Research Topics
Species | Michael SittingerSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical resultsChristian Ossendorf
Department of Traumotology and Orthopaedic Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
Arthritis Res Ther 9:R41. 2007..The results suggest that implanting BioSeed-C is an effective treatment option for the regeneration of posttraumatic and/or osteoarthritic defects of the knee...- Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regenerationKristin Andreas
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Arthritis Res Ther 11:R15. 2009..This study aimed to disclose major mechanisms of antirheumatic drug action on human chondrocytes and to reveal marker and pharmacological target genes that are involved in cartilage dysfunction and regeneration... - Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro studyKristin Andreas
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Arthritis Res Ther 10:R9. 2008..Hence, the objective of this study was to establish a standardized in vitro model to profile the key regulatory molecules of RA-related destruction of cartilage that are expressed by human chondrocytes... - Tissue engineering in the rheumatic diseasesJochen Ringe
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystr 2, 10117 Berlin, Germany
Arthritis Res Ther 11:211. 2009..Tissue engineering also provides highly organized three-dimensional in vitro culture models of human cells and their extracellular matrix for arthritis research... - Current strategies for cell delivery in cartilage and bone regenerationMichael Sittinger
Tissue Engineering Laboratory, Charite University Medicine Berlin, Germany
Curr Opin Biotechnol 15:411-8. 2004..Thus, to expand the clinical potential, next generation therapies will depend on smart delivery concepts that make use of the regenerative potential of stem cells, morphogenetic growth factors and biomimetic materials... - Joint cartilage regeneration by tissue engineeringM Sittinger
German Rheumatism Research Center, Berlin
Z Rheumatol 58:130-5. 1999.... - Can engineered cartilage transplants be used for treating rheumatic diseases?Michael Sittinger
Tissue Engineering Laboratory, Department of Medicine and Clinical Rheumatology, , Berlin, Germany
Nat Clin Pract Rheumatol 2:172-3. 2006 - Gene expression profiling of human mesenchymal stem cells chemotactically induced with CXCL12Stefan Stich
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
Cell Tissue Res 336:225-36. 2009..The obtained data provide further insights into the molecular mechanisms involved in chemotactic processes in cell migration and designate CXCL12 as a promising candidate for in situ recruitment in regenerative therapies... - Human periosteum-derived progenitor cells express distinct chemokine receptors and migrate upon stimulation with CCL2, CCL25, CXCL8, CXCL12, and CXCL13Stefan Stich
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
Eur J Cell Biol 87:365-76. 2008..These results are promising towards in situ bone repair therapies based on guiding PCs to bone defects, and encourage further in vivo studies... - Extracellular matrix expression of human tenocytes in three-dimensional air-liquid and PLGA cultures compared with tendon tissue: implications for tendon tissue engineeringChristiane Stoll
Department of Trauma and Reconstructive Surgery, Charité University of Medicine, Campus Benjamin Franklin, Berlin, Germany
J Orthop Res 28:1170-7. 2010..These results suggest that the 3D high-density or biodegradable scaffolds cultures encourage the differentiation of expanded monolayer tenocytes in vitro to tendon-like tissue... - Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantationTilo Dehne
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, Berlin, 10117, Germany
Arthritis Res Ther 11:R133. 2009.... - Chemokine profile of human serum from whole blood: migratory effects of CXCL-10 and CXCL-11 on human mesenchymal stem cellsGregor Kalwitz
TransTissue Technologies GmbH and Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Berlin, Germany
Connect Tissue Res 51:113-22. 2010..Therefore, human serum derived from whole blood contains chemokines that may contribute to serum-mediated recruitment of human mesenchymal progenitors from bone marrow... - Differential gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenic developmentAdriane Menssen
Tissue Engineering Laboratory, Clinic for Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Charite Platz 1, 10117 Berlin, Germany
