Ozgur Sahin

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance
    Ozgur Sahin
    German Cancer Research Center, Heidelberg, Germany
    BMC Syst Biol 3:1. 2009
  2. ncbi Contact spotting of protein microarrays coupled with spike-in of normalizer protein permits time-resolved analysis of ERBB receptor signaling
    Christian Löbke
    Division of Molecular Genome Analysis, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Proteomics 8:1586-94. 2008
  3. ncbi MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1F
    Sarah Jurmeister
    Address correspondence to Özgür Sahin
    Mol Cell Biol 32:633-51. 2012
  4. ncbi Reverse-phase protein arrays for application-orientated cancer research
    Ulrike Korf
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Proteomics Clin Appl 3:1140-50. 2009
  5. ncbi Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation
    Jitao David Zhang
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 6:e22176. 2011
  6. ncbi Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer
    Stefan Uhlmann
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Mol Syst Biol 8:570. 2012
  7. ncbi Utilization of RNAi to validate antibodies for reverse phase protein arrays
    Heiko Mannsperger
    Division of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Methods Mol Biol 785:45-54. 2011
  8. ncbi Deterministic Effects Propagation Networks for reconstructing protein signaling networks from multiple interventions
    Holger Frohlich
    German Cancer Research Center, Molecular Genome Analysis, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    BMC Bioinformatics 10:322. 2009
  9. ncbi Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells
    Pedro de Souza Rocha Simonini
    Division of Functional Genome Analysis, Helmholtz University Young Investigator Group Molecular RNA Biology and Cancer, German Cancer Research Center DKFZ and Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer Res 70:9175-84. 2010
  10. ncbi RNAi-based validation of antibodies for reverse phase protein arrays
    Heiko A Mannsperger
    German Cancer Research Center, Division of Molecular Genome Analysis, Heidelberg, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Proteome Sci 8:69. 2010

Collaborators

Detail Information

Publications12

  1. ncbi Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance
    Ozgur Sahin
    German Cancer Research Center, Heidelberg, Germany
    BMC Syst Biol 3:1. 2009
    ....
  2. ncbi Contact spotting of protein microarrays coupled with spike-in of normalizer protein permits time-resolved analysis of ERBB receptor signaling
    Christian Löbke
    Division of Molecular Genome Analysis, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Proteomics 8:1586-94. 2008
    ....
  3. ncbi MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1F
    Sarah Jurmeister
    Address correspondence to Özgür Sahin
    Mol Cell Biol 32:633-51. 2012
    ..Thus, miR-200c impacts on metastasis by regulating several EMT-related processes, including a novel mechanism involving the direct targeting of actin-regulatory proteins...
  4. ncbi Reverse-phase protein arrays for application-orientated cancer research
    Ulrike Korf
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Proteomics Clin Appl 3:1140-50. 2009
    ..Here we summarize recent methodological advancements in the field of reverse-phase protein arrays and demonstrate their potential for clinical research as well as for in vitro applications...
  5. ncbi Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation
    Jitao David Zhang
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 6:e22176. 2011
    ..Our work establishes RTCA technology as a novel robust tool with biological and pharmacological relevance amenable for high-throughput screening...
  6. ncbi Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer
    Stefan Uhlmann
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Mol Syst Biol 8:570. 2012
    ....
  7. ncbi Utilization of RNAi to validate antibodies for reverse phase protein arrays
    Heiko Mannsperger
    Division of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Methods Mol Biol 785:45-54. 2011
    ....
  8. ncbi Deterministic Effects Propagation Networks for reconstructing protein signaling networks from multiple interventions
    Holger Frohlich
    German Cancer Research Center, Molecular Genome Analysis, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    BMC Bioinformatics 10:322. 2009
    ..In combination with mRNA or protein expression data this allows to gain insights into the behavior of complex biological systems...
  9. ncbi Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells
    Pedro de Souza Rocha Simonini
    Division of Functional Genome Analysis, Helmholtz University Young Investigator Group Molecular RNA Biology and Cancer, German Cancer Research Center DKFZ and Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer Res 70:9175-84. 2010
    ..Additionally, we found that RASD1 negatively regulates ER? expression. Our findings define a forward feedback pathway in control of ER? expression, highlighting new strategies to treat ER?-positive invasive breast tumors...
  10. ncbi RNAi-based validation of antibodies for reverse phase protein arrays
    Heiko A Mannsperger
    German Cancer Research Center, Division of Molecular Genome Analysis, Heidelberg, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Proteome Sci 8:69. 2010
    ..abstract:..
  11. ncbi Functional genomics and proteomics approaches to study the ERBB network in cancer
    Ozgur Sahin
    Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    FEBS Lett 583:1766-71. 2009
    ..Here, we describe the potential of applying functional genomics and proteomics, taking the ERBB family of growth-factor receptors as an example to study the signaling network and its impact on cancer...
  12. ncbi Combinatorial RNAi for quantitative protein network analysis
    Ozgur Sahin
    Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 104:6579-84. 2007
    ..This experimental approach combines multiple gene knockdown with a subsequent quantitative validation of reduced protein expression and is a major advancement toward the analysis of signaling pathways in systems biology...