Research Topics
Genomes and GenesSpecies | Gudrun A BrockmannSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Genetic and diet effects on Ppar-? and Ppar-? signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesityAsja Wagener
Humboldt Universitat zu Berlin, Department for Crop and Animal Sciences, Invalidenstraße 42, 10115 Berlin, Germany
Lipids Health Dis 9:99. 2010..Here, we studied the expression patterns of the different Ppar genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes...- Genetic control of lipids in the mouse cross DU6i x DBA/2Gudrun A Brockmann
Institute of Animal Sciences, Humboldt Universitat zu Berlin, 10115 Berlin, Germany
Mamm Genome 18:757-66. 2007..The identified QTLs for cholesterol and its transport proteins as subcomponents of risk for coronary heart disease will further improve our understanding of the genetic net controlling plasma lipid concentrations... - Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or bothGudrun A Brockmann
Breeding Biology and Molecular Genetics, Institute of Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstrasse 42, Berlin, Germany
Physiol Genomics 36:114-26. 2009..These results shed new light on the action of genes in quantitative trait locus regions potentially influencing muscle and fat mass and thus controlling body weight as a composite trait... - QTLs for pre- and postweaning body weight and body composition in selected miceGudrun A Brockmann
Research Institute for the Biology of Farm Animals, 18196, Dummerstorf, Germany
Mamm Genome 15:593-609. 2004..Sex-dimorphic QTLs were found for body weight and fat deposition. The identified early-growth QTLs could be the target of epigenetic modifications which might influence body weight at later ages... - Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 miceChristina Neuschl
Humboldt University of Berlin, Institute of Livestock Sciences, Berlin, Germany
Genet Res 89:47-59. 2007..Regions on Chr 1, 2, 7 and 14 for body weights at different early ages and regions on Chr 1, 2, 4, 7, 14, 17 and 19 for organ weights at 6 weeks were found to have significant multiple effects at the genome-wide level... - Genetic, sex, and diet effects on body weight and obesity in the Berlin Fat Mouse Inbred linesAsja Wagener
Institute of Animal Sciences, , Berlin, Germany
Physiol Genomics 27:264-70. 2006..Our results demonstrate that the genetically related BFMI lines are novel models to study the genetic as well as the nutritional aspects of obesity... - IGF-I contributes to glucose homeostasis in the Berlin Fat Mouse Inbred lineNadine Schäfer
Department for Crop and Animal Sciences, Humboldt Universitat zu Berlin, Germany
Growth Factors 29:298-309. 2011..Serum IGF-I levels corresponded with the expression pattern for both hepatic and one class II splice variants in reproductive adipose tissue, but not in muscle. High insulin and high IGF-I levels likely prevent BFMI mice from diabetes... - Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse linesSoner Aksu
Institute for Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstrasse 42, 10115 Berlin, Germany
J Appl Genet 48:133-43. 2007..14 out of these genes, occur in QTL regions for body weight or abdominal fat weight. Further analyses are necessary to discriminate between genes directly causing QTL effects and indirectly regulated differentially expressed genes... - Features of the metabolic syndrome in the Berlin Fat Mouse as a model for human obesityClaudia Hantschel
Department for Crop and Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
Obes Facts 4:270-7. 2011..To elucidate adult bodily responses in BFMI860 mice that develop juvenile obesity, we studied features of the metabolic syndrome at 20 weeks... - CandiSNPer: a web tool for the identification of candidate SNPs for causal variantsArmin O Schmitt
Department for Crop and Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstrasse 42, 10115 Berlin, Germany
Bioinformatics 26:969-70. 2010..The source code is available to academic users 'as is' upon request. The web site is implemented in Perl and R and runs on an Apache server. The Ensembl database is queried for SNP data via Perl APIs... - Fine mapping of mouse QTLs for fatness using SNP dataArmin O Schmitt
Institute for Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
OMICS 11:341-50. 2007..Viewing the genomic region of fatness-related QTLs under several different aspects is appropriate to assess the many thousands of genes that reside in such QTLs and to produce lists of more robust candidate genes... - The F279Y polymorphism of the GHR gene and its relation to milk production and somatic cell score in German Holstein dairy cattleSiham A Rahmatalla
