Frank Buttgereit

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi The association between rheumatoid arthritis and periodontal disease
    Jacqueline Detert
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:218. 2010
  2. ncbi Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University Berlin, Germany
    Biochem Pharmacol 58:363-8. 1999
  3. ncbi Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 69:1275-80. 2010
  4. ncbi The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Scand J Rheumatol 34:14-21. 2005
  5. ncbi New glucocorticoids on the horizon: repress, don't activate!
    In Ho Song
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Rheumatol 32:1199-1207. 2005
  6. ncbi Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, Berlin, Germany
    Ann Rheum Dis 61:718-22. 2002
  7. ncbi Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, , Schumannstrasse 20/21, 10117 Berlin, Germany
    Arthritis Rheum 50:3408-17. 2004
  8. ncbi How should impaired morning function in rheumatoid arthritis be treated?
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Scand J Rheumatol Suppl 125:28-39. 2011
  9. ncbi Rapid glucocorticoid effects on immune cells
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, Berlin, Germany
    Steroids 67:529-34. 2002
  10. ncbi [Disease-modifying effects of glucocorticoids in rheumatoid arthritis]
    F Buttgereit
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Deutschland
    Z Rheumatol 66:522-4. 2007

Detail Information

Publications86

  1. ncbi The association between rheumatoid arthritis and periodontal disease
    Jacqueline Detert
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:218. 2010
    ....
  2. ncbi Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University Berlin, Germany
    Biochem Pharmacol 58:363-8. 1999
    ..Examples are the choice between methylprednisolone and prednisolone in pulse therapy, and the completely different clinical usage of dexamethasone and betamethasone, despite their similar affinities for nuclear receptors...
  3. ncbi Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 69:1275-80. 2010
    ....
  4. ncbi The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Scand J Rheumatol 34:14-21. 2005
    ....
  5. ncbi New glucocorticoids on the horizon: repress, don't activate!
    In Ho Song
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Rheumatol 32:1199-1207. 2005
    ..Finally, we describe the state of research on membrane-bound glucocorticoid receptors as possible further targets for specific glucocorticoid actions...
  6. ncbi Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, Berlin, Germany
    Ann Rheum Dis 61:718-22. 2002
    ..A question-answer rationale presentation style has been chosen to convey the messages, to summarise the meeting in a readable format, and to avoid dogmatism...
  7. ncbi Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, , Schumannstrasse 20/21, 10117 Berlin, Germany
    Arthritis Rheum 50:3408-17. 2004
  8. ncbi How should impaired morning function in rheumatoid arthritis be treated?
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Scand J Rheumatol Suppl 125:28-39. 2011
    ..Clinical studies suggest that morning stiffness in patients with RA could be treated successfully with the use of low-dose modified-release prednisone...
  9. ncbi Rapid glucocorticoid effects on immune cells
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, Berlin, Germany
    Steroids 67:529-34. 2002
    ..This article gives a detailed presentation of the data available at present concerning rapid glucocorticoid effects on immune cells...
  10. ncbi [Disease-modifying effects of glucocorticoids in rheumatoid arthritis]
    F Buttgereit
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Deutschland
    Z Rheumatol 66:522-4. 2007
    ..For these reasons, glucocorticoids can be considered DMARDs if they are used to treat patients suffering from early RA and, according to the current knowledge, are used in combination with other DMARDs...
  11. ncbi Therapeutically targeting lymphocyte energy metabolism by high-dose glucocorticoids
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, 10117, Berlin, Germany
    Biochem Pharmacol 59:597-603. 2000
    ....
  12. ncbi Gastrointestinal toxic side effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2-specific inhibitors
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, FB, GRB, Berlin, Germany
    Am J Med 110:13S-9S. 2001
    ..Finally, we offer recommendations on the clinical use of these drugs, emphasizing the need to balance clinical effectiveness with the avoidance of potential gastrointestinal side effects...
  13. ncbi Mechanisms and clinical relevance of nongenomic glucocorticoid actions
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Z Rheumatol 59:II/119-23. 2000
    ..It is proposed that the additional therapeutic benefit of higher doses is obtained via these nongenomic effects...
