W L Gross

Summary

Country: Germany

Publications

  1. ncbi CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis
    P Lamprecht
    Department of Rheumatology, University of Luebeck, 23538 Luebeck, Germany
    Thorax 56:751-7. 2001
  2. ncbi Immunological and clinical follow up of hepatitis C virus associated cryoglobulinaemic vasculitis
    P Lamprecht
    Department of Rheumatology, , and Rheumaklinik Bad Bramstedt, Oskar-Alexander-Str. 26, 24576 Bad Bramstedt, Germany
    Ann Rheum Dis 60:385-90. 2001
  3. ncbi The endotoxin-binding bactericidal/permeability-increasing protein (BPI): a target antigen of autoantibodies
    H Schultz
    Department of Rheumatology, University of Lubeck, Rheumaklinik Bad Bramnstedt GmbH, Germany
    J Leukoc Biol 69:505-12. 2001
  4. ncbi Prevalence of ANCA in mixed cryoglobulinemia and chronic hepatitis C virus infection
    P Lamprecht
    Department of Rheumatology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Clin Exp Rheumatol 21:S89-94. 2003
  5. ncbi ANCA against bactericidal/permeability-increasing protein, azurocidin, calprotectin and defensins in rheumatic and infectious diseases: prevalence and clinical associations
    H Schultz
    Department of Rheumatology, , , Germany
    Clin Exp Rheumatol 21:S117-20. 2003
  6. ncbi Severe CNS manifestations as the clinical hallmark in generalized Wegener's granulomatosis consistently negative for antineutrophil cytoplasmic antibodies (ANCA). A report of 3 cases and a review of the literature
    E Reinhold-Keller
    Department of Rheumatology, Medical University of Lübeck and Rheumaklinik Bad Bramstedt GmbH, Germany
    Clin Exp Rheumatol 19:541-9. 2001
  7. ncbi B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions
    J Voswinkel
    Department of Rheumatology, University Hospital of Schleswig Holstein, Lubeck, Germany
    Ann Rheum Dis 65:859-64. 2006
  8. ncbi Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis
    C Metzler
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Rheumatology (Oxford) 46:1087-91. 2007
  9. ncbi Variations in performance characteristics of commercial enzyme immunoassay kits for detection of antineutrophil cytoplasmic antibodies: what is the optimal cut off?
    J U Holle
    Department of Rheumatology, , Germany
    Ann Rheum Dis 64:1773-9. 2005
  10. ncbi Sustained success of therapy with inhaled iloprost for severe pulmonary arterial hypertension associated with systemic sclerosis and pulmonary fibrosis
    K Ahmadi-Simab
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Clin Exp Rheumatol 25:760-2. 2007

