D A Groneberg

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Scoliosis: density-equalizing mapping and scientometric analysis
    Karin Vitzthum
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin and Humboldt University Berlin, Germany
    Scoliosis 4:15. 2009
  2. ncbi Reduced inclination of cervical spine in a novel notebook screen system - implications for rehabilitation
    David Quarcoo
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, D 14195 Berlin, Germany
    J Occup Med Toxicol 6:30. 2011
  3. ncbi Editorial: Experimental models of asthma
    Armin Braun
    Fraunhofer Institute of Toxicology and Experimental Medicine, D 30625 Hannover, Germany
    J Occup Med Toxicol 3:S1. 2008
  4. ncbi Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat
    Rene Schmidt
    Department of Internal Medicine, Division of Pneumology, Klinik Loewenstein, Geißhoelzle 62, D 74245 Loewenstein, Germany
    J Occup Med Toxicol 3:5. 2008
  5. ncbi Mobile Air Quality Studies (MAQS)-an international project
    David A Groneberg
    Department of Informatics, The Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Medical School of the Freie University Berlin and the Humboldt University Berlin, Berlin, Germany
    J Occup Med Toxicol 5:8. 2010
  6. ncbi New drugs targeting Th2 lymphocytes in asthma
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    J Occup Med Toxicol 3:S6. 2008
  7. ncbi High abundances of neurotrophin 3 in atopic dermatitis mast cell
    David Quarcoo
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, D 14195 Berlin, Germany
    J Occup Med Toxicol 4:8. 2009
  8. ncbi Air pollution research: visualization of research activity using density-equalizing mapping and scientometric benchmarking procedures
    Hanna Zell
    Department of Information Science, Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin and Humboldt University Berlin, Thielallee 69 73, 14195 Berlin, Germany
    J Occup Med Toxicol 5:5. 2010
  9. ncbi Psychotrauma and effective treatment of post-traumatic stress disorder in soldiers and peacekeepers
    Karin Vitzthum
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin and Humboldt University Berlin, Thielallee 69 73, D 14195 Berlin, Germany
    J Occup Med Toxicol 4:21. 2009
  10. ncbi The impact of shift work induced chronic circadian disruption on IL-6 and TNF-alpha immune responses
    Anke van Mark
    Institute of Occupational Medicine, University of Lubeck, 23538 Lubeck, Ratzeburger Allee 160, Germany
    J Occup Med Toxicol 5:18. 2010

Collaborators

Detail Information

Publications122 found, 100 shown here

  1. ncbi Scoliosis: density-equalizing mapping and scientometric analysis
    Karin Vitzthum
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin and Humboldt University Berlin, Germany
    Scoliosis 4:15. 2009
    ..Scientometric data on developments and tendencies in scoliosis research has not been available to date. The aim of the current study was to evaluate the scientific efforts of scoliosis research both quantitatively and qualitatively...
  2. ncbi Reduced inclination of cervical spine in a novel notebook screen system - implications for rehabilitation
    David Quarcoo
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, D 14195 Berlin, Germany
    J Occup Med Toxicol 6:30. 2011
    ..abstract:..
  3. ncbi Editorial: Experimental models of asthma
    Armin Braun
    Fraunhofer Institute of Toxicology and Experimental Medicine, D 30625 Hannover, Germany
    J Occup Med Toxicol 3:S1. 2008
    ..Over the years the topics within the extensive field of asthma and COPD have ranged from methodological aspects to the influence of infections and environmental factors up to perspectives in the development of new therapeutic strategies...
  4. ncbi Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat
    Rene Schmidt
    Department of Internal Medicine, Division of Pneumology, Klinik Loewenstein, Geißhoelzle 62, D 74245 Loewenstein, Germany
    J Occup Med Toxicol 3:5. 2008
    ..Therefore, the aim of this study was to evaluate the effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity...
  5. ncbi Mobile Air Quality Studies (MAQS)-an international project
    David A Groneberg
    Department of Informatics, The Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Medical School of the Freie University Berlin and the Humboldt University Berlin, Berlin, Germany
    J Occup Med Toxicol 5:8. 2010
    ..Primarily, the MAQS-platform will focus on particulate matter. With the establishment of advanced mobile analysis tools, it is planed to extend the analysis to other pollutants including NO2, SO2, nanoparticles and ozone...
  6. ncbi New drugs targeting Th2 lymphocytes in asthma
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    J Occup Med Toxicol 3:S6. 2008
    ..Some of these new Th2-oriented strategies may in the future not only control symptoms and modify the natural course of asthma, but also potentially prevent or cure the disease...
  7. ncbi High abundances of neurotrophin 3 in atopic dermatitis mast cell
    David Quarcoo
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, D 14195 Berlin, Germany
    J Occup Med Toxicol 4:8. 2009
    ..Their cellular sources and role in the recruitment of mast cell precursors in atopic dermatitis have not been characterized in detail so far...
  8. ncbi Air pollution research: visualization of research activity using density-equalizing mapping and scientometric benchmarking procedures
    Hanna Zell
    Department of Information Science, Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin and Humboldt University Berlin, Thielallee 69 73, 14195 Berlin, Germany
    J Occup Med Toxicol 5:5. 2010
    ..Although there has been a large amount of research on this topic, bibliometric data is still to be collected. Thus this study provides a scientometric approach to the material published on this subject so far...
