Walter E Muller

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi Membrane-disordering effects of beta-amyloid peptides
    W E Muller
    Department of Pharmacology, Biocenter University of Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    Biochem Soc Trans 29:617-23. 2001
  2. ncbi Neuropharmacology of the anxiolytic drug opipramol, a sigma site ligand
    W E Muller
    Department of Pharmacology, Biocenter University Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    Pharmacopsychiatry 37:S189-97. 2004
  3. ncbi Current St John's wort research from mode of action to clinical efficacy
    Walter E Muller
    Department of Pharmacology, Biocenter JW Goethe University, Marie Curie Street 9, 60439, Frankfurt, Germany
    Pharmacol Res 47:101-9. 2003
  4. ncbi Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice
    Katrin Schuessel
    Department of Pharmacology, Biocentre, University of Frankfurt, Germany
    Free Radic Biol Med 40:850-62. 2006
  5. ncbi Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761)
    Reham Abdel Kader
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Germany
    Pharmacol Res 56:493-502. 2007
  6. ncbi Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production
    Gero P Hooff
    Department of Pharmacology, Goethe University, Campus Riedberg, Biocenter N260, Max von Laue St 9, 60438, Frankfurt, Germany
    Mol Neurobiol 41:341-50. 2010
  7. ncbi Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?
    Kristina Leuner
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Germany
    Antioxid Redox Signal 9:1659-75. 2007
  8. ncbi Plant derived omega-3-fatty acids protect mitochondrial function in the brain
    Gunter P Eckert
    Department of Pharmacology, Campus Riedberg, Biocenter, University of Frankfurt, Germany
    Pharmacol Res 61:234-41. 2010
  9. ncbi Hyperforin modifies neuronal membrane properties in vivo
    Gunter P Eckert
    Institute of Pharmacology, J W Goethe University, Biocenter N260, Marie Curie Strasse 9, 60439 Frankfurt, Germany
    Neurosci Lett 367:139-43. 2004
  10. ncbi Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment
    Christian J Fehske
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Frankfurt, Germany
    Pharmacol Res 60:68-73. 2009

Collaborators

Detail Information

Publications47

  1. ncbi Membrane-disordering effects of beta-amyloid peptides
    W E Muller
    Department of Pharmacology, Biocenter University of Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    Biochem Soc Trans 29:617-23. 2001
    ..By contrast, membrane properties at the level of the polar heads of the phospholipid bilayer at the interface with membrane proteins are much less affected...
  2. ncbi Neuropharmacology of the anxiolytic drug opipramol, a sigma site ligand
    W E Muller
    Department of Pharmacology, Biocenter University Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    Pharmacopsychiatry 37:S189-97. 2004
    ....
  3. ncbi Current St John's wort research from mode of action to clinical efficacy
    Walter E Muller
    Department of Pharmacology, Biocenter JW Goethe University, Marie Curie Street 9, 60439, Frankfurt, Germany
    Pharmacol Res 47:101-9. 2003
    ..John's wort extract as an antidepressant are supported by a large number of scientific publications. Within the wide range of components in St. John's wort extract, hyperforin plays an important, if not an outstanding role...
  4. ncbi Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice
    Katrin Schuessel
    Department of Pharmacology, Biocentre, University of Frankfurt, Germany
    Free Radic Biol Med 40:850-62. 2006
    ..Hence, oxidative stress caused by the combined effects of aging and PS1 mutations may be causative for triggering neurodegenerative events in FAD patients...
  5. ncbi Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761)
    Reham Abdel Kader
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Germany
    Pharmacol Res 56:493-502. 2007
    ..The single components of EGb 761 showed in both cell models protection of the mitochondrial membrane potential indicating that a complementary action of the components is responsible for the versatile actions of EGb 761...
  6. ncbi Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production
    Gero P Hooff
    Department of Pharmacology, Goethe University, Campus Riedberg, Biocenter N260, Max von Laue St 9, 60438, Frankfurt, Germany
    Mol Neurobiol 41:341-50. 2010
    ....
  7. ncbi Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?
    Kristina Leuner
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Germany
    Antioxid Redox Signal 9:1659-75. 2007
    ..Herein, the authors suggest that mitochondrial protection and subsequent reduction of oxidative stress are important components of the neuroprotective activity of Ginkgo biloba extract...
  8. ncbi Plant derived omega-3-fatty acids protect mitochondrial function in the brain
    Gunter P Eckert
    Department of Pharmacology, Campus Riedberg, Biocenter, University of Frankfurt, Germany
    Pharmacol Res 61:234-41. 2010
    ....