Detail Information

Publications32

  1. ncbi CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis
    P Lamprecht
    Department of Rheumatology, University of Luebeck, 23538 Luebeck, Germany
    Thorax 56:751-7. 2001
    ..Lack of CD28 expression on peripheral blood CD4+ and CD8+ T cells has been reported in patients with Wegener's granulomatosis (WG), suggesting a pathogenetic role of CD28- T cells in WG...
  2. ncbi Immunological and clinical follow up of hepatitis C virus associated cryoglobulinaemic vasculitis
    P Lamprecht
    Department of Rheumatology, , and Rheumaklinik Bad Bramstedt, Oskar-Alexander-Str. 26, 24576 Bad Bramstedt, Germany
    Ann Rheum Dis 60:385-90. 2001
    ..The data indicate that activity of the humoral (cryoglobulinaemia, RF, autoantibodies) and cellular (sIL2r, sICAM-1, sCD30) immune response and endothelial damage (sICAM-1) are found in HCV associated CV...
  3. ncbi The endotoxin-binding bactericidal/permeability-increasing protein (BPI): a target antigen of autoantibodies
    H Schultz
    Department of Rheumatology, University of Lubeck, Rheumaklinik Bad Bramnstedt GmbH, Germany
    J Leukoc Biol 69:505-12. 2001
    ..BPI-ANCA may further worsen inflammation by reducing the ability of BPI to promote clearance of gram-negative bacteria and bacterial-associated endotoxin...
  4. ncbi Prevalence of ANCA in mixed cryoglobulinemia and chronic hepatitis C virus infection
    P Lamprecht
    Department of Rheumatology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Clin Exp Rheumatol 21:S89-94. 2003
    ....
  5. ncbi ANCA against bactericidal/permeability-increasing protein, azurocidin, calprotectin and defensins in rheumatic and infectious diseases: prevalence and clinical associations
    H Schultz
    Department of Rheumatology, , , Germany
    Clin Exp Rheumatol 21:S117-20. 2003
    ..In inflammatory bowel diseases BPI-ANCA is predominant, AZ-ANCA are also present to a lesser extend. Both were not useful characterize clinical subgroups. No ANCA were detected against calprotectin or defensins...
  6. ncbi Severe CNS manifestations as the clinical hallmark in generalized Wegener's granulomatosis consistently negative for antineutrophil cytoplasmic antibodies (ANCA). A report of 3 cases and a review of the literature
    E Reinhold-Keller
    Department of Rheumatology, Medical University of Lübeck and Rheumaklinik Bad Bramstedt GmbH, Germany
    Clin Exp Rheumatol 19:541-9. 2001
    ..The authors report 3 young patients with biopsy-proven active generalized WG who were consistently negative for ANCA over observation times ranging from 58 to 114 months...
  7. ncbi B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions
    J Voswinkel
    Department of Rheumatology, University Hospital of Schleswig Holstein, Lubeck, Germany
    Ann Rheum Dis 65:859-64. 2006
    ..Evidence for a pivotal role of PR3-ANCA in the induction of vasculitis has been demonstrated. B cell clusters have been observed within endonasal biopsy specimens...
  8. ncbi Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis
    C Metzler
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Rheumatology (Oxford) 46:1087-91. 2007
    ..Results from open-label trials suggest that methotrexate (MTX) and leflunomide (LEF) are effective for maintenance of remission in Wegener's granulomatosis (WG), but data from randomized controlled clinical trails are not yet available...
  9. ncbi Variations in performance characteristics of commercial enzyme immunoassay kits for detection of antineutrophil cytoplasmic antibodies: what is the optimal cut off?
    J U Holle
    Department of Rheumatology, , Germany
    Ann Rheum Dis 64:1773-9. 2005
    ..Comparative analyses using sera from well characterised patients may help identify optimum cut off levels of commercial ANCA ELISA tests, resulting in better comparability of results among assays from different manufacturers...
  10. ncbi Sustained success of therapy with inhaled iloprost for severe pulmonary arterial hypertension associated with systemic sclerosis and pulmonary fibrosis
    K Ahmadi-Simab
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Clin Exp Rheumatol 25:760-2. 2007
    ..In cases where bosentan is contraindicated, inhaled iloprost is an effective alternative for the treatment of severe PAH...
  11. ncbi ANCA-associated vasculitides: pathogenetic aspects and current evidence-based therapy
    J U Holle
    University Hospital of Schleswig Holstein, Campus Luebeck, Dept of Rheumatology and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Autoimmun 32:163-71. 2009
    ..Rituximab and TNFalpha-antagonists represent promising options for refractory disease. The current evidence of therapy of ANCA-associated vasculitides is summarized in this review...
  12. ncbi Bosentan for severe pulmonary arterial hypertension related to systemic sclerosis with interstitial lung disease
    K Ahmadi-Simab
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Eur J Clin Invest 36:44-8. 2006
    ..ET is believed to be a key pathogenic mediator in systemic sclerosis (scleroderma, SSc), causing fibrotic, hypertrophic and inflammatory processes. PAH is one of the resulting deleterious effects in approximately 15% of SSc patients...
  13. ncbi Small vessel vasculitis and relapsing panniculitis in tumour necrosis factor receptor associated periodic syndrome (TRAPS)
    P Lamprecht
    Department of Rheumatology, University Hospital of Schleswig Holstein, 23538 Luebeck, Germany
    Ann Rheum Dis 63:1518-20. 2004
    ..The cases underline the importance of TNF alpha regulation in inflammatory processes including vasculitis. Genetically determined causes of fever may account for some cases of WCD...
  14. ncbi Rituximab induces remission in refractory HCV associated cryoglobulinaemic vasculitis
    P Lamprecht
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Ann Rheum Dis 62:1230-3. 2003
    ....
  15. ncbi Standardized neurologic evaluations of 128 patients with Wegener granulomatosis
    K de Groot
    Department of Rheumatology, University of Lübeck and Rheumaklinik Bad Bramstedt, Germany
    Arch Neurol 58:1215-21. 2001
    ..To assess the frequency and type of neurologic involvement in a cohort of patients with generalized Wegener granulomatosis (WG)...
