Susanne Fetzner

Summary

Country: Germany

Publications

  1. ncbi Ring-cleaving dioxygenases with a cupin fold
    Susanne Fetzner
    Institute of Molecular Microbiology and Biotechnology, Westfalian Wilhelms University Munster, Munster, Germany
    Appl Environ Microbiol 78:2505-14. 2012
  2. ncbi Cofactor-independent oxidases and oxygenases
    Susanne Fetzner
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Appl Microbiol Biotechnol 86:791-804. 2010
  3. ncbi Quercetinase QueD of Streptomyces sp. FLA, a monocupin dioxygenase with a preference for nickel and cobalt
    Hedda Merkens
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    Biochemistry 47:12185-96. 2008
  4. ncbi Transcriptional analysis of the queD gene coding for quercetinase of Streptomyces sp. FLA
    Hedda Merkens
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Munster, Germany
    FEMS Microbiol Lett 287:100-7. 2008
  5. ncbi Complete nucleotide sequence of the 113-kilobase linear catabolic plasmid pAL1 of Arthrobacter nitroguajacolicus Rü61a and transcriptional analysis of genes involved in quinaldine degradation
    Katja Parschat
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Bacteriol 189:3855-67. 2007
  6. ncbi A novel replicative enzyme encoded by the linear Arthrobacter plasmid pAL1
    Stephan Kolkenbrock
    Institute of Molecular Microbiology and Biotechnology, Westfalian Wilhelms University Munster, Corrensstrasse 3, D 48149 Munster, Germany
    J Bacteriol 192:4935-43. 2010
  7. ncbi A new monocupin quercetinase of Streptomyces sp. FLA: identification and heterologous expression of the queD gene and activity of the recombinant enzyme towards different flavonols
    Hedda Merkens
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstr 3, 48149 Munster, Germany
    Arch Microbiol 187:475-87. 2007
  8. ncbi EstA from Arthrobacter nitroguajacolicus Rü61a, a thermo- and solvent-tolerant carboxylesterase related to class C beta-lactamases
    Marcus Schütte
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 3, D 48149, Munster
    Curr Microbiol 54:230-6. 2007
  9. ncbi Identification and in vitro deoxynucleotidylation of the terminal protein of the linear plasmid pAL1 of Arthrobacter nitroguajacolicus Rü61a
    Stephan Kolkenbrock
    Institute of Molecular Microbiology and Biotechnology, University of Munster, Munster, Germany
    FEMS Microbiol Lett 304:169-76. 2010
  10. ncbi Thermodynamic analysis of denaturant-induced unfolding of HodC69S protein supports a three-state mechanism
    Kristian Boehm
    Institut fur Physikalische Chemie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 30, 48149 Munster, Germany
    Biochemistry 47:7116-26. 2008

Collaborators

  • Michael Hippler
  • Roberto A Steiner
  • Kalina Ranguelova
  • Axel W Strittmatter
  • Karsten Rose
  • Hedda Merkens
  • Stephan Kolkenbrock
  • Ursula Frerichs-Deeken
  • Katja Parschat
  • Jörg Overhage
  • Heiko Niewerth
  • Kristian Boehm
  • Marcus Schütte
  • Reinhard Kappl
  • Sonja Sielker
  • Klaus Bergander
  • Siri Ram Chhabra
  • Paul Williams
  • Bianca Naumann
  • Jessica Guddorf
  • H J Hinz
  • Tadashi Kamiyama
  • H-J Hinz
  • Franz X Schmid
  • Alexander Albers
  • Roman P Jakob
  • Anke Henne
  • Gerhard Gottschalk
  • Stefan Homburg
  • Jurgen Huttermann

