Research Topics
Genomes and GenesSpecies | Jochen RingeSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiationZahia Hamidouche
Laboratory of Osteoblast Biology and Pathology, INSERM U606, Paris F 75475, France
BMC Cell Biol 11:44. 2010..In this study, we used microarray analysis to identify signalling molecules that promote osteogenic differentiation in human bone marrow stroma derived MSCs...- Tissue engineering in the rheumatic diseasesJochen Ringe
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystr 2, 10117 Berlin, Germany
Arthritis Res Ther 11:211. 2009..Tissue engineering also provides highly organized three-dimensional in vitro culture models of human cells and their extracellular matrix for arthritis research... - Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineagesJochen Ringe
Department of Rheumatology, University Medical Center, Charite, The Humboldt University of Berlin, Germany
Cell Tissue Res 307:321-7. 2002..Therefore, porcine MSC may be introduced as a valuable model system with which to study the mesenchymal lineages for basic research and tissue engineering... - Stem cells for regenerative medicine: advances in the engineering of tissues and organsJochen Ringe
Department of Rheumatology, Medical Faculty Charité, Humboldt University of Berlin, Germany
Naturwissenschaften 89:338-51. 2002..Furthermore, several issues of importance, especially with regard to the clinical application of mesenchymal stem cells, are discussed... - Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2Jochen Ringe
Tissue Engineering Laboratory, Department of Rheumatology, Charite University Medicine Berlin, Berlin, Germany
J Cell Biochem 101:135-46. 2007..In combination with already known data on MSC recruitment and differentiation these are promising results towards in situ regenerative medicine approaches based on guiding of MSC to sites of degenerated tissues... - [Mesenchymal stem cells for tissue engineering of bone and cartilage]Jochen Ringe
Labor für Tissue Engineering, Medizinische Klinik mit Schwerpunkt für Rheumatologie und Klinische Immunologie, Universitatsklinikum Charite, Humboldt Uni versität Berlin
Med Klin (Munich) 98:35-40. 2003..In this article, important aspects of tissue engineering of bone and cartilage will be reviewed with emphasis on mesenchymal stem cells... - Future of tissue engineering in rheumatic diseasesJochen Ringe
Charite University Medicine Berlin, Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Tucholskystr 2, 10117 Berlin, Germany
Expert Opin Biol Ther 7:283-7. 2007..This review focuses on state-of-the-art and future in situ mesenchymal stem cell-based tissue engineering approaches for joint repair in patients with rheumatic diseases... - Human mastoid periosteum-derived stem cells: promising candidates for skeletal tissue engineeringJ Ringe
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
J Tissue Eng Regen Med 2:136-46. 2008..These results suggest MSC-like PCs from mastoid as candidates for therapy of complex skeletal defects... - Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiationTilo Dehne
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Gene 462:8-17. 2010..Cultivation longer than 6 weeks leads to progressing dedifferentiation of chondrocytes that should be considered on long-term evaluations... - Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regenerationKristin Andreas
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Arthritis Res Ther 11:R15. 2009..This study aimed to disclose major mechanisms of antirheumatic drug action on human chondrocytes and to reveal marker and pharmacological target genes that are involved in cartilage dysfunction and regeneration... - Human periosteum-derived progenitor cells express distinct chemokine receptors and migrate upon stimulation with CCL2, CCL25, CXCL8, CXCL12, and CXCL13Stefan Stich
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
Eur J Cell Biol 87:365-76. 2008..These results are promising towards in situ bone repair therapies based on guiding PCs to bone defects, and encourage further in vivo studies... - Migration potential and gene expression profile of human mesenchymal stem cells induced by CCL25Tabea Binger
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, CCM, Tucholskystr 2, 10117 Berlin, Germany
Exp Cell Res 315:1468-79. 2009..These results suggest CCL25 as a new potential candidate for further in situ regeneration approaches... - BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass cultureKatja Neumann
TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
J Cell Biochem 102:626-37. 2007..These results suggest that BMP7 promotes the adipogenic and not the osteogenic or chondrogenic lineage development of human stem cells when assembled three-dimensionally in micro-masses... - Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantationTilo Dehne
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, Berlin, 10117, Germany
Arthritis Res Ther 11:R133. 2009.... - Chondrogenic differentiation capacity of human mesenchymal progenitor cells derived from subchondral cortico-spongious boneKatja Neumann
TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
J Orthop Res 26:1449-56. 2008..CSP cells from subchondral bone, as known from microfracture, are multipotent stem cell-like mesenchymal progenitors with a high chondrogenic differentiation potential... - Chemokine profile of human serum from whole blood: migratory effects of CXCL-10 and CXCL-11 on human mesenchymal stem cellsGregor Kalwitz
TransTissue Technologies GmbH and Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Berlin, Germany
Connect Tissue Res 51:113-22. 2010..Therefore, human serum derived from whole blood contains chemokines that may contribute to serum-mediated recruitment of human mesenchymal progenitors from bone marrow... - Chondrogenic differentiation of human mesenchymal stem cells in micro-masses is impaired by high doses of the chemokine CXCL7Gregor Kalwitz
TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
J Tissue Eng Regen Med 5:50-9. 2011..These results suggest that low doses of CXCL7 do not impair the chondrogenic differentiation of bone marrow-derived stem cells and may suited for in situ cartilage tissue engineering... - Gene expression profiling of human mesenchymal stem cells chemotactically induced with CXCL12Stefan Stich
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
Cell Tissue Res 336:225-36. 2009..The obtained data provide further insights into the molecular mechanisms involved in chemotactic processes in cell migration and designate CXCL12 as a promising candidate for in situ recruitment in regenerative therapies... - Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro studyKristin Andreas
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Arthritis Res Ther 10:R9. 2008..Hence, the objective of this study was to establish a standardized in vitro model to profile the key regulatory molecules of RA-related destruction of cartilage that are expressed by human chondrocytes... - BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density cultureBernhard Schmitt
Tissue Engineering Laboratory, Department of Rheumatology, Medical Faculty Charit, Humboldt University of Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Differentiation 71:567-77. 2003..These results suggest BMP2 as a promising candidate for tissue engineering approaches regenerating articular cartilage on the basis of mesenchymal progenitors from bone marrow... - Differential gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenic developmentAdriane Menssen
Tissue Engineering Laboratory, Clinic for Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Charite Platz 1, 10117 Berlin, Germany
BMC Genomics 12:461. 2011..For data processing and selection of adipogenic candidate genes, we used the online database SiPaGene for Affymetrix microarray expression data... - Tissue-engineered cartilage of porcine and human origin as in vitro test system in arthritis researchAxel R Göhring
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Dept of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, Berlin, Germany
Biotechnol Prog 26:1116-25. 2010..Therefore, we demonstrate that engineered cartilage of porcine and human origin represents a powerful in vitro model for cartilage in vivo... - Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrowMichaela Endres
TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
J Orthop Res 25:1299-307. 2007..0001). The chemotactic activity of SF obtained from normal donors and from patients with degenerative joint diseases suggests that SF may be actively involved in the migration of progenitors in cartilage defects after microfracture... - Tracheal remodeling: comparison of different composite cultures consisting of human respiratory epithelial cells and human chondrocytesCosima Pfenninger
Tissue Engineering Laboratory, Department of Rheumatology, Charite University Medicine Berlin, Campus Mitte, Tucholskystrasse 2, 10117 Berlin, Germany