  16. ncbi Elevated monocytic IL-12 and TNF-alpha production in Wegener's granulomatosis is normalized by cyclophosphamide and corticosteroid therapy
    P Lamprecht
    Department of Rheumatology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Clin Exp Immunol 128:181-6. 2002
    ..Normalization of the skewed cytokine pattern may be a prerequisite and an indicator of inducing a remission in WG...
  17. ncbi Lack of association between antiphospholipid antibodies and thrombocytopenia in patients with Wegener's granulomatosis
    M F Meyer
    Department of Rheumatology, , Germany
    Semin Arthritis Rheum 31:4-11. 2001
    ..We found a frequency of aPL in WG that exceeds frequencies seen in the general population but does not approximate those detected in systemic lupus erythematosus and closely related disorders. Semin Arthritis Rheum 31:4-11...
  18. ncbi Current knowledge on cellular interactions in the WG-granuloma
    P Lamprecht
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Clin Exp Rheumatol 25:S49-51. 2007
    ..Subsequent PR3-ANCA associated systemic vasculitis gives rise to new inflammatory lesions in many other organs, thereby promoting a self-perpetuating pathology characterized by inflammation and autoimmunity to PR3...
  19. ncbi Proteinase 3, protease-activated receptor-2 and interleukin-32: linking innate and autoimmunity in Wegener's granulomatosis
    E Csernok
    Department of Rheumatology, University Lübeck and Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany
    Clin Exp Rheumatol 26:S112-7. 2008
    ....
  20. ncbi Development and validation of a disease extent index for Wegener's granulomatosis
    K de Groot
    Department of Rheumatology, Medical University of Lubeck, and Rheumaklinik, Bad Bramstedt, Germany
    Clin Nephrol 55:31-8. 2001
    ..We present a validation study of the Disease Extent Index (DEI)...
  21. ncbi Immunopathology and new therapeutic considerations in ANCA-associated vasculitides
    W L Gross
    Department of Rheumatology, University Hospital of Schleswig-Holstein, Campus Luebeck, Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Autoimmun Rev 3:S47-8. 2004
  22. ncbi Difficult to diagnose manifestations of vasculitis: does an interdisciplinary approach help?
    Bernhard Hellmich
    Department of Rheumatology, Poliklinik fur Rheumatologie, Universitätsklinfikum Schleswig Holstein, Campus Lübeck and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Best Pract Res Clin Rheumatol 19:243-61. 2005
    ..These two examples of difficult to diagnose manifestations of vasculitis illustrate the necessity of an interdisciplinary approach to the diagnostic work-up...
  23. ncbi Successful therapy of bosentan-refractory pulmonary arterial hypertension (PAH) with inhalative iloprost
    K Ahmadi-Simab
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, Luebeck, Germany
    Clin Exp Rheumatol 23:402-3. 2005
    ..Our case report demonstrates that patients with bosentan-refractory PAH can be successfully treated with iloprost inhalation...
  24. ncbi Maintenance of remission with leflunomide in Wegener's granulomatosis
    C Metzler
    Department of Rheumatology, University of Schleswig-Holstein, , Rheumaklinik Bad Bramstedt GmbH, Oskar-Alexander-Strasse 26, D-24576 Bad Bramstedt, Germany
    Rheumatology (Oxford) 43:315-20. 2004
    ..The results of this pilot study encourage further controlled trials comparing leflunomide with alternative remission maintenance therapies...
  25. ncbi Effectiveness of TNF-alpha blockade with infliximab in refractory Wegener's granulomatosis
    P Lamprecht
    Department of Rheumatology, , , Germany
    Rheumatology (Oxford) 41:1303-7. 2002
    ..Five patients remained in remission for 6-24 months of follow-up. CONCLUSION: The data suggest that infliximab may provide an effective and more specific therapeutic option in the treatment of active WG refractory to standard treatment...
  26. ncbi Immune phenomena in localized and generalized Wegener's granulomatosis
    A Mueller
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Clin Exp Rheumatol 21:S49-54. 2003
    ..e. from localized to generalized WG with a special emphasis on granulomatous lesions of the upper respiratory tract and their alterations during the disease course...
  27. ncbi Update on the pathogenesis of Churg-Strauss syndrome
    B Hellmich
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, Germany
    Clin Exp Rheumatol 21:S69-77. 2003
    ....
  28. ncbi A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis
    E Csernok
    Department of Rheumatology, , Germany
    Rheumatology (Oxford) 41:1313-7. 2002
    ..The in-house PR3 and MPO-ANCA capture ELISAs performed better than the commercial ELISAs, combining higher specificity with similar sensitivity. IFT remains the best method for ANCA detection in both diseases...
  29. ncbi BPI-ANCA in transporter associated with antigen presentation (TAP) deficiency: possible role in susceptibility to Gram-negative bacterial infections
    H Schultz
    Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, Germany
    Clin Exp Immunol 133:252-9. 2003
    ....
  30. ncbi [B lymphocyte differentiation in granulomatous tissues of the lung and the nasal mucosa in Wegener's granulomatosis: origin of anti-neutrophil cytoplasmic antibody formation?]
    J A Kramer
    Poliklinik fur Rheumatologie, Universitatsklinikum Schleswig Holstein, Campus Lübeck und Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Z Rheumatol 66:421-9. 2007
    ..WG granulomata could be the place of autoantigen presentation and formation of high-affinity ANCA within neoformed ectopic or tertiary lymphoid-like tissue areas...
  31. ncbi Correlation between HRCT findings, pulmonary function tests and bronchoalveolar lavage cytology in interstitial lung disease associated with rheumatoid arthritis
    J Biederer
    Department of Diagnostic Radiology, Christian Albrechts University Kiel, Arnold Heller Strasse 9, 24105 Kiel, Gemany
    Eur Radiol 14:272-80. 2004
    ..The PFT and BAL correlate only partially with lesion profusion or grading on HRCT, but they contribute valuable information about dynamic lung function and differential diagnoses (pneumonia, medication side effects)...