  14. ncbi Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Lancet 371:205-14. 2008
    ..We aimed to assess the efficacy and safety of a new modified-release prednisone tablet compared with immediate-release prednisone in patients with this disease...
  15. ncbi Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:24-32. 2010
    ..It is implied that these effects contribute to the well-known beneficial anti-inflammatory and immunomodulatory effects of glucocorticoid therapy...
  16. ncbi Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, 10117 Berlin, Germany
    J Immunol 186:764-74. 2011
    ..Therefore, we suggest that HIF and/or MIF could be useful targets to optimize GC therapy when treating inflammation...
  17. ncbi Origin and functional activity of the membrane-bound glucocorticoid receptor
    Cindy Strehl
    Charité University Hospital and German Rheumatism Research Centre, Berlin, Germany
    Arthritis Rheum 63:3779-88. 2011
    ..Most likely, membrane-bound GRs (mGR) are involved in nongenomic GC signaling. The aim of this study was to investigate the origin and functional activity of mGR...
  18. ncbi Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells
    Manja M Krause
    University Hospital Charit, Humboldt-University Berlin, Berlin, Germany
    Arthritis Rheum 48:1438-44. 2003
    ..They both uncouple mitochondrial respiration and inhibit substrate oxidation and ATP turnover. However, the topical effect and selective COX-2 inhibition may not be sufficient to cause NSAID-like damage to the GI tract...
  19. ncbi Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
    Robert Tripmacher
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Eur J Immunol 38:1631-42. 2008
    ..Our data demonstrate an unexpectedly high, clinically relevant adaptive potential of human CD4(+) T cells to maintain specific functions even under severely impaired bioenergetic conditions...
  20. ncbi Membrane glucocorticoid receptor expression on peripheral blood mononuclear cells in patients with ankylosing spondylitis
    Anita B Tryc
    Department of Rheumatology and Clinical Immunology, , Campus Mitte, , 10117 Berlin, Germany
    J Rheumatol 33:2249-53. 2006
    ..Our findings may be related to the limited benefit of low-dose and the efficacy of high-dose (intravenous pulse or intraarticular) glucocorticoid treatment in AS. Drugs binding selectively to mGCR may be a new therapeutic option for AS...
  21. ncbi Potencies of topical glucocorticoids to mediate genomic and nongenomic effects on human peripheral blood mononuclear cells
    Lydia Naumann
    Department of Medicine Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Biochem Pharmacol 71:530-9. 2006
    ....
  22. ncbi Human early fracture hematoma is characterized by inflammation and hypoxia
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Clin Orthop Relat Res 469:3118-26. 2011
    ..An effective immune system, especially during the inflammatory phase, putatively influences the quality and likelihood of bone healing. If and how this is reflected within the initial fracture hematoma is unclear...
  23. ncbi Pharmacology of glucocorticoids in rheumatoid arthritis
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Curr Opin Pharmacol 10:302-7. 2010
    ..This short review summarises the current knowledge in this regard, with particular emphasis on recently published articles...
  24. ncbi Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    J Rheumatol 36:2655-69. 2009
    ..Inflamed tissues are usually characterized by low oxygen levels. We investigated whether pathophysiological hypoxia (pO(2) < 1%) as found in the rheumatoid synovium modulates the transcriptome of human CD4+ T cells...
  25. ncbi Non-genomic glucocorticoid effects to provide the basis for new drug developments
    In-Ho Song
    Department of Rheumatology and Clinical Immunology, , Schumannstrasse 20/21, 10117 Berlin, Germany
    Mol Cell Endocrinol 246:142-6. 2006
    ..The clinical use of the latter two mechanisms is still speculative, but intriguing ideas are being discussed in this regard...
  26. ncbi Hypothalamus-pituitary-adrenal axis function in patients with rheumatoid arthritis treated with nighttime-release prednisone
    Rieke Alten
    Department of Internal Medicine II, Rheumatology, Clinical Immunology, Schlosspark Klinik, Teaching Hospital, Charite University Medicine, Berlin, Germany
    J Rheumatol 37:2025-31. 2010
    ..This consisted of a 3-month active-controlled phase and a 9-month open-label extension with MR prednisone including patients previously treated with prednisone (ClinicalTrials.gov number NCT00146640)...
