Steffen Weikert

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Expression of the apoptosis inhibitor survivin in testicular tissue of infertile patients
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus B Franklin, Berlin, Germany
    Int J Androl 27:161-5. 2004
  2. ncbi Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis
    Steffen Weikert
    Department of Urology, Charite, Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 116:100-4. 2005
  3. ncbi Expression levels of the inhibitor of apoptosis survivin in testes of patients with normal spermatogenesis and spermatogenic failure
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Fertil Steril 83:1100-5. 2005
  4. ncbi The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes
    Steffen Weikert
    Department of Urology, Charite, University Medicine in Berlin, Joint Faculty of Medicine of the Free University Berlin and Humboldt University Berlin, Campus Benjamin Franklin, Hindenburgdamm 30 D 12200 Berlin, Germany
    Cancer Lett 223:331-7. 2005
  5. ncbi Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus B Franklin, Berlin, Germany
    Int J Cancer 117:274-80. 2005
  6. ncbi Quantitative real-time RT-PCR of CD24 mRNA in the detection of prostate cancer
    M Schostak
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    BMC Urol 6:7. 2006
  7. ncbi Intrinsic resistance to tyrosine kinase inhibitors is associated with poor clinical outcome in metastatic renal cell carcinoma
    Jonas Busch
    Department of Hematology, Hemostases, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    BMC Cancer 11:295. 2011
  8. ncbi Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer
    Carsten Kempkensteffen
    Institute of Surgical Pathology, Universitatsspital Zurich, 8091 Zurich, Switzerland
    BMC Cancer 9:276. 2009
  9. ncbi Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition
    Steffen Weikert
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Am J Epidemiol 167:438-46. 2008
  10. ncbi [Introduction of interdisciplinary prostate cancer centers based on the recommendations of the German Cancer Society. A cost-benefit analysis 3 years after accreditation]
    S Weikert
    Klinik für Urologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Deutschland
    Urologe A 50:1083-8. 2011

Detail Information

Publications42

  1. ncbi Expression of the apoptosis inhibitor survivin in testicular tissue of infertile patients
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus B Franklin, Berlin, Germany
    Int J Androl 27:161-5. 2004
    ..Thus, survivin is a potential molecular marker of spermatogenesis, whose expression is altered in specific spermatogenic disorders...
  2. ncbi Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis
    Steffen Weikert
    Department of Urology, Charite, Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 116:100-4. 2005
    ..When analyzed by RT-PCR in urine, survivin is a highly specific biomarker for TCC detection...
  3. ncbi Expression levels of the inhibitor of apoptosis survivin in testes of patients with normal spermatogenesis and spermatogenic failure
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Fertil Steril 83:1100-5. 2005
    ..To determine the expression of the inhibitor of apoptosis survivin in men with and without spermatogenic failure...
  4. ncbi The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes
    Steffen Weikert
    Department of Urology, Charite, University Medicine in Berlin, Joint Faculty of Medicine of the Free University Berlin and Humboldt University Berlin, Campus Benjamin Franklin, Hindenburgdamm 30 D 12200 Berlin, Germany
    Cancer Lett 223:331-7. 2005
    ..Survivin expression correlates with the differentiation state of TGCTs and may be relevant for their tumorigenesis and malignant potential...
  5. ncbi Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus B Franklin, Berlin, Germany
    Int J Cancer 117:274-80. 2005
    ..These data suggest that quantitative hTR analysis is the most accurate telomerase-based test for bladder cancer detection and has the potential to replace cytology as a noninvasive biomarker for disease diagnosis and follow-up...
  6. ncbi Quantitative real-time RT-PCR of CD24 mRNA in the detection of prostate cancer
    M Schostak
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    BMC Urol 6:7. 2006
    ..We tested the usefulness of real-time RT-PCR for specific and sensitive detection of CD24 transcripts as a supplementary measure for discriminating between malignant and benign lesions in prostatic tissues...