BMC Genomics 12:461. 2011..For data processing and selection of adipogenic candidate genes, we used the online database SiPaGene for Affymetrix microarray expression data... - Tracheal remodeling: comparison of different composite cultures consisting of human respiratory epithelial cells and human chondrocytesCosima Pfenninger
Tissue Engineering Laboratory, Department of Rheumatology, Charite University Medicine Berlin, Campus Mitte, Tucholskystrasse 2, 10117 Berlin, Germany
In Vitro Cell Dev Biol Anim 43:28-36. 2007.... - Tissue-engineered cartilage of porcine and human origin as in vitro test system in arthritis researchAxel R Göhring
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Dept of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, Berlin, Germany
Biotechnol Prog 26:1116-25. 2010..Therefore, we demonstrate that engineered cartilage of porcine and human origin represents a powerful in vitro model for cartilage in vivo... - Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2Jochen Ringe
Tissue Engineering Laboratory, Department of Rheumatology, Charite University Medicine Berlin, Berlin, Germany
J Cell Biochem 101:135-46. 2007..In combination with already known data on MSC recruitment and differentiation these are promising results towards in situ regenerative medicine approaches based on guiding of MSC to sites of degenerated tissues... - Biodegradable insulin-loaded PLGA microspheres fabricated by three different emulsification techniques: investigation for cartilage tissue engineeringKristin Andreas
Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
Acta Biomater 7:1485-95. 2011..Our results should encourage further studies applying protein-loaded PLGA microspheres in combination with cell transplants or cell-free in situ tissue engineering implants to regenerate cartilage... - Tissue-engineered polymer-based periosteal bone grafts for maxillary sinus augmentation: five-year clinical resultsWolfram Trautvetter
Laboratory for Tissue Engineering, Department of Rheumatology, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
J Oral Maxillofac Surg 69:2753-62. 2011..Therefore, the aim of our study was to evaluate the long-term clinical repair effect of autologous periosteal bone grafts on atrophic maxillary bone... - Gene expression profiling of human articular cartilage grafts generated by tissue engineeringChristian Kaps
Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystr 2, 10117 Berlin, Germany
Biomaterials 27:3617-30. 2006..Three-dimensional tissue culture of expanded articular chondrocytes initiates chondrocyte re-differentiation in vitro and leads to the maturation of cartilage grafts towards hyaline cartilage in vivo... - Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugsThomas Häupl
Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystrasse 2, 10117 Berlin, Germany
J Biomol Screen 12:328-40. 2007..Synovial fibroblasts reflect the disease-related pathophysiology and are useful tools for screening putative antirheumatic compounds... - Endomyocardial biopsy derived adherent proliferating cells - a potential cell source for cardiac tissue engineeringMarion Haag
Tissue Engineering Laboratory, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystr 2, 10117 Berlin, Germany
J Cell Biochem 109:564-75. 2010..Results indicate that these cells rather support angiogenesis than cardiomyocyte differentiation... - Future of tissue engineering in rheumatic diseasesJochen Ringe
Charite University Medicine Berlin, Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Tucholskystr 2, 10117 Berlin, Germany
Expert Opin Biol Ther 7:283-7. 2007..This review focuses on state-of-the-art and future in situ mesenchymal stem cell-based tissue engineering approaches for joint repair in patients with rheumatic diseases... - Bone repair by cell-seeded 3D-bioplotted composite scaffolds made of collagen treated tricalciumphosphate or tricalciumphosphate-chitosan-collagen hydrogel or PLGA in ovine critical-sized calvarial defectsKathrin Haberstroh
Department of Rheumatology, Tissue Engineering Laboratory, Charite University Medical Center Berlin, Berlin, Germany
J Biomed Mater Res B Appl Biomater 93:520-30. 2010.... - Creating artificial perichondrium by polymer complex membrane macroencapsulation: immune protection and stabilization of subcutaneously transplanted tissue-engineered cartilageAndreas Haisch
Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Eur Arch Otorhinolaryngol 262:338-44. 2005..Thus, PEC membrane encapsulation appears to be a novel approach for protecting cartilage implants from host immune response after autologous transplantation... - [Mesenchymal stem cells for tissue engineering of bone and cartilage]Jochen Ringe