  27. ncbi Genomic and nongenomic effects of glucocorticoids
    Cindy Stahn
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Nat Clin Pract Rheumatol 4:525-33. 2008
    ..Increased understanding of these mechanisms of glucocorticoid action could enable the development of novel drugs with which to treat patients with inflammatory and autoimmune disease...
  28. ncbi The early fracture hematoma and its potential role in fracture healing
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tissue Eng Part B Rev 16:427-34. 2010
    ....
  29. ncbi Inflammatory phase of bone healing initiates the regenerative healing cascade
    Katharina Schmidt-Bleek
    Julius Wolff Institut and Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Cell Tissue Res 347:567-73. 2012
    ..In conclusion, identifying beneficial aspects may lead to promising therapeutical approaches that might benefit further by eliminating the unfavorable factors...
  30. ncbi Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis
    Burkhard Bartholome
    Department of Rheumatology and Clinical Immunology, , Berlin, Germany
    FASEB J 18:70-80. 2004
    ..These receptors may reflect a feedback mechanism of the organism upon immunostimulation and/or play a role in pathogenesis...
  31. ncbi Optimised glucocorticoid therapy: the sharpening of an old spear
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, , Berlin, Germany
    Lancet 365:801-3. 2005
    ..A further improvement needs qualitatively new drugs, which are currently in the development pipeline, with the most promising being the nitrosoglucocorticoids (nitrosteroids) and selective glucocorticoid-receptor agonists...
  32. ncbi Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!
    T Gaber
    Department of Rheumatology and Clinical Immunology, , Schumannstrasse 20/21, 10117 Berlin, Germany
    Ann Rheum Dis 64:971-80. 2005
    ....
  33. ncbi Takayasu arteritis is characterised by disturbances of B cell homeostasis and responds to B cell depletion therapy with rituximab
    Bimba F Hoyer
    Correspondence to Falk Hiepe, Department of Medicine, Clinic for Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin and German Rheumatism Research Center Berlin Leibniz Institute, Chariteplatz 1, D 10117 Berlin, Germany
    Ann Rheum Dis 71:75-9. 2012
    ..Introduction Takayasu arteritis (TA) is a large vessel vasculitis involving the aorta and its major branches. T cell-mediated autoimmunity is thought to play a major role in its pathogenesis, while the role of B cells is still unclear...
  34. ncbi Correlation of different bone markers with bone density in patients with rheumatic diseases on glucocorticoid therapy
    Konstanze Loddenkemper
    Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin Campus Charité Mitte, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Rheumatol Int 26:331-6. 2006
    ....
  35. ncbi Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists
    Cindy Stahn
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Mol Cell Endocrinol 275:71-8. 2007
    ..Here, we review the above-mentioned mechanisms of glucocorticoid action and give particular attention to the development of optimized glucocorticoids and SEGRAs...
  36. ncbi More night than day--circadian rhythms in polymyalgia rheumatica and ankylosing spondylitis
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    J Rheumatol 37:894-9. 2010
    ..This review summarizes the current knowledge on circadian rhythms in other rheumatic diseases, focusing on polymyalgia rheumatica and ankylosing spondylitis...
  37. ncbi Short-term effects of the 21-aminosteroid lazaroid tirilazad mesylate (PNU-74006F) and the pyrrolopyrimidine lazaroid PNU-101033E on energy metabolism of human peripheral blood mononuclear cells
    D Schmid
    Department of Medicine (Rheumatology, , Humboldt University, Berlin, Germany
    Biosci Rep 21:101-10. 2001
    ....
  38. ncbi Modulation of intracellular calcium signaling and mitochondrial function in cultured osteoblastic cells by dexamethasone and celecoxib during mechanical stimulation
    S Schuchmann
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitatsklinikum Charite, Humboldt Universitat Berlin, Germany
    Clin Exp Rheumatol 22:184-96. 2004
    ..Evaluation of potentially therapeutically relevant effects of dexamethasone and celecoxib on crucial parameters of bone physiology during and following mechanical stimulation in cultured osteoblasts...
