Research Topics
Species | Hendrik FreiseSummaryCountry: Germany Publications
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Publications
Intestinal effects of thoracic epidural anesthesiaHendrik Freise
Department of Anesthesiology and Intensive Care, University Hospital Muenster, Muenster, Germany
Curr Opin Anaesthesiol 22:644-8. 2009..Thoracic epidural anesthesia (TEA) is most frequently used after major surgery. However, despite ongoing research, the influence of TEA on the intestinal perioperative pathophysiology is not fully understood...
Continuous thoracic epidural anesthesia induces segmental sympathetic block in the awake ratHendrik Freise
Department of Anesthesiology and Intensive Care Medicine, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
Anesth Analg 100:255-62. 2005..DeltaT on day 3 was comparable to day 1. TEA induced stable segmental sympathetic block without cardiorespiratory and motor side effects in awake rats. This new technique may be applied in prolonged models of critical illness...
Inhibition of angiotensin-converting enzyme reduces rat liver reperfusion injury via bradykinin-2-receptorHendrik Freise
Department of General Surgery, Surgical Research, University Hospital Muenster, Muenster, Germany
J Surg Res 134:231-7. 2006..On the other hand, B-2-inhibition has been shown to reduce liver reperfusion injury. This study was designed to investigate the role of Bradykinin in hepatic reperfusion injury...
Thoracic epidural analgesia with low concentration of bupivacaine induces thoracic and lumbar sympathetic block: a randomized, double-blind clinical trialHendrik Freise
Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster, Albert Schweitzer Strasse33, 48149 Muenster, Germany
Anesthesiology 109:1107-12. 2008..This prospective, randomized, double-blind study evaluated the segmental propagation of sympathetic block after low-concentration, high-volume TEA using digital thermography...
Thoracic epidural anesthesia reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in septic ratsHendrik Freise
Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
Crit Care 13:R116. 2009..Therefore, we investigated hepatic microcirculation and inflammatory response during TEA in septic rats...
Hepatic effects of thoracic epidural analgesia in experimental severe acute pancreatitisHendrik Freise
Department of Anesthesiology and Intensive Care Medicine, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
Anesthesiology 111:1249-56. 2009..Its impact on hepatic microcirculation, however, in health and critical illness is unknown. Therefore, the authors studied the effect of TEA on the liver in healthy rats and in experimental severe acute pancreatitis...
Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic ratsStefan Lauer
Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster, Albert Schweitzer Str, 33, 48149 Muenster, Germany
Crit Care 13:R109. 2009....
The role of thoracic epidural analgesia in receptor-dependent and receptor-independent pulmonary vasoconstriction in experimental pancreatitisStefan Lauer
Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster, Germany
Anesth Analg 105:453-9. 2007..Although there is evidence that epidural analgesia improves lung function through effective pain relief, the influence of continuously applied epidural local anesthetics on pulmonary endothelial dysfunction is still unknown...
Thoracic epidural analgesia augments ileal mucosal capillary perfusion and improves survival in severe acute pancreatitis in ratsHendrik Freise
Department of Anesthesiology and Intensive Care Medicine, University Hospital Muenster, Germany
Anesthesiology 105:354-9. 2006..05). CONCLUSION: Thoracic epidural analgesia attenuated systemic response and improved survival in severe acute pancreatitis. These effects might be explained by improved mucosal perfusion...
Bradykinin-induced pulmonary vasoconstriction is time and inducible nitric oxide synthase dependent in a peritonitis sepsis modelLars G Fischer
Department of Anesthesiology and Intensive Care, University of Munster, 48149 Munster, Germany
Anesth Analg 99:864-71, table of contents. 2004....
Altered blood flow in terminal vessels after local application of ropivacaine and prilocaineHolger Wienzek
Department of Anesthesiology and Intensive Care Medicine, Muenster University Hospital, Muenster, Germany
Reg Anesth Pain Med 32:233-9. 2007..One hypothesis is that local application of ropivacaine in tissues supplied by end arteries reduces tissue blood flow because of arterial vasoconstriction...
Efficacy of intravenous paracetamol compared to dipyrone and parecoxib for postoperative pain management after minor-to-intermediate surgery: a randomised, double-blind trialGerhard Brodner
Department of Anaesthesiology, Intensive Care and Pain Therapy, Fachklinik Hornheide, Muenster, Germany
Eur J Anaesthesiol 28:125-32. 2011..This double-blind, placebo-controlled study was designed to compare the efficacy of intravenous paracetamol with other intravenous non-opioids as part of a multimodal concept for perioperative pain therapy...
Hypoglycemia aggravates critical illness-induced neurocognitive dysfunctionThomas Duning
Department of Neurology, University Hospital of Muenster, Muenster, Germany
Diabetes Care 33:639-44. 2010....
Continuous thoracic epidural anesthesia improves gut mucosal microcirculation in rats with sepsisFritz Daudel
Department of Intensive Care Medicine, University Hospital of Bern, Bern, Switzerland
Shock 28:610-4. 2007..Additional studies are warranted to assess the microcirculatory effects of sympathetic blockade on other splanchnic organs in systemic inflammation...
Arginine vasopressin compromises gut mucosal microcirculation in septic ratsMartin Westphal
Department of Anaesthesiology and Intensive Care, University of Muenster, Germany
Crit Care Med 32:194-200. 2004..The effects of AVP on microvascular blood flow in this model may be related to AVP activities on larger arterioles (>40 microm), a concomitant reduction in cardiac output, or even both...