  9. ncbi Psychotrauma and effective treatment of post-traumatic stress disorder in soldiers and peacekeepers
    Karin Vitzthum
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin and Humboldt University Berlin, Thielallee 69 73, D 14195 Berlin, Germany
    J Occup Med Toxicol 4:21. 2009
    ..Further research is needed to understand the influence and unique psychological requirements of each specific military operation on the internationally deployed soldiers...
  10. ncbi The impact of shift work induced chronic circadian disruption on IL-6 and TNF-alpha immune responses
    Anke van Mark
    Institute of Occupational Medicine, University of Lubeck, 23538 Lubeck, Ratzeburger Allee 160, Germany
    J Occup Med Toxicol 5:18. 2010
    ..The particular impact of shift work induced chronic circadian disruption on specific immune responses has not been addressed so far...
  11. ncbi Bidirectional Assessment of Stress, job satisfaction and work ability of Educators in day care centres: a real-time observation study - the study protocol (BASE)
    Bianca Kusma
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, Thielallee 69 73, 14195 Berlin, Germany
    J Occup Med Toxicol 5:16. 2010
    ..Previous studies were mainly based on questionnaire data. Objective data does not exist. Therefore the aim of this investigation is to collect precise data relating to work of educators...
  12. ncbi Medical work Assessment in German hospitals: a Real-time Observation study (MAGRO) - the study protocol
    Stefanie Mache
    Institute of Occupational Medicine, Charite School of Medicine, Free University and Humboldt University, Thielallee 69 73, 14195 Berlin, Germany
    J Occup Med Toxicol 4:12. 2009
    ..Little attention has been devoted to the effects of hospital ownership on physicians' working routines.The aim of this observational real time study is to deliver exact data about physicians' work at hospitals of different ownership...
  13. ncbi Influenza A (H1N1) 2009: Impact on Frankfurt in due consideration of health care and public health
    Sabine Wicker
    Occupational Health Service, Hospital of the Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Occup Med Toxicol 5:10. 2010
    ..Most of the countries established infection surveillance systems in order to track the number of (laboratory-confirmed) H1N1 cases, hospitalizations and deaths...
  14. ncbi Development and evaluation of a computer-based medical work assessment programme
    Stefanie Mache
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, Thielallee 69 73, 14195 Berlin, Germany
    J Occup Med Toxicol 3:35. 2008
    ..In addition reliability and validity data of this instrument will be demonstrated...
  15. ncbi Does type of hospital ownership influence physicians' daily work schedules? An observational real-time study in German hospital departments
    Stefanie Mache
    Institute of Occupational Medicine, , Free University and Humboldt University, Berlin, Germany
    Hum Resour Health 7:41. 2009
    ..The study provides an objective insight into physicians' daily work routines at hospitals of different ownership, with additional information on effects of hospital privatization...
  16. ncbi Physicians' working conditions and job satisfaction: does hospital ownership in Germany make a difference?
    Stefanie Mache
    Institute of Occupational Medicine, Charite School of Medicine, Free University and Humboldt University, 14195 Berlin, Germany
    BMC Health Serv Res 9:148. 2009
    ..To that end, this study's purpose is to compare how physicians, working for both public and privatized hospitals, rate their respective psychosocial working conditions and job satisfaction...
  17. ncbi Specific immunotherapy in Albanian patients with anaphylaxis to hymenoptera venoms
    Ervin Mingomataj
    Dept of Allergy, Mother Theresa School of Medicine, University of Tirana, Tirana, Albania
    BMC Dermatol 2:11. 2002
    ..The objective of the present study was to examine the characteristics of allergic reactions during Rush-SIT in a cohort of patients with allergy towards hymenoptera venom in the mediterranean population of Albania...
  18. ncbi Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease
    David A Groneberg
    Otto Heubner Centre, Pneumology and Immunology, Free University Berlin and Humboldt University, D 13353 Berlin, Germany
    Biol Chem 386:53-9. 2005
    ..The present data on neurotrophin-specific transcriptional down-regulation of NT-3 in human COPD indicate a pathophysiological role for neurotrophins in COPD...
  19. ncbi Models of chronic obstructive pulmonary disease
    David A Groneberg
    Pneumology and Immunology, Otto Heubner Centre, Charite School of Medicine, Free University and Humboldt University, Berlin, Germany
    Respir Res 5:18. 2004
    ..Future approaches should aim to mimic irreversible airflow obstruction, associated with cough and sputum production, with the possibility of inducing exacerbations...
  20. ncbi Neuropeptide Y (NPY)
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charite School of Medicine, Free University and Humboldt University, Berlin, Germany
    Pulm Pharmacol Ther 17:173-80. 2004
    ..However, since selective antagonists and agonists and gene-depleted animals for the different receptors are now available, NPY may be of value for future strategies in airway nerve modulation...
  21. ncbi Severe acute respiratory syndrome: global initiatives for disease diagnosis
    D A Groneberg
    Department of Medicine Pediatric Pneumology and Immunology, Charite School of Medicine, Humboldt University, Berlin, Germany
    QJM 96:845-52. 2003
    ..Even in a situation of no new cases of infection, SARS remains a major respiratory health hazard. As with influenza virus outbreaks, new epidemics may arise at the end of each year...