  39. ncbi Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells
    M Wiontzek
    Department of Rheumatology and Clinical Immunology and Deutsches Rheumaforschungszentrum (DRFZ, , Humboldt University, , 10117 Berlin, Germany
    Clin Exp Rheumatol 24:366-72. 2006
    ..In contrast, celecoxib did not show any measurable short-term or long-term effects on the parameters of bone physiology measured...
  40. ncbi Preferred use of polyhexanide in orthopedic surgery
    Eric Röhner
    Department of Traumatology and Orthopedics, Charite Universitatsmedizin, Berlin, Germany
    Orthopedics 34:e664-8. 2011
    ..The data show that polyhexanide promotes apoptosis on primary human chondrocytes in vitro, which may indicate the use of polyhexanide in septic joint surgery...
  41. ncbi [Selective COX-2 inhibition improves endothelial function in coronary artery disease]
    Olaf Schultz
    , , Schumannstrasse 20/21, 10117 Berlin, Germany
    Z Rheumatol 62:422-4. 2003
  42. ncbi Effects of tacrolimus, cyclosporin A and sirolimus on MG63 cells
    Dörte Krocker
    Center for Musculoskeletal Surgery, Charite, University Medicine Berlin, Berlin, Germany
    Transpl Int 19:563-9. 2006
    ..They do not have antiproliferative or toxic effects. We postulate that the shown changes of osteoblast differentiation cause post-transplantation disease...
  43. ncbi Tumoral calcinosis revisited: pathophysiology and treatment
    Gregor Möckel
    Orthopaedic Department, Humboldt University Berlin Charité, Berlin, Germany
    Rheumatol Int 25:55-9. 2005
    ..In view of the high risk of recurrence, local excision is a treatment procedure to be considered in exceptional cases only...
  44. ncbi [Glucocorticoids in rheumatology]
    R Dziurla
    Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin
    Z Rheumatol 67:583-91; quiz 592. 2008
    ..The musculoskeletal, gastrointestinal, neuro-endocrino-immunological, opthalmological and neuropsychiatric systems are examples where adverse effects may occur...
  45. ncbi [Pathogenesis of parodontitis in rheumatic diseases]
    J Detert
    Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, Charite Universitatsmedizin Berlin, Berlin, Deutschland
    Z Rheumatol 69:109-12, 114-6. 2010
    ..PD and rheumatologic diseases such as RA share many pathological aspects and immunological findings...
  46. ncbi Effects of Porphyromonas gingivalis on cell cycle progression and apoptosis of primary human chondrocytes
    N Pischon
    Department of Periodontology, Charite Universitatsmedizin, Berlin, Campus Virchow, 13353 Berlin, Germany
    Ann Rheum Dis 68:1902-7. 2009
    ..It has been suggested that bacterial infections have a role in the pathogenesis of rheumatoid arthritis (RA). P gingivalis, a Gram-negative, anaerobic rod, is one of the major pathogens associated with periodontal disease...
  47. ncbi Induced apoptosis of chondrocytes by Porphyromonas gingivalis as a possible pathway for cartilage loss in rheumatoid arthritis
    E Rohner
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Calcif Tissue Int 87:333-40. 2010
    ..The data show that P. gingivalis promotes early and later stages of apoptosis of primary human chondrocytes, which might contribute to the joint damage seen in the pathogenesis of RA...
  48. ncbi Periodontal disease in patients with ankylosing spondylitis
    N Pischon
    Department of Periodontology, Charite Universitatsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Ann Rheum Dis 69:34-8. 2010
    ..AS has been related to other inflammatory diseases, however, there is a paucity of data on whether AS is associated with inflammatory PD...
  49. ncbi Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes
    R Dziurla
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:97-105. 2010
    ..Hypoxia seems to facilitate inflammatory reactions and angiogenesis...