  9. ncbi Hyperforin modifies neuronal membrane properties in vivo
    Gunter P Eckert
    Institute of Pharmacology, J W Goethe University, Biocenter N260, Marie Curie Strasse 9, 60439 Frankfurt, Germany
    Neurosci Lett 367:139-43. 2004
    ..Our data emphasises a membrane interaction of hyperforin that possibly contributes to its pharmacological effects...
  10. ncbi Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment
    Christian J Fehske
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Frankfurt, Germany
    Pharmacol Res 60:68-73. 2009
    ....
  11. ncbi Increased apoptotic cell death in sporadic and genetic Alzheimer's disease
    Anne Eckert
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt am Main, Germany
    Ann N Y Acad Sci 1010:604-9. 2003
    ..Finally, we propose a hypothetical sequence of the pathogenic steps linking sporadic AD, FAD, Abeta production, mitochondrial dysfunction with caspase pathway, and neuronal loss...
  12. ncbi Isoprenoids, small GTPases and Alzheimer's disease
    Gero P Hooff
    Department of Pharmacology, Campus Riedberg, Goethe University, 60438 Frankfurt, Germany
    Biochim Biophys Acta 1801:896-905. 2010
    ....
  13. ncbi Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing
    Gunter P Eckert
    Department of Pharmacology, Goethe University, Biocenter, D 60438 Frankfurt, Germany
    Biochim Biophys Acta 1808:236-43. 2011
    ..Our data suggest that liposomal DHA is able to restore or maintain physiological membrane properties, which are required for neuroprotective sAPP? secretion and autocrine modulation of neuronal survival...
  14. ncbi Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients
    Gunter P Eckert
    Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Campus Riedberg, Max von Laue St 9, Frankfurt 60438, Germany
    Neurobiol Dis 35:251-7. 2009
    ..A tentative conclusion is that if indeed regulation of FPP and GGPP is altered in AD brain such changes may stimulate protein prenylation and contribute to AD neuropathophysiology...
  15. ncbi A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS
    Gero P Hooff
    Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Max von Laue Str 9, 60438 Frankfurt, Germany
    Anal Bioanal Chem 398:1801-8. 2010
    ....
  16. ncbi Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects
    Walter E Muller
    Department of Pharmacology, Biocenter, University of Frankfurt, Max von Laue Strasse 9, 60438, Frankfurt, Germany
    Mol Neurobiol 41:159-71. 2010
    ..We suggest that mitochondrial protection and subsequent reduction of oxidative stress are important targets for prevention and long-term treatment of early stages of AD...
  17. ncbi Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells
    Sebastian Schaffer
    Institute of Pharmacology, Biocenter Niederursel, University of Frankfurt, Max von Laue Strasse 9, 60438 Frankfurt am Main, Germany
    Pharmacol Res 62:322-7. 2010
    ..Furthermore, correlation analyses revealed that the observed cytoprotective effects in PC12 cells are likely due to HT present in the extract...
  18. ncbi Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease
    Anne Eckert
    Department of Pharmacology, Biocenter, J W Goethe University of Frankfurt, Marie Curie Str 9, D 60439 Frankfurt am Main, Germany
    Biochem Pharmacol 66:1627-34. 2003
    ..Finally, we emphasize a hypothetical sequence of the pathogenic steps linking sporadic AD, FAD, and Abeta production with mitochondrial dysfunction, caspase pathway, and neuronal loss...
  19. ncbi Isoprenoid quantitation in human brain tissue: a validated HPLC-fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP)
    Gero P Hooff
    Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Max von Laue Str 9, 60438, Frankfurt, Germany
    Anal Bioanal Chem 392:673-80. 2008
    ..Overall, this new method introduces the ability to simultaneously quantify FPP and GGPP in human brain tissue, and is potentially applicable to several other tissues and species...
  20. ncbi The interaction of beta-amyloid protein with cellular membranes stimulates its own production
    Imke Peters
    Department of Pharmacology, Goethe University of Frankfurt am Main, Campus Riedberg, Biocenter Geb N260, R 1 09, Max von Laue Str 9, D 60438 Frankfurt, Germany
    Biochim Biophys Acta 1788:964-72. 2009
    ..Based on our novel findings, we propose that oligoAbeta((1-40)) accelerates the proteolytic cleavage of APP by decreasing membrane fluidity...
  21. ncbi Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment
    Cornelia Franke
    Department of Pharmacology, ZAFES, Biocenter Niederursel, N260 Max von Laue Str 9, University of Frankfurt, Germany
    Neurobiol Dis 25:438-45. 2007
    ..These results provide new insight into potential mechanisms for the protective actions of statins within the CNS where programmed cell death has been implicated...
  22. ncbi Impact of aging: sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease
    Katharina Schindowski
    Department of Pharmacology, Biocenter, J.W. Goethe University of Frankfurt, Marie-Curie-Str. 9, D-60439 Frankfurt am Main, Germany
    Neuromolecular Med 4:161-78. 2003
    ..In contrast, normal aging results in an increased susceptibility to apoptosis of both, CD4+ and CD8+ T cells...
