Research Topics
Genomes and Genes | R MrowkaSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
An evolutionary approach for identifying potential transcription factor binding sites: the renin gene as an exampleRalf Mrowka
Johannes Müller Institut für Physiologie, Charite, Humboldt Universitat zu Berlin, D 10117 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 284:R1147-50. 2003..The algorithm TFprofile may be used to integrate information on cross-species evolutionary conservation and aspects of TF binding characteristics to provide putative regulatory DNA regions for experimental verification...- Blunted arterial baroreflex causes "pathological" heart rate turbulenceR Mrowka
Johannes Müller Institut für Physiologie, Charite, Humboldt Universitat zu Berlin, D 10117 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 279:R1171-5. 2000..The results of the model suggest that the recently established risk parameters TO and TS characterize baroreflex function, a known risk stratifier in patients... - Sequence-related human proteins cluster by degree of evolutionary conservationRalf Mrowka
Systems Biology Group, Department of Physiology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
Phys Rev E Stat Nonlin Soft Matter Phys 70:051908. 2004..Our results support that small-world network properties constitute a footprint of an evolutionary mechanism and extend the traditional interpretation of protein families... - Dissecting the action of an evolutionary conserved non-coding region on renin promoter activityRalf Mrowka
Institute for Physiology, Systems Biology Computational Physiology, Charite Universitatsmedizin, Berlin
Nucleic Acids Res 35:5120-9. 2007..Mapping of the sub-sequences on phylogenetic conservation data reveals that the dominant regulatory region is the one with the highest multi-species conservation score... - Seed-based systematic discovery of specific transcription factor target genesRalf Mrowka
Paul Ehrlich Zentrum für Experimentelle Medizin, AG Systems Biology Computational Physiology, Tucholskystrasse 2, Berlin, Germany
FEBS J 275:3178-92. 2008..We present a robust and reliable method to enhance the genome-wide prediction of specific transcription factor target genes that exploits the vast amount of expression information available in public databases today... - Oligodb--interactive design of oligo DNA for transcription profiling of human genesRalf Mrowka
Johannes Müller Institut für Physiologie, Charite, Humboldt Universitat zu Berlin, Germany
Bioinformatics 18:1686-7. 2002..All data and results are tightly web-linked to the corresponding data entries of ENSEMBL project... - Blood pressure control in eNOS knock-out mice: comparison with other species under NO blockadeH M Stauss
Johannes Müller Institut für Physiologie, Humboldt Universitat Charite, Tucholskystr 2, Berlin, Germany
Acta Physiol Scand 168:155-60. 2000.... - A Java applet for visualizing protein-protein interactionR Mrowka
Johannes Müller Institut für Physiologie, Charite, Humboldt Universitat zu Berlin, Tucholsky Str 2, D 10117 Berlin, Germany
Bioinformatics 17:669-71. 2001..It enables the display of interaction relationships, based upon neighboring distance and biological function. AVAILABILITY: The Java applet is available at http://www.charite.de/bioinformatics.. - Nitric oxide counteracts angiotensin II induced contraction in efferent arterioles in miceA Patzak
, Humboldt-University of Berlin, University Hospital Charit, Berlin, Germany
Acta Physiol Scand 181:439-44. 2004.... - Wilms' tumor protein (-KTS) modulates renin gene transcriptionAndreas Steege
Institut für Physiologie CCM, Charite Universitatsmedizin Berlin, Berlin, Germany
Kidney Int 74:458-66. 2008..Our findings show that renin gene transcription is regulated by the WT1(-KTS) protein and this may explain findings in patients with WT1 gene mutations of increased plasma renin and hypertension... - Linear and non-linear properties of heart rate in postnatal maturationR Mrowka
Institut fur Physiologie, Humboldt Universitat zu Berlin, Germany
Cardiovasc Res 31:447-54. 1996..An investigation was made of how postnatal maturation of cardiac control can be described by linear and non-linear methods of time series analysis... - Rhythms and complexity of respiration during sleep in pre-term infantsA Patzak
Johannes Müller Institut für Physiologie, Universitatsklinikum Charite, Humboldt Universitat zu Berlin, Berlin, Germany
Clin Physiol 19:458-66. 1999..The behaviour of RR, spectral parameters and D2 indicates a specific, functional setting rather than a regulatory impairment in infants with BPD... - [Heart rate variability--physiology, methods of registration and application in pediatric sleep laboratory]A Patzak
Institut fur Physiologie, Humboldt Universitat zu Berlin, Bundesrepublik Deutschland
Wien Klin Wochenschr 112:234-50. 2000..In addition, technical requirements and methods of analysis which have a major impact on calculated parameters are being presented... - Interaction of angiotensin II and nitric oxide in isolated perfused afferent arterioles of miceA Patzak
Johannes Muller Institute of Physiology, Humboldt University of Berlin, Germany
