Research Topics
| Kathrin KochSummaryAffiliation: Friedrich Schiller University Country: Germany Publications
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Detail Information
Publications
Neural correlates of emotion recognition in schizophreniaUte Habel
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
Schizophr Res 122:113-23. 2010....- White matter structure and symptom dimensions in obsessive-compulsive disorderKathrin Koch
Department of Psychiatry and Psychotherapy, University Hospital Jena, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
J Psychiatr Res 46:264-70. 2012..Hence, different symptom dimensions must be taken into account in order to disentangle the neurobiological underpinnings of OCD... - Altered activation in association with reward-related trial-and-error learning in patients with schizophreniaKathrin Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jahnstr, Philosophenweg 3, 07740 Jena, Germany
Neuroimage 50:223-32. 2010..They moreover suggest that the activation deficits which patients exhibit in association with the processing of reinforcement might constitute the basis for the learning deficits and their accompanying activation alterations... - Neural activation and radial diffusivity in schizophrenia: combined fMRI and diffusion tensor imaging studyKathrin Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Germany
Br J Psychiatry 198:223-9. 2011..Most studies have investigated changes in fractional anisotropy, whereas alterations in radial or axial diffusivity have barely been investigated until now... - Altered error-related activity in patients with schizophreniaKathrin Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
Neuropsychologia 47:2843-9. 2009..Thus, present results clearly indicate that disorder-characteristic activation abnormalities become manifest during dysfunctional executive processing even when the moderating effect of performance is largely eliminated... - The neural correlates of reward-related trial-and-error learning: an fMRI study with a probabilistic learning taskKathrin Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
Learn Mem 15:728-32. 2008..In contrast, learning on the basis of predictable stimulus-outcome associations enables the brain to reduce resources in association with the processes of prediction... - Fronto-striatal hypoactivation during correct information retrieval in patients with schizophrenia: an fMRI studyK Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
Neuroscience 153:54-62. 2008..Given the relevant role of the caudate and the ACC in dopaminergically mediated executive processing, the results bear crucial implications for the psychopathology of schizophrenia... - Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophreniaKathrin Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jahnstr 3, Philosophenweg 3, 07740, Jena, Germany
Eur Arch Psychiatry Clin Neurosci 260:419-26. 2010..They corroborate preceding findings of white matter structural deficits in mainly long-ranging association fibers and provide first evidence for neuroplastic changes in terms of an increased directionality in more inferior fiber tracts... - Temporal modeling demonstrates preserved overlearning processes in schizophrenia: an fMRI studyK Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
Neuroscience 146:1474-83. 2007..Our data suggest that in subacute patients learning and associated decreases in cerebral activation brought about by short-term practice are left unimpaired... - Structure-function relationships in the context of reinforcement-related learning: a combined diffusion tensor imaging-functional magnetic resonance imaging studyK Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
Neuroscience 168:190-9. 2010..These findings indicate that interindividual variations in white matter characteristics within the normal population might be linked to neuronal activation and critically influence individual learning performance... - Association between learning capabilities and practice-related activation changes in schizophreniaKathrin Koch
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
Schizophr Bull 36:486-95. 2010..The findings also suggest that successful learners can better compensate potentially interfering effects exerted by disorder-related psychopathology... - Inefficient executive cognitive control in schizophrenia is preceded by altered functional activation during information encoding: an fMRI studyRalf G M Schlösser
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
Neuropsychologia 46:336-47. 2008..These results could be explained by increased top-down control processing from prefrontal cortex as a compensation for functional deficits occurring during encoding... - White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI studyRalf G M Schlösser
Department of Psychiatry and Psychotherapy, Friedrich Schiller University, 07743 Jena, Germany
Schizophr Res 89:1-11. 2007..It highlights a potential relationship between anatomical changes in a frontal-temporal anatomical circuit and functional alterations in the prefrontal cortex... - Emotion-cognition interactions in schizophreniaUte Habel
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
World J Biol Psychiatry 11:934-44. 2010..This may have clinical implications in mental illnesses, such as schizophrenia, where negative emotions often prevail. Experimentally this influence can be studied by using olfactory emotion induction... - Gender differences in the cognitive control of emotion: An fMRI studyKathrin Koch
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
Neuropsychologia 45:2744-54. 2007..These results provide new insights in gender-specific cerebral mechanisms... - Reduced anterior cingulate cognitive activation is associated with prefrontal-temporal cortical thinning in schizophreniaC Christoph Schultz
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
Biol Psychiatry 71:146-53. 2012..Therefore, this study investigated the association of anterior cingulate cognitive activation and cortical thickness in schizophrenia combining functional magnetic resonance imaging (fMRI) and surface-based morphometry... - Psychopathological correlates of the entorhinal cortical shape in schizophreniaC Christoph Schultz
