Research Topics
Genomes and Genes | Martin GötteSummaryCountry: Germany Publications
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Publications
Effect of testosterone on E1S-sulfatase activity in non-malignant and cancerous breast cells in vitroMartin Götte
Department of Gynecology and Obstetrics, University Clinic of Muenster, Muenster, Germany
J Steroid Biochem Mol Biol 117:168-75. 2009....- An expression signature of syndecan-1 (CD138), E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situMartin Götte
Department of Obstetrics and Gynecology, Munster University Hospital, Domagkstrasse 11, Munster, D 48149, Germany
Breast Cancer Res 9:R8. 2007.... - Defective glycosaminoglycan substitution of decorin in a patient with progeroid syndrome is a direct consequence of two point mutations in the galactosyltransferase I (beta4GalT-7) geneMartin Götte
Department of Obstetrics and Gynecology, Munster University Hospital, Domagkstr 11, D 48149 Munster, Germany
Biochem Genet 43:65-77. 2005.... - MicroRNAs in breast cancer pathogenesisM Gotte
Research Laboratory, Department of Gynecology and Obstetrics, Munster University Hospital, Munster, Germany
Minerva Ginecol 62:559-71. 2010..The future application of locked-nucleic acid miRNA inhibitors, and synergistic approaches involving conventional breast cancer therapeutics opens up promising new perspectives in breast cancer therapy... - Age-related molecular polymorphism of the heterodimeric proteoglycan BisdermicanMartin Götte
Departments of Obstetrics and Gynecology, Munster University Hospital, Munster, Germany
ScientificWorldJournal 4:1017-26. 2004..5 kDa for the large subunit, and a molecular weight of 22 kDa for the small subunit. Thus, Bisdermican displays a molecular polymorphism that is related to its chronological age and proliferative state... - Biglycan is internalized via a chlorpromazine-sensitive routeMartin Götte
Department of Physiological Chemistry, Munster University Hospital, Domagkstr 11, D 48149 Munster, Germany
Cell Mol Biol Lett 9:475-81. 2004..Based on the differential susceptibility to pharmacological inhibition, it appears that BGN endocytosis seems to be at least in part mechanistically different from decorin uptake... - miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasivenessM Gotte
Department of Gynecology and Obstetrics, Munster University Hospital, Munster, Germany
Oncogene 29:6569-80. 2010..Our data provide a rationale for future miR-145-targeted approaches of antimetastatic cancer therapy... - Predictive value of syndecan-1 expression for the response to neoadjuvant chemotherapy of primary breast cancerMartin Götte
Department of Obstetrics and Gynecology, Munster University Hospital, Germany
Anticancer Res 26:621-7. 2006..The effect of syndecan-1 expression on tumor response to neoadjuvant chemotherapy was determined in locally advanced breast cancer... - ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozoleMartin Smollich
Department of Obstetrics and Gynecology, University Hospital of Munster, Albert Schweitzer Str 33, 48129, Munster, Germany
Breast Cancer Res Treat 123:345-57. 2010..Our data strongly support a rationale for the clinical use of ZD4054 in combination with endocrine therapies... - Differential effects of aromatase inhibitors and antiestrogens on estrogen receptor expression in breast cancer cellsMartin Smollich
Department of Obstetrics and Gynecology, University of Munster, 48129 Munster, Germany
Anticancer Res 29:2167-71. 2009..Compared to antiestrogens, third-generation aromatase inhibitors (anastrozole and letrozole) exhibit an improved efficacy and tolerability... - Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signalingDavid Denis Sofeu Feugaing
Department of Obstetrics and Gynecology, Domagkstr 11, Munster University Hospital, D 48149 Munster, Germany
Biochimie 89:637-57. 2007..Of note, lipid-raft-dependent EGFR signaling modulates decorin uptake, suggesting the presence of a potential feedback regulation mechanism for desensitization of signaling events mediated by decorin... - Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndromeMartin Götte
Department of Gynecology and Obstetrics, University of Munster, Medical Center, Albert Schweitzer Str 33, D 48149 Munster, Germany
Hum Mol Genet 17:996-1009. 2008..Our study suggests an HS-dependent basic mechanism behind the altered wound repair phenotype of beta4GalT-7-deficient EDS patients... - On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancerMartin Smollich
Department of Obstetrics and Gynecology, University Hospital of Munster, Albert Schweitzer Str 33, 48149, Munster, Germany
Breast Cancer Res Treat 106:361-9. 2007..Thus, expression of ECE-1 and NEP may have prognostic relevance. Due to the anti-invasive effect of the selective ECE-1 inhibitor, targeting ECE-1 may represent an innovative option in future breast cancer therapy... - A novel 110-kDa receptor protein is involved in endocytic uptake of decorin by human skin fibroblastsDavid Denis Sofeu Feugaing
Department of Obstetrics and Gynecology, Munster University Hospital, Munster, Germany
ScientificWorldJournal 6:35-52. 2006..The identification of a 110-kDa protein as a novel endocytosis receptor for decorin provides further support for the emerging concept of a redundancy of receptor molecules in the endocytosis of SLRP... - Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cellsJeanett Fischgräbe
Department of Obstetrics and Gynecology, University of Munster, Munster, Germany
Int J Cancer 127:696-706. 2010..This study suggests complex interactions between HER2/EGFR and ET pathways in breast cancer and supports the hypothesis that dual HER2-ET(A)R targeting may represent a highly effective approach in breast cancer treatment... - Overexpression of Endothelin-A-receptor in breast cancer: regulation by estradiol and cobalt-chloride induced hypoxiaPia Wülfing
Department of Obstetrics and Gynecology, Munster University Hospital, D 48129 Munster, Germany