Labor für Tissue Engineering, Medizinische Klinik mit Schwerpunkt für Rheumatologie und Klinische Immunologie, Universitatsklinikum Charite, Humboldt Uni versität Berlin
Med Klin (Munich) 98:35-40. 2003..In this article, important aspects of tissue engineering of bone and cartilage will be reviewed with emphasis on mesenchymal stem cells... - Does low-intensity pulsed ultrasound stimulate maturation of tissue-engineered cartilage?Georg N Duda
Trauma and Reconstructive Surgery, Charite, Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
J Biomed Mater Res B Appl Biomater 68:21-8. 2004..An acceleration of the maturation of tissue-engineered neocartilage in a clinical setting by means of low-intensity pulsed ultrasound therefore appears rather unrealistic... - Stem cells for regenerative medicine: advances in the engineering of tissues and organsJochen Ringe
Department of Rheumatology, Medical Faculty Charité, Humboldt University of Berlin, Germany
Naturwissenschaften 89:338-51. 2002..Furthermore, several issues of importance, especially with regard to the clinical application of mesenchymal stem cells, are discussed... - Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiationTilo Dehne
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Gene 462:8-17. 2010..Cultivation longer than 6 weeks leads to progressing dedifferentiation of chondrocytes that should be considered on long-term evaluations... - Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineagesJochen Ringe
Department of Rheumatology, University Medical Center, Charite, The Humboldt University of Berlin, Germany
Cell Tissue Res 307:321-7. 2002..Therefore, porcine MSC may be introduced as a valuable model system with which to study the mesenchymal lineages for basic research and tissue engineering... - BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density cultureBernhard Schmitt
Tissue Engineering Laboratory, Department of Rheumatology, Medical Faculty Charit, Humboldt University of Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Differentiation 71:567-77. 2003..These results suggest BMP2 as a promising candidate for tissue engineering approaches regenerating articular cartilage on the basis of mesenchymal progenitors from bone marrow... - The morphology and biomechanical characteristics of subcutaneously implanted tissue-engineered human septal cartilageAndreas Haisch
Department of Otorhinolaryngology, University Medical Center Charite, Campus Benjamin Franklin, Berlin, Germany
Eur Arch Otorhinolaryngol 262:993-7. 2005..Its elasticity and failure load are of sufficient quality to meet the clinical requirements for reconstructive surgery... - Changes in the gene expression pattern of cytokeratins in human respiratory epithelial cells during cultureMichaela Endres
Tissue Engineering Laboratory, University Medical Center Charite, Tucholskystr 2, 10117 Berlin, Germany
Eur Arch Otorhinolaryngol 262:390-6. 2005..Our results suggest that culture-expanded hREC have the potential to colonize collagen-coated biomaterials and to regenerate epithelial cell types for tracheal tissue engineering... - Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditisKapka Miteva
Berlin Brandenburg Center for Regenerative Therapies, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
PLoS ONE 6:e28513. 2011..We explored whether CAPs application could be a novel strategy to improve acute Coxsackievirus B3 (CVB3)-induced myocarditis... - Tissue engineering: advances in in vitro cartilage generationMakarand V Risbud
Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
Trends Biotechnol 20:351-6. 2002..The ability to manipulate and reconstitute tissue structure and function in vitro has tremendous clinical implications and is likely to have a key role in cell and gene therapies in coming years... - Distinct roles of BMP receptors Type IA and IB in osteo-/chondrogenic differentiation in mesenchymal progenitors (C3H10T1/2)Christian Kaps
Signaling and Gene Regulation, Gesellschaft fur Biotechnologische Forschung, Braunschweig, Germany
Biofactors 20:71-84. 2004..In addition this indicates that type IB and IA BMP receptors may transmit different signals during the specification and differentiation of mesenchymal lineages... - Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systemsDietmar W Hutmacher
Division of Bioengineering and Department of Orthopaedic Surgery, National University of Singapore, 119260, Singapore