J Am Soc Nephrol 12:1122-7. 2001..High Ang II sensitivity in eNOS (-/-) mice underscores the considerable role of endothelial-derived NO to balance Ang II vasoconstriction in Af... - Role of nucleolin in posttranscriptional control of MMP-9 expressionMichael Fähling
Charite, Universitatsmedizin Berlin, Institut für Vegetative Physiologie, 10117 Berlin, Germany
Biochim Biophys Acta 1731:32-40. 2005..The results show that MMP-9 expression can be regulated posttranscriptionally, affecting the efficiency of translation and localization of the mRNA... - Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stabilityMichael Fähling
Charite, Universitatsmedizin Berlin, Institut für Vegetative Physiologie, D 10117 Berlin, Germany
J Biol Chem 281:9279-86. 2006..In a data set representing 686 independent physiological conditions, we found a significant positive correlation between hnRNP-A2/B1 and C-P4H-alpha (I) mRNAs... - AT1 receptors mediate angiotensin II-induced release of nitric oxide in afferent arteriolesAndreas Patzak
Institute of Physiology, Humboldt University of Berlin, University Hospital Charite, Berlin, Germany
Kidney Int 66:1949-58. 2004..We investigated the role of AT receptor subtypes (AT-R) in mediating the Ang II-induced NO release in afferent arterioles (Af) of mice... - Control of renin synthesisPontus B Persson
Tucholskystr 2, 10783 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 285:R491-7. 2003..This occurs via the 3'-untranslated region, to which several proteins can bind. The binding proteins were identified as hnRNP K and E1, dynamin, nucleolin, MINT homologous protein, and Y-Box 1... - Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxiaMichael Fähling
Charite, Universitatsmedizin Berlin, Institut für Vegetative Physiologie, D 10117 Berlin, Germany
J Biol Chem 281:26089-101. 2006..Thus, the alteration of translational efficiency by nucleolin, which occurs through a hypoxia inducible factor independent pathway, is an important step in C-P4H-alpha(I) regulation under hypoxia... - Time of measurement influences the variability of tidal breathing parameters in healthy and sick infantsA Patzak
Johannes Muller Institute of Physiology, University Hospital Charite, Humboldt University of Berlin, Tucholskystr 2, 10117, Berlin, Germany
Respir Physiol 128:187-94. 2001.... - Is there a bias in proteome research?R Mrowka
Johannes Müller Institut für Physiologie, Humboldt Universitat zu Berlin, Berlin, Germany
Genome Res 11:1971-3. 2001..If, however, the true fraction of false positives is considerably lower than estimated here, the data from hypothesis-driven experiments must have been subjected to a serious selection process... - Enhanced blood pressure variability in eNOS knockout miceH M Stauss
Institute of Physiology, Humboldt University Charite, Berlin, Germany
Hypertension 33:1359-63. 1999..In addition, endothelial nitric oxide is most effective in buffering blood pressure oscillations at frequencies that range from 0.05 to 0.40 s-1 (Hz) in conscious mice... - A novel standardization method for two-dimensional DNA fingerprintsJ Hampe
Institute of Medical Genetics, Charite University Hospital, Berlin, Germany
Electrophoresis 18:2874-9. 1997..In conclusion, a standardization tool for a broader application of 2-D DNA fingerprinting in both tumor analysis and possibly parallel mutation screening is now available... - Translational regulation of the human achaete-scute homologue-1 by fragile X mental retardation proteinMichael Fähling
Charite, Universitatsmedizin Berlin, Institut für Vegetative Physiologie, Tucholskystrasse 2, D 10117 Berlin
J Biol Chem 284:4255-66. 2009..In conclusion, we identified hASH1 as a novel downstream target of FMRP. Improved translation efficiency of hASH1 mRNA by FMRP may represent an important regulatory switch in neuronal differentiation... - Adenosine restores angiotensin II-induced contractions by receptor-independent enhancement of calcium sensitivity in renal arteriolesEn Yin Lai
Department of Medical Cell Biology, Division of Physiology, University of Uppsala, Sweden
Circ Res 99:1117-24. 2006..Additionally, this mechanism may contribute to the mediation of the tubuloglomerular feedback by adenosine in the juxtaglomerular apparatus of the kidney... - Does mapping reveal correlation between gene expression and protein-protein interaction?Ralf Mrowka
Nat Genet 33:15-6; author reply 16-7. 2003 - Influence of the adenosine A1 receptor on blood pressure regulation and renin releaseRussell D Brown
Dept of Medical Cell Biology, Division of Integrative Physiology, Uppsala Univ, S 751 23 Uppsala, Sweden
Am J Physiol Regul Integr Comp Physiol 290:R1324-9. 2006..Our results confirm that adenosine, acting through the adenosine A1 receptor, plays an important role in regulating blood pressure, renin release, and sodium excretion... - Identification of coupling direction: application to cardiorespiratory interactionMichael G Rosenblum
Department of Physics, University of Potsdam, Am Neuen Palais, PF 601553, D 14415 Potsdam, Germany
Phys Rev E Stat Nonlin Soft Matter Phys 65:041909. 2002..We find a tendency to change from nearly symmetric bidirectional interaction to nearly unidirectional one (from respiration to the cardiovascular system)...