R Gutzmer

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi Human monocyte-derived dendritic cells are chemoattracted to C3a after up-regulation of the C3a receptor with interferons
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    Immunology 111:435-43. 2004
  2. ncbi Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation
    Kristine Rossbach
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
    Exp Dermatol 18:57-63. 2009
  3. ncbi Comparison of classification systems in melanoma sentinel lymph nodes--an analysis of 697 patients from a single center
    Andre Meier
    Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany
    Cancer 116:3178-88. 2010
  4. ncbi Management of cutaneous side effects of EGFR inhibitors: recommendations from a German expert panel for the primary treating physician
    Ralf Gutzmer
    Department of Dermatology, Allergy and Venereology, Skin Cancer Center, Hannover Medical School, Germany
    J Dtsch Dermatol Ges 9:195-203. 2011
  5. ncbi Sentinel node biopsy in melanoma delays recurrence but does not change melanoma-related survival: a retrospective analysis of 673 patients
    R Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, D 30449 Hannover, Germany
    Br J Dermatol 153:1137-41. 2005
  6. ncbi Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus
    Ralf Gutzmer
    Hannover Medical School, Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover, Germany
    Front Biosci (Schol Ed) 3:985-94. 2011
  7. ncbi Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    J Invest Dermatol 126:2422-9. 2006
  8. ncbi The histamine H4 receptor is functionally expressed on T(H)2 cells
    Ralf Gutzmer
    Department of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany
    J Allergy Clin Immunol 123:619-25. 2009
  9. ncbi Sentinel lymph node status is the most important prognostic factor for thick (> or = 4 mm) melanomas
    Ralf Gutzmer
    Department of Dermatology and Venereology, Skin Tumor Center Hannover HTZH, Hannover Medical School, Hannover, Germany
    J Dtsch Dermatol Ges 6:198-203. 2008
  10. ncbi Identification of two distinct deletion targets at 11q23 in cutaneous malignant melanoma
    R A Herbst
    Department of Dermatology and Allergology, Hannover Medical University, Germany
    Int J Cancer 80:205-9. 1999

Detail Information

Publications59

  1. ncbi Human monocyte-derived dendritic cells are chemoattracted to C3a after up-regulation of the C3a receptor with interferons
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    Immunology 111:435-43. 2004
    ..Therefore, dendritic cells represent another group of target cells that might be recruited by C3a to areas of inflammation, in particular under conditions where IFNs are increased in the surrounding environment...
  2. ncbi Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation
    Kristine Rossbach
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
    Exp Dermatol 18:57-63. 2009
    ..Thus, a combination of H(4) and H(1) receptor antagonism might be a new strategy to treat pruritus related to allergic diseases like atopic dermatitis...
  3. ncbi Comparison of classification systems in melanoma sentinel lymph nodes--an analysis of 697 patients from a single center
    Andre Meier
    Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany
    Cancer 116:3178-88. 2010
    ..The authors of this report compared the RFS and OS of 697 melanoma patients as predicted by various classification systems...
  4. ncbi Management of cutaneous side effects of EGFR inhibitors: recommendations from a German expert panel for the primary treating physician
    Ralf Gutzmer
    Department of Dermatology, Allergy and Venereology, Skin Cancer Center, Hannover Medical School, Germany
    J Dtsch Dermatol Ges 9:195-203. 2011
    ..A panel of German dermatologists developed on the basis of personal experience and current literature consensus recommendations for the management of cutaneous side effects of EGFR inhibitors...
  5. ncbi Sentinel node biopsy in melanoma delays recurrence but does not change melanoma-related survival: a retrospective analysis of 673 patients
    R Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, D 30449 Hannover, Germany
    Br J Dermatol 153:1137-41. 2005
    ....
  6. ncbi Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus
    Ralf Gutzmer
    Hannover Medical School, Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover, Germany
    Front Biosci (Schol Ed) 3:985-94. 2011
    ..Taken together, several lines of evidence suggest a role of the H4R in chronic inflammatory skin disease and the H4R might be a therapeutic target for diseases such as AD...
  7. ncbi Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    J Invest Dermatol 126:2422-9. 2006
    ..This might be relevant in the direction of pDC to cutaneous lesions of inflammation, for example, in lupus erythematosus or contact dermatitis...
  8. ncbi The histamine H4 receptor is functionally expressed on T(H)2 cells
    Ralf Gutzmer
    Department of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany
    J Allergy Clin Immunol 123:619-25. 2009
    ..The histamine receptor 4 (H(4)R) is the most recently identified histamine receptor and is also expressed on human CD4(+) T cells; however, its regulation and function are unclear...