  50. ncbi Association among rheumatoid arthritis, oral hygiene, and periodontitis
    N Pischon
    Department of Periodontology, Charite Medical Faculty Berlin, Augustenburger Platz 1, Berlin, Germany
    J Periodontol 79:979-86. 2008
    ..Further, it is unclear to what extent poor oral hygiene among patients with RA may account for this association...
  51. ncbi Methotrexate treatment in large vessel vasculitis and polymyalgia rheumatica
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Clin Exp Rheumatol 28:S172-7. 2010
    ..Further attempts should be made for a better identification of patients with glucocorticoid-refractory courses and a more precise formulation of guidelines on indication, optimal dosing and duration...
  52. ncbi Analyses of similarities and differences in glucocorticoid therapy between rheumatoid arthritis and ankylosing spondylitis - a systematic comparison
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Clin Exp Rheumatol 27:S152-8. 2009
    ..Translation of insights on GC action and resistance obtained in RA to AS may contribute to a better understanding of the pathophysiology of both diseases...
  53. ncbi [Influence of adjuvant pain medication on quality of life in the treatment of postmenopausal osteoporosis]
    D Krocker
    Klinik für Orthopädie, Centrum für Muskuloskeletale Chirurgie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin
    Orthopade 37:435-9. 2008
    ..The second question was if a recommendation can be formulated whether a peripheral or a central acting pain medication is more effective to prevent osteoporosis induced chronic pain...
  54. ncbi [Pharmacotherapy of rheumatic diseases in the aged]
    S Kary
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitätsklinikum Humboldt Universität Berlin
    Internist (Berl) 44:951-8. 2003
    ..The administration of these drugs in elderly patients is discussed...
  55. ncbi Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway
    C M Spies
    Department of Rheumatology and Clinical Immunology, , Campus Mitte, Berlin, Germany
    Ann Rheum Dis 65:1139-46. 2006
    ..Drugs binding selectively to mGCR may in future prove to be of therapeutic value...
  56. ncbi Prevalence and clinical significance of anticardiolipin and anti-beta2-glycoprotein-I antibodies in patients with non-Hodgkin's lymphoma
    I Genvresse
    Internal Medicine, Hematology Oncology, Humboldt University, University Hospital Charite, Virchow Klinikum, Germany
    Eur J Haematol 68:84-90. 2002
    ..3%). Vessel compression by lymphoma but not elevated APA remains the main cause of thrombosis in NHL patients...
  57. ncbi [Reduction of arthrosis associated knee pain through a single intra-articular injection of synthetic hyaluronic acid]
    D Krocker
    Centrum für Muskuloskeletale Chirurgie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany
    Z Rheumatol 65:327-31. 2006
    ..Clinical outcome using Durolane should be compared with the results of studies using hyaluronic acids or glucocorticoids...
  58. ncbi Calcium, vitamin D and etidronate for the prevention and treatment of corticosteroid-induced osteoporosis in patients with rheumatic diseases
    K Loddenkemper
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Berlin, Germany
    Clin Exp Rheumatol 21:19-26. 2003
    ..At present there are no generally accepted guidelines for the prevention or treatment of steroid-induced osteoporosis...
  59. ncbi Bioenergetics of immune cells to assess rheumatic disease activity and efficacy of glucocorticoid treatment
    A Kuhnke
    Department of Rheumatology and Clinical Immunology, , Humboldt University, Schumannstrasse 20/21, 10117 Berlin, Germany
    Ann Rheum Dis 62:133-9. 2003
    ....
  60. ncbi [Chrysiasis]
    K Loddenkemper
    Universitätsklinikum Charité Berlin Innere Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie Schumannstr 20 21, 10117 Berlin, Germany
    Z Rheumatol 61:173-4. 2002
    ..Chrysiasis is a rare permanent pigmentation of the skin resulting from the parenteral administration of gold. The cause of the pigmentation is multifactorial and not fully established at the moment...