Trends Biotechnol 22:354-62. 2004..Here, we review the application, advancement and future directions of SFF techniques in the design and creation of scaffolds for use in clinically driven tissue engineering... - Periosteal cells in bone tissue engineeringDietmar W Hutmacher
Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore
Tissue Eng 9:S45-64. 2003..This review discusses the history and state of the art of bone tissue engineering from a periosteum and periosteal cell source point of view and attempts to indicate future research directions... - Soft tissue and hard tissue engineering in oral and maxillofacial surgeryRainer Schmelzeisen
Department of Oral and Cranio Maxillofacial Surgery, Albert Ludwigs University, Freiburg i Br, Germany
Ann R Australas Coll Dent Surg 16:50-3. 2002..Our results suggest that periosteum-derived osteoblasts on a suitable matrix can form lamellar bone within four months after transplantation and provide a reliable basis for implant insertion... - Elastic cartilage engineering using novel scaffold architectures in combination with a biomimetic cell carrierDietmar W Hutmacher
Division of Bioengineering, Faculty of Engineering and Department of Orthopaedics, National University of Singapore, E3 05 15 10 10 Kent Ridge Crescent, Singapore 119260, Singapore
Biomaterials 24:4445-58. 2003..Hence, future experiments will be designed to evaluate an initial 3D culture of chondrocytes, effect on cell phenotype and their subsequent culture within biomimetic 3D scaffold/cell constructs... - Immunomodulation of tissue-engineered transplants: in vivo bone generation from methylprednisolone-stimulated chondrocytesAndreas Haisch
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
Eur Arch Otorhinolaryngol 261:216-24. 2004..This study found that immunomodulation by intramuscular methylprednisolone application protects tissue-engineered autogenous chondrocyte transplants from fibrous tissue infiltration and induces trabecular bone formation... - Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destructionChristian Kaps
, Humboldt University of Berlin, Germany
Arthritis Rheum 46:149-62. 2002..These properties advance BMPs as promising tools for engineering of cartilaginous joint bioprostheses and as candidate biologic agents or genes for cartilage stabilization in arthritis... - Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary reportRainer Schmelzeisen
Department of Oral and Craniomaxillofacial Surgery, University Hospital Freiburg, Freiburg, Germany
J Craniomaxillofac Surg 31:34-9. 2003..The results suggest that periosteum-derived osteoblasts on a suitable matrix form lamellar bone within 4 months which allows reliable implant insertion... - A tissue-engineering model for the manufacture of auricular-shaped cartilage implantsAndreas Haisch
Department of Otorhinolaryngology, University Medical Center Benjamin Franklin, FU Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
Eur Arch Otorhinolaryngol 259:316-21. 2002..The model of cartilage implant manufacturing presented here meets all biocompatible requirements for in vitro prefabrication and in vivo maturation of autogenous, individually shaped cartilage transplants... - A microcarrier-based cultivation system for expansion of primary mesenchymal stem cellsSimone Frauenschuh
Department of Bioengineering, Institute for Biotechnology, Technical University of Berlin, Seestrasse 13 Sek GG 2, 13353 Berlin, Germany
Biotechnol Prog 23:187-93. 2007..Totaling the results, we have shown that the three-dimensional expansion of MSC on microcarriers represents a beneficial alternative to the conventional two-dimensional monolayer cultivation method... - Chondrogenic differentiation capacity of human mesenchymal progenitor cells derived from subchondral cortico-spongious boneKatja Neumann
TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
J Orthop Res 26:1449-56. 2008..CSP cells from subchondral bone, as known from microfracture, are multipotent stem cell-like mesenchymal progenitors with a high chondrogenic differentiation potential... - Osteogenic potential of human periosteum-derived progenitor cells in PLGA scaffold using allogeneic serumYi xiong Zheng
Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
J Zhejiang Univ Sci B 7:817-24. 2006..The results of this study support the concept that this tissue engineering method presents a promising method for creation of new bone in vivo... - Mechanical testing of fixation techniques for scaffold-based tissue-engineered graftsSven Knecht
Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