  22. ncbi Treatment and vaccines for severe acute respiratory syndrome
    David A Groneberg
    Department of Pneumology, Hannover Medical School, Hannover, Germany
    Lancet Infect Dis 5:147-55. 2005
    ..Efforts should be made to evaluate the most promising treatments and vaccines in controlled clinical trials, should another SARS outbreak occur...
  23. ncbi Novel strategies of aerosolic pharmacotherapy
    David A Groneberg
    Departmnt of Respiratory Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Exp Toxicol Pathol 57:49-53. 2006
    ..Since genotype analysis revealed no significant differences amongst different transporter genotypes concerning expression and function, the transporter displays an interesting novel target for pulmonary delivery of drugs...
  24. ncbi Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport
    David A Groneberg
    Deptartment of Pediatric Pneumology and Immunology Medicine, Charite School of Medicine, Humboldt University CVK OR 1 R 3 0073, Augustenburger Platz 1, D 13353 Berlin, Germany
    Am J Respir Cell Mol Biol 30:251-60. 2004
    ....
  25. ncbi Gene expression and regulation of nerve growth factor in atopic dermatitis mast cells and the human mast cell line-1
    David A Groneberg
    Allergy Centre Charité, Charite School of Medicine, Free and Humboldt University, Augustenburger Platz 1 OR 1, D 13353 Berlin, Germany
    J Neuroimmunol 161:87-92. 2005
    ..These findings demonstrate an increased expression of NGF in AD and effects on tryptase and histamine. Mast cells may be major mediators of neurotrophin effects in AD...
  26. ncbi Tachykinins in the respiratory tract
    David A Groneberg
    Otto Heubner Centre, Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Curr Drug Targets 7:1005-10. 2006
    ..Together with other novel tachykinin peptides such as C14TKL-1 and virokinin further research is required to define their respiratory biological role in health and disease...
  27. ncbi [Vasoactive intestinal polypeptide in the respiratory tract: physiology and pathophysiology]
    D A Groneberg
    Klinische Forschergruppe Allergologie, Charite Universitatsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, 13353 Berlin
    Pneumologie 58:330-8. 2004
    ..However, recent data from animal experiments indicate potent immunomodulatory effects which suggest a future use of this mediator and its agonists in the therapy of immune diseases...
  28. ncbi Smads as intracellular mediators of airway inflammation
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Exp Lung Res 30:223-50. 2004
    ....
  29. ncbi Toxic rhinitis-induced changes of human nasal mucosa innervation
    David A Groneberg
    Department of Otorhinolaryngology, Karlsruhe Teaching Hospital, University of Freiburg, Karlsruhe, Germany
    Toxicol Pathol 31:326-31. 2003
    ..Airway innervation may have a major role in the pathophysiology of toxic rhinitis associated with chronic cigarette smoke exposure...
  30. ncbi Berlin's medical students' smoking habits, knowledge about smoking and attitudes toward smoking cessation counseling
    Bianca Kusma
    Institute of Occupational Medicine, Charite School of Medicine, Free University and Humboldt University, Thielallee 69 73, 14195 Berlin, Germany
    J Occup Med Toxicol 5:9. 2010
    ..Eliminating smoking can do more to improve health and prolong life than any other measure in the field of preventive medicine. Today's medical students will play a prominent role in future efforts to prevent and control tobacco use...
  31. ncbi In vitro models to study hepatotoxicity
    David A Groneberg
    Department of Pediatric Pneumology and Immunology, Charite School of Medicine, Humboldt University Berlin, Germany
    Toxicol Pathol 30:394-9. 2002
    ....
  32. ncbi Expression of immediate early genes in sensory ganglia
    D A Groneberg
    Division of Allergy Research, Biomedical Research Center, Charite Medical School, Humboldt University of Berlin, Germany
    Neurochem Res 26:1113-7. 2001
    ....
  33. ncbi Vasoactive intestinal polypeptide as mediator of asthma
    D A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Humboldt University, Berlin, Germany
    Pulm Pharmacol Ther 14:391-401. 2001
    ....
  34. ncbi [Chronic cough: associations between clinical symptoms and the nervous system]
    D A Groneberg
    Klinische Forschergruppe Allergologie, Charit,
    Pneumologie 57:473-4. 2003
  35. ncbi Distribution of respiratory mucin proteins in human nasal mucosa
    David A Groneberg
    Department of Medicine, Charite School of Medicine, Humboldt University, Charite Campus Virchow, BMFZ Forum 4 Fach 40, Augustenburger Platz 1, D 13353 Berlin, Germany
    Laryngoscope 113:520-4. 2003
    ..We examined the cellular expression and distribution of two major respiratory mucus-forming glycoproteins, MUC5AC and MUC5B, in normal human nasal tissues...
  36. ncbi Endogenous opioids as mediators of asthma
    D A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Humboldt University, Berlin, Germany
    Pulm Pharmacol Ther 14:383-9. 2001
    ..In conclusion, opioids resemble a group of regulatory peptides which are present within airway-innervating nerve fibres and influence a multitude of airway functions via modification of neural transmission...