  61. ncbi Fatal atypical T-cell proliferation associated with Epstein-Barr virus infection
    S Hauptmann
    Institute of Pathology and Department of Rheumatology, Charité Hospital Berlin, and Institute of Pathology, University Erlangen, Erlangen, Germany
    Br J Haematol 112:377-80. 2001
    ..The remarkable features of this case are (i) the occurrence in a Caucasian patient, (ii) the absence of detectable immunodeficiency, and (iii) the myocardial destruction by EBV-infected monoclonal T cells...
  62. ncbi Arterial thrombosis associated with anticardiolipin and anti-beta2-glycoprotein-I antibodies in patients with non-Hodgkin's lymphoma: a report of two cases
    I Genvresse
    Internal Medicine II Hematology Oncology, Humboldt University, University Hospital Charite, Berlin, Germany
    Eur J Haematol 65:344-7. 2000
    ....
  63. ncbi The influence of obesity on perioperative morbidity and mortality in revision total hip arthroplasty
    C Perka
    Orthopädische Klinik und Poliklinik der Charité, Berlin, Germany
    Arch Orthop Trauma Surg 120:267-71. 2000
    ..We conclude that obesity does not have any significant influence on perioperative morbidity and mortality but is clearly related to operation time and, therefore, to higher costs per operation...
  64. ncbi Glucocorticoids
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Best Pract Res Clin Rheumatol 25:891-900. 2011
    ..Improved knowledge of the immunomodulatory role of endogenous glucocorticoids has evolved, and we report on the therapeutic potential of targeting glucocorticoid pre-receptor metabolism for metabolic and inflammatory diseases...
  65. ncbi Molecular mechanisms of glucocorticoid-induced osteoporosis
    D Patschan
    Department of Rheumatology and Clinical Immunology, , , Berlin, Germany
    Bone 29:498-505. 2001
    ..It is possible, but has yet to be shown, that these effects play a role in the pathogenesis of glucocorticoid-induced osteoporosis...
  66. ncbi [Prescription of glucocorticoids by rheumatologists in patients with rheumatoid arthritis in Germany]
    K Thiele
    Deutsches Rheuma-Forschungszentrum Berlin, Forschungsbereich Epidemiologie, 10117 Berlin, Germany
    Z Rheumatol 64:149-54. 2005
    ..The data emphasize the high importance of GCs in modern rheumatology...
  67. ncbi [Current insights into the development of new glucocorticoid receptor ligands]
    F Buttgereit
    Medizinische Klinik m.S. Rheumatologie und Klinische Immunologie, , Schumannstr. 20/21, 10117 Berlin, Germany
    Z Rheumatol 64:170-6. 2005
    ....
  68. ncbi Morning stiffness and its influence on early retirement in patients with recent onset rheumatoid arthritis
    G Westhoff
    Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany
    Rheumatology (Oxford) 47:980-4. 2008
    ..To describe the association between morning stiffness (MS) and early retirement in patients with early RA...
  69. ncbi Effects of celecoxib on the expression of osteoprotegerin, energy metabolism and cell viability in cultured human osteoblastic cells
    P Kolar
    Department of Rheumatology and Clinical Immunology and Deutsches Rheumaforschungszentrum, Humboldt University, Berlin, Germany
    Clin Exp Rheumatol 27:99-107. 2009
    ..This study aimed to investigate the dose-dependent effects of celecoxib on cell viability, energy metabolism and bone remodeling processes in cultured human osteoblastic cells...
  70. ncbi [Polyarteritis nodosa - a "classical" case]
    H U Scherer
    , , Berlin, Germany
    Z Rheumatol 65:311-4. 2006
    ..This case underlines the interdisciplinary character of the disease, challenging neurologists, dermatologists, rheumatologists and orthopedics alike...
  71. ncbi Effects of norepinephrine on oxygen consumption of quiescent and activated human peripheral blood mononuclear cells
    Jan D Lunemann
    Department of Neurology, Division of Neuroimmunology, , Berlin, Germany
    Ann N Y Acad Sci 966:365-8. 2002
  72. ncbi Cellular composition of the initial fracture hematoma compared to a muscle hematoma: a study in sheep
    Katharina Schmidt-Bleek
    Julius Wolff Institut, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Orthop Res 27:1147-51. 2009
    ..B cell percentage increased in the fracture but not in the muscle hematoma from 1 to 4 h. This is the first study that compares the immune cell subpopulations of a fracture and muscle hematoma...