  9. ncbi Sentinel lymph node status is the most important prognostic factor for thick (> or = 4 mm) melanomas
    Ralf Gutzmer
    Department of Dermatology and Venereology, Skin Tumor Center Hannover HTZH, Hannover Medical School, Hannover, Germany
    J Dtsch Dermatol Ges 6:198-203. 2008
    ..The value of the status of the sentinel lymph node (SLN) in patients with thick melanomas (Breslow thickness > or = 4 mm) is controversial...
  10. ncbi Identification of two distinct deletion targets at 11q23 in cutaneous malignant melanoma
    R A Herbst
    Department of Dermatology and Allergology, Hannover Medical University, Germany
    Int J Cancer 80:205-9. 1999
    ..Thus, these 2 putative melanoma-suppressor loci are likely to harbor tumor-suppressor genes relevant to tumorigenesis of melanoma and a number of other common human malignancies...
  11. ncbi Sentinel node dissection delays recurrence and prolongs melanoma-related survival: an analysis of 673 patients from a single center with long-term follow-up
    I Satzger
    Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
    Ann Surg Oncol 18:514-20. 2011
    ..A large series of melanoma patients from a single center with long-term follow-up was analyzed with regard to a possible effect of SLND on the prognosis...
  12. ncbi Specificity of tyrosinase and HMB45 PCR in the detection of melanoma metastases in sentinel lymph node biopsies
    R Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, D 30449 Hannover, Germany
    Histopathology 41:510-8. 2002
    ..The aim of this study was to determine the specificity of polymerase chain reaction (PCR) techniques for the evaluation of lymph nodes with regard to melanoma metastases in comparison with histology and immunohistology...
  13. ncbi Murine and human Langerhans cells express a functional histamine H4 receptor: modulation of cell migration and function
    M Gschwandtner
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
    Allergy 65:840-9. 2010
    ....
  14. ncbi Sorafenib and pegylated interferon-?2b in advanced metastatic melanoma: a multicenter phase II DeCOG trial
    F Egberts
    Department of Dermatology, University of Kiel, Kiel, Germany
    Ann Oncol 22:1667-74. 2011
    ..Previously, combinations of interferon and sorafenib have been used in renal cell cancer...
  15. ncbi Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Immunol 174:5224-32. 2005
    ..Histamine induces chemotaxis and IL-12p70 suppression via different receptors using different signaling pathways, which might be important for the pathogenesis of and therapeutic interventions in allergic diseases...
  16. ncbi Prognostic significance of histopathological parameters in sentinel nodes of melanoma patients
    I Satzger
    Department of Dermatology and Allergology, Skin Cancer Centre Hannover, Hannover Medical School, Ricklinger Strasse 5, D 30449 Hannover, Germany
    Histopathology 50:764-72. 2007
    ..The aim was to determine the prognostic relevance of histopathological characteristics of micrometastases in the SLN, which has not been adequately addressed thus far...
  17. ncbi Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group
    Thomas K Eigentler
    Department of Dermatology, Skin Cancer Program, Eberhard Karls University, Tuebingen, Germany
    Melanoma Res 18:353-8. 2008
    ..Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended...
  18. ncbi Does basal cell carcinoma belong to the spectrum of sorafenib-induced epithelial skin cancers?
    A Degen
    Department of Dermatology and Allergy, Hannover Medical School, Skin Cancer Center Hannover, Hannover, Germany
    Dermatology 221:193-6. 2010
    ..Patients should be informed of this possible side effect and undergo regular dermatological controls before and during sorafenib therapy...
  19. ncbi Application of imiquimod by suppositories (anal tampons) efficiently prevents recurrences after ablation of anal canal condyloma
    M Kaspari
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, Germany
    Br J Dermatol 147:757-9. 2002
    ..After surgical removal, anal canal condyloma (ACC) has a higher risk of recurrence compared with extragenital warts...
  20. ncbi Adjuvant low-dose interferon {alpha}2a with or without dacarbazine compared with surgery alone: a prospective-randomized phase III DeCOG trial in melanoma patients with regional lymph node metastasis
    C Garbe
    Division of Dermatologic Oncology, Department of Dermatology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Ann Oncol 19:1195-201. 2008
    ..The aim of the study was to improve disease-free survival (DFS) and overall survival (OS) with interferon (IFN) alpha2a with or without dacarbazine (DTIC) compared with observation alone...
