Marco Essig

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..Recent studies with Multi-Hance suggest that only a single dose of this agent is needed to cause a signal drop of about 30% which is sufficient to allow the calculation of high quality rCBV and rCBF maps...

..The principle of functional MRT will be described and the diagnostic possibilities with respect to AVM will be discussed...

..Although developed for vascular imaging, gadofosveset trisodium may also allow assessment of brain vascularity, blood-brain barrier breakdown and neurodegenerative disease...

..The advantages over conventional, anatomical MRI techniques will be discussed as well as possible pitfalls and drawbacks...

..Detailed results of structural and functional imaging are presented in other articles of this issue...

..An additional contribution will discuss the control of the course of glial tumors after radiotherapy...

..As a result of its unique longer lasting contrast, the use of gadofosveset might enable a new approach to imaging mild or nonenhancing tumors...

..Thus, the purpose was to assess whether resistance strength training influences resting skeletal muscle microcirculation in vivo...

..Such differences may indicate that high-molar (1.0 M) agents offer advantages for perfusion-weighted imaging (PWI) at 3T, as has been previously reported at 1.5 T...

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..To evaluate low-dose contrast-enhanced magnetic resonance angiography (CE-MRA) at high temporal and spatial resolution for imaging of abdominal vascular structures...

..Computed tomography angiography (CTA) and magnetic resonance angiography (MRA) are noninvasive alternatives for therapy monitoring of cerebral arteriovenous malformation (AVM)...

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..However, it is unclear whether the recommended biopsy targets based on these various functional imaging modalities correspond with each other. Thus, the purpose was to evaluate whether they identify similar target areas...

..The aim of this study was to assess morphology, metabolism, and microcirculation in skeletal muscles of patients with cancer-related cachexia and to compare these data with matched healthy volunteers...

..This allows for the quantification of perfusion of liver tissue and hepatic metastases and provides promising parameters of tissue viability and tumor characterization...

..Here we summarise the benefits of higher relaxivity for the most common neuroimaging applications including MRI, perfusion-weighted imaging and MRA for evaluation of brain tumours, cerebrovascular disease and other CNS lesions...

..In this study, we aimed to compare direct and indirect quantification approaches for hippocampal formation changes in patients with mild cognitive impairment and Alzheimer's disease (AD)...

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..How the ApoE genotype and brain morphology relate to each other is only partly understood, particularly in mild cognitive impairment, the assumed prestage of AD...

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..To assess metabolism and microcirculation of healthy skeletal muscle by magnetic resonance (MR) and ultrasound techniques and to compare these data with muscle histology, and anthropometric and blood parameters...

..To measure the T1 times in blood after the administration of the intravascular contrast agent gadofosveset trisodium in humans...

..The aim was also to find out which of the aforementioned techniques had the best diagnostic performance compared with each other and standard magnetic resonance imaging (MRI)...

..To evaluate relative cerebral blood flow (rCBF) in normal brain tissue using arterial spin-labeling (ASL) methods and first-pass dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI)...

..Conclusion: In partially resected gliomas, encapsulation of resection cavity, presumably by tumor cells, manifests as SI increase on FLAIR images and indicates tumor progression with very high specificity. (c) RSNA, 2010...

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..To evaluate the spatiotemporal evolution of radiosurgical induced changes both in metastases and in normal brain tissue adjacent to the lesions by serial magnetic resonance (MR) imaging...

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..In this study, the presence and strength of HSA interaction with different CM was investigated...

..Therefore, we evaluated Gadofluorine M with other gadolinium chelates for a T1-weighted positive enhancement for cell tracking in vitro. In addition, Gadofluorine M was tested in vivo...

..The study was conducted to evaluate the benefits of this increased relaxivity for MR imaging of intracranial enhancing brain lesions...

..The higher relaxivity of Gd-BOPTA also helps to optimize functional MR imaging studies e.g. perfusion MRI and dynamic MR angiographic protocols...

