Research Topics
| R J LudwigSummaryAffiliation: Frankfurt am Main Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Management of cutaneous type IV hypersensitivity reactions induced by heparinRalf J Ludwig
Department of Dermatology, Clinic of the Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Thromb Haemost 96:611-7. 2006..As the proposed management of patients with cutaneous hypersensitivity reactions to heparin may have fatal consequences when applied in patients with HIT type II, diagnosis of skin lesions in heparin-treated patients needs to be precise...- How shingles can be beachedRalf J Ludwig
Department of Dermatology, , Frankfurt, Germany
Lancet 370:1240. 2007 - P-selectin: a common therapeutic target for cardiovascular disorders, inflammation and tumour metastasisRalf J Ludwig
Johann Wolfgang Goethe University, Department of Dermatology, Theodor Stern Kai 7, Frankfurt am Main, Germany
Expert Opin Ther Targets 11:1103-17. 2007..The authors aim to critically evaluate the contribution of P-selectin in these diseases, and discuss the value of therapeutic inhibition of P-selectin functions in coagulation, inflammation and metastasis... - Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activitiesRalf J Ludwig
Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Mini Rev Med Chem 6:1009-23. 2006.... - Molecular weight determines the frequency of delayed type hypersensitivity reactions to heparin and synthetic oligosaccharidesRalf J Ludwig
Department of Dermatology, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Thromb Haemost 94:1265-9. 2005..842, p = 0.009). Hence, fondaparinux may be used as a therapeutic alternative in patients with cutaneous DTH relations towards heparin and other polysaccharides... - Chronic venous insufficiency - a potential trigger for localized sclerodermaR J Ludwig
Department of Dermatology, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Frankfurt am Main, Germany
J Eur Acad Dermatol Venereol 20:96-9. 2006..In addition, localized scleroderma may only develop if a certain amount of trigger factors are present - and resolves if one or more of the contributing factors (i.e. CVI) can be treated... - Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammationRalf J Ludwig
Department of Dermatology, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
J Invest Dermatol 125:969-76. 2005..In conclusion, interactions with JAM-B and -C are essential for development of cutaneous inflammation... - Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrinRalf J Ludwig
Department of Dermatology, Clinic of the J W Goethe University, Frankfurt am Main, Germany
Immunology 128:196-205. 2009..037; analysis of variance (anova)]. Overall, JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion... - Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammationMichael P Schön
Department of Dermatology, Otto von Guericke University, Magdeburg, Germany
Nat Med 8:366-72. 2002..Molecular modeling demonstrated a spatial conformation of efomycines mimicking naturally occurring selectin ligands. Efomycine M might be efficacious in the treatment of human inflammatory disorders through a similar mechanism... - Development of a simple enzyme-linked immunosorbent assay for the detection of autoantibodies in anti-p200 pemphigoidS Groth
Department of Dermatology, University of Lubeck, 23538 Lubeck, Germany
Br J Dermatol 164:76-82. 2011..However, preparation of dermal extract is not widely available, limiting the possibility of diagnosing this disease to a few laboratories... - The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on bloodborne metastasis in vivoRalf J Ludwig
Department of Dermatology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
Thromb Haemost 95:535-40. 2006..Hence, P-selectin inhibition may constitute a valuable feature to identify anticoagulants that are suitable for anticancer therapy... - Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivityRalf J Ludwig
Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Am J Pathol 176:1339-45. 2010..Our observations indicate that platelet, not endothelial, P-selectin contributes to generation of immunity in DNFB-induced contact hypersensitivity... - Therapeutic use of heparin beyond anticoagulationRalf J Ludwig
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
Curr Drug Discov Technol 6:281-9. 2009.... - Intolerance of fondaparinux in a patient allergic to heparinsKatrin Hirsch
Department of Dermatology, Johann Wolfgang Goethe-University, Frankfurt, Germany
Contact Dermatitis 50:383-4. 2004 - Psoriasis patients show signs of insulin resistanceS Boehncke
Department of Internal Medicine, Section for Endocrinology, Metabolism and Diabetology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Br J Dermatol 157:1249-51. 2007..Recent observations suggest that psoriasis is a risk factor for the development of coronary artery calcification which in turn represents an indicator for atherosclerosis... - Low allergenic potential with fondaparinux: results of a prospective investigationMarc Schindewolf
Department of Internal Medicine, J W Goethe University Hospital, Theodor Stern Kai 7, Bldg 13A, 60590 Frankfurt am Main, Germany
Mayo Clin Proc 85:913-9. 2010..To determine the incidence and causes of skin reactions to the synthetic pentasaccharide fondaparinux... - Dimethylfumarate reduces leukocyte rolling in vivo through modulation of adhesion molecule expressionSimone A Rubant
Department of Dermatology, Clinic of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany
J Invest Dermatol 128:326-31. 2008..We provide early evidence that DMF affects adhesion molecule expression on human leukocytes and their rolling behavior in vivo, indicating that DMF directly affects the initial step of leukocyte extravasation... - Experimental approaches to lymphocyte migration in dermatology in vitro and in vivoHeinfried H Radeke