J Biomed Mater Res B Appl Biomater 83:50-7. 2007..Our findings serve as basis for selecting the most suitable fixation technique for scaffold-based tissue-engineered grafts according to the expected in vivo loads... - Treatment of articular cartilage defects in horses with polymer-based cartilage tissue engineering graftsDirk Barnewitz
Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany
Biomaterials 27:2882-9. 2006.... - BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass cultureKatja Neumann
TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
J Cell Biochem 102:626-37. 2007..These results suggest that BMP7 promotes the adipogenic and not the osteogenic or chondrogenic lineage development of human stem cells when assembled three-dimensionally in micro-masses... - Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrowMichaela Endres
TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
J Orthop Res 25:1299-307. 2007..0001). The chemotactic activity of SF obtained from normal donors and from patients with degenerative joint diseases suggests that SF may be actively involved in the migration of progenitors in cartilage defects after microfracture... - Growth characterization of neo porcine cartilage pellets and their use in an interactive culture modelCarsten Lübke
VasoTissue Technologies GmbH, Department of Research and Development, Tucholskystrasse 2, 10117 Berlin, Germany
Osteoarthritis Cartilage 13:478-87. 2005.... - Emulsion-based synthesis of PLGA-microspheres for the in vitro expansion of porcine chondrocytesFranziska Gabler
Technical University Berlin, Institute of Biotechnology, Ackerstrasse 71 76, Berlin 13355, Germany
Biomol Eng 24:515-20. 2007..The degradation of the microspheres was determined in a long-term experiment in culture medium for 3 months. Adherent cells were characterized after 3 and 5 days by FDA+EB vital staining and in SEM... - Regeneration of ovine articular cartilage defects by cell-free polymer-based implantsChristoph Erggelet
Department of Traumatology and Orthopaedic Surgery, University of Freiburg, Hugstetter Street 55, 79106 Freiburg, Germany
Biomaterials 28:5570-80. 2007.... - Development of a high-throughput screening assay based on the 3-dimensional pannus model for rheumatoid arthritisYvonne Ibold
Department of Bioprocess Engineering, Institute of Biotechnology, Technical University of Berlin, Germany
J Biomol Screen 12:956-65. 2007..In addition, automated cell seeding and media exchange increased the efficiency due to a reduction of labor intensity and handling time... - Chitosan: a versatile biopolymer for orthopaedic tissue-engineeringAlberto Di Martino
Department of Orthopaedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA 19017, USA
Biomaterials 26:5983-90. 2005..In this paper we will review the current applications and future directions of CS in articular cartilage, intervertebral disk and bone tissue engineering... - Regenerative treatment strategies in spinal surgeryAldemar Andres Hegewald
Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Front Biosci 13:1507-25. 2008..Here, additional regenerative interventions would have a preventive intention, whereas interventions for painful degenerative disc disease as an alternative to spinal fusion or disc arthroplasty would be a curative approach... - The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee jointChristoph Erggelet
Department for Orthopaedic Surgery and Traumatology, University of Freiburg, Freiburg, Germany
Arthroscopy 19:108-10. 2003..Tibial defects can be addressed. The arthroscopic technique for the implantation of autologous chondrocytes eliminates a substantial amount of the side effects known to occur after open autologous chondrocyte implantation procedures... - The characterisation of human respiratory epithelial cells cultured on resorbable scaffolds: first steps towards a tissue engineered tracheal replacementBrian W Ziegelaar
Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich, Germany
Biomaterials 23:1425-38. 2002..Furthermore, that UEA and PNA staining is a useful tool in the characterisation of cells cultured on biomaterials, therefore helpful in identifying biomaterials that are suitable for specific tissue engineering purposes... - Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degenerationAlexander Abbushi
Department of Neurosurgery, Charite, Campus Virchow Klinikum, University Medicine of Berlin, Germany
Spine (Phila Pa 1976) 33:1527-32. 2008..In our one-step-approach, a resorbable cell-free polyglycolic acid (PGA)-based implant is immersed in serum from whole blood and implanted into the disc defect directly after discectomy...