Florian Grabellus

Summary

Country: Germany

Publications

  1. ncbi The BRAF V600E mutation in papillary thyroid carcinoma is associated with glucose transporter 1 overexpression
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Thyroid 22:377-82. 2012
  2. ncbi Glucose transporter 1 expression, tumor proliferation, and iodine/glucose uptake in thyroid cancer with emphasis on poorly differentiated thyroid carcinoma
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Clin Nucl Med 37:121-7. 2012
  3. ncbi Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis
    Max D Kauther
    Department of Trauma Surgery, University Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    BMC Musculoskelet Disord 12:186. 2011
  4. ncbi Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrences
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, 45122 Essen, Germany
    Ann Surg Oncol 16:676-86. 2009
  5. ncbi Tumor vascularization and histopathologic regression of soft tissue sarcomas treated with isolated limb perfusion with TNF-? and melphalan
    Florian Grabellus
    Institute of Pathology and Neuropathology, Sarcoma Center, West German Cancer Center, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    J Surg Oncol 103:371-9. 2011
  6. ncbi [Giant cell tumors of soft tissue arising in surgical scars]
    F Grabellus
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Deutschland
    Pathologe 30:401-6. 2009
  7. ncbi Overexpression of the drug resistance-associated protein metallothionein does not correlate with response of sarcomas to isolated limb perfusion treatment
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, Essen, Germany
    J Surg Oncol 101:465-70. 2010
  8. ncbi Induction of the matrix metalloproteinase-2 activation system in arteries by tensile stress. Involvement of the p38 MAP-kinase pathway
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, Essen, Germany
    Pathol Res Pract 203:135-43. 2007
  9. ncbi MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Tumour Biol 31:157-63. 2010
  10. ncbi The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general population
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen, Essen, Germany
    J Clin Pathol 64:1021-4. 2011