  37. ncbi Molecular mechanisms of severe acute respiratory syndrome (SARS)
    David A Groneberg
    Pneumology and Immunology, Otto Heubner Centre, Charite School of Medicine, Free University and Humboldt University, D 13353 Berlin, Germany
    Respir Res 6:8. 2005
    ..Even in a situation of no new infections, SARS remains a major health hazard, as new epidemics may arise. Therefore, further experimental and clinical research is required to control the disease...
  38. ncbi Phenotypic alteration of neuropeptide-containing nerve fibres in seasonal intermittent allergic rhinitis
    W Heppt
    Department of Otorhinolaryngology, Karlsruhe Teaching Hospital, University of Freiburg, Karlsruhe, Germany
    Clin Exp Allergy 34:1105-10. 2004
    ..CONCLUSION: The increase of neuropeptide expression in mucosal nerve fibres indicates a major role of the autonomous mucosal innervation in the pathophysiology of intermittent (seasonal) AR...
  39. ncbi Expression of tyrosine hydroxylase and neuropeptide tyrosine in mouse sympathetic airway-specific neurons under normal situation and allergic airway inflammation
    Q T Dinh
    Department of Internal Medicine, Charite School of Medicine, Humboldt University, Berlin, Germany
    Clin Exp Allergy 34:1934-41. 2004
    ..The traditional neurotransmitter catecholamine and the neuropeptide tyrosine in sympathetic airway nerves have been proposed to be involved in the pathogenesis of airway diseases...
  40. ncbi Allergic airway inflammation induces tachykinin peptides expression in vagal sensory neurons innervating mouse airways
    Q T Dinh
    Department of Internal Medicine, Charite School of Medicine, Humboldt and Freie University Berlin, Berlin, Germany
    Clin Exp Allergy 35:820-5. 2005
    ....
  41. ncbi Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1
    D A Groneberg
    Department of Pediatrics, , Humboldt University, 13353 Berlin, Germany
    Am J Physiol Gastrointest Liver Physiol 281:G697-704. 2001
    ..This is the first study that visualizes dipeptide transport across the mammalian intestine and indicates that uptake assays using D-Ala-Lys-AMCA might be useful for characterizing PEPT1-specific substrates or inhibitors...
  42. ncbi Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice
    H D Lauenstein
    Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Clin Exp Allergy 41:592-601. 2011
    ....
  43. ncbi Nerve growth factor-induced substance P in capsaicin-insensitive vagal neurons innervating the lower mouse airway
    Q T Dinh
    Department of Medicine, Charite Humboldt University, Berlin, Germany
    Clin Exp Allergy 34:1474-9. 2004
    ..Nerve growth factor (NGF) is elevated in allergic diseases such as bronchial asthma and can lead to an induction of substance P (SP) and related neuropeptides in guinea-pigs large-diameter, neurofilament-positive airway neurons...
  44. ncbi Cell type-specific regulation of brain-derived neurotrophic factor in states of allergic inflammation
    D A Groneberg
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, Berlin, Germany
    Clin Exp Allergy 37:1386-91. 2007
    ..Because the precise regulation of gene transcription in mast cells MCs is not clear, the present studies assessed the gene regulation of BDNF in this inflammatory cell type...
  45. ncbi Pan-neurotrophin receptor p75NTR expression is strongly induced in lesional atopic mast cells
    T C Fischer
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Free University and Humboldt University, Berlin, Germany
    Clin Exp Allergy 38:1168-73. 2008
    ..Because the precise regulation of p75NTR gene transcription in mast cells under states of allergic inflammation has not been investigated in detail so far, the present studies assessed the gene regulation and expression of this receptor...
  46. ncbi Gene expression and regulation of transcription factor activator protein-2 alpha in human mast cells
    P Welker
    Department of Dermatology and Allergy, , Free University and Humboldt-University, Berlin, Germany
    Allergy 60:1046-52. 2005
    ..CONCLUSIONS: These findings suggest a continuous activation of AP-2alpha in mastocytomas and mast cell leukemia and its transient upregulation during c-Kit dependent early steps of normal mast cell differentiation...
  47. ncbi Aspirin-sensitive rhinitis-associated changes in upper airway innervation
    D A Groneberg
    Dept of Otorhinolaryngology, Karlsruhe Teaching Hospital, University of Freiburg, Karlsruhe, Germany
    Eur Respir J 22:986-91. 2003
    ..These differences may reflect a pathophysiological role of upper airway innervation in pseudoallergic reactions...
  48. ncbi Abundant expression of c-Jun in guinea pig sympathetic ganglia under basal conditions and allergen challenge
    D A Groneberg
    Department of Pediatric Pneumology and Immunology, , Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Lung 180:221-8. 2002
    ..5-positive sympathetic neurons were labeled for c-Jun. The high basal levels of c-Jun expression indicate that the presence of c-Jun is not exclusively related to noxious stimulation such as allergic airway inflammation in the guinea pig...