  23. ncbi Treatment duration (persistence) of basal insulin supported oral therapy (BOT) in Type-2 diabetic patients: comparison of insulin glargine with NPH insulin
    Renate Quinzler
    DAPI German Institute for Drug Use Evaluation, Eschborn, Germany
    Int J Clin Pharmacol Ther 50:24-32. 2012
    ..To compare the persistence (treatment duration) of basal insulin supported oral therapy (BOT) using insulin glargine (GLA) or NPH insulin (NPH) in Type-2 diabetic patients...
  24. ncbi Increased T-cell reactivity and elevated levels of CD8+ memory T-cells in Alzheimer's disease-patients and T-cell hyporeactivity in an Alzheimer's disease-mouse model: implications for immunotherapy
    Katharina Schindowski
    Institute of Pharmacology, Biocenter building N260, Johann Wolfgang Goethe University, Max von Laue Strasse 9, 60438 Frankfurt am Main, Germany
    Neuromolecular Med 9:340-54. 2007
    ..Our data implicate the generation of reactive memory T-cell in AD and of anergic memory T-cells in transgenic mice and should be taken into concern when designing immunotherapy...
  25. ncbi Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice
    Katrin Schuessel
    Department of Pharmacology, Biocentre, J W Goethe University of Frankfurt, Germany
    Neurobiol Dis 18:89-99. 2005
    ..Our results demonstrate that impaired Cu/Zn-SOD activity contributes to oxidative damage in Thy1-APP751(SL) transgenic mice, and these findings are closely linked to increased beta-amyloidogenic cleavage of APP...
  26. ncbi Cholesterol: Coupling between membrane microenvironment and ABC transporter activity
    Sascha Meyer dos Santos
    Department of Pharmacology, ZAFES, Biocenter Niederursel, N260, Max von Laue Str 9, University of Frankfurt, Germany
    Biochem Biophys Res Commun 354:216-21. 2007
    ..Enrichment of membrane cholesterol changed lipid raft distribution but not the localisation of Pgp. From our data we conclude that Pgp-transport capacity depends on accurate lipid raft properties...
  27. ncbi Cholesterol modulates amyloid beta-peptide's membrane interactions
    Gunter P Eckert
    Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Germany
    Pharmacopsychiatry 36:S136-43. 2003
    ..Thus, elucidation of the structure and function of different cholesterol pools is necessary in understanding the coherence between cholesterol and AD...
  28. ncbi Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761
    Anne Eckert
    Department of Pharmacology, Biocenter, University of Frankfurt, Germany
    Ann N Y Acad Sci 1056:474-85. 2005
    ..Taken together, our findings clearly show stabilization and protection of mitochondrial function as a specific and very sensitive property of EGb 761 at therapeutically relevant doses...
  29. ncbi Presenilin 1 modifies lipid raft composition of neuronal membranes
    Gunter P Eckert
    Department of Pharmacology, ZAFES, Campus Riedberg, Biocenter Niederursel, University of Frankfurt, Frankfurt, Germany
    Biochem Biophys Res Commun 382:673-7. 2009
    ..Moreover, our data reveal significant changes in membrane micro-domains and indicate that PS1 induces the formation of lipid rafts...
  30. ncbi The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis
    Donat Kogel
    Interdisciplinary Center for Clinical Research IZKF, Research Group Apoptosis and Cell Death, University Münster Clinics, Munster, Germany
    J Neurochem 87:248-56. 2003
    ..Our data indicate that APP plays an important physiological role in protecting neurons from the consequences of prolonged ER stress, and that APP mutations associated with familial Alzheimer's disease may impair this protective activity...
  31. ncbi Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease
    Susanne Hauptmann
    Department of Pharmacology Biocentrs, University of Frankfurt, 60439 Frankfurt, Germany
    Exp Gerontol 41:668-73. 2006
    ....
  32. ncbi Tocotrienols: constitutional effects in aging and disease
    Sebastian Schaffer
    Institute of Pharmacology ZAFES Member, Biocenter Niederursel, University of Frankfurt, Frankfurt am Main, Germany
    J Nutr 135:151-4. 2005
    ..This review summarizes the main antioxidant and nonantioxidant effects of tocotrienols and assesses their potential as health-maintaining compounds...
  33. ncbi Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
    Uta Keil
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt, Germany
    J Biol Chem 279:50310-20. 2004
    ..We suggest a hypothetical sequence of pathogenic steps linking mutant APP expression and amyloid production with enhanced NO production and mitochondrial dysfunction finally leading to cell death...