Detail Information

Publications40

  1. ncbi The BRAF V600E mutation in papillary thyroid carcinoma is associated with glucose transporter 1 overexpression
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Thyroid 22:377-82. 2012
    ..In this study, we hypothesized that the common BRAF V600E mutation was associated with GLUT1 overexpression and proliferation in papillary thyroid carcinomas (PTCs)...
  2. ncbi Glucose transporter 1 expression, tumor proliferation, and iodine/glucose uptake in thyroid cancer with emphasis on poorly differentiated thyroid carcinoma
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Clin Nucl Med 37:121-7. 2012
    ..We investigated the relationship among GLUT1 expression, proliferation, iodine concentration, and glucose uptake in different TC types, with emphasis on "poorly differentiated thyroid carcinoma" (PDTC)...
  3. ncbi Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis
    Max D Kauther
    Department of Trauma Surgery, University Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    BMC Musculoskelet Disord 12:186. 2011
    ..This study investigates the impact of CT (calcitonin) deficiency and CT substitution under in-vivo circumstances on particle-induced osteolysis in Calca -/- mice...
  4. ncbi Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrences
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, 45122 Essen, Germany
    Ann Surg Oncol 16:676-86. 2009
    ..Isolated limb perfusion (TM-ILP) is an effective limb-sparing treatment for primarily nonresectable soft tissue sarcomas (STS). Surgical margins of STS after ILP were yet not systematically studied...
  5. ncbi Tumor vascularization and histopathologic regression of soft tissue sarcomas treated with isolated limb perfusion with TNF-? and melphalan
    Florian Grabellus
    Institute of Pathology and Neuropathology, Sarcoma Center, West German Cancer Center, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    J Surg Oncol 103:371-9. 2011
    ..Some tumors show an insufficient association between radiological and pathological response. We investigated STS after TM-ILP with a primary emphasis on histologic regression patterns...
  6. ncbi [Giant cell tumors of soft tissue arising in surgical scars]
    F Grabellus
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Deutschland
    Pathologe 30:401-6. 2009
    ....
  7. ncbi Overexpression of the drug resistance-associated protein metallothionein does not correlate with response of sarcomas to isolated limb perfusion treatment
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, Essen, Germany
    J Surg Oncol 101:465-70. 2010
    ..Objective of this study was to investigate the influence of MT expression on tumor responses in HILP-TM-treated soft tissue (STSs) and bone sarcomas (BS)...
  8. ncbi Induction of the matrix metalloproteinase-2 activation system in arteries by tensile stress. Involvement of the p38 MAP-kinase pathway
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, Essen, Germany
    Pathol Res Pract 203:135-43. 2007
    ..The regulation of the vascular gelatinolytic system by MAP kinases suggests a therapeutic option against cardiovascular diseases at the level of MAPK signal transduction...
  9. ncbi MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Tumour Biol 31:157-63. 2010
    ..A clear influence of polysomy 7 on MET protein expression could not be statistically demonstrated for this cohort. Moreover, gene fusions with the ability to cause MET overexpression do not occur in chordomas...
  10. ncbi The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general population
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen, Essen, Germany
    J Clin Pathol 64:1021-4. 2011
    ..1621 A>C) in aggressive fibromatosis (AF) was recently determined to be 2.5-fold higher than in healthy controls. It was thus hypothesised that M541L could be associated with the development of AF...
  11. ncbi The XbaI G>T polymorphism of the glucose transporter 1 gene modulates 18F-FDG uptake and tumor aggressiveness in breast cancer
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    J Nucl Med 51:1191-7. 2010
    ..We investigated the relevance of single-nucleotide polymorphisms (SNPs) in the glucose transporter 1 (GLUT1) gene to the uptake of (18)F-FDG and tumor aggressiveness in breast cancer...
  12. ncbi Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma
    Henrike Westekemper
    Department of Ophthalmology, University of Duisburg Essen, Germany
    Br J Ophthalmol 95:853-8. 2011
    ....
  13. ncbi Increased shedding of soluble TNF-receptor 1 during hyperthermic TNF-?-based isolated limb perfusion
    Florian Grabellus
    Institute of Pathology and Neuropathology, West German Cancer Center, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Int J Hyperthermia 27:33-41. 2011
    ..Shedding of soluble TNF-receptor (sTNF-R) negatively modulates the effects of TNF-?, whereas hyperthermia (HT) induces shedding. Here, we investigated whether sTNF-R shedding in response to HT occurs during HILP...
  14. ncbi Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma
    Sien Yi Sheu
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Germany
    Histopathology 56:632-40. 2010
    ..To compare the expression pattern of five microRNAs (miRNAs) (146b, -181b, -21, -221, -222) of papillary thyroid carcinoma (PTC) and hyalinizing trabecular tumour of the thyroid (HTT)...
  15. ncbi High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome
    Klaus Jürgen Schmitz
    Institute of Pathology, University Hospital of Essen Duisburg, Essen, Germany
    Breast Cancer Res 7:R194-203. 2005
    ..In particular, with regard to lymph node-negative breast cancer it is important to identify high-risk patients who would benefit from further adjuvant therapy...
  16. ncbi Unusual aggressive course of a giant cell tumor of soft tissue during immunosuppressive therapy
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Virchows Arch 448:847-51. 2006
    ..Therefore, we suggest that in patients with immunosuppression, even low malignant cancerous lesions should be carefully observed, as their local behavior may be aggressive with development of metastasis...
  17. ncbi Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection
    Ying Yong Hou
    Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany
    J Gastrointest Surg 13:1583-92. 2009
    ..To investigate the impact of KIT and PDGFRA gene mutations on the prognosis of gastrointestinal stromal tumors (GIST)...
  18. ncbi Heat shock protein 72 and apoptosis indicate cardiac decompensation during early multiple organ failure in sheep
    Hideo A Baba
    Institut fur Pathologie, Universitat Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Intensive Care Med 30:1405-13. 2004
    ..Inducible heat shock protein 72 (HSP 72) preserves myocardial function and prevents apoptosis. We investigated the expression and localization of HSP 72 and apoptosis in our previously described new model of multiple organ failure...
  19. ncbi Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT
    Jun Li
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    J Surg Oncol 98:438-43. 2008
    ..The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma...
  20. ncbi Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation
    Florian Grabellus
    Institute of Pathology, University Hospital of Essen, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Virchows Arch 448:85-9. 2006