  21. ncbi Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine
    W Baumer
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover Foundation, Hannover, Germany
    Allergy 63:1387-94. 2008
    ..However, the distribution of histamine receptors on murine DC has not been studied yet...
  22. ncbi Human dendritic cells express the IL-18R and are chemoattracted to IL-18
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Immunol 171:6363-71. 2003
    ..Therefore, IL-18 might represent a novel mechanism to recruit DC to areas of inflammation, in particular under Th1 cytokine conditions where IFN-gamma is increased such as psoriasis or inflammatory bowel diseases...
  23. ncbi Up-regulation of C5a receptor expression and function on human monocyte derived dendritic cells by prostaglandin E2
    Oliver Weinmann
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    Immunology 110:458-65. 2003
    ..Therefore, up-regulation of the C5aR on human DC alters their chemotactic and immunologic response to C5a...
  24. ncbi Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Allergy Clin Immunol 109:524-31. 2002
    ..However, a possible link between histamine and dendritic cells has not been investigated thus far...
  25. ncbi [Successful treatment of pemphigus foliaceus with rituximab. Report of 3 cases]
    M Alter
    Klinik und Poliklinik fur Dermatologie, Venerologie und Allergologie, Medizinische Hochschule Hannover, Ricklinger Strasse 5, 30449, Hannover
    Hautarzt 60:743-8. 2009
    ..We report on three patients with pemphigus foliaceus who responded to rituximab after failing multiple other immunosuppressive therapies. We also examine the controversial issue of continuation therapy with rituximab in detail...
  26. ncbi Allelic loss at the neurofibromatosis type 1 (NF1) gene locus is frequent in desmoplastic neurotropic melanoma
    R Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Germany
    Hum Genet 107:357-61. 2000
    ..DNM may represent an interesting tumour model tor the further elucidation of the cellular functions and tumour-suppressive potential of neurofibromin...
  27. ncbi [Intravascular lymphoma: two case reports demonstrating the heterogeneity of the disease]
    I Satzger
    Klinik und Poliklinik fur Dermatologie und Venerologie, Medizinische Hochschule Hannover, Hauttumorzentrum Hannover HTZH, Ricklinger Strasse 5, Hannover, Germany
    Hautarzt 60:131-6. 2009
    ..The other patient had distinctive cutaneous and neurological symptoms which did not respond to therapy. By means of these two patients, we present the heterogeneity of IVL and discuss current aspects of diagnosis and treatment...
  28. ncbi Therapy of noninfectious granulomatous skin diseases with fumaric acid esters
    K Breuer
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, 30449 Hannover, Germany
    Br J Dermatol 152:1290-5. 2005
    ..Recently, in several case reports, fumaric acid esters (FAE) have proved beneficial in granulomatous skin diseases, but studies on a larger collection of consecutive patients have not yet been performed...
  29. ncbi Detection of clonal T cell receptor gamma gene rearrangements in cutaneous T cell lymphoma by LightCycler-polymerase chain reaction
    R Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Invest Dermatol 116:926-32. 2001
    ....
  30. ncbi Sensitive detection of Borrelia burgdorferi sensu lato DNA and differentiation of Borrelia species by LightCycler PCR
    S Mommert
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Clin Microbiol 39:2663-7. 2001
    ..burgdorferi sensu lato...
  31. ncbi [Giant keratoacanthoma in an immunocompetent patient with detection of HPV 11]
    M Niebuhr
    Klinik und Poliklinik fur Dermatologie und Allergologie, Medizinische Hochschule Hannover, Hannover
    Hautarzt 60:229-32. 2009
    ..In addition to ultraviolet exposure, trauma, genetic factors and chemical carcinogens, HPV should be considered as a possible cofactor in the etiology of keratoacanthoma...
  32. ncbi [Cutaneous side effects of medical tumor therapy]
    A Degen
    Klinik fur Dermatologie, Allergologie und Venerologie, Hauttumorzentrum Hannover HTZH, Medizinische Hochschule Hannover
    Hautarzt 62:444-50. 2011
    ..Knowledge of these side effects is important to avoid interruption or termination of the tumor therapy, in particular since some of the cutaneous reactions have been shown to correlate with the therapeutic benefit of the tumor therapy...
  33. ncbi [Facial pigmentation following therapy with terbinafine]
    K Breuer
    Klinik und Poliklinik fur Dermatologie und Venerologie, Medizinische Hochschule Hannover
    Hautarzt 56:1056-9. 2005
    ..This case report shows that drug-induced hyperpigmentation should also be considered if the patient takes drugs not known for this kind of side effect...
