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Genomes and Genes | P DielSummaryAffiliation: German Sport University Country: Germany Publications
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Publications
Effects of genistein on the expression of hepatic genes in two rat strains (Sprague-Dawley and Wistar)Renate-B Geis
, Molekulare Zellphysiologie und Endokrinologie, , 01062 Dresden, Germany
Toxicol Lett 157:21-9. 2005..Gene expression of apolipoprotein AI (ApoAI) was not affected in both strains neither by EE nor by GEN. These results are indicative of strain specific differences in the response of liver genes to GEN or EE...- Selective estrogen receptor-? activation stimulates skeletal muscle growth and regenerationMartina Velders
1 Department Molecular and Cellular Sports Medicine, Deutsche Sporthochschule Koln, Am Sportpark Müngersdorf 6, 50933 Koln, Germany
FASEB J 26:1909-20. 2012..Velders, M., Schleipen, B., Fritzemeier, K. H., Zierau, O., Diel, P. Selective estrogen receptor-? activation stimulates skeletal muscle growth and regeneration... - Pulsed estradiol exposure has a limited ability to induce uterine proliferation in ovariectomised female Wistar ratsPatrick Diel
Department of Molecular and Cellular Sports Medicine, Deutsche Sporthochschule Koln, Carl Diem Weg 6, 50927 Koln, Germany
Mol Cell Endocrinol 230:7-15. 2005..PCNA was significantly induced after continuous administration but only slightly after pulsed E2 (250 microg/kg). In summary, pulsed E2 leads to a more limited proliferative effect than with continuous E2 in the uterus... - The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expressionPatrick Diel
Department Molecular and Cellular Sports Medicine, DSHS Cologne, Carl Diem Weg 6, 50927 Koln, Germany
Mol Cell Endocrinol 221:21-32. 2004..Our results indicate that GEN has only a limited ability to activate molecular mechanisms involved in the induction of proliferation whereas estrogen sensitive genes are induced in a estrogen like manner... - C2C12 myoblastoma cell differentiation and proliferation is stimulated by androgens and associated with a modulation of myostatin and Pax7 expressionP Diel
Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, Center for Preventive Doping Research, German Sport University Cologne, 50927 Cologne, Germany
J Mol Endocrinol 40:231-41. 2008..Our findings may have implications not only for the treatment of muscular diseases but also for the improvement of doping analytical methods... - Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for dopingP Diel
Center for Preventive Doping Research, Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sports University Cologne, 50927 Cologne, Germany
Toxicol Lett 169:64-71. 2007..Therefore, there is a need for a strict control of a possible misuse... - In vivo test systems for the quantitative and qualitative analysis of the biological activity of phytoestrogensP Diel
Institute for Morphology und Cancer Research, Deutsche Sporthochschule Koln, D 50927, Koln, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 777:191-202. 2002..A reasonable supplement to this enhanced uterotrophic assay are selected estrogen sensitive tumor models, which can be used to test for potential chemopreventive properties of phytoestrogens... - The prohormone 19-norandrostenedione displays selective androgen receptor modulator (SARM) like properties after subcutaneous administrationP Diel
Center for Preventive Doping Research, Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sports University Cologne, Carl Diem Weg 6, Cologne 50927, Germany
Toxicol Lett 177:198-204. 2008..This observation may have relevance with respect to therapeutic aspects but also doping prevention... - Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive immuno PCRPatrick Diel
Centre of Preventive Doping Research, Dept of Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne, Germany
Mol Cell Endocrinol 330:1-9. 2010..In summary our data demonstrate that moderate training does not affect the concentrations of MYOPRO to FOLLI. In contrast androgen treatment results in a significant increase of MYOPRO in skeletal muscle and serum... - 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic propertiesA Friedel
Center for Preventive Doping Research, Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, 50927 Cologne, Germany
Toxicol Lett 165:149-55. 2006..It has to be assumed that consumption of this substance is associated with adverse side effects typical for this class of compounds. Therefore, a strict control of its ban is essential... - Tetrahydrogestrinone is a potent but unselective binding steroid and affects glucocorticoid signalling in the liverA Friedel
Center for Preventive Doping Research, Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne, 50927 Colonge, Germany
Toxicol Lett 164:16-23. 2006..Therefore, it is conceivable that an intake will result in adverse side effects... - Responses of estrogen sensitive tissues in female Wistar rats to pre- and postnatal isoflavone exposureT Hertrampf
Institut für Kreislaufforschung und Sportmedizin, Abt molekulare und zelluläre Sportmedizin, Deutsche Sporthochschule Koln, Cologne, Germany
Toxicol Lett 191:181-8. 2009.... - Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activityP Diel
Institut für Morphologie und Tumorforschung, Deutsche Sporthochschule Koln, Cologne, Germany
J Steroid Biochem Mol Biol 73:1-10. 2000.... - ER?-specific agonists and genistein inhibit proliferation and induce apoptosis in the large and small intestineB Schleipen
Abt molekulare und zelluläre Sportmedizin, Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Koln, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany
Carcinogenesis 32:1675-83. 2011..This observation can be taken as an indication that intake of GEN and specific ER? agonists may protect the ileal and colonic epithelium from tumor development via modulation of tissue homeostasis... - Comparison of the bone protective effects of an isoflavone-rich diet with dietary and subcutaneous administrations of genistein in ovariectomized ratsT Hertrampf
Institute for Cardiovascular Research and Sport Medicine, Department of Molecular and Cellular Sport Medicine, Deutsche Sporthochschule Koln, Germany
Toxicol Lett 184:198-203. 2009..Dietary intake of isoflavones by an IRD also did not result in a stimulation of UWW, yet IRD appeared to be more effective in bone protection than administration of pure GEN... - Myosin heavy chain expression pattern as a marker for anabolic potency: desoxymethyltestosterone (madol), norandrostenedione and testosterone repress MHC-IIb expression and stimulate MHC-IId/x expression in orchiectomized rat gastrocnemius muscleS Frese
Center for Preventive Doping Control, Institute of Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sports College of Köln, German Sports University, Carl Diem Weg 6, 50927, Cologne, Germany
Arch Toxicol 85:635-43. 2011..The molecular mechanisms as well as the androgen-dependent regulation of MHC expression in intact skeletal muscle remain to be further investigated... - Anabolic and androgenic activity of 19-norandrostenedione after oral and subcutaneous administration--analysis of side effects and metabolismM K Parr
Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Cologne, Germany
Toxicol Lett 188:137-41. 2009..In summary, oral administration of NOR, at least in the rat, seems to be a very ineffective strategy for stimulating skeletal muscle mass increases but may be associated with side effects... - Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the ratA Matsakas
Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Carl Diem Weg 6, 50933 Cologne, Germany
Acta Physiol Scand 183:299-307. 2005..To assess the impact of the training stimulus, mRNA levels of metabolic genes were analysed simultaneously... - Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogensT Hertrampf
Department of Molecular and Cellular Sports Medicine, , DSHS, Carl Diem Weg 6, Cologne, , Germany
Mol Cell Endocrinol 243:51-7. 2005..cava without effecting its uterine expression. These observations may be of great importance with respect to potential beneficial or adverse effects of estrogens, SERMs and phytoestrogens on the cardiovascular tissue... - Estradiol and genistein antagonize the ovariectomy effects on skeletal muscle myosin heavy chain expression via ER-beta mediated pathwaysM Velders
Institute of Sports Medicine, Dept of Molecular and Cellular Sports Medicine, German Sports University, Carl Diem Weg 6, 50927 Koln, Cologne, Germany
J Steroid Biochem Mol Biol 120:53-9. 2010..This is of great importance with respect to skeletal muscle health and potential treatment with ER selective agonists... - Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar ratsPatrick Diel
, , , Carl Diem Weg 6, , Germany
J Steroid Biochem Mol Biol 102:60-70. 2006.... - Analysis of the effects of oestrogen receptor alpha (ERalpha)- and ERbeta-selective ligands given in combination to ovariectomized ratsT Hertrampf
Institut für Kreislaufforschung und Sportmedizin, Abt molekulare und zelluläre Sportmedizin, DSHS Köln, Cologne, Germany
Br J Pharmacol 153:1432-7. 2008..This study was based on the hypothesis that activation of ERbeta may antagonize ERalpha-mediated effects and designed to investigate potential effects of ERalpha/ERbeta heterodimers... - Hormonal activity of combinations of genistein, bisphenol A and 17beta-estradiol in the female Wistar ratSimone Schmidt
, , , Carl-Diem-Weg 6, 50933 Cologne, Germany
Arch Toxicol 80:839-45. 2006..This is not the case for Gen. Our results point to the involvement of complex molecular mechanisms in the action of Gen. These mechanisms, especially the role of ERbeta have to be characterized in further investigations... - Comparative responses of three rat strains (DA/Han, Sprague-Dawley and Wistar) to treatment with environmental estrogensP Diel
, , Cologne, Germany
Arch Toxicol 78:183-93. 2004.... - Effects of genistein on the mammary gland proliferation of adult ovariectomised Wistar ratsTorsten Hertrampf
, , , , Germany
Planta Med 72:304-10. 2006..In further investigations it is important to identify molecular differences between healthy and malignant breast tissue which may explain the different sensitivity towards Gen treatment... - Investigations on the estrogenic activity of the metallohormone cadmium in the rat intestineNicola Höfer
Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sports University Cologne, Koln, Germany
Arch Toxicol 84:541-52. 2010.... - In vitro test systems for the evaluation of the estrogenic activity of natural productsP Diel
Institut für Experimentelle Morphologie, Deutsche Sporthochschule Koln, Germany
Planta Med 65:197-203. 1999..Summarising the advantages and the issues of all presented in vitro test systems, it seems to be evident that only the analysis of results obtained in a combination of several in vitro test systems may validly predict effects in vivo... - Effect of voluntary exercise on the expression of IGF-I and androgen receptor in three rat skeletal muscles and on serum IGF-I and testosterone levelsA Matsakas
Institute of Morphology and Tumor Research, German Sport University Cologne, 50933 Cologne, Germany
Int J Sports Med 25:502-8. 2004..e., IGF-I and testosterone. It is concluded that IGF-I, AR and testosterone seem to play a marginal role during the adaptation process of rat skeletal muscle to long-term wheel running... - Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7Patrick Diel
, , Carl-Diem-Weg 6, 50927, , Germany
J Steroid Biochem Mol Biol 80:61-70. 2002..For this reason and in agreement to the effects of BPA on the molecular parameters analysed, we conclude that BPA does not act in a classical estrogen like manner in MCF-7 breast cancer cells... - The growth factor myostatin, a key regulator in skeletal muscle growth and homeostasisA Matsakas
Department of Molecular and Cellular Sports Medicine, Institute of Sports Medicine and Cardiovascular Research, German Sport University Cologne, Carl-Diem-Weg 6, 50933 Cologne, Germany
Int J Sports Med 26:83-9. 2005..Drugs with the ability to modulate myostatin signalling may have the potential to enhance physical performance in athletes and therefore they probably represent a new class of doping substances... - Treatment with the pure antiestrogen faslodex (ICI 182780) induces tumor necrosis factor receptor 1 (TNFR1) expression in MCF-7 breast cancer cellsK Smolnikar
Institute of Morphology and Tumor Research, DSHS Cologne, Germany
Breast Cancer Res Treat 63:249-59. 2000..The superiority of the pure antiestrogen ICI to induce apoptosis in MCF-7 cells may result from its capability to modulate the induction of apoptosis via Bcl-2 as well as TNF-associated signal transduction pathways... - Estrogen receptor subtype-specific effects on markers of bone homeostasisT Hertrampf
Institut für Kreislaufforschung und Sportmedizin, Abt molekulare und zelluläre Sportmedizin, DSHS Köln, Germany
Mol Cell Endocrinol 291:104-8. 2008.... - Tissue-specific estrogenic response and molecular mechanismsPatrick Diel
Deutsche Sporthochschule Koln, Institute of Morphology and Tumor Research, Carl Diem Weg 6, 50927 Cologne, Germany
Toxicol Lett 127:217-24. 2002..For these reasons it is important to point out that a toxicological evaluation of endocrine modulators should include an analysis of potential SERM-like properties... - Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitisJan Seibel
Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, IG I, 9 OG, Am Sportpark Müngersdorf, 50933, Cologne, Germany
Eur J Nutr 48:213-20. 2009..Exposure to high levels of isoflavones such as genistein (Gen) in traditional East Asian diets has been associated with a decreased risk of developing breast cancer and may also be beneficial for the prevention of IBD... - Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female ratsTorsten Hertrampf
, , , , Germany
Planta Med 72:484-7. 2006..All these effects could not be observed in animals fed an isoflavone-rich diet... - Physical activity and estrogen treatment reduce visceral body fat and serum levels of leptin in an additive manner in a diet induced animal model of obesityNora Zoth
Department of Cellular and Molecular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sports University, Cologne, Germany
J Steroid Biochem Mol Biol 122:100-5. 2010..The results of this study provide evidence that the combination of HRT with physical activity could be a very effective strategy to prevent the development of a metabolic syndrome induced by overnutrition... - In utero and postnatal exposure to a phytoestrogen-enriched diet increases parameters of acute inflammation in a rat model of TNBS-induced colitisJan Seibel
Department of Molecular and Cellular Sports Medicine, DSHS Cologne, Am Sportpark Müngersdorf, 50933 Cologne, Germany
Arch Toxicol 82:941-50. 2008..Our results suggest that early-in-life exposure to PE might not protect against the development of IBD but enhances the extent of acute inflammation... - Combinatory effects of phytoestrogens and 17beta-estradiol on proliferation and apoptosis in MCF-7 breast cancer cellsSimone Schmidt
, , , , Germany
J Steroid Biochem Mol Biol 94:445-9. 2005..The additive growth stimulatory effects of Gen, Dai and Cou in the presence of E2 are not the result of a stimulation of proliferation; these phytoestrogens, at least in MCF-7 cells, could be characterised as inhibitors of apoptosis... - Dose- and route-dependent hormonal activity of the metalloestrogen cadmium in the rat uterusNicola Höfer
Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sports University Cologne, Am Sportpark Müngersdorf 6, D 50933 Köln, Germany
Toxicol Lett 191:123-31. 2009.... - Intense exercise increases adenosine concentrations in rat brain: implications for a homeostatic sleep driveM Dworak
Institute of Motor Control and Movement Technique, German Sport University Cologne, Carl Diem Weg 6, 50933 Cologne, Germany
Neuroscience 150:789-95. 2007.... - Estrogenic isoflavones in rodent dietsGisela H Degen
Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
Toxicol Lett 128:145-57. 2002.... - Regulation of gene expression by 8-prenylnaringenin in uterus and liver of Wistar ratsPatrick Diel
Molekulare Zellphysiologie and Endokrinologie, , , Dresden, Germany
Planta Med 70:39-44. 2004.... - Effect of phytoestrogens on gene expression of carbonic anhydrase II in rat uterus and liverAntonio Caldarelli
Molecular Cell Physiology and Endocrinology, Institute for Zoology, Technische Universitat Dresden, Germany
J Steroid Biochem Mol Biol 97:251-6. 2005..Further, it exhibits a differential sensitivity thereby being capable to discriminate between different molecular qualities of phytoestrogens, like demonstrated for Gen and 8PN... - Detection of anabolic steroid abuse using a yeast transactivation systemOliver Zierau
Molecular Cell Physiology and Endocrinology, Institute of Zoology, Technical University Dresden, Germany
Steroids 73:1143-7. 2008.... - Analysis of the promoter-specific estrogenic potency of the phytoestrogens genistein, daidzein and coumestrolOliver Zierau
Institute for Zoology, Technische Universitat Dresden, Zellescher Weg 20, 02127 Dresden, Germany
Planta Med 72:184-6. 2006..We assume that the demonstrated promoter-specific potency therefore could be an important mechanism to explain a tissue-specific action of some of these compounds... - Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenboloneSusanne B Dorn
Leibniz Research Centre for Working Environment and Human Factors, Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Dortmund, Germany
Arch Toxicol 82:257-63. 2008....