Research Topics
Species | Karl EgererSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Clinical and serological evaluation of a novel CENP-A peptide based ELISAMichael Mahler
Dr Fooke Laboratorien, Mainstrasse 85, 41469 Neuss, Germany
Arthritis Res Ther 12:R99. 2010..Historically, ACA were detected by indirect immunofluorescence (IIF) on HEp-2 cells and confirmed by immunoassays using recombinant CENP-B. The objective of this study was to evaluate a novel CENP-A peptide ELISA...- Automated evaluation of autoantibodies on human epithelial-2 cells as an approach to standardize cell-based immunofluorescence testsKarl Egerer
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
Arthritis Res Ther 12:R40. 2010..Comparing automated and visual interpretation, the usefulness for routine laboratory diagnostics was investigated... - Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assayKarl Egerer
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Augustenburger Platz 01, 13555 Berlin, Germany
Arthritis Res Ther 13:R118. 2011..Diagnosis of antiphospholipid syndrome (APS) still remains a laboratory challenge due to the great diversity of antiphospholipid antibodies (aPL) and their significance regarding APS-diagnostic criteria... - The serological diagnosis of rheumatoid arthritis: antibodies to citrullinated antigensKarl Egerer
Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charite Universitatsmedizin Berlin, Germany
Dtsch Arztebl Int 106:159-63. 2009..Recommendations are also given for differential diagnosis and sequential testing in rheumatoid arthritis, with a view towards improving early diagnosis, so that irreparable joint damage can be avoided... - Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohortKatharina Hanke
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin 10117, Germany
Arthritis Res Ther 11:R28. 2009..In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monocentric cohort... - Immediate determination of ACPA and rheumatoid factor--a novel point of care test for detection of anti-MCV antibodies and rheumatoid factor using a lateral-flow immunoassayFranziska Renger
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
Arthritis Res Ther 12:R120. 2010..The aim of this study was to develop and evaluate a point of care test (POCT) for detection of anti-MCV antibodies immediately at the first visit or at the bed side... - Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosusRobert Biesen
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin D 10117, Germany
Arthritis Res Ther 13:R26. 2011.... - Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosusFidan Barkhudarova
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin D 10117, Germany
Arthritis Res Ther 13:R20. 2011..In this study, we sought to determine the diagnostic value and clinical laboratory associations of autoantibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in systemic lupus erythematosus (SLE)... - Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28Michael Brychcy
Department of Rheumatology and Clinical Immunology, , Schumannstrasse 20/21, D-10117 Berlin, Germany
Arthritis Rheum 54:2175-83. 2006..Antibody targeting of the interaction between 20S proteasome and PA28 represents a novel mechanism of proteasome inhibition... - Lack of evidence for a pathogenic role of proteasome-directed autoimmunity in dilated cardiomyopathyAntje Voigt
Medizinische Klinik für Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
Basic Res Cardiol 105:557-67. 2010..In conclusion, our data argue against a direct impact of ProtAb in the pathogenesis of DCM... - Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosusJan Broder Engler
Correspondence to Professor Gabriela Riemekasten, Klinik für Rheumatologie und Klinische Immunologie, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
Ann Rheum Dis 70:2176-83. 2011..The authors assess autoreactive CD4 T cells in a representative SLE collective (n=38) by flow cytometry and study the influence of regulatory T cells (Treg) on their antigenic challenge... - Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndromeLars Morawietz
Department of Rheumatology and Clinical Immunology, Institute of Pathology, and Institute of Biochemistry, Charite Universitatsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany
J Rheumatol 36:2694-703. 2009..Minor salivary gland specimens were analyzed to investigate dysregulation of the proteasome system in patients with Sjögren's syndrome (SS) and patients with sicca syndrome... - Circulating proteasome levels are an independent prognostic factor for survival in multiple myelomaChristian Jakob
Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Germany
Blood 109:2100-5. 2007..38) survival analysis in patients with active MM. We demonstrate for the first time that increased serum proteasome concentrations correlate with advanced disease and are an independent prognostic factor in MM... - Prevalence of 20S proteasome, anti-nuclear and thyroid antibodies in young patients at onset of type 1 diabetes mellitus and the risk of autoimmune thyroiditisOlga Kordonouri
Clinics of General Pediatrics, Otto Heubner Centrum für Kinder und Jugendmedizin Charité, Berlin, Germany
J Pediatr Endocrinol Metab 17:975-81. 2004..In particular, patients with positive thyroid and anti-nuclear antibodies are at high risk to develop autoimmune thyroiditis during the first 5 years of DM1... - Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patientsKatharina Hanke
Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin, Humboldt University Berlin, Chariteplatz 1, Berlin 10117, Germany
Arthritis Res Ther 11:R22. 2009..Furthermore, it remains speculative whether commercially available test systems detecting only anti-PM/Scl-100 antibodies are sufficient in SSc patients... - Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseasesKarl Egerer
Department of Rheumatology and Clinical Immunology, Institute of Biochemistry, Humboldt University of Berlin, Berlin, Germany
J Rheumatol 29:2045-52. 2002..The cProteasomes represent novel sensitive markers of the autoimmune inflammatory processes and/or reflect the magnitude of cellular damage...