    ..The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies...
  21. ncbi Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements
    Sien Yi Sheu
    Institute of Pathology and Neuropathology, University Hospital of Essen, Essen, Germany
    Mod Pathol 20:779-87. 2007
    ..Additionally, this rare variant of papillary thyroid carcinoma may represent a tumour type susceptible to RET-targeted therapies...
  22. ncbi Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model
    Semra Aydin
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Eur J Haematol 87:10-9. 2011
    ..This model could be useful for evaluating the biological basis of CLL growth in the context of the hematopoietic microenvironment as well as preclinical testing of novel compounds...
  23. ncbi Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis
    Claudia Stolz
    Department of Medicine Cancer Research, West German Cancer Center, University Hospital Essen, Essen, USA
    Blood 112:3312-21. 2008
    ..Pharmacologic modulation of Bcl-2 family proteins or their upstream regulators is a promising strategy to overcome rituximab resistance...
  24. ncbi Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacement
    Stefan Landgraeber
    Department of Orthopaedics, University of Duisburg Essen, Essen, Germany
    Arch Orthop Trauma Surg 130:441-5. 2010
    ..These methods are associated with radiation exposure and some of them have an increased morbidity. Furthermore, in some cases the results are not conclusive...
  25. ncbi Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors
    Thomas Mühlenberg
    Sarcoma Center, West German Cancer Center, University of Essen, Medical School, Essen, Germany
    Cancer Res 69:6941-50. 2009
    ..These results provide preclinical evidence for a disease-specific effect of HDACI in KIT-positive GIST, which could translate into therapeutic activity...
  26. ncbi Resolved hypersensitivity myocarditis after ventricular circulatory assist
    Florian Grabellus
    Institute of Pathology, University of Essen, Essen, Germany
    Ann Thorac Surg 76:2102-4. 2003
    ..Ten months later this lesion showed complete reversibility within specimens of the explanted heart, maybe as a result of the termination of inotropic therapy after implantation of the left ventricular assist device...
  27. ncbi Growth patterns of lung metastases from sarcomas
    Stefan Welter
    Department of Thoracic Surgery, Ruhrlandklinik Essen, Essen, Germany
    Virchows Arch 459:213-9. 2011
    ..Almost half of all pulmonary sarcoma metastases could be identified with aggressive patterns of local growth, and only 17.2% are surrounded by a pseudocapsule which might allow safe resection margins...
  28. ncbi Expression of MCSP and PRAME in conjunctival melanoma
    Henrike Westekemper
    Department of Ophthalmology, University Hospital of Essen, Hufelandstrasse 55, Essen, Germany
    Br J Ophthalmol 94:1322-7. 2010
    ....
  29. ncbi Resection of residual disease in patients with metastatic gastrointestinal stromal tumors responding to treatment with imatinib
    Sebastian Bauer
    Department of Internal Medicine (Cancer Research, University of Essen Medical School, Essen, Germany
    Int J Cancer 117:316-25. 2005
    ..Further trials investigating a combined surgical and pre/postoperative treatment with imatinib in patients with advanced metastatic GIST are warranted...
  30. ncbi A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease
    Jan Dürig
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Cancer Res 67:8653-61. 2007
    ..These results suggest that this model reflects the heterogeneity and important clinical characteristics of the disease, and thus may serve as a tool for preclinical drug testing and investigation of the pathophysiology of CLL...
  31. ncbi Impact of intraoperative radiotherapy (IORT) on survival of patients with unresectable hilar cholangiocarcinoma
    Gernot Maximilian Kaiser
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    Hepatogastroenterology 55:1951-4. 2008
    ..The aim of this study was to compare the efficacy of IORT to surgery alone in patients with unresectable hilar cholangiocarcinoma...
  32. ncbi Feasibility of real-time magnetic resonance-guided stent-graft placement in a swine model of descending aortic dissection
    Holger Eggebrecht
    Department of Cardiology, University of Duisburg Essen, Germany
    Eur Heart J 27:613-20. 2006
    ..Endovascular stent-graft placement for thoracic aortic disease is usually performed under X-ray guidance. The feasibility of rtMRI-guided stent-graft placement is currently not known...
  33. ncbi Magnetic resonance colonography without bowel cleansing: a prospective cross sectional study in a screening population
    Christiane A Kuehle
    Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Gut 56:1079-85. 2007
    ..To evaluate the diagnostic accuracy of magnetic resonance colonography (MRC) without bowel cleansing in a screening population and compare the results to colonoscopy as a standard of reference...
  34. ncbi Association between apoptotis and CD4(+)/CD8(+) T-lymphocyte ratio in aseptic loosening after total hip replacement
    Stefan Landgraeber
    Department of Orthopaedics, University of Duisburg Essen, Essen, Germany
    Int J Biol Sci 5:182-91. 2009
    ..It is possible that these findings may lead to a new understanding of particle-induced osteolysis...
  35. ncbi Contrast-enhanced dark lumen PET/CT and MR colonography in a rodent polyp model: initial results with histopathologic correlation
    Christiane A Kuehle
    Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    AJR Am J Roentgenol 185:1045-7. 2005
    ..CONCLUSION: Detection of small tumors with PET/CT and MR colonography is possible in a rodent model. The technique thus warrants further evaluation in animal studies as well as in patients with suspected colorectal disease...
  36. ncbi Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism
    Hideo A Baba
    Institute of Pathology, University of Essen, Essen, Germany
    Cardiovasc Res 59:390-9. 2003
    ..CONCLUSION: Erks and Akt/GSK-3 beta are highly responsive to myocyte stretch in vitro and in vivo, and may be sensitive molecular parameters of 'reverse remodeling' under LVAD support...
  37. ncbi Melanotic schwannoma of the neck mimicking a malignant melanoma
    Klaus Jürgen Schmitz
    Institute of Pathology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Eur Arch Otorhinolaryngol 262:182-5. 2005
    ..Although the occurrence of multiple schwannomas points to a hereditary syndrome, our patient did not fulfill the criteria of Carney's syndrome or other known syndromes, suggesting a so far unknown genetic background...
  38. ncbi Reduction of hypoxia-inducible heme oxygenase-1 in the myocardium after left ventricular mechanical support
    Florian Grabellus
    Institute of Pathology, University of Essen, Essen, Germany
    J Pathol 197:230-7. 2002
    ..This supports the concept that restoration of cardiac normoxia by mechanical unloading, particularly in the subendocardium, may be in part responsible for the phenomenon of 'reverse remodelling'...
  39. ncbi Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure
    Michaela Kuhn
    Institute of Pharmacology and Toxicology and Interdisciplinary Center for Clinical Research, Universitatsklinikum Munster, Domagkstrasse 12, D 48129 Munster, Germany
    Cardiovasc Res 64:308-14. 2004
    ....