Int J Oncol 26:951-60. 2005..The present data suggest a novel mechanism in the regulation of ETAR expression in breast cancer. Based on these findings, a combination of ETAR-antagonists with adjuvant endocrine treatment seems to be a reasonable therapeutic strategy... - Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7)Daniela G Seidler
Department of Physiological Chemistry and Pathobiochemistry, Munster University Hospital, Munster, Germany
J Mol Med (Berl) 84:583-94. 2006.... - Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivityBehzad Kharabi Masouleh
Department of Gynecology and Obstetrics, Medical Center, University of Munster, Munster, Germany
J Immunol 182:4985-93. 2009..Collectively, our results show an important role of syndecan-1 in the contact DTH reaction, identifying syndecan-1 as a novel target in anti-inflammatory therapy... - Differential effect of hormone therapy on E1S-sulfatase activity in non-malignant and cancerous breast cells in vitroPetra Stute
Department of Obstetrics and Gynecology, Munster University Hospital, Muenster, Germany
Breast Cancer Res Treat 108:363-74. 2008..On the contrary, E2 exerts a differential effect on STS in HBL-100 and MCF-7 cells. The transition from normal to malignant breast cells may be accompanied by an abolished autoregulation of local estrogen formation... - Effects of the FSH receptor gene polymorphism p.N680S on cAMP and steroid production in cultured primary human granulosa cellsVerena Nordhoff
Centre of Reproductive Medicine and Andrology, University Hospital of Munster, Domagkstrasse 11, D 48149 Munster, Germany
Reprod Biomed Online 23:196-203. 2011..However, the experiments suggest that factors down-stream of progesterone production or external to GC might be involved in the clinically observed differences in an FSHR variant-mediated response to FSH... - Effects of hormone therapy on estrogen synthesis from E1S in the mammary gland of postmenopausal womenPetra Stute
Department of Gynecology and Obstetrics, University Clinic of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
Maturitas 59:163-73. 2008..To investigate the effect of hormone therapy (HT) on the expression of hormone receptors and the ex vivo estrogen biosynthesis in the breast... - Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progressionViktoriya Nikolova
Department of Gynecology and Obstetrics, University Hospital Munster, Munster, Germany
Carcinogenesis 30:397-407. 2009..Proteolytic conversion of Sdc1 from a membrane-bound into a soluble molecule marks a switch from a proliferative to an invasive phenotype, with implications for breast cancer diagnostics and potential glycosaminoglycan-based therapies... - Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnosticsAndreas N Schuring
Department of Gynecology and Obstetrics, University Clinic of Münster, Munster, Germany
Fertil Steril 95:423-6. 2011..We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells... - Effects of black cohosh on estrogen biosynthesis in normal breast tissue in vitroPetra Stute
Department of Obstetrics and Gynecology, University Clinic of Muenster, 48149 Muenster, Germany
Maturitas 57:382-91. 2007..To investigate the effect of black cohosh on the estrogen biosynthesis in the breast in vitro... - The role for decorin in delayed-type hypersensitivityDaniela G Seidler
Institute of Physiological Chemistry and Pathobiochemistry, D 48149 Munster, Germany
J Immunol 187:6108-19. 2011..This occurs via two nonmutually exclusive mechanisms that involve a direct antiadhesive effect on polymorphonuclear leukocytes and a negative regulation of ICAM-1 and syndecan-1 expression... - Aberrant expression of the pluripotency marker SOX-2 in endometriosisMartin Götte
Department of Gynecology and Obstetrics, University of Munster, Medical Center, Munster, Germany
Fertil Steril 95:338-41. 2011..Aberrant expression of SOX-2 may indicate a stem cell origin of endometriosis, whereas the presence of all progenitor markers in endometrial tissue marks the endometrium as a potential source for induced pluripotent stem cell generation... - Metformin alters insulin signaling and viability of human granulosa cellsBarbara Sonntag
Department of Obstetrics and Gynecology, University Hospital of Munster, Munster, Germany
Fertil Steril 84:1173-9. 2005..To study whether insulin signaling pathways in the ovary are altered by metformin... - The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophagesLiliana Schaefer
Department of Medicine D, Interdisciplinary Center of Clinical Research, Muenster, University of Muenster, Muenster, Germany
J Clin Invest 115:2223-33. 2005..These findings are potentially relevant for the development of new strategies in the treatment of sepsis... - Evaluation of placental syndecan-1 expression in early pregnancy as a predictive fetal factor for pregnancy outcomeAnna Schmedt
Department of Gynecology and Obstetrics, Munster University Hospital, Albert Schweitzer Str 33, D 48149, Munster, Germany
Prenat Diagn 32:131-7. 2012..The aim of this study was to examine the correlation between early placental syndecan expression and fetal outcome in ongoing pregnancies... - Role of syndecan-3 polymorphisms in obesity and female hyperandrogenismAndreas N Schuring
Department of Gynecology and Obstetrics, University Hospital of Munster, 48149 Munster, Germany
J Mol Med (Berl) 87:1241-50. 2009..These findings indicate that SDC3 polymorphisms could contribute to the link between female hyperandrogenism and obesity and suggest a novel potential role for SDC3 as a modulator of gonadal steroid function... - Syndecans in inflammationMartin Götte
Protogeneia, Inc, Munster, Germany
FASEB J 17:575-91. 2003..Recently generated transgenic and knockout mouse models will facilitate analysis of the individual processes that each syndecan is involved in... - Heterologous expression of syntaxin 6 in Saccharomyces cerevisiaeMartin Götte
Protogenia Research Laboratory, Protogeneia, Inc, D 48149 Munster, Germany
Biol Res 35:347-57. 2002..We conclude that syntaxin 6 and Pep12p do not act at the same vesicular trafficking step(s) in yeast and higher eukaryotes...