Research Topics
| Stanislao MorgeraSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Intermittent high-permeability hemofiltration modulates inflammatory response in septic patients with multiorgan failureStanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Berlin, Germany
Nephron Clin Pract 94:c75-80. 2003..The present study examines whether intermittent high-permeability hemofiltration has an immunomodulatory effect on polymorphonuclear leukocytes and mononuclear cells...- Metabolic complications during regional citrate anticoagulation in continuous venovenous hemodialysis: single-center experienceStanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Germany
Nephron Clin Pract 97:c131-6. 2004.... - Long-term outcomes after acute kidney injuryStanislao Morgera
Department of Nephrology, University Hospital Charite, Campus Mitte, Berlin, Germany
Crit Care Med 36:S193-7. 2008..There is no doubt that aggressive intensive care unit treatment is justified in these patients, irrespective of the health costs... - Renal replacement therapy with high-cutoff hemofilters: Impact of convection and diffusion on cytokine clearances and protein statusStanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Germany
Am J Kidney Dis 43:444-53. 2004..This study compares diffusive versus convective high-cutoff renal replacement therapy (RRT) in terms of cytokine clearance rates and effects on plasma protein levels... - Combined ETA/ETB receptor blockade of human peritoneal mesothelial cells inhibits collagen I RNA synthesisStanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Berlin, Germany
Kidney Int 64:2033-40. 2003..We studied osmolarity and physical stress-induced effects on collagen I RNA synthesis in human peritoneal mesothelial cells (HPMCs) and focused on endothelin as a possible mediator... - High permeability haemofiltration improves peripheral blood mononuclear cell proliferation in septic patients with acute renal failureStanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Schumannstrasse 20 21, D 10098 Berlin, Germany
Nephrol Dial Transplant 18:2570-6. 2003..The present study examines whether HP-HF has an impact on peripheral blood mononuclear cell (PBMC) proliferation and whether ultrafiltrate can alter PBMC function in isolates from healthy volunteers... - Intermittent high permeability hemofiltration in septic patients with acute renal failureStanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Schumannstrasse 20 21, 10098, Berlin, Germany
Intensive Care Med 29:1989-95. 2003..In addition, the clearance capacity for interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) is analyzed... - Regional citrate anticoagulation in continuous hemodialysis--acid-base and electrolyte balance at an increased dose of dialysisStanislao Morgera
Department of Nephrology, University Hospital Charité Campus Mitte, Berlin, Germany
Nephron Clin Pract 101:c211-9. 2005..This study aimed at establishing a citrate anticoagulation protocol designed for a dialysate flow rate of about 2 l/h... - TNF-alpha elimination with high cut-off haemofilters: a feasible clinical modality for septic patients?Stanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Germany
Nephrol Dial Transplant 18:1361-9. 2003..We analysed the cytokine elimination capacity of a newly developed polyflux high cut-off haemofilter. Different renal replacement therapies are compared and tested for their clinical feasibility... - Novel renal replacement strategies for the elimination of serum free light chains in patients with kappa light chain nephropathyL Kleeberg
Department of Nephrology, Charite Universitatsmedizin Berlin, Charite Platz 1, 10117 Berlin, Germany
Eur J Med Res 14:47-54. 2009..Hemodiafiltration and to lesser extend also hemodialysis with the HCO 1100 hemofilter are able to eliminate substantial amounts of sFLC kappa in MM patients... - A safe citrate anticoagulation protocol with variable treatment efficacy and excellent control of the acid-base statusStanislao Morgera
Departmentsof Nephrology, University Hospital Charité Campus Mitte, Berlin, Germany
Crit Care Med 37:2018-24. 2009..In this article, we provide a safe and an easy-to-handle citrate anticoagulation protocol with variable treatment doses and excellent control of the acid-base status... - Long-term outcomes in acute renal failure patients treated with continuous renal replacement therapiesStanislao Morgera
Department of Nephrology and Institute for Medical Biometrics, Charite, Germany
Am J Kidney Dis 40:275-9. 2002..Limited health care budgets have raised the issue of how much therapy should be dedicated to critically ill patients with multiorgan and acute renal failure (ARF). No data are available on patients with ARF after hospital discharge... - A simple, safe and effective citrate anticoagulation protocol for the genius dialysis system in acute renal failureStanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Berlin, Germany
Nephron Clin Pract 98:c35-40. 2004..A standard heparin anticoagulation protocol served as control... - Glucose-mediated transforming growth factor-beta1 release in human mesothelial cells is endothelin independentStanislao Morgera