  49. ncbi Neurokinin-1 receptor activation induces reactive oxygen species and epithelial damage in allergic airway inflammation
    J Springer
    Department of Cardiology, Division of Applied Cachexia Research, Charite Medical School, Berlin, Germany
    Clin Exp Allergy 37:1788-97. 2007
    ..An induction of reactive oxygen species (ROS) is characteristic for inflammation but the exact pathways have not been identified for allergic airway diseases so far...
  50. ncbi Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung
    D A Groneberg
    Department of Pediatric Pneumology and Immunology, , Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany
    Thorax 57:55-60. 2002
    ....
  51. ncbi Expression of PEPT2 peptide transporter mRNA and protein in glial cells of rat dorsal root ganglia
    D A Groneberg
    Department of Pediatric Pneumology and Immunology, , Humboldt-University, Augustenburger Platz 1, D-13353 Berlin, Germany
    Neurosci Lett 304:181-4. 2001
    ....
  52. ncbi Fundamentals of pulmonary drug delivery
    D A Groneberg
    Department of Pediatric Pneumology and Immunology, , Humboldt University, Berlin, Germany
    Respir Med 97:382-7. 2003
    ..Based on the growing knowledge on pulmonary cell biology and pathophysiology due to modern methods of molecular biology, the future characterization of pulmonary drug transport pathways can lead to new strategies in aerosol drug therapy...
  53. ncbi Neuronal plasticity in persistent perennial allergic rhinitis
    Axel Fischer
    Occupational and Environmental Medicine Research Unit, Division of Allergy Research, Otto-Heubner-Centre, , Free University and Humboldt-University, Berlin, Germany
    J Occup Environ Med 47:20-5. 2005
    ....
  54. ncbi An observational real-time study to analyze junior physicians' working hours in the field of gastroenterology
    S Mache
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, Germany
    Z Gastroenterol 47:814-8. 2009
    ..However, such data is not available in the research literature. Therefore the aim of the current study is to deliver exact data about physicians' work in different gastroenterology departments to analyze and to optimize work routines...
  55. ncbi Mast cells and vasculature in atopic dermatitis--potential stimulus of neoangiogenesis
    D A Groneberg
    Department of Pediatric Pneumology and Immunology, Division of Allergy Research, , Free University and Humboldt University, Berlin, Germany
    Allergy 60:90-7. 2005
    ..Via the new vessels, inflammatory cells, together with complement components and antibodies, can be transported to the epidermis to aid in the defense against environmental antigens and to maintain chronic inflammation...
  56. ncbi Effects of different perfusates on functional parameters of isolated perfused dog kidneys
    Joachim Höchel
    Institute of Veterinary Physiology, Freie Universitat Berlin, Berlin, Germany
    Nephrol Dial Transplant 18:1748-54. 2003
    ..Thus, an additional aim was to determine whether blood could be replaced by synthetic cell-free perfusion solutions...
  57. ncbi Innervation of human nasal mucosa in environmentally triggered hyperreflectoric rhinitis
    Werner Heppt
    Department of Otorhinolaryngology, Karlsruhe Teaching Hospital, University of Freiburg, Karlsruhe, Germany
    J Occup Environ Med 44:924-9. 2002
    ....
  58. ncbi Novel concepts of neuropeptide-based drug therapy: vasoactive intestinal polypeptide and its receptors
    David A Groneberg
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Eur J Pharmacol 533:182-94. 2006
    ....
  59. ncbi Down-regulation of vasoactive intestinal polypeptide receptor expression in atopic dermatitis
    David A Groneberg
    Clinical Research Unit of Allergology, Department of Pediatric Pneumology and Immunology, , Humboldt-University, Berlin, Germany
    J Allergy Clin Immunol 111:1099-105. 2003
    ..CONCLUSION: The downregulation of VPAC(2) in human mast cells in acute lesions of atopic dermatitis suggests a role of this G-protein;coupled receptor in the pathophysiology of the disease...
  60. ncbi Hemoperfused isolated porcine slaughterhouse kidneys as a valid model for pharmacological studies
    Christian Grosse-Siestrup
    Department of Comparative Medicine and Facilities of Experimental Animal Sciences, , Humboldt University, D-13353 Berlin, Germany
    J Pharm Sci 92:1147-54. 2003
    ....
  61. ncbi Influence of cold storage on renal ischemia reperfusion injury after non-heart-beating donor explantation
    Sven Dittrich
    Department of Congenital Heart Diseases, German Heart Center, Berlin, Germany
    Nephron Exp Nephrol 96:e97-102. 2004
    ..Cold storage augmented deterioration of the kidney as histologically and functionally demonstrated. Thus, preservation times for non-heart-beating kidneys should be carefully reappraised...
  62. ncbi Monocytes of allergics and non-allergics produce, store and release the neurotrophins NGF, BDNF and NT-3
    Bettina Rost
    Allergy and Asthma Clinic, Department of medicine Infectious and Respiratory diseases, Charite, Humboldt University, Augustenburger Platz 1, Berlin 13353, Germany
    Regul Pept 124:19-25. 2005
    ..However, the exact cellular sources involved in the regulation and release of neurotrophins in allergic inflammation are still not well defined...
  63. ncbi Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus
    Christian Peiser
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charit, Virchow Campus, Humboldt-University, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurosci Lett 320:41-4. 2002
    ..These findings suggest that leptin may use a neural route to relay its message from peripheral sites of leptin synthesis such as the gastric fundus to the brain...