  34. ncbi Hyperforin activates nonselective cation channels (NSCCs)
    Kristina Treiber
    Department of Pharmacology, Biocenter, N260, University of Frankfurt, Marie-Curie-Str. 9, 60439 Frankfurt, Germany
    Br J Pharmacol 145:75-83. 2005
    ..British Journal of Pharmacology (2005) 145, 75-83. doi:10.1038/sj.bjp.0706155...
  35. ncbi Piracetam improves mitochondrial dysfunction following oxidative stress
    Uta Keil
    Department of Pharmacology, Biocenter, N260, University of Frankfurt, Marie-Curie-Strasse 9, 60439 Frankfurt, Germany
    Br J Pharmacol 147:199-208. 2006
    ..Mitochondrial stabilization and protection might be an important mechanism to explain many of piracetam's beneficial effects in elderly patients...
  36. ncbi Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death
    Steffen Leutz
    Department of Pharmacology, Biocenter, University of Frankfurt, Germany
    J Mol Neurosci 18:189-201. 2002
    ..Our study further emphasizes the pathogenic role of mutant APP and may provide new insights in the mechanisms underlying the massive neurodegeneration in brain from patients bearing the APPsw mutation...
  37. ncbi Enhancement of proteolytic processing of the beta-amyloid precursor protein by hyperforin
    Bettina Froestl
    Department of Pharmacology, Biocenter, University of Frankfurt, Marie-Curie-Str. 9, D-60439 Frankfurt, Germany
    Biochem Pharmacol 66:2177-84. 2003
    ..These results suggest that hyperforin is an activator of secretory processing of APP with a novel mechanism of action not solely dependent on its effects on intracellular pH...
  38. ncbi Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations
    Uta Keil
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt, Germany
    J Alzheimers Dis 9:139-46. 2006
    ..Thus, both Alzheimer relevant protein alterations seem to have synergistic actions probably at the level of mitochondria leading to synaptic dysfunction and apoptotic cell death...
  39. ncbi Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo
    Sebastian Schaffer
    Institute of Pharmacology ZAFES, Biocenter Niederursel, University of Frankfurt, 60438 Frankfurt am Main, Germany
    J Agric Food Chem 55:5043-9. 2007
    ..In synthesis, the ex vivo data provide the first evidence of neuroprotective effects of oral hydroxytyrosol intake. Keywords: Hydroxytyrosol; olive mill wastewater; dissociated brain cells; oxidative stress; brain; Mediterranean diet...
  40. ncbi Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains
    Gunter P Eckert
    Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Marie-Curie-Str. 9, D-60439, Frankfurt, Germany
    Brain Res 962:144-50. 2003
    ..Lipid rafts from the nerve terminal of neurons prepared with or without detergents may represent different membrane domains each with unique specialized functions...
  41. ncbi Generic switch after ramipril patent expiry is not associated with decreased pharmacy refill compliance: a retrospective study using the DAPI database
    Miriam Ude
    Department of Pharmacology, Goethe University Frankfurt, Frankfurt am Main, Germany
    J Hypertens 29:1837-45. 2011
    ..The purpose of this study was to evaluate whether switching from brand name ramipril to a generic product after patent expiry may negatively affect patients' refill compliance...
  42. ncbi Age-related impairment of human T lymphocytes' activation: specific differences between CD4(+) and CD8(+) subsets
    Katharina Schindowski
    Department of Pharmacology, Johann Wolfgang Goethe University Biocenter, Marie Curie Strasse 9, 60439 Frankfurt Main, Germany
    Mech Ageing Dev 123:375-90. 2002
    ..The results will be discussed in relation to their relevance in neurodegenerative and psychiatric disorders...
  43. ncbi Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway
    Celio A Marques
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt, Germany
    J Biol Chem 278:28294-302. 2003
    ....
  44. ncbi Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation
    Kristina Leuner
    Institute of Pharmacology, Biocenter Niederursel, Johann Wolfgang Goethe University, Frankfurt, Germany
    PLoS ONE 6:e14716. 2011
    ..As TRPC6 channel activation can partially overcome this Ca(2+) entry defect, specific TRPC channel activators may be potential new drug candidates for the topical treatment of psoriasis...
  45. ncbi Effects of antidepressants on the brain/plasma distribution of corticosterone
    Claudia-Carolin Weber
    Department of Pharmacology, Biocenter (ZAFES, University of Frankfurt, Frankfurt, Germany
    Neuropsychopharmacology 31:2443-8. 2006
    ..In addition, St John's wort is the only antidepressant tested which slightly elevated Pgp protein level in the brain...
  46. ncbi [Tricyclics as co-analgesics. Therapeutic options for chronic pain]
    Kristina Leuner
    , Biozentrum Niederursel, Max-von-Laue-Str. 9, 60438 Frankfurt am Main
    Pharm Unserer Zeit 37:220-5. 2008