In Vitro Cell Dev Biol Anim 43:28-36. 2007.... - Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7Gregor Kalwitz
TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
Int J Biochem Cell Biol 41:649-58. 2009..Pathway analysis suggests that recruitment of human MSC by CXCL7 is supported by the induction of ligands of the interleukin 8 receptors, synergistically activating the respective signaling pathways... - Gene expression profiling of human articular cartilage grafts generated by tissue engineeringChristian Kaps
Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystr 2, 10117 Berlin, Germany
Biomaterials 27:3617-30. 2006..Three-dimensional tissue culture of expanded articular chondrocytes initiates chondrocyte re-differentiation in vitro and leads to the maturation of cartilage grafts towards hyaline cartilage in vivo... - Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugsThomas Häupl
Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystrasse 2, 10117 Berlin, Germany
J Biomol Screen 12:328-40. 2007..Synovial fibroblasts reflect the disease-related pathophysiology and are useful tools for screening putative antirheumatic compounds... - Endomyocardial biopsy derived adherent proliferating cells - a potential cell source for cardiac tissue engineeringMarion Haag
Tissue Engineering Laboratory, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystr 2, 10117 Berlin, Germany
J Cell Biochem 109:564-75. 2010..Results indicate that these cells rather support angiogenesis than cardiomyocyte differentiation... - In vivo effect of bone marrow-derived mesenchymal stem cells in a rat kidney transplantation model with prolonged cold ischemiaYoshiaki Hara
Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
Transpl Int 24:1112-23. 2011..In addition, fewer antigen-presenting cells were recruited into the renal allograft. In conclusion, rat MSCs ameliorate inflammation induced by prolonged cold ischemia in kidney transplantation... - Changes in the gene expression pattern of cytokeratins in human respiratory epithelial cells during cultureMichaela Endres
Tissue Engineering Laboratory, University Medical Center Charite, Tucholskystr 2, 10117 Berlin, Germany
Eur Arch Otorhinolaryngol 262:390-6. 2005..Our results suggest that culture-expanded hREC have the potential to colonize collagen-coated biomaterials and to regenerate epithelial cell types for tracheal tissue engineering... - Biodegradable insulin-loaded PLGA microspheres fabricated by three different emulsification techniques: investigation for cartilage tissue engineeringKristin Andreas
Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
Acta Biomater 7:1485-95. 2011..Our results should encourage further studies applying protein-loaded PLGA microspheres in combination with cell transplants or cell-free in situ tissue engineering implants to regenerate cartilage... - Growth characterization of neo porcine cartilage pellets and their use in an interactive culture modelCarsten Lübke
VasoTissue Technologies GmbH, Department of Research and Development, Tucholskystrasse 2, 10117 Berlin, Germany
Osteoarthritis Cartilage 13:478-87. 2005.... - [Tissue engineering: chances and challenges for application in rheumatic diseases]T Haupl
Humboldt Universitat, Tucholskystr 2, 10117 Berlin, Germany
Z Rheumatol 62:II46-9. 2003..These together with the advances in biological therapies of rheumatic diseases are the basis of new concepts, which promise application of tissue engineering also in inflammatory joint diseases... - Effect of different ascorbate supplementations on in vitro cartilage formation in porcine high-density pellet culturesY Ibold
Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Tissue Cell 41:249-56. 2009..Besides that, we could not detect a pronounced difference between ascorbate and its derivates as well as between the different concentrations... - Human polymer-based cartilage grafts for the regeneration of articular cartilage defectsM Endres
Charite University Medicine Berlin, Department of Rheumatology, Tissue Engineering Laboratories, Berlin, Germany
Tissue Cell 39:293-301. 2007..These results suggest that human polymer-based cartilage tissue engineering grafts made of human chondrocytes, human fibrin and PGA are clinically suited for the regeneration of articular cartilage defects... - Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditisKapka Miteva
Berlin Brandenburg Center for Regenerative Therapies, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