  64. ncbi Expression and distribution of vasoactive intestinal polypeptide receptor VPAC(2) mRNA in human airways
    D A Groneberg
    Research Division of Allergy, Department of Pediatrics, Charite, Humboldt University, Berlin, Germany
    Lab Invest 81:749-55. 2001
    ..However, a paracrine modulation of the two most prominent effects of VIP in the respiratory tract by VPAC(2) cannot be excluded...
  65. ncbi Depression and suicide publication analysis, using density equalizing mapping and output benchmarking
    B H Vogelzang
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, D 14195 Berlin, Germany
    Indian J Psychol Med 33:59-65. 2011
    ..This association has been reflected by numerous scientific publications reporting about studies to this theme. There is currently no overall evaluation of the global research activities in this field...
  66. ncbi Animal models of allergic and inflammatory conjunctivitis
    D A Groneberg
    Department of Pediatric Pneumology and Immunology, , Humboldt-University Berlin, Germany
    Allergy 58:1101-13. 2003
    ..In the future, combined ocular, nasal and aerosolic challenges with allergens may provide a model of allergy that encompasses simultaneously the target organs eye, nose and airways with conjunctivitis, rhinitis and asthma...
  67. ncbi [Erythropoietin - state of science]
    N Schöffel
    Institut für Arbeitsmedizin, Charite Universitatsmedizin Berlin, Berlin Dahlem
    Sportverletz Sportschaden 22:201-6. 2008
    ..This detection offered approaches in treatment for apoplexia and cardiac infarction and even in preventive treatment of cardiovascular diseases which led to an interest of manifold subject categories...
  68. ncbi [Always out of breath? An analysis of a doctor's tasks in pneumology]
    S Mache
    Institut für Arbeitsmedizin, Charite Universitatsmedizin Berlin, Freie Universität und Humboldt Universität, Berlin
    Pneumologie 63:369-73. 2009
    ..Therefore, the aim of the current study was to collect precise data about physicians' work in respiratory medicine in order to analyse working routines...
  69. ncbi [Intermittent hypoxic training--the state of science]
    N Schöffel
    Abteilungen Pneumologie und Sportmedizin des Instituts für Arbeitsmedizin, Charite Universitatsmedizin Berlin, Freie Universität Berlin und Humboldt Universität zu Berlin, Berlin, Germany
    Pneumologie 62:279-83. 2008
    ..This study analyses the results of selected studies that deal with IHT, evaluating the performance improvements in general and possible haematological variances/changes specifically...
  70. ncbi Cancer care and residents' working hours in oncology and hematology departments: an observational real-time study in German hospitals
    Stefanie Mache
    Institut für Arbeitsmedizin, Charite Universitatsmedizin Berlin, Humboldt Universität zu Berlin und Freie Universität Berlin, Thielallee 69 73, 14195 Berlin, Germany
    Jpn J Clin Oncol 41:81-6. 2011
    ..However, to date, there have been no real-time observational studies to verify these subjective reports. Therefore, this study is the first to provide objective data about residents' workload...
  71. ncbi Is TRPV1 a useful target in respiratory diseases?
    Masaya Takemura
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin and Humboldt University Berlin, D 14195 Berlin, Germany
    Pulm Pharmacol Ther 21:833-9. 2008
    ..Because of its key role in initiating inflammatory processes, TRPV1 receptor antagonists have been proposed as therapeutic candidates. Therefore, a critical update of recent therapeutic results is also given in this review...
  72. ncbi Evaluation of renal functional parameters in different settings of isolated organ hemoperfusions
    Volker Unger
    Department of Experimental Animal Sciences, Charite Universitaetsmedizin Berlin, Free University and Humboldt University, D 13353 Berlin, Germany
    Physiol Meas 27:1167-75. 2006
    ..The method may be of use to differentiate various kidney perfusion parameters both at the experimental and clinical levels...
  73. ncbi Multiple-organ harvesting for models of isolated hemoperfused organs of slaughtered pigs
    Christan Grosse-Siestrup
    Dept and Facilities of Experimental Animal Sciences, Humboldt University of Berlin, Germany
    ALTEX 19:9-13. 2002
    ..The harvesting process did not disturb the commercial use of the animals. Thus, multiple or single organ harvesting may be a useful method to reduce the use of laboratory animals...
  74. ncbi Isolated hemoperfused slaughterhouse livers as a valid model to study hepatotoxicity
    Christian Grosse-Siestrup
    Department of Comparative Medicine and Experimental Animal Sciences, Charite School of Medicine, Humboldt University, Berlin, Germany
    Toxicol Pathol 30:749-54. 2002
    ..As a major economic advantage in comparison to setups using laboratory animals, the new model can be run with blood and organs obtained from slaughterhouse animals...
  75. ncbi The role of endocarditis, myocarditis and pericarditis in qualitative and quantitative data analysis
    Norman Schöffel
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin, Berlin, Germany
    Int J Environ Res Public Health 6:2919-33. 2009
    ..e., h-index, impact factor) that limit their suitability as measures of research quality. In this respect, self-citations should be generally excluded from calculations of h-index and impact factor...