Department of Nephrology, Charite, Humboldt University of Berlin, Germany
J Cardiovasc Pharmacol 44:S216-8. 2004..In conclusion, HPMC TGF-beta1 release by glucose and mechanical stress seems not to be related to the activity of the peritoneal endothelin system - at least in our in vitro model... - Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failureStanislao Morgera
Department of Nephrology, Charit, Humboldt University of Berlin, Germany
Crit Care Med 34:2099-104. 2006..In addition, we demonstrate that high cutoff hemofiltration is superior to conventional hemofiltration in the elimination of IL-6 and IL-1ra from the circulating blood of septic patients... - Protracted bleeding after hirudin anticoagulation for cardiac surgery in a patient with HIT II and chronic renal failureOrtrud Vargas Hein
Department of Anesthesiology and Intensive Care Medicine, Charite University Hospital Berlin, Campus Mitte, Berlin, Germany
Artif Organs 29:507-10. 2005.... - Intermittent hirudin versus continuous heparin for anticoagulation in continuous renal replacement therapyOrtrud Vargas Hein
Department of Anesthesiology and Intensive Care, University Hospital Charite, Berlin, Germany
Ren Fail 26:297-303. 2004..Aim of this prospective-controlled pilot study was to compare the efficacy and safety of intermittent hirudin and continuous heparin for anticoagulation during CRRT in critically ill patients... - Iloprost for additional anticoagulation in continuous renal replacement therapy--a pilot studyJurgen Birnbaum
Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Charité Virchow Klinikum, Charite University Medicine, Berlin, Germany
Ren Fail 29:271-7. 2007..The aim of this pilot study was to compare the effect of heparin anticoagulation with and without iloprost administration during continuous renal replacement therapy (CRRT) in critically ill patients... - The use of contrast-enhanced US in renal transplant: first results and potential clinical benefitThomas Fischer
Department of Radiology, Universitatsmedizin Berlin, Campus Charite Mitte, Schumannstrasse 20 21, 10098 Berlin, Germany
Eur Radiol 15:E109-16. 2005.... - Use of fondaparinux (ARIXTRA) in a dialysis patient with symptomatic heparin-induced thrombocytopaenia type IIMichael Haase
Department of Nephrology, University and Teaching Hospitals, Humboldt Univeristy of Berlin, Germany
Nephrol Dial Transplant 20:444-6. 2005 - Does endothelin B receptor deficiency ameliorate the induction of peritoneal fibrosis in experimental peritoneal dialysis?Philipp Kalk
Department of Pharmacology and Toxicology, Center for Cardiovascular Research, Charite, Berlin, Germany
Nephrol Dial Transplant 25:1474-8. 2010..Thus, our study aimed at elucidating the impact of the endothelin B (ETB) receptor on peritoneal membrane thickening by means of an ETB-deficient rat model (ETB(-)(/)(-)) in experimental PD... - A systematic approach to managing pregnant dialysis patients--the importance of an intensified haemodiafiltration protocolMichael Haase
Departments of Nephrology, Charité University Hospital CCM, Berlin, Germany
Nephrol Dial Transplant 20:2537-42. 2005..Here, we report the successful multidisciplinary management of five consecutive pregnant dialysis patients... - Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative glomerulosclerosisStephanie Kramer
Dept of Nephrology, Charite Universitatsmedizin Berlin, Campus Mitte, Humboldt Univ, Chariteplatz 1, D 10098 Berlin, Germany
Am J Physiol Renal Physiol 294:F801-11. 2008..The results suggest that rosuvastatin and an AT(1) blocker independently interfere with separate key pathways involved in the progression of chronic mesangioproliferative GS... - Improved diagnosis of early kidney allograft dysfunction by ultrasound with echo enhancer--a new method for the diagnosis of renal perfusionThomas Fischer
Institut für Radiologie Charité, Universitatsmedizin Berlin, Campus Charite Mitte, Schumannstrasse 20 21, 10098 Berlin, Germany
Nephrol Dial Transplant 21:2921-9. 2006..We, therefore, performed a prospective study to compare the value of ultrasound contrast media (USCM) with conventional US in the diagnosis of early allograft dysfunction... - Quality of life of living kidney donors in Germany: a survey with the Validated Short Form-36 and Giessen Subjective Complaints List-24 questionnairesMarkus Giessing
Department of Urology, Charite University Hospital, Campus Mitte, Berlin, Germany
Transplantation 78:864-72. 2004..Most studies evaluating the impact of kidney donation on donors' quality of life (QOL) have limitations such as small cohort size, unmatched references, use of nonstandardized and nonvalidated questionnaires, or low response rates... - Low-dose prostacyclin preserves renal function in high-risk patients after coronary bypass surgeryStanislao Morgera
Department of Nephrology, University Hospital Charit, Berlin, Germany
Crit Care Med 30:107-12. 2002..CONCLUSION: This first pilot study indicates that low-dose prostacyclin may be of substantial value for preserving renal function in high-risk patients after coronary bypass surgery... - Renal vascular resistance in sepsisChristoph Langenberg