..Assessment of changes in the hemodynamics of Arteriovenous malformations (AVM) induced by radiosurgery by MR Phase contrast (PC) measurements of the internal carotid arteries (ICA)...

..To investigate the correlation of radiation-induced changes of brain tissue after radiosurgery in patients with cerebral arteriovenous malformations (AVMs) with treatment planning and dose distribution parameters...

..We employed dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and quantitative immunohistochemistry (IHC) to characterize the microvascularity of MM using both a physiologic and ultrastructural method...

..To prospectively examine whether sodium 23 (23Na) magnetic resonance (MR) imaging can be used to visualize acute intracellular Na+ accumulation and the effects of specific therapy in patients with paramyotonia congenita (PC)...

..On the other hand, it may be of special importance in the early detection and assessment of small AVMs that are difficult to diagnose with other MR methods...

..Compared with Gd-DTPA it provides a more intense contrast enhancement and a better tumor contrast which might be of importance for the further management of these patients...

..This study aims to investigate the use of hippocampal atrophy markers for the automatic detection of MCI converters and to compare the predictive value to manually obtained hippocampal volume and temporal horn width...

..Our findings indicate that neurodegeneration in OBT and MTL regions is linked and suggest that OBT volume might be a surrogate marker in AD...

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..The objective of this study was to compare 0.1 and 0.2 mmol/kg body weight (bw) doses gadobenate dimeglumine (Gd-BOPTA; MultiHance) and gadobutrol (Gd-BT-DO3A; Gadovist) for cerebral perfusion magnetic resonance (MR) imaging at 1.5 T...

..The higher relaxivity of Gd-BOPTA helps to optimize functional MR imaging studies e.g. perfusion MR imaging and other dynamic MR imaging protocols...

..However, these changes may not be BPD specific since similar changes were found in the clinical control group. Changes in limbic brain volumes and white matter structures might occur over the course of the illness...

..To evaluate prospectively contrast-enhanced ultrasound (CEUS) in patients suspected of having dermatomyositis or polymyositis...

..The preliminary results show that DSC MRI is a diagnostic tool depicting regional variations in microvasculature of normal and diseased brains...

..This study evaluates whether MR perfusion imaging and spectroscopic imaging (MRSI) can depict anaplastic areas in WHO grade II astrocytomas, whether these areas are co-localized, and whether the prognosis can be better predicted...

..Characteristic imaging findings are presented and correlated to micro- and macro-pathology...

..Arterial-spin-labeling techniques are noninvasive tools for measuring rCBF within 5 min, using a standard MRI scanner...

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..To assess the value of spectroscopic and perfusion MRI for glioma grading and for distinguishing glioblastomas from metastases and from CNS lymphomas...

..We will discuss the principles of DTI and possibilities for sequence optimization. Finally we will give an overview of DTI and its application in Alzheimer's disease...

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..The temporal horn volume (THV) and index in patients with mild cognitive impairment (MCI) and in those with AD were evaluated...

..By detecting and spatially localizing pathophysiological phenomena, these new techniques can increase the role of radiology in muscular diseases...

..They have gained clinical impact particularly in the fields of psychiatry and neurosurgery...

..Thus, changes of tumor perfusion, which may indicate tumor response, as well as the perifocal liver reaction after radiotherapy, which must be differentiated from perifocal tumor growth, can be sensitively visualized using CEUS...

..Szenario (2): External consultation of an internal CT examination (teleradiology according to ROV). Scenario (3): Complete in-house radiology department. To evaluate economic aspects of teleradiology service providers...

..This review article presents the treatment options and also summarizes available data from the literature on which therapy should be chosen in which situation and when watchful waiting should be preferred...

..Training effects in the working memory task follow an inverse U-shape function, suggesting that cerebral activation reaches a peak before economics of the brain find a more efficient method and activation decreases...

..In this connection non-invasive methods such as fMRI and ASL are of increasing importance...

..1 mmol/kg bw with physiologic absolute values for regional CBV and CBF. The susceptibility effect is comparable for both agents and stronger than with conventional MR contrast media...