  7. ncbi Intrinsic resistance to tyrosine kinase inhibitors is associated with poor clinical outcome in metastatic renal cell carcinoma
    Jonas Busch
    Department of Hematology, Hemostases, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    BMC Cancer 11:295. 2011
    ..Data on sequential therapy in patients with metastatic renal cell carcinoma (mRCC) and intrinsic resistance to receptor tyrosine kinase inhibitor (rTKI) treatment remains vague...
  8. ncbi Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer
    Carsten Kempkensteffen
    Institute of Surgical Pathology, Universitatsspital Zurich, 8091 Zurich, Switzerland
    BMC Cancer 9:276. 2009
    ..However, little is yet known about its potential implication in the tumour biology of clear-cell renal cell cancer (ccRCC)...
  9. ncbi Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition
    Steffen Weikert
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Am J Epidemiol 167:438-46. 2008
    ..These results support the hypothesis that hypertension, rather than its medications, increases the risk of RCC in both sexes, while effective blood pressure control may lower the risk...
  10. ncbi [Introduction of interdisciplinary prostate cancer centers based on the recommendations of the German Cancer Society. A cost-benefit analysis 3 years after accreditation]
    S Weikert
    Klinik für Urologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Deutschland
    Urologe A 50:1083-8. 2011
    ..Short-term improvements in quality of care cannot be unequivocally demonstrated. Prostate cancer centers serve an important role in counseling and medical education and may thus help disseminate evidence-based treatment strategies...
  11. ncbi Testicular expression of survivin and human telomerase reverse transcriptase (hTERT) associated with spermatogenic function in infertile patients
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus B Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Asian J Androl 8:95-100. 2006
    ..To characterize the coexpression of survivin, an inhibitor of apoptosis (IAF), and human telomerase reverse transcriptase (hTERT) in human testes with varying spermatogenic function...
  12. ncbi Acucise endopyelotomy: a technique with limited efficacy for primary ureteropelvic junction obstruction in adults
    Steffen Weikert
    Department of Urology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Urol 12:864-8. 2005
    ..To retrospectively evaluate the ef fi cacy of Acucise endopyelotomy in a series of patients with primary ureteropelvic junction obstruction (UPJO)...
  13. ncbi Quantification of survivin mRNA in testes of infertile patients and in testicular germ cell tumours: high levels of expression associated with normal spermatogenesis
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Androl 28:224-9. 2005
    ..Its downregulation in spermatogenic disorders indicates that survivin may contribute to the normal balance between germ cell proliferation and apoptosis. In TGCTs, survivin expression appears to be lost with somatic differentiation...
  14. ncbi Contemporary epidemiology of renal cell carcinoma: perspectives of primary prevention
    Steffen Weikert
    Department of Urology, Charite University Medicine Berlin, 10117 Berlin, Germany
    World J Urol 28:247-52. 2010
    ..In this review, we give an overview of recent trends in incidence and mortality and summarize the current knowledge on risk factors of RCC...
  15. ncbi Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas
    Steffen Weikert
    Charite University Medicine in Berlin, Campus Benjamin Franklin, Department of Urology, Hindenburgdamm 30, D 12200 Berlin, Germany
    Int J Mol Med 16:349-53. 2005
    ..In conclusion, expression levels of EZH2 are elevated in aggressive and invasive urothelial carcinomas, suggesting that deregulated EZH2 expression may be involved in the progression of bladder tumors...
  16. ncbi Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Cancer Res Clin Oncol 134:543-50. 2008
    ..This study characterized the mRNA expression levels and evaluated the prognostic effect of the mitochondrial inhibitor of apoptosis antagonists Smac/DIABLO and Omi/HtrA2 in tumor tissue from clear-cell RCC patients...
  17. ncbi Comparative promoter methylation analysis of p53 target genes in urogenital cancers
    Frank Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Urol Int 80:398-404. 2008
    ....