Detail Information

Publications14

  1. ncbi Ring-cleaving dioxygenases with a cupin fold
    Susanne Fetzner
    Institute of Molecular Microbiology and Biotechnology, Westfalian Wilhelms University Munster, Munster, Germany
    Appl Environ Microbiol 78:2505-14. 2012
    ..The tentative hypothesis that quercetinase catalysis involves direct electron transfer from metal-bound flavonolate to O(2) is supported by model chemistry...
  2. ncbi Cofactor-independent oxidases and oxygenases
    Susanne Fetzner
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Appl Microbiol Biotechnol 86:791-804. 2010
    ..Nevertheless, they all may share the common mechanistic concept of initial base-catalyzed activation of their organic substrate and "substrate-assisted catalysis"...
  3. ncbi Quercetinase QueD of Streptomyces sp. FLA, a monocupin dioxygenase with a preference for nickel and cobalt
    Hedda Merkens
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    Biochemistry 47:12185-96. 2008
    ..On the basis of spectroscopic data, and considering the organic chemistry of flavonols, a nonredox role of the metal center in catalysis is discussed...
  4. ncbi Transcriptional analysis of the queD gene coding for quercetinase of Streptomyces sp. FLA
    Hedda Merkens
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Munster, Germany
    FEMS Microbiol Lett 287:100-7. 2008
    ..Sequence analysis of the queD promoter region indicated possible binding sites for an LmrA/YxaF-like repressor...
  5. ncbi Complete nucleotide sequence of the 113-kilobase linear catabolic plasmid pAL1 of Arthrobacter nitroguajacolicus Rü61a and transcriptional analysis of genes involved in quinaldine degradation
    Katja Parschat
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Bacteriol 189:3855-67. 2007
    ..Even if the putative proteins encoded by ORFs 101 to 103 share motifs with the Tap and terminal proteins involved in telomere patching of Streptomyces linear replicons, their overall sequences and domain structures differ significantly...
  6. ncbi A novel replicative enzyme encoded by the linear Arthrobacter plasmid pAL1
    Stephan Kolkenbrock
    Institute of Molecular Microbiology and Biotechnology, Westfalian Wilhelms University Munster, Corrensstrasse 3, D 48149 Munster, Germany
    J Bacteriol 192:4935-43. 2010
    ..Enzyme assays suggested that the protein exhibits DNA topoisomerase, DNA helicase, and DNA- and protein-primed DNA polymerase activities. The pAL1.101 protein, therefore, may act as a replicase of pAL1...
  7. ncbi A new monocupin quercetinase of Streptomyces sp. FLA: identification and heterologous expression of the queD gene and activity of the recombinant enzyme towards different flavonols
    Hedda Merkens
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstr 3, 48149 Munster, Germany
    Arch Microbiol 187:475-87. 2007
    ..This arrangement suggests that queD is not part of a catabolic gene cluster. Quercetinases might play a major role as detoxifying rather than catabolic enzymes...
  8. ncbi EstA from Arthrobacter nitroguajacolicus Rü61a, a thermo- and solvent-tolerant carboxylesterase related to class C beta-lactamases
    Marcus Schütte
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 3, D 48149, Munster
    Curr Microbiol 54:230-6. 2007
    ....
  9. ncbi Identification and in vitro deoxynucleotidylation of the terminal protein of the linear plasmid pAL1 of Arthrobacter nitroguajacolicus Rü61a
    Stephan Kolkenbrock
    Institute of Molecular Microbiology and Biotechnology, University of Munster, Munster, Germany
    FEMS Microbiol Lett 304:169-76. 2010
    ..Consistent with its proposed role as a protein primer in DNA synthesis, pORF102 was deoxynucleotidylated in vitro with dCMP, complementary to the 3'-ends (... GCAGG) of pAL1...
  10. ncbi Thermodynamic analysis of denaturant-induced unfolding of HodC69S protein supports a three-state mechanism
    Kristian Boehm
    Institut fur Physikalische Chemie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 30, 48149 Munster, Germany
    Biochemistry 47:7116-26. 2008
    ..This was the case for the CD-monitored urea unfolding curve...
  11. ncbi Identification of large linear plasmids in Arthrobacter spp. encoding the degradation of quinaldine to anthranilate
    Jörg Overhage
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, Corrensstrasse 3, D 48149 Munster, Germany
    Microbiology 151:491-500. 2005
    ..A 478 bp fragment that on pAL1 represents an intergenic region showed 100 % sequence identity in all isolates harbouring a pAL1-like plasmid, suggesting horizontal dissemination of the linear plasmid among the genus Arthrobacter...
  12. ncbi Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440
    Heiko Niewerth
    Institute of Molecular Microbiology and Biotechnology, University of Munster, 48149 Munster, Germany
    Appl Microbiol Biotechnol 91:1399-408. 2011
    ..putida KT2440 [pBBR-pqsH]. PQS can be isolated from methanolic cell extracts by HPLC, or be precipitated as Fe(III)-PQS complex. Preparation of a library of AQs will facilitate studies on the biological functions of these compounds...
  13. ncbi Dioxygenases without requirement for cofactors and their chemical model reaction: compulsory order ternary complex mechanism of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase involving general base catalysis by histidine 251 and single-electron oxidation of
    Ursula Frerichs-Deeken
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Biochemistry 43:14485-99. 2004
    ..Subsequent intramolecular attack would result in the 2,4-endoperoxy (di)anion that may collapse to the reaction products...
  14. ncbi Dioxygenases without requirement for cofactors: identification of amino acid residues involved in substrate binding and catalysis, and testing for rate-limiting steps in the reaction of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase
    Ursula Frerichs-Deeken
    , , , Germany
    Curr Microbiol 51:344-52. 2005
    ....