  76. ncbi Pediatricians' working conditions in German hospitals: a real-time task analysis
    Stefanie Mache
    Institute of Occupational Medicine, Charité Universitätsmedizin Berlin Free University and Humboldt University, Thielallee 69 73, Berlin, Germany
    Eur J Pediatr 169:551-5. 2010
    ..Improvements in work organization and a new allocation of responsibilities among the medical staff may prove helpful in improving the quality of patient care by reducing the burden on pediatricians...
  77. ncbi [Interdisciplinary strategies versus doping]
    Karin Vitzthum
    Abteilungen Pneumologie und Sportmedizin des Instituts für Arbeitsmedizin, Charite Universitatsmedizin Berlin, Freie Universität Berlin und Humboldt Universität zu Berlin, Berlin Dahlem, Deutschland
    Wien Klin Wochenschr 122:325-33. 2010
    ..By means of this data an all-embracing view should be given over the current situation, problems and prospects in German-speaking countries...
  78. ncbi Dopamine D2 receptor mRNA expression is increased in the jugular-nodose ganglia of rats with nitrogen dioxide-induced chronic bronchitis
    Christian Peiser
    Department of Pediatric Pneumology and Immunology, Charite Campus Virchow, Medical University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurosci Lett 465:143-6. 2009
    ....
  79. ncbi A model of isolated autologously hemoperfused porcine slaughterhouse kidneys
    Christian Grosse-Siestrup
    Department of Experimental Animal Sciences, Biomedical Research Center, Charité Faculty of Medicine, Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Nephron 92:414-21. 2002
    ..Numerous models of isolated perfused kidneys have been established in the past years but limitations such as organ size, perfusate and ethical standards have restricted a widespread research in this area...
  80. ncbi Real time analysis of psychiatrists' workflow in German hospitals
    Stefanie Mache
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University and Humboldt University, Thielallee 69 73, 14195 Berlin, Germany
    Nord J Psychiatry 65:112-6. 2011
    ..Previous studies have assessed job satisfaction by conducting surveys among medical professionals. However, to date, no objective work task analysis has been conducted to investigate the workflow of psychiatrists in Germany...
  81. ncbi General and visceral surgery practice in German hospitals: a real-time work analysis on surgeons' work flow
    Stefanie Mache
    Institute of Occupational Medicine, Charite, Universitatsmedizin Berlin, Free University and Humboldt University, Thielallee 69 73, 14195, Berlin, Germany
    Langenbecks Arch Surg 395:81-7. 2010
    ..In this study, we sought to report precise data on surgeons' workflow in several German hospitals...
  82. ncbi Rheumatoid arthritis: scientific development from a critical point of view
    Norman Schöffel
    Institute of Occupational Medicine, Charite Universitatsmedizin Berlin, Free University Berlin, Humboldt University Berlin, Thielallee 69 73, Berlin, Germany
    Rheumatol Int 30:505-13. 2010
    ..Nevertheless, statements concerning the scientific quality should be considered critical due to a bias according to self-citation and co-authorship...
  83. ncbi Observation and analysis of junior OB/GYNs' workflow in German hospitals
    Lisa Kloss
    Institute of Occupational Medicine, Charite, Universitatsmedizin Berlin, Free University, Thielallee 69 73, 14195, Berlin, Germany
    Arch Gynecol Obstet 281:871-8. 2010
    ..However, there is a lack of objective work task analysis. The aim of this study is to monitor the workflow of German obstetrician/gynecologists (OB/GYN) through an objective, computer-based analysis...
  84. ncbi Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa
    Q Thai Dinh
    Department of Medicine, Charite, Humboldt University, Berlin, Germany
    Neuropeptides 37:245-50. 2003
    ....
  85. ncbi An improved model of isolated hemoperfused porcine livers using pneumatically driven pulsating blood pumps
    Stefan Nagel
    Department of Comparative Medicine and Experimental Animal Science, Charite University Medicine Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Toxicol Pathol 33:434-40. 2005
    ..In conclusion this optimized perfusion system provides a sound basis for future studies in the area of hepatotoxicity and pharmacology...
  86. ncbi Albumin and hydroxyethyl starch 130 kDa/0.4 improve filter clearance and haemocompatibility in haemo- and plasmafiltration--an in vitro study
    Juliane K Unger
    Department of Anaesthesiology, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Nephrol Dial Transplant 20:1922-31. 2005
    ..We hypothesized that solutions which reduce cell aggregability may lead to both improved filter clearance and better haemocompatibility due to decreasing rates of clogged hollow fibres...
  87. ncbi Direct visualization of peptide uptake activity in the central nervous system of the rat
    David A Groneberg
    Biomedical Research Center, Otto-Heubner-Centre, , Free University Berlin and Humboldt-University, Augustenburger Platz 1 OR1, D-13353 Berlin, Germany
    Neurosci Lett 364:32-6. 2004
    ..The presence of PEPT2 was confirmed by RT-PCR and Northern blot analysis. This first CNS peptide and drug transport-visualizing assay may be used to examine new compounds which are carried by the proton-driven CNS peptide transporter...