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
Eur Arch Psychiatry Clin Neurosci 260:351-8. 2010..As cortical folding is a stable neuroanatomical parameter terminated in early neonatal stages, our data give reason to assume that the vulnerability to develop psychotic symptoms might be manifest at an early level of brain maturation... - Reduced cortical thickness in first episode schizophreniaC Christoph Schultz
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
Schizophr Res 116:204-9. 2010..In an extension of these earlier studies, we used an entire cortex vertex-wise approach and an automated clustering for the detection and exact quantification of cortical thickness alterations in first episode schizophrenia... - Increased parahippocampal and lingual gyrification in first-episode schizophreniaC Christoph Schultz
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
Schizophr Res 123:137-44. 2010.... - Complex pattern of cortical thinning in schizophrenia: results from an automated surface based analysis of cortical thicknessC Christoph Schultz
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, Jena, Germany
Psychiatry Res 182:134-40. 2010..This pattern is consistent with a disruption of neurofunctional networks previously implicated in the pathophysiology of schizophrenia... - ADC changes in schizophrenia: a diffusion-weighted imaging studyIgor Nenadic
Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, 07743, Jena, Germany
Eur Arch Psychiatry Clin Neurosci 261:213-6. 2011..Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder... - Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depressionGerd Wagner
Department of Psychiatry and Psychotherapy, University of Jena, Germany
J Psychiatry Neurosci 35:247-57. 2010..We predicted that pretreatment hyperactivity in the rostral anterior cingulate cortex would predict better treatment outcomes... - The influence of olfactory-induced negative emotion on verbal working memory: individual differences in neurobehavioral findingsUte Habel
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
Brain Res 1152:158-70. 2007..Results confirm the importance of incorporating individual differences in emotion processing and its interaction with cognitive functions in neuroimaging... - Temporal changes in neural activation during practice of information retrieval from short-term memory: an fMRI studyKathrin Koch
Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
Brain Res 1107:140-50. 2006..The temporal changes in brain activation patterns could be attributed to enhanced efficiency of information processing as a result of cognitive practice... - Metacognition and reflexivity in patients with schizophreniaTilo T J Kircher
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
Psychopathology 40:254-60. 2007..Many patients with schizophrenia demonstrate a lack of insight into their disorder and often do not complain about their cognitive impairments. This might be due to generally reduced metacognitive abilities... - Assessing the neural basis of uncertainty in perceptual category learning through varying levels of distortionReka Daniel
Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Jahnstrasse 3, 07743 Jena, Germany
J Cogn Neurosci 23:1781-93. 2011..This study characterizes the cortico-striatal network underlying the classification of distorted visual patterns that is directly related to decision uncertainty... - Reduced cortical thickness is associated with the glutamatergic regulatory gene risk variant DAOA Arg30Lys in schizophreniaC Christoph Schultz
Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
Neuropsychopharmacology 36:1747-53. 2011..Our finding thus underlines the importance of DAOA and related glutamatergic processes as a putative target for therapeutic interventions in schizophrenia... - Interaction of negative olfactory stimulation and working memory in schizophrenia patients: development and evaluation of a behavioral neuroimaging taskFrank Schneider
Department of Psychiatry and Psychotherapy, University of Aachen, Pauwelsstr 30, 52074 Aachen, Germany
Psychiatry Res 144:123-30. 2006..The present data indicate a differential effect of negative mood induction on working memory performance in schizophrenia patients and healthy subjects... - Aberrant anterior cingulate activation in obsessive-compulsive disorder is related to task complexityKathrin Koch
Department of Psychiatry and Psychotherapy, University Hospital Jena, Philosophenweg 3, 07740 Jena, Germany
Neuropsychologia 50:958-64. 2012..However, findings regarding the underlying neural substrates are heterogeneous. Moreover, the influence of cognitive demand on the severity of these deficits and associated activation alterations is a matter of debate... - Structural brain alterations in patients with major depressive disorder and high risk for suicide: evidence for a distinct neurobiological entity?Gerd Wagner
Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany
Neuroimage 54:1607-14. 2011.... - Impairment in the specificity of emotion processing in schizophreniaFrank Schneider
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
Am J Psychiatry 163:442-7. 2006..The authors also sought to establish whether the deficit affects sensitivity or specificity of performance... - Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modelingRalf G M Schlösser
Department of Psychiatry, University of Jena, Germany
Hum Brain Mapp 31:1834-50. 2010..These findings are consistent with an overactive error control system in OCD subserving suppression of prepotent responses during decision-making... - Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depressionGerd Wagner
Department of Psychiatry, University of Jena, Ersatztext Jena, Germany
J Psychiatry Neurosci 33:199-208. 2008.... - The special involvement of the rostrolateral prefrontal cortex in planning abilities: an event-related fMRI study with the Tower of London paradigmGerd Wagner
Department of Psychiatry, University of Jena, Germany
Neuropsychologia 44:2337-47. 2006....