Research Topics
Genomes and GenesSpecies | Oliver H KramerSummaryAffiliation: Friedrich Schiller University Country: Germany Publications
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Detail Information
Publications
A phosphorylation-acetylation switch regulates STAT1 signalingOliver H Kramer
Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine CMB, University of Jena, 07743 Jena, Germany
Genes Dev 23:223-35. 2009..These findings reveal a new layer of physiologically relevant STAT1 regulation and suggest that a previously unidentified balance between phosphorylation and acetylation affects cytokine signaling...- Phosphorylation-acetylation switch in the regulation of STAT1 signalingOliver H Kramer
Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine CMB, University of Jena, Hans Knöll Str 2, 07743 Jena, Germany
Mol Cell Endocrinol 315:40-8. 2010..We discuss how these observations can be integrated into our current understanding of STAT-dependent cytokine signaling and its potential relevance for endocrine functions... - HDAC2: a critical factor in health and diseaseOliver H Kramer
Center for Molecular Biomedicine CMB, Institute of Biochemistry and Biophysics, University of Jena, Hans Knöll Str 2, 07743 Jena, Germany
Trends Pharmacol Sci 30:647-55. 2009..Beyond clarifying the role of HDAC2 for cellular fate, such data position the epigenetic regulator HDAC2 as a therapeutically important prognostic marker that can be subjected to pharmacological control... - Histone deacetylases: salesmen and customers in the post-translational modification marketAndré Brandl
Friedrich Schiller University Jena, Center for Molecular Biomedicine, Institute of Biochemistry and Biophysics, Hans Knöll Str 2, 07745 Jena, Germany
Biol Cell 101:193-205. 2009..This review summarizes aspects of the current knowledge on the biological role and enzymology of the phosphorylation, acetylation, ubiquitylation and sumoylation of HDACs... - Differential regulation of PML-RAR? stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1Kristin Pietschmann
Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine CMB, Department of Biochemistry, University of Jena, Jena, Germany
Int J Biochem Cell Biol 44:132-8. 2012..In summary, our data exclude TRIAD1 as crucial regulator of the leukemic determinant PML-RAR?, but highlight the prominence of the UBCH8/SIAH axis in PML-RAR? degradation... - HDACi--targets beyond chromatinMarc Buchwald
Center for Molecular Biomedicine, Institute for Biochemistry and Biophysics, Friedrich Schiller Universitat Jena, Jena, Germany
Cancer Lett 280:160-7. 2009..Here, we summarize these findings and discuss how these substances could be beneficial for the treatment and prevention of human ailments, such as cancer and unbalanced immune functions... - Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalphaOliver H Kramer
Institute of Biochemistry and Biophysics, University of Jena, Philosophenweg 12, D 07743 Jena, Germany
FASEB J 22:1369-79. 2008..Our observations shed light on the mechanism determining the interplay between E2-conjugases, E3-ligases, and their substrates and suggest a strategy for utilizing the ubiquitylation machinery in a therapeutic setting... - Inhibitors of HDACs--effective drugs against cancer?S Muller
Friedrich Schiller University Jena, Center for Molecular Biomedicine, Institute of Biochemistry and Biophysics, Hans Knöll Str 2, 07745 Jena, Germany
Curr Cancer Drug Targets 10:210-28. 2010..Here, we summarize molecular actions of HDACs and of different classes of HDACIs. In addition, we review data obtained in clinical studies involving HDACIs and we discuss how such agents might be beneficial for the treatment of cancer...