..To show the potential of various methods in magnetic resonance imaging for the evaluation of renal function...

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..J. Magn. Reson. Imaging 2012;35:1207-1209. © 2012 Wiley Periodicals, Inc...

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..CONCLUSIONS: Multiphase MRA is a highly robust technique with reproducible accuracy for different observers and different institutions. It can therefore be recommended for screening of atherosclerotic abdominal and pelvic disease...

..Therefore, the feasibility of a 3-D determination of respiratory lung tumor movements by the use of a multislice CT scanner was investigated...

..However, how these changes are related to brain morphological alterations is so far only partly understood...

..Thus, MEMRI can serve as a reproducible surrogate measure of the clinical status of the spinal cord in mice, potentially becoming a standard approach for evaluating experimental therapies...

..Signal hyperintensities at the ventricular border were present in 92% of the patients. They are common findings in fast FLAIR and should be included into the image interpretation...

..The combination of different breath hold techniques in a single, standardized MR exam allows to detect the hemodynamic and functional significance of a renal artery stenosis...

..With IGEPI CINE-PC, all high-grade stenoses (n = 5) were detected, whereas only 66% (n = 3) were found with conventional CINE-PC...

..The reconstructed venograms were compared with TOF-MR angiography using qualitative and quantitative criteria with the conventional DSA serving as the reference gold standard...

..Contrast-enhanced MRA is thus an important additional imaging technique for treatment planning and follow-up of AVMs...

..With respect to this unwanted effect, an improvement in HIRE imaging will be possible by using a self-weighted subtraction algorithm. In a forthcoming study this concept will first be tested on appropriate phantom fluids...

..The results show that DTI-derived parameters can be determined reproducibly and may have a strong impact on evaluation of contralateral extent of primary brain tumors...

..To assess disk position and the prevalence of disk displacement (DD) in a sample of the elderly by use of contrast agent-enhanced magnetic resonance imaging (MRI)...

..Due to its better delineation of tumor spread, it was found to be the imaging method of choice and should therefore be integrated into the MR imaging protocol of these patients...

..Therefore the delineation of the macroscopic tumor parts, which are of great importance for the treatment planning is substantially worsened...

..We attempted to assess pretherapeutic rCBV values and time- and dose-dependent changes following radiotherapy...

..The aim was to assess the prevalence of osteoarthrosis (OA) in the temporomandibular joint (TMJ) in a sample of older people by use of contrast agent-enhanced MRI...

..The HIRE sequence utilizes the very long T2 value of CSF to suppress its high signal contribution in T2-weighted imaging by an image subtraction technique...

..g. in ischemia or tumors with intact blood-brain barrier. In patients with suspected strong enhancing lesions, an SE EPI sequence should be used...

..The aim of the study was to assess the value of a FLAIR technique in the planning process of stereotactic radiotherapy in patients with cerebral gliomas and metastases...

..The role of AVM occlusion on cognitive function is not clear at present. CONCLUSION: Radiosurgery does not induce measurable deterioration of cognitive function in patients with cerebral AVMs...

..Tumor perfusion was dependent on tumor size and localization, but not on histology. Furthermore, perfusion CT disclosed blood supply from both pulmonary and/or bronchial vessels in some tumors...

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..Anatomical details of the lungs of a volunteer were visualized with the FLASH technique demonstrating the potential of the method for fast imaging of airways in the human body and for pulmonary ventilation studies...

..The method was tested in five patients after surgical resection of a brain tumor, where FLAIR MRI with and without contrast agent was performed to identify remaining tumor fragments at the margin of the resection cavity...

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..The higher relaxivity of Gd-BOPTA helps to optimize functional MR imaging studies, for example, perfusion MR imaging and dynamic MR angiographic protocols...

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..Thus, neutralization of CD95L promoted axonal regeneration and functional improvement in injured adult animals. This therapeutic strategy may constitute a potent future treatment for human spinal injury...

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