Research Topics
Genomes and GenesSpecies | Florian SchlagenhaufSummaryAffiliation: Humboldt University Country: Germany Publications
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Publications
Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapineFlorian Schlagenhauf
Department of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
Psychopharmacology (Berl) 196:673-84. 2008..This may not be the case with newer neuroleptics such as olanzapine, which show less dopamine D2 receptor blockade and a faster off-rate from the receptor...- Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusionsFlorian Schlagenhauf
Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
Biol Psychiatry 65:1032-9. 2009..Increased attribution of incentive salience to neutral or aversive stimuli might be associated with dysfunction of neuronal processing of positive and negative reinforcement and contribute to the formation of delusions in schizophrenia... - Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activationFlorian Schlagenhauf
Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
Schizophr Res 118:189-200. 2010..However, little is known about specific medication effects on the modulation of frontal activation during WM performance... - Switching schizophrenia patients from typical neuroleptics to olanzapine: effects on BOLD response during attention and working memoryFlorian Schlagenhauf
Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
Eur Neuropsychopharmacol 18:589-99. 2008..However, medication status had influences on the activation during attentional task (0-back), emphasizing the importance of baseline selection in pharmacological fMRI studies... - Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholicsAnne Beck
Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
Biol Psychiatry 66:734-42. 2009..We explored whether functional brain activation during anticipation of incentive stimuli is associated with impulsiveness in detoxified alcoholics and healthy control subjects... - 5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controlsEva Friedel
Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
Psychopharmacology (Berl) 205:261-71. 2009..This prefrontal-limbic interaction has been shown to be modulated by serotonin (5-HTT) genotype, indicating a higher risk for major depressive disorder (MDD) with increasing number of 5-HTT low-expression alleles... - Childhood methylphenidate treatment of ADHD and response to affective stimuliLorna Schlochtermeier
Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
Eur Neuropsychopharmacol 21:646-54. 2011..Further prospective studies need to clarify direct and indirect mechanisms of MPH treatment that may contribute to emotional processing, which is dysfunctional in males without pharmacological treatment in childhood... - Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neurolepticsGeorg Juckel
Department of Psychiatry, , , Schumannstr. 20/21, Berlin 10117, Germany
Psychopharmacology (Berl) 187:222-8. 2006..Significant blunting of ventral striatal activation was not observed in patients treated with atypical neuroleptics, which may reflect the improved efficacy of these drugs in treating negative symptoms... - A preliminary study of increased amygdala activation to positive affective stimuli in maniaFelix Bermpohl
Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Berlin, Germany
Bipolar Disord 11:70-5. 2009..The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of the stimuli presented... - Dopaminergic dysfunction in schizophrenia: salience attribution revisitedAndreas Heinz
Department of Psychiatry, Charite Universitatsmedizin Berlin, Charite Campus Mitte, 10117 Berlin, Germany
Schizophr Bull 36:472-85. 2010.... - Different neural systems adjust motor behavior in response to reward and punishmentJana Wrase
Department of Psychiatry, Charité Universitätsmedizin Berlin Charité Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
Neuroimage 36:1253-62. 2007..Our results provide evidence that different but somewhat overlapping circuits mediate the same behavioral adaptation when it is driven by different incentive outcomes... - Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipationKatharina Schmack
Department of Psychiatry, Charite University Medicine, Chariteplatz 1, 10117 Berlin, Germany
Neuroimage 42:1631-8. 2008..Current evidence and our results are compatible with an interpretation that construes this effect of COMT genotype on striatal reactivity as a result of a cortico-striatal interaction... - Regional patterns and clinical correlates of basal ganglia morphology in non-medicated schizophreniaMartina Ballmaier
Department of Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
Schizophr Res 106:140-7. 2008.... - Reward processing in male adults with childhood ADHD--a comparison between drug-naïve and methylphenidate-treated subjectsMeline Stoy
Department of Psychiatry and Psychotherapy Campus Charité Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
Psychopharmacology (Berl) 215:467-81. 2011..Dysfunctional reward processing has been proposed as a main deficit in attention-deficit/hyperactivity disorder (ADHD), which could be modulated by treatment with methylphenidate (MPH)... - Dopamine in amygdala gates limbic processing of aversive stimuli in humansThorsten Kienast
Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
Nat Neurosci 11:1381-2. 2008..Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament... - Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophreniaLorenz Deserno
Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
J Neurosci 32:12-20. 2012..Moreover, this study in a large sample of patients reveals a mechanism underlying prefrontal inefficiency and cognitive deficits in schizophrenia, thereby providing direct experimental evidence for the dysconnectivity hypothesis... - Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorderAndreas Strohle
Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Schumannstr 20 21, 10117 Berlin, Germany
Neuroimage 39:966-72. 2008..These findings suggest that male adults with ADHD show neural signs of abnormal reward processing. Future studies will have to investigate whether these dysfunctional patterns might be normalized by treatment... - Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholicsJana Wrase
Department of Psychiatry and Psychotherapy, Charite, Universitatsmedizin Berlin, Charité Campus Mitte CCM, Berlin, Germany
Neuroimage 35:787-94. 2007..This may lead alcoholics to crave the pharmacological effects of alcohol to a greater extent than other conventional rewards. The present study investigated neural mechanisms underlying these phenomena... - Dysfunction of ventral striatal reward prediction in schizophreniaGeorg Juckel
Department of Psychiatry, , , CCM, Schumannstr. 20/21, 10117 Berlin, Germany
Neuroimage 29:409-16. 2006..This, in turn, may contribute to negative symptoms as such as anhedonia, apathy, and loss of drive and motivation... - Regional cerebral glucose metabolism and anxiety symptoms in bipolar depression: effects of levothyroxineMichael Bauer
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
Psychiatry Res 181:71-6. 2010..Results indicate that comorbid anxiety symptoms have specific regional cerebral metabolic correlates in bipolar depression and cannot only be explained exclusively by the depressive state of the patients... - Novelty seeking modulates medial prefrontal activity during the anticipation of emotional stimuliFelix Bermpohl
Berenson Allen Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Psychiatry Res 164:81-5. 2008..BOLD responses to emotional expectancy were positively correlated with novelty-seeking scores in the medial prefrontal cortex. This correlation was strongest for the sub-dimension of exploratory excitability... - Orbitofrontal cortical dysfunction in akinetic catatonia: a functional magnetic resonance imaging study during negative emotional stimulationGeorg Northoff
University of Magdeburg, Department of Psychiatry, Leipziger Strasse 44, 39120 Magdeburg, Germany
Schizophr Bull 30:405-27. 2004..Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis...