Research Topics
Genomes and Genes | Alexandr V BazhinSummaryAffiliation: German Cancer Research Center Country: Germany Publications
| Collaborators
|
Detail Information
Publications
cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cellsAlexandr V Bazhin
Skin Cancer Unit, German Cancer Research Center, 69120, Heidelberg, Germany
Cell Mol Life Sci 67:817-28. 2010..Thus, the aberrant expression of PDE6 may control cGMP metabolism and calcium homeostasis in melanoma cells...- Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cellsAlexandr V Bazhin
Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, 69120 Heidelberg, Germany
Mol Immunol 47:678-84. 2010.... - Photoreceptor proteins as cancer-retina antigensAlexandr V Bazhin
German Cancer Research Center, Skin Cancer Unit D070, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Int J Cancer 120:1268-76. 2007..Our work provides the basis for analyzing regulation of photoreceptor gene expression in normal and malignant cells as well as possible therapeutic tumor targeting using the newly defined class of cancer-retina antigens... - Visible light modulates the expression of cancer-retina antigensAlexandr V Bazhin
Skin Cancer Unit, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, Germany
Mol Cancer Res 6:110-8. 2008..The visual cascade and retinoic acid as its derivate do not play any role in this process. Putative explanations for light-dependent modulation of cancer-retina antigen expression in melanoma cells are discussed... - Cancer-retina antigens as potential paraneoplastic antigens in melanoma-associated retinopathyAlexandr V Bazhin
Skin Cancer Unit, German Cancer Research Center, Heidelberg and University Hospital, Mannheim, Germany
Int J Cancer 124:140-9. 2009..We suggest that melanoma-associated retinopathy can be mediated by humoral and/or cellular immune responses against a number of cancer-retina antigens which may function as paraneoplastic antigens in melanoma-associated retinopathy... - Vitamin A metabolism in benign and malignant melanocytic skin cells: Importance of lecithin/retinol acyltransferase and RPE65Philipp M Amann
Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany Department of Dermatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
J Cell Physiol 227:718-28. 2012..Consequently, the decreasing cellular amount of retinoic acid and its precursor molecules could result in a change of gene regulation. J. Cell. Physiol. © 2011 Wiley Periodicals, Inc... - Expression of GAGE family proteins in malignant melanomaAlexandr V Bazhin
Skin Cancer Unit, German Cancer Research Center, Heidelberg and University Hospital, Mannheim, Germany
Cancer Lett 251:258-67. 2007..Through upregulation of protein expression GAGE family proteins might develop into promising targets for immunotherapy of melanoma and other tumors... - Detergent fractionation with subsequent subtractive suppression hybridization as a tool for identifying genes coding for plasma membrane proteinsAndreas Lange
German Cancer Research Center, Skin Cancer Unit, Heidelberg, Germany
Exp Dermatol 18:527-35. 2009..In summary, we developed a new technique, which allows identifying overexpressed genes coding preferentially for membrane-associated proteins... - Recoverin as a cancer-retina antigenAlexandr V Bazhin
Skin Cancer Unit D070, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Cancer Immunol Immunother 56:110-6. 2007..This paper reviews the present knowledge on paraneoplastic syndromes associated with the aberrant expression of recoverin. A possible application of recoverin as a potential target for immunotherapy of cancer is discussed... - Expression and activity of alcohol and aldehyde dehydrogenases in melanoma cells and in melanocytesPhilipp M Amann
Skin Cancer Unit, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
J Cell Biochem 113:792-9. 2012..The decreasing cellular amount of the precursor molecules of retinoic acid could result in a changed gene regulation in melanoma cells... - SEREX identification of new tumor antigens linked to melanoma-associated retinopathyTanja B Hartmann
Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 114:88-93. 2005..Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html.).. - Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaTPhilipp M Amann
Skin Cancer Unit, German Cancer Research Center Heidelberg and Department of Dermatology, University of Heidelberg, University Hospital Mannheim, Mannheim, Germany Department of Dermatology, University Hospital Essen, Essen, Germany Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany Surgery Department, University Hospital Heidelberg, Heidelberg, Germany
Exp Dermatol 20:373-5. 2011..Based on the data, we propose that ATRol and all-trans retinal, in addition to all-trans retinoic acid, can function as important regulators of gene expression manifesting their effect through the nuclear receptors RARs and RXRs... - Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma modelChristiane Meyer
Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 108:17111-6. 2011..Our data imply that inhibition of chronic inflammation in the tumor microenvironment should be applied in conjunction with melanoma immunotherapies to increase their efficacy... - Recoverin as a paraneoplastic antigen in lung cancer: the occurrence of anti-recoverin autoantibodies in sera and recoverin in tumorsAlexandr V Bazhin
Laboratory of Biomedicine, Department of Cell Signalling, A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, 119992 Moscow, Russia
Lung Cancer 44:193-8. 2004..However, taking into account the high occurrence of aberrant expression of recoverin in lung tumors, this PNA could be considered as a potential target for immunotherapy of lung cancer... - Stimulation of the aberrant expression of a paraneoplastic antigen, recoverin, in small cell lung cancer cell linesAlexandr V Bazhin
Laboratory of Biomedicine, Department of Cell Signalling, A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, 119992 Moscow, Russia
Lung Cancer 45:299-305. 2004..This result opens the way to investigation of the mechanisms underlying the aberrant expression of recoverin, as well as other paraneoplastic antigens, in tumor cells... - Antirecoverin autoantibodies in the patient with non-small cell lung cancer but without cancer-associated retinopathyMarina S Savchenko
Laboratory of Biomedicine, Department of Cell Signalling, A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, 119992 Moscow, Russia
Lung Cancer 41:363-7. 2003..To our knowledge, this is the first case of the presence of serum anti-Rc in NSCLC patients in the absence of paraneoplastic retina degeneration...