  34. ncbi MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma
    Imke Satzger
    Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany
    Int J Cancer 126:2553-62. 2010
    ..MiR-15b appears to represent a particular important miRNA in melanoma that is associated with poor prognosis and tumorigenesis...
  35. ncbi The role of the histamine H4 receptor in atopic dermatitis
    Susanne Mommert
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Ricklinger Str 5, 30449, Hannover, Germany
    Curr Allergy Asthma Rep 11:21-8. 2011
    ..We do so in the context of whether the histamine H4 receptor offers a novel target for effective treatments of inflammatory skin diseases...
  36. ncbi Criteria in sentinel lymph nodes of melanoma patients that predict involvement of nonsentinel lymph nodes
    Imke Satzger
    Department of Dermatology and Allergology, Skin Cancer Center Hannover, Hannover Medical School, Ricklinger Str 5, 30449 Hannover, Germany
    Ann Surg Oncol 15:1723-32. 2008
    ..Such criteria may facilitate the selection of patients who might benefit from a completion lymph node dissection (CLND). However, it is currently unclear which parameters are most important...
  37. ncbi Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions
    Rahul Purwar
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 05, D 30449 Hannover, Germany
    J Immunol 177:4444-50. 2006
    ....
  38. ncbi Histamine upregulates keratinocyte MMP-9 production via the histamine H1 receptor
    Maria Gschwandtner
    Department of Dermatology, Hannover Medical School, Hannover, Germany
    J Invest Dermatol 128:2783-91. 2008
    ..Our findings demonstrate enhanced MMP-9 production and cell migration after histamine stimulation and may represent a new mechanism by which KCs contribute to the pathology of skin diseases...
  39. ncbi Therapeutic use of erythropoietin in dermatooncology
    Imke Satzger
    Department of Dermatology and Venereology, Skin Tumor Center, Hannover Medical School, Hannover, Germany
    J Dtsch Dermatol Ges 5:280-5. 2007
    ..We review here current guidelines on the use of erythropoietin in cancer patients and report on our own melanoma patients treated with erythropoietin for chemotherapy-induced anemia...
  40. ncbi Critical involvement of IL-12 in IFN-gamma induction by calcineurin antagonists in activated human lymphocytes
    Miriam Wittmann
    Department of Dermatology and Allergology, Ricklinger Str 5, D 30449 Hannover, Germany
    J Leukoc Biol 80:75-86. 2006
    ..g., autoimmune disease)...
  41. ncbi Histamine downregulates monocyte CCL2 production through the histamine H4 receptor
    Dorothea Dijkstra
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Allergy Clin Immunol 120:300-7. 2007
    ..The expression of the recently cloned histamine H(4) receptor (H(4)R) by leukocytes suggests a role in immunomodulation...
  42. ncbi Prognostic significance of isolated HMB45 or Melan A positive cells in Melanoma sentinel lymph nodes
    Imke Satzger
    Department of Dermatology, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany
    Am J Surg Pathol 31:1175-80. 2007
    ..In conclusion, with short-term follow-up IPC in melanoma SLN are without prognostic significance...
  43. ncbi Autoimmunity as a prognostic factor in melanoma patients treated with adjuvant low-dose interferon alpha
    Imke Satzger
    Department of Dermatology and Allergology, Hannover Medical School, Hautklinik Linden, Klinikum Region Hannover, Skin Cancer Center Hannover, Hannover, Germany
    Int J Cancer 121:2562-6. 2007
    ..Thus, autoimmunity triggered by low-dose IFN therapy appears to indicate an improved prognosis and should encourage continuation of IFN therapy...
  44. ncbi Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor
    Dorothea Dijkstra
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    J Invest Dermatol 128:1696-703. 2008
    ..This might have implications for the treatment of atopic dermatitis, since H(4)R agonists may have beneficial effects in downregulating inflammation...
  45. ncbi Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseases
    Miriam Wittmann
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Invest Dermatol 124:1225-33. 2005
    ..These findings further support an important role of IL-18 in inflammatory skin diseases in the epidermal compartment...
  46. ncbi Tumoral melanosis involving the sentinel lymph nodes: a case report
    Imke Satzger
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Cutan Pathol 34:284-6. 2007
    ..We present a patient with nodular melanosis involving also the sentinel lymph nodes and discuss possible differential diagnoses as well as prognostic and therapeutic implications...