PLoS ONE 6:e28513. 2011..We explored whether CAPs application could be a novel strategy to improve acute Coxsackievirus B3 (CVB3)-induced myocarditis... - In vitro expression of cartilage-specific markers by chondrocytes on a biocompatible hydrogel: implications for engineering cartilage tissueM Risbud
Tissue Engineering Laboratory, University Medical Centre, , Humboldt University of Berlin, Germany
Cell Transplant 10:755-63. 2001..This hydrogel needs to be further evaluated for its ability to support chondrocyte-specific marker expression to explore the possibility of forming a tissue resembling natural cartilage in vitro... - Biocompatible hydrogel supports the growth of respiratory epithelial cells: possibilities in tracheal tissue engineeringM Risbud
Tissue Engineering Laboratory, University Medical Centre, , Humboldt University of Berlin, Tucholkystrasse-2, 10117 Berlin, Germany
J Biomed Mater Res 56:120-7. 2001..This hydrogel is suitable as a culture substratum for respiratory epithelial cells and could be used as a potential candidate for coating tracheal prostheses... - Microencapsulation and chondrogenic differentiation of human mesenchymal progenitor cells from subchondral bone marrow in Ca-alginate for cell injectionM Endres
TransTissue Technologies GmbH, Berlin, Germany
Acta Biomater 6:436-44. 2010..Therefore, from the cell biology point of view, Ca-alginate, an established hydrogel scaffold material is suited for regenerative therapies of cartilage defects based on the injection of progenitor cells... - Hyaluronic acid and autologous synovial fluid induce chondrogenic differentiation of equine mesenchymal stem cells: a preliminary studyA A Hegewald
Tissue Engineering Laboratory, Department of Rheumatology, , Campus Mitte, Berlin, Germany
Tissue Cell 36:431-8. 2004.... - Osteogenic potential of human periosteum-derived progenitor cells in PLGA scaffold using allogeneic serumYi xiong Zheng
Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
J Zhejiang Univ Sci B 7:817-24. 2006..The results of this study support the concept that this tissue engineering method presents a promising method for creation of new bone in vivo... - A microcarrier-based cultivation system for expansion of primary mesenchymal stem cellsSimone Frauenschuh
Department of Bioengineering, Institute for Biotechnology, Technical University of Berlin, Seestrasse 13 Sek GG 2, 13353 Berlin, Germany
Biotechnol Prog 23:187-93. 2007..Totaling the results, we have shown that the three-dimensional expansion of MSC on microcarriers represents a beneficial alternative to the conventional two-dimensional monolayer cultivation method... - Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cellsBruno Delorme
INSERM, Equipe ESPRI EA 3855, Faculty of Medicine, University Francois Rabelais, 10 boulevard Tonnelle, Tours, France
Blood 111:2631-5. 2008..In addition, the expression of CD73, CD146, and CD200 was down-regulated in differentiated cells. The new marker CD200, because of its specificity and immunomodulatory properties, deserves further in-depth studies... - Development of a high-throughput screening assay based on the 3-dimensional pannus model for rheumatoid arthritisYvonne Ibold
Department of Bioprocess Engineering, Institute of Biotechnology, Technical University of Berlin, Germany
J Biomol Screen 12:956-65. 2007..In addition, automated cell seeding and media exchange increased the efficiency due to a reduction of labor intensity and handling time... - Treatment of articular cartilage defects in horses with polymer-based cartilage tissue engineering graftsDirk Barnewitz
Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany
Biomaterials 27:2882-9. 2006.... - Regenerative treatment strategies in spinal surgeryAldemar Andres Hegewald
Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Front Biosci 13:1507-25. 2008..Here, additional regenerative interventions would have a preventive intention, whereas interventions for painful degenerative disc disease as an alternative to spinal fusion or disc arthroplasty would be a curative approach... - Emulsion-based synthesis of PLGA-microspheres for the in vitro expansion of porcine chondrocytesFranziska Gabler
Technical University Berlin, Institute of Biotechnology, Ackerstrasse 71 76, Berlin 13355, Germany
Biomol Eng 24:515-20. 2007..The degradation of the microspheres was determined in a long-term experiment in culture medium for 3 months. Adherent cells were characterized after 3 and 5 days by FDA+EB vital staining and in SEM...