  18. ncbi Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors
    Carsten Kempkensteffen
    Department of Urology, Charite, University Medicine Berlin, Berlin, Germany
    Tumour Biol 29:76-82. 2008
    ..Considering that livin expression is restricted to malignant testicular tissue, it appears reasonable to conduct further investigations regarding its targeted inhibition in TGCT...
  19. ncbi Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications
    Frank Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, and Department of Urology, Klinikum Fulda gAG, Fulda, Germany
    Clin Cancer Res 12:5040-6. 2006
    ..We examined the usefulness of quantitative methylation analysis with a new set of p53 target genes for determining the clinical outcome and aggressiveness of the tumor disease...
  20. ncbi Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome
    Carsten Kempkensteffen
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Tumour Biol 28:132-8. 2007
    ..Our findings suggest that livin expression in RCC is not of prognostic relevance. Further studies to clarify the role of livin expression in RCC and its potential value as a target for immune-mediated tumor destruction are warranted...
  21. ncbi Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors
    Carsten Kempkensteffen
    Department of Urology, Charite, Campus Benjamin Franklin, Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Cancer Res Clin Oncol 132:765-70. 2006
    ..This study aimed at identifying the CpG sites relevant for testisin gene silencing when methylated and evaluating the potential of aberrant methylation as a biomarker in TGCT...
  22. ncbi Expression of the polycomb group protein EZH2 and its relation to outcome in patients with urothelial carcinoma of the bladder
    Stefan Hinz
    Department of Urology, Universitatsmedizin Berlin, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Cancer Res Clin Oncol 134:331-6. 2008
    ..This study was done to examine a potential correlation of EZH2 mRNA expression with clinicopathological parameters and outcome in patients with urothelial carcinoma (UC) of the bladder...
  23. ncbi A gene expression profile of tumor suppressor genes commonly methylated in bladder cancer
    Frank Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Cancer Res Clin Oncol 133:343-9. 2007
    ....
  24. ncbi Deregulation of EZH2 expression in human spermatogenic disorders and testicular germ cell tumors
    Stefan Hinz
    Department of Urology, Universitatsmedizin Berlin, Charite, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    World J Urol 28:631-5. 2010
    ..The objective of this study was to investigate the expression profile of EZH2 in testicular germ cell tumors (TGCT) and spermatogenic defects...
  25. ncbi Gene expression and promoter methylation of the XIAP-associated Factor 1 in renal cell carcinomas: correlations with pathology and outcome
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Cancer Lett 254:227-35. 2007
    ..Promoter methylation may be one, but probably not the essential mechanism for transcriptional downregulation of the XAF1 gene in RCC...
  26. ncbi Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder
    Frank Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 119:1396-402. 2006
    ..The extent of promoter methylation of specific genes offers additional prognostical information and is associated with the outcome in patients with nonmuscleinvasive and muscleinvasive bladder cancer...
  27. ncbi The equilibrium of XIAP and Smac/DIABLO expression is gradually deranged during the development and progression of testicular germ cell tumours
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Androl 30:476-83. 2007
    ..Thus the expression of proapoptotic Smac/DIABLO is lowest in NSGCT and stage III tumours...
  28. ncbi Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance
    Carsten Kempkensteffen
    Department of Urology, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Berlin, Germany
    Int J Cancer 120:1081-6. 2007
    ..001). The results of uni- and multivariate analysis suggest a prognostic value of cIAP1 expression for RCC patients, downregulation indicating an aggressive, potentially lethal phenotype...
  29. ncbi Sequence therapy in patients with metastatic renal cell carcinoma: comparison of common targeted treatment options following failure of receptor tyrosine kinase inhibitors
    Jonas Busch
    Department of Urology, Charite University Medicine Berlin, Berlin, Germany
    Eur Urol 60:1163-70. 2011
    ..The best sequence of targeted therapy in patients with metastatic renal cell carcinoma (mRCC) has not been sufficiently defined...