  88. ncbi Regulation of NGF and BDNF by dexamethasone and theophylline in human peripheral eosinophils in allergics and non-allergics
    Oliver Noga
    Allergy and Asthma Clinic, Dept of Medicine Infectious and Respiratory Diseases, Charite, Virchow Klinikum, Humboldt University, Augustenburger Platz 1, Berlin 13353, Germany
    Regul Pept 132:74-9. 2005
    ..Recent studies have shown that the neurotrophins NGF and BDNF are produced by eosinophils. The influence of neurotrophins in allergic diseases including asthma has been described. The regulation by pharmacological substance remains unclear...
  89. ncbi Substance P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung
    Q Thai Dinh
    Department of Medicine, Charite, School of Medicine, Humboldt University, Ostring 3, R 3 0066, Augustenburger Platz 1, Berlin D 13353, Germany
    Respir Physiol Neurobiol 144:15-24. 2004
    ....
  90. ncbi Dopamine type 2 receptor expression and function in rodent sensory neurons projecting to the airways
    Christian Peiser
    Department of Pediatric Pneumology and Immunology, Charité Virchow Campus, Berlin, Germany
    Am J Physiol Lung Cell Mol Physiol 289:L153-8. 2005
    ..Our results provide support to the hypothesis that dopamine D(2) receptor activation inhibits neurogenic inflammation and proinflammatory reflex responses...
  91. ncbi Protective effects of B2 preservation solution in comparison to a standard solution (histidine-tryptophan-ketoglutarate/Bretschneider) in a model of isolated autologous hemoperfused porcine kidney
    Claudia Fehrenberg
    Department of Comparative Medicine and Experimental Animal Science, Humboldt University, Berlin, Germany
    Nephron Physiol 96:p52-8. 2004
    ..B2 may also be an interesting model for optimizing preservation within other organ perfusion models...
  92. ncbi Nanomedicine for respiratory diseases
    Ulrich Pison
    Department of Anesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
    Eur J Pharmacol 533:341-50. 2006
    ..Based on the recent progress in nanobiotechnology there is potential for nanoparticles and -systems to become useful tools as therapeutic and diagnostic tools in the near future...
  93. ncbi SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke
    Jochen Springer
    Pneumology and Immunology, Otto-Heubner-Centre, , Campus Buch, Charit, Free University and Humboldt-University, D-13353 Berlin, Germany
    Biol Chem 385:649-53. 2004
    ..Also, the effects of non-volatile components in tobacco smoke may partly be regulated via a smoke-induced down-regulation of inhibitory SMADs...
  94. ncbi Role of lipid rafts in membrane delivery of renal epithelial Na+-K+-ATPase, thick ascending limb
    Pia Welker
    Center of Anatomy, Cardio Renal Unit, Charite Universitatsmedizin Berlin, Philippstrasse 12, 10115 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 292:R1328-37. 2007
    ..These results may have functional implications regarding the turnover, trafficking, and regulated surface expression of NKA as the major basolateral ion transporter of TAL...
  95. ncbi Expression of substance P and nitric oxide synthase in vagal sensory neurons innervating the mouse airways
    Q Thai Dinh
    Department of Internal Medicine, Charite School of Medicine, Humboldt University, Berlin, Germany
    Regul Pept 126:189-94. 2005
    ..The aim of the present study was to investigate substance P and neuronal nitric oxide synthase (NOS-1) expression in airway-specific sensory neurons...
  96. ncbi BDNF-overexpression regulates the reactivity of small pulmonary arteries to neurokinin A
    Jochen Springer
    Div of Allergy Research, Dept of Pediatric Pneumology and Immunology, Charite, Humboldt University, 13353 Berlin, Germany
    Regul Pept 118:19-23. 2004
    ..These findings point to a modulatory role of neurotrophins in small respiratory vessel tone regulation...
  97. ncbi Neurogenic mechanisms in bronchial inflammatory diseases
    D A Groneberg
    Otto-Heubner-Centre, Pneumology and Immunology, , Free University Berlin and Humboldt-University Berlin, Berlin, Germany
    Allergy 59:1139-52. 2004
    ....
  98. ncbi [Cruciate ligament injuries under gender aspects]
    D E Grabau
    Institut für Arbeitsmedizin, Charite Universitatsmedizin Berlin, Freie Universität and Humboldt Universität zu Berlin, Berlin
    Sportverletz Sportschaden 25:235-40. 2011
    ..Training programs including endurance aspects, strengthening knee musculature, balance as well as plyometric trainings were most effective. Further studies should focus more on concomitants of course of injuries...
  99. ncbi Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, , , Germany
    Am J Respir Crit Care Med 170:1276-80. 2004
    ..Our findings indicate that TRPV-1 receptors may contribute to an enhanced cough reflex and the cough response in chronic persistent cough of diverse causes...
  100. ncbi Differential effects of ethanol on IFN-gamma- and TNF-alpha-producing splenic T lymphocytes in a murine model of gram-negative pneumonia
    Nadine Lanzke
    Department of Anesthesiology and Intensive Care Medicine, Charité Campus Mitte and Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Addict Biol 12:59-68. 2007
    ..This suggests a role of T cells in the increased susceptibility of the alcoholic host to nosocomial infection due to inadequate cytokine response...