Department for Crop and Animal Sciences, Humboldt Universitat zu Berlin, Germany
J Appl Genet 52:459-65. 2011..Finally, the high-milk-yield tyrosine allele was also associated with lower SCS (p?<?0.05). The data support the high potential of the F279Y polymorphism as a marker for the improvement of milk traits in selection programs... - Tracking chromosomal positions of oligomers - a case study with Illumina's BovineSNP50 beadchipArmin O Schmitt
Department of Crop and Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstrasse 42, 10115 Berlin, Germany
BMC Genomics 11:80. 2010..This, however, is a challenge if the genome sequence is still subject to changes... - Using mouse models to dissect the genetics of obesityGudrun A Brockmann
Research Institute for the Biology of Farm Animals, Dept of Molecular Biology, Wilhelm Stahl Allee 2, D 18196, Dummerstorf, Germany
Trends Genet 18:367-76. 2002..Congenic, recombinant inbred, advanced intercross, and chromosome substitution strains are needed to map QTLs finely, to identify the genes underlying the traits, and to examine interactions between them... - Genetic determinants for intramuscular fat content and water-holding capacity in mice selected for high muscle massStefan Kärst
Department for Crop and Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstraße 42, 10115 Berlin, Germany
Mamm Genome 22:530-43. 2011..Therefore, these muscle-weight-selected mouse lines and the produced intercross populations are valuable genetic resources to identify genes that could also contribute to meat quality in other species... - Deletions in the genomes of fifteen inbred mouse lines and their possible implications for fat accumulationArmin O Schmitt
Institute for Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstrasse 42, 10115, Berlin, Germany
J Zhejiang Univ Sci B 8:777-81. 2007..We furthermore detected statistically significant association between hundreds of deletion sites and fat weight at the age of eight weeks... - The action of key factors in protein evolution at high temporal resolutionArmin Schmitt
Institute for Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
PLoS ONE 4:e4821. 2009..Further details, however, on how the influence of these factors varies with time are unknown to date... - RandoMate: a program for the generation of random mating schemes for small laboratory animalsArmin O Schmitt
Institute for Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
Mamm Genome 20:321-5. 2009..RandoMate is freely available at http://www2.hu-berlin.de/RandoMate ... - Where in the genome are significant single nucleotide polymorphisms from genome-wide association studies located?Torsten Günther
Institute of Animal Sciences, Humboldt Universtät zu Berlin, Germany
OMICS 15:507-12. 2011..A Gene Ontology term analysis showed that genes putatively causing a phenotype often code for membrane associated proteins or signal transduction genes... - Protein evolution within and between speciesArmin O Schmitt
Institute for Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstrasse 42, 10115 Berlin, Germany
J Theor Biol 249:376-83. 2007..The currently available huge body of SNP data allows to characterize the role of two major shaping forces of protein evolution more quantitatively than before... - Chromosome-wise dissection of the genome of the extremely big mouse line DU6iMarianna R Bevova
Institute for Animal Sciences, , D-10115 Berlin, Germany
Genetics 172:401-10. 2006..The effects were age specific, with some chromosomes showing opposite effects at different stages of development... - Combined analysis of data from two granddaughter designs: A simple strategy for QTL confirmation and increasing experimental power in dairy cattleJörn Bennewitz
Institut für Tierzucht und Tierhaltung, Christian Albrechts Universitat, 24098 Kiel, Germany
Genet Sel Evol 35:319-38. 2003..This study demonstrated the potential benefits of a combined analysis of data from different granddaughter designs... - Simultaneous mapping of epistatic QTL in DU6i x DBA/2 miceOrjan Carlborg
Roslin Institute, Roslin, Midlothian, EH25 9PS, United Kingdom
Mamm Genome 16:481-94. 2005..Five of these patterns resembled previously published patterns of QTL interactions... - Expressionview: visualization of quantitative trait loci and gene-expression data in EnsemblGertrud Fischer
University of Rostock, Institute of Immunology, Joachim-Jungius-Strasse 9, 18059 Rostock, Germany
Genome Biol 4:R77. 2003..It supports the visualization of gene clusters and the selection of functional candidate genes in the context of research on complex traits...