  30. ncbi Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC)
    Steffen Weikert
    Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal
    Int J Cancer 118:3133-9. 2006
    ..The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation...
  31. ncbi Expression of Mcl-1 splicing variants in clear-cell renal cancer and their correlation with histopathological parameters and prognosis
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tumour Biol 30:73-9. 2009
    ....
  32. ncbi Expression profile of the polycomb group protein enhancer of Zeste homologue 2 and its prognostic relevance in renal cell carcinoma
    Stefan Hinz
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    J Urol 182:2920-5. 2009
    ..To our knowledge this is the first study of the association of EZH2 expression with histopathological features and disease outcomes in a large cohort of patients who underwent surgery for renal cell carcinoma...
  33. ncbi Body size and risk of prostate cancer in the European prospective investigation into cancer and nutrition
    Tobias Pischon
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Cancer Epidemiol Biomarkers Prev 17:3252-61. 2008
    ....
  34. ncbi Urinary cytokeratin 20 mRNA expression has the potential to predict recurrence in superficial transitional cell carcinoma of the bladder
    Frank Christoph
    Department of Urology, Universitatsmedizin Berlin, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cancer Lett 245:121-6. 2007
    ..It helps to categorize patients prior to TUR-B, so that the cystoscopy interval during follow-up may be extended in those with low-risk superficial TCC...
  35. ncbi Presence of gallstones or kidney stones and risk of type 2 diabetes
    Cornelia Weikert
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Am J Epidemiol 171:447-54. 2010
    ..86, 1.27). These findings suggest that gallstones, but not kidney stones, may predict the risk of developing type 2 diabetes, providing physicians with an interventional opportunity to implement adequate prevention measures...
  36. ncbi Germ cell tumors of the gonads: a selective review emphasizing problems in drug resistance and current therapy options
    Mark Schrader
    Department of Urology, Charite Universitatsmedizin, Freie Universitat Berlin, Berlin, Germany
    Oncology 76:77-84. 2009
    ..This review article summarizes theoretical models for the high chemotherapy sensitivity of germ cell tumors and points out new therapeutic prospects...
  37. ncbi Extraperitoneal radical cystectomy with extraperitonealization of the ileal neobladder: a comparison to the transperitoneal technique
    Florian Jentzmik
    Department of Urology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany
    World J Urol 28:457-63. 2010
    ..This retrospective study compares the results of the two procedures with a focus on the peri- and postoperative course...
  38. ncbi Time trends in prostate cancer surgery: data from an Internet-based multicentre database
    Martin Schostak
    Charite, Universitatsmedizin Berlin, Urologische Klinik und Hochschulambulanz, Berlin, Germany
    BJU Int 109:355-9. 2012
    ..The system was used to assess the quality of prostate cancer surgery and to analyze possible time-dependent trends in the quality of care...
  39. ncbi The tumour-targeting human L19-IL2 immunocytokine: preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma
    Manfred Johannsen
    Department of Urology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Eur J Cancer 46:2926-35. 2010
    ..This phase I/II trial was performed to evaluate safety, tolerability, recommended phase II dose (RD) and early signs of activity of L19-IL2...
  40. ncbi Paper tigers--do clinical guidelines improve health care quality in patients with testicular germ cell tumors in Germany?
    Mark Schrader
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Health Policy 75:338-46. 2006
    ..Future research is required to create a better theoretical basis and to develop further strategies for guideline dissemination and implementation...
  41. ncbi Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment
    Jens Kollermann
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Oncol 26:4928-33. 2008
    ..To explore whether the presence of occult disseminated tumor cells (DTCs) in the bone marrow before neoadjuvant hormone therapy influences the prognosis of patients with organ confined prostate cancer treated by radical prostatectomy...
  42. ncbi Urine telomerase and bladder cancer detection
    Steffen Weikert
    JAMA 295:998-9; author reply 999. 2006