  47. ncbi Histamine H(4) receptor activation on human slan-dendritic cells down-regulates their pro-inflammatory capacity
    Maria Gschwandtner
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
    Immunology 132:49-56. 2011
    ..Hence, H(4) R agonists might have therapeutic potential to down-regulate immune reactions, e.g. in allergic inflammatory skin diseases...
  48. ncbi Analysis of c-KIT expression and KIT gene mutation in human mucosal melanomas
    I Satzger
    Department of Dermatology and Allergology, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany
    Br J Cancer 99:2065-9. 2008
    ..Our data encourage therapeutic attempts with tyrosine kinase inhibitors blocking c-KIT in these patients...
  49. ncbi Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy--case report and review of the literature
    Imke Satzger
    Skin Cancer Center Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany satzger imke mh hannover de
    Dermatology 220:77-81. 2010
    ..We report here on one of our patients with KIT-activating mutation in metastatic anal mucosal melanoma, who showed a response to imatinib therapy and summarize the available literature regarding this new therapeutic option...
  50. ncbi Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells
    M Pincha
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Gene Ther 18:750-64. 2011
    ..GCV administration after immunotherapy did not abrogate DC vaccination efficacy. This demonstrates proof-of-principle of genetically programmed DCs that can be ablated pharmacologically...
  51. ncbi Successful treatment of anogenital Bowen's disease with the immunomodulator imiquimod, and monitoring of therapy by DNA image cytometry
    R Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str 5, Germany
    Br J Dermatol 147:160-5. 2002
    ..Therefore, imiquimod might be a treatment option for Bowen's disease, particularly in patients where other treatment modalities such as surgery are contraindicated...
  52. ncbi Management of primary and metastasized melanoma in Germany in the time period 1976-2005: an analysis of the Central Malignant Melanoma Registry of the German Dermatological Society
    Silke S Schwager
    Department of Dermatology, Skin Cancer Program, Central Malignant Melanoma Registry of the German Dermatological Society, Eberhard Karls University of Tuebingen, Tuebingen, Germany
    Melanoma Res 18:112-9. 2008
    ..Management of metastasized melanoma showed a tendency towards surgical procedures in limited disease and an ongoing trend to systemic treatment in advanced disease...
  53. ncbi Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians
    Lars Boeckmann
    Department of Dermatology, Georg August University Goettingen, Germany
    Pharmacogenet Genomics 19:760-9. 2009
    ..The aim of this study was to identify individual host markers for hematologic side effects and the treatment efficacy of TMZ or DTIC in melanoma treatment...
  54. ncbi Absence of HHV-8 DNA in hobnail hemangiomas
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Cutan Pathol 29:154-8. 2002
    ..Since DNA of the human herpesvirus type 8 (HHV-8) has been detected in more than 90% of Karposi sarcomas and could recently be demonstrated in RHE, we sought to detect HHV-8 DNA in HH...
  55. ncbi Rapid identification and differentiation of fungal DNA in dermatological specimens by LightCycler PCR
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str 5, D 30449 Hannover, Germany
    J Med Microbiol 53:1207-14. 2004
    ..Thus the LightCycler PCR protocol established here represents a rapid diagnostic tool that aids in the diagnosis of fungal skin disease in a substantial number of patients...
  56. ncbi Imiquimod 5% cream in the treatment of human papillomavirus-16-positive erythroplasia of Queyrat
    Markus Kaspari
    Department of Dermatology and Allergology, Hannover Medical University, Germany
    Dermatology 205:67-9. 2002
    ..Imiquimod, a new topically applied immunomodulatory agent, has been successfully used in the treatment of anogenital warts. We report the complete clearance of HPV-16-positive erythroplasia of Queyrat with 5% imiquimod cream...
  57. ncbi A tumor-associated glycoprotein that blocks MHC class II-dependent antigen presentation by dendritic cells
    Ralf Gutzmer
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 173:1023-32. 2004
    ..These results demonstrate a novel mechanism by which tumors may evade CD4(+) T cell-dependent immune responses through expression of a TAA...
  58. ncbi Atypical cutaneous herpes virus infection associated with fludarabine chemotherapy of lymphoma
    Imke Satzger
    Eur J Dermatol 17:165-6. 2007
  59. ncbi Spontaneous regression of melanoma with distant metastases - report of a patient with brain metastases
    Imke Satzger
    Eur J Dermatol 16:454-5. 2006