Pharmazentrum Frankfurt, Dr Hans Schleussner Foundation Immune Pharmacology, Frankfurt, Germany
Exp Dermatol 14:641-66. 2005.... - Eukaryotic expression of the broad-spectrum chemokine receptor antagonist vMIP-II and its effects on T-cell function in vitro and in vivoSimone Rubant
Department of Dermatology, Clinic of the Johann Wolfgang Goethe University, Frankfurt, Germany
Exp Dermatol 15:634-42. 2006..8 and 3.6 cm x 10(-3) for controls and vMIP-II treated mice (2.5 mg/kg), respectively) of cutaneous hypersensitivity. These data indicate that vMIP-II is a promising agent to interfere with chronic inflammatory (skin) diseases... - C-terminally truncated kindlin-1 leads to abnormal adhesion and migration of keratinocytesC Has
Department of Dermatology, University Medical Center Freiburg, Hauptstr 7, 79104 Freiburg, Germany
Br J Dermatol 159:1192-6. 2008..Loss of kindlin-1 leads to abnormalities of cell adhesion and motility, and to skin blistering and progressive poikiloderma as clinical symptoms... - Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasisRalf J Ludwig
Department of Dermatology, , Frankfurt am Main, Germany
Cancer Res 64:2743-50. 2004.... - Tolerance of fondaparinux in a patient allergic to heparins and other glycosaminoglycansRalf J Ludwig
Department of Dermatology, Johann Wolfgang Goethe-University, Frankfurt, Germany
Contact Dermatitis 49:158-9. 2003 - Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion moleculesRalf J Ludwig
Department of Dermatology, J W Goethe University, Frankfurt, Germany
J Invest Dermatol 122:830-6. 2004..This increased rolling is due to the aggregate formation of platelets with leukocytes. We also provide evidence for a potential role of this mechanism in the pathogenesis of chronic inflammatory skin diseases... - Psoriasis: a possible risk factor for development of coronary artery calcificationR J Ludwig
Department of Dermatology and Department of Radiology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Br J Dermatol 156:271-6. 2007..Epidemiological data on the prevalence and degree of coronary artery calcification (CAC) as an indicator for cardiovascular diseases in patients with psoriasis are contradictory... - Computer-aided analysis of cell interactions under dynamic flow conditionsOliver Giegold
Pharmazentrum frankfurt ZAFES, Clinic of the Goethe University Frankfurt am Main, Frankfurt am Main, Germany
Exp Dermatol 18:238-45. 2009.... - Clearance rates of circulating and tissue-bound autoantibodies to type VII collagen in experimental epidermolysis bullosa acquisitaM Kasperkiewicz
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Br J Dermatol 162:1064-70. 2010..However, little is known about their natural clearance rates in these different compartments... - Incidence and causes of heparin-induced skin lesionsMarc Schindewolf
Department of Internal Medicine, Division of Angiology, Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany
CMAJ 181:477-81. 2009..The 2 most commonly reported causes of heparin-induced skin lesions are immune-mediated heparin-induced thrombocytopenia and delayed-type hypersensitivity reactions... - Pathogenicity of IgG subclass autoantibodies to type VII collagen: induction of dermal-epidermal separationAndreas Recke
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
J Autoimmun 34:435-44. 2010..e. the generation of subclass-specific adsorbers, used for extracorporal immunoapheresis, or the shifting of the autoimmune response to production of non-pathogenic autoantibodies... - Eosinophilic cellulitis (Wells' syndrome) associated with colon carcinomaKatrin Hirsch
Dept. of Dermatology, , Theodor-Stern-Kai 7, Frankfurt am Main, Germany
J Dtsch Dermatol Ges 3:530-1. 2005..We report the association of eosinophilic cellulitis with adenocarcinoma of the colon. Curative hemicolectomy led to a complete remission, suggesting that underlying malignancies can trigger eosinophilic cellulitis... - Diminished lymphocyte adhesion and alleviation of allergic responses by small-molecule- or antibody-mediated inhibition of L-selectin functionsGertie J Oostingh
Rudolf Virchow Center, and Department of Dermatology, Julius Maximilians University, Wurzburg, Germany
J Invest Dermatol 127:90-7. 2007..0002 and P=0.0001, respectively). Our data demonstrate that it is possible, in principle, to diminish T-cell-mediated allergic reactions through interference with L-selectin functions during the early sensitization phase... - Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functionsGertie J Oostingh
University of Wurzburg, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Wurzburg Germany
Haematologica 92:502-12. 2007..P-selectin ctin has been implicated in important platelet functions. However, neither its role in thrombus formation and cardiovascular disorders nor its suitability as a therapeutic target structure is entirely clear... - The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibitory capacityJuliane Fritzsche
Institute of Pharmaceutical Chemistry, Rheinische Friedrich Wilhelms University Bonn, Germany
Biochem Pharmacol 72:474-85. 2006..Our study indicates that semisynthetic glucan sulfates with optimal structures block P-selectin excellently and might become promising candidates for anti-inflammatory drugs to replace heparin for certain applications... - Lymphocyte trafficking to inflamed skin--molecular mechanisms and implications for therapeutic target moleculesMichael P Schön
Department of Dermatology and Venereology, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Bayerische Julius Maximilians University, Wurzburg, Germany
Expert Opin Ther Targets 9:225-43. 2005....