Departments of Intensive Care and Medicine, Austin Hospital and University of Melbourne, Heidelberg, Melbourne, Australia
Nephron Physiol 104:p1-11. 2006..A high cardiac output and the use of large animals predict a decreased RVR, while a decreased cardiac output and the use of small animals predict an increased RVR... - Cytokine dialysis: an ex vivo studyShigehiko Uchino
Department of Intensive Care and Medicine, Austin and Repatriation Medical Centre, Melbourne, Victoria, Australia
ASAIO J 48:650-3. 2002..We conclude that cytokine dialysis is achievable through a membrane with a high cut-off point with negligible albumin loss. These findings support the technical feasibility of this new approach to blood purification in sepsis... - The hazards of whirlpoolingLutz Liefeldt
Lancet 361:534. 2003 - Treatment of severe hypercalcemia using continuous renal replacement therapy with regional citrate anticoagulationDetlef Kindgen-Milles
University Hospital Dusseldorf, Department of Anaesthesiology, Heinrich Heine University, Dusseldorf, Germany
ASAIO J 54:442-4. 2008..The time delay between adjustment in calcium infusion rate and the first detectable change in ionized calcium level was below 4 hours. However, the full response to a change of the calcium substitution was found after 8-12 hours... - N-Acetylcysteine does not artifactually lower plasma creatinine concentrationMichael Haase
Director of Intensive Care Research, Austin Hospital, University of Melbourne, 3084 Heidelberg, Victoria, Australia
Nephrol Dial Transplant 23:1581-7. 2008..However, it has been suggested that NAC may lower plasma creatinine levels independent of any effects on glomerular filtration rate (GFR)... - Sodium citrate anticoagulation during sustained low efficiency dialysis (SLED) in patients with acute renal failure and severely impaired liver functionChristian Morath
Nephrol Dial Transplant 23:421-2. 2008 - Septic acute kidney injury in critically ill patients: clinical characteristics and outcomesSean M Bagshaw
Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
Clin J Am Soc Nephrol 2:431-9. 2007..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT... - Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigatorsShigehiko Uchino
Jikei University School of Medicine, Intensive Care Unit, Department of Anesthesiology, Tokyo, Japan
Intensive Care Med 33:1563-70. 2007..Little information is available regarding current practice in continuous renal replacement therapy (CRRT) for the treatment of acute renal failure (ARF) and the possible clinical effect of practice variation... - External validation of severity scoring systems for acute renal failure using a multinational databaseShigehiko Uchino
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Crit Care Med 33:1961-7. 2005..A large, multiple-center database might be needed to improve the discrimination and calibration of acute renal failure scoring system... - Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trialMichael Haase
Intensive Care Unit, Austin Hospital, University of Melbourne, Australia
Am J Kidney Dis 50:296-304. 2007..However, standard hemodialysis membranes achieve only little diffusive removal of circulating cytokines. Modified membranes may enable both successful IHD treatment and simultaneous diffusive cytokine removal... - Acute renal failure in critically ill patients: a multinational, multicenter studyShigehiko Uchino
Department of Intensive Care, Austin Hospital, Melbourne, Australia
JAMA 294:813-8. 2005..87; 95% CI, 1.07-3.28; P = .03). CONCLUSION: In this multinational study, the period prevalence of ARF requiring RRT in the ICU was between 5% and 6% and was associated with a high hospital mortality rate... - Renal blood flow in sepsisChristoph Langenberg
Department of Intensive Care, Austin Hospital, and University of Melbourne, Heidelberg, Melbourne, Australia
Crit Care 9:R363-74. 2005.... - Diuretics and mortality in acute renal failureShigehiko Uchino
Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Australia
Crit Care Med 32:1669-77. 2004..There is full equipoise for a randomized controlled trial of diuretics in critically ill patients with renal dysfunction... - Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patientsMichael Haase
Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
Crit Care Med 35:1324-31. 2007..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure... - Successful pregnancies in dialysis patients including those suffering from cystinosis and familial Mediterranean feverMichael Haase
Department of Nephrology, , Berlin-Germany
J Nephrol 19:677-81. 2006..These modified management guidelines have led to a favourable outcome in all our patients including two patients with familial Mediterranean fever and with cystinosis, and may help to guide therapy in other pregnant dialysis patients... - Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case reportToshio Naka
Department of Intensive Care, Melbourne University, Austin Hospital, Melbourne, Australia
Crit Care 9:R90-5. 2005..CONCLUSIONS: SHF hemofiltration achieved a much greater clearance of myoglobin than conventional hemofiltration, and it may provide a potential modality for the treatment of myoglobinuric acute renal failure...