-42. 2007..aureus population is highly favoured during chronic CF lung infection, supporting the general hypothesis that maintenance of intrahost diversity can be of adaptive value, increasing the fitness of the bacterial community... - The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolatesSilke Besier
Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt am Main, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
Antimicrob Agents Chemother 52:2183-9. 2008..In conclusion, these data provide direct evidence that TD-SCVs are hypermutators. This hypermutability apparently favors the acquisition of antibiotic resistance and facilitates bacterial adaptation during long-term persistence... - Increased frequency of genomic alterations in Staphylococcus aureus during chronic infection is in part due to phage mobilizationChristiane Goerke
Instituts für Allgemeine Hygiene und Umwelthygiene, Universitat Tubingen, Wilhelmstrasse 31, 72074 Tubingen, Germany
J Infect Dis 189:724-34. 2004..Genome plasticity may facilitate the adaptation to various host conditions... - Enhanced post-stationary-phase survival of a clinical thymidine-dependent small-colony variant of Staphylococcus aureus results from lack of a functional tricarboxylic acid cycleIndranil Chatterjee
Institute of Medical Microbiology and Hygiene, University of Saarland, Kirrberger Str, Building 43, Homburg Saar 66421, Germany
J Bacteriol 189:2936-40. 2007..These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence... - Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infectionsRichard A Proctor
University of Wisconsin Medical School, 436 SMI, 1300 University Avenue, Madison, Wisconsin 53706, USA
Nat Rev Microbiol 4:295-305. 2006..This Review covers the phenotypic, genetic and clinical picture associated with small colony variants, with an emphasis on staphylococci, for which the greatest amount of information is available... - Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin BOrjan Samuelsen
Department of Medical Microbiology, University Hospital of North Norway, Tromsø, Norway
J Antimicrob Chemother 56:1126-9. 2005..To assess if deficiency in transmembrane potential, a common characteristic of SCVs that are haemin- or menadione-auxotrophs, affects the uptake of the peptide into the bacterial cytoplasm...