  73. ncbi A case of Erdheim-Chester disease initially mistaken for Ormond's disease
    Konstanze Loddenkemper
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Nat Clin Pract Rheumatol 4:50-5. 2008
    ..Re-evaluation of the CT scans and histological biopsy samples revealed unusual sclerosis of the long bones and diffuse infiltrates of foamy histiocytes in the bone marrow and the retroperitoneum...
  74. ncbi Dose-related patterns of glucocorticoid-induced side effects
    D Huscher
    German Rheumatism Research Centre Berlin, Epidemiology Unit, Berlin, Germany
    Ann Rheum Dis 68:1119-24. 2009
    ..To identify patterns of self-reported health problems relating to dose and duration of glucocorticoid intake in unselected patients with rheumatoid arthritis from routine practice...
  75. ncbi [Acute mesenteric ischemia in a patient with relapsing polychondritis]
    O Schultz
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, , Berlin
    Z Rheumatol 65:63-8. 2006
    ..The unusual presentation should be considered in the differential diagnosis of uncommon abdominal symptoms during the course of relapsing polychondritis...
  76. ncbi Circadian rhythms of nocturnal hormones in rheumatoid arthritis: translation from bench to bedside
    Maurizio Cutolo
    Ann Rheum Dis 67:905-8. 2008
  77. ncbi Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands
    Mark Lowenberg
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Steroids 73:1025-9. 2008
    ..As a consequence, membrane-linked GC receptors might be a potential candidate target for GC therapy. The ultimate goal is to convert these molecular insights into new GC receptor modulators with an improved therapeutic index...
  78. ncbi Current use of glucocorticoids in patients with rheumatoid arthritis in Germany
    Katja Thiele
    German Rheumatism Research Centre, Berlin
    Arthritis Rheum 53:740-7. 2005
    ..There is increasing awareness of the risk of osteoporosis in long-term glucocorticoid treatment, demonstrated by the fact that osteoporosis medication is prescribed for a large proportion of patients taking glucocorticoids...
  79. ncbi Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn
    Mark Lowenberg
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Blood 106:1703-10. 2005
    ..These results identify the inhibition of Lck and Fyn kinases as rapid targets of GCs, mediated via a GC receptor-dependent pathway...
  80. ncbi Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
    Mark Lowenberg
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    EMBO Rep 7:1023-9. 2006
    ..These observations support a model for nongenomic GC-induced immunosuppression on the basis of dissolution of membrane-bound GC-receptor multiprotein complexes after GC-receptor ligation...
  81. ncbi Developments in glucocorticoid therapy
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Box 85500, 3508 GA Utrecht, The Netherlands
    Rheum Dis Clin North Am 31:1-17, vii. 2005
    ..One is the improvement in new GC compounds--designer GCs, alterations in bioactivity, and alterations in formulations. The other is a better understanding and management of the toxicity of GCs...
  82. ncbi Quantitating protein synthesis, degradation, and endogenous antigen processing
    Michael F Princiotta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Immunity 18:343-54. 2003
    ....
  83. ncbi Development of cervical interspinous bursitis after prolonged sports trauma: a case report
    Carsten Perka
    Joint Bone Spine 73:118-20. 2006
  84. ncbi Oxygen consumption and mitochondrial membrane potential indicate developmental adaptation in energy metabolism of rat cortical neurons
    Sebastian Schuchmann
    Institut für Diagnostische Radiologie und Neuroradiologie, Ernst Moritz Arndt Universitat, Friedrich Loeffler Strasse 23a, D 17487 Greifswald, Germany
    Eur J Neurosci 21:2721-32. 2005
    ....
  85. ncbi Arthritis and endogenous glucocorticoids: the emerging role of the 11beta-HSD enzymes
    Frank Buttgereit
    Ann Rheum Dis 67:1201-3. 2008