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Genomes and GenesSpecies | S M FellerSummaryCountry: Germany Publications
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Publications
Physiological signals and oncogenesis mediated through Crk family adapter proteinsS M Feller
Laboratory of Molecular Oncology, MSZ Institute for Medical Radiation and Cell Research, University Würzberg, Germany
J Cell Physiol 177:535-52. 1998..More detailed analyses of the enzymatic activities triggered through Crk-type adapters will also be crucial to fully define the signalling pathways controlled by this protein family...- The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifM Lewitzky
Laboratory of Molecular Oncology, MSZ, Universitat Wurzburg, Germany
Oncogene 20:1052-62. 2001.... - Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexesC Kardinal
Laboratory of Molecular Oncology, , , Germany
Blood 98:1773-81. 2001..These results show that, in addition to the direct targeting of Bcr-Abl, selective inhibition of Grb2 protein complexes may be a therapeutic option for a significant number of CML patients... - The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathwaysJ Voss
Laboratory of Molecular Oncology, Institut fur Medizinische Strahlenkunde und Zellforschung, Wurzburg, Germany
Oncogene 19:1684-90. 2000.... - Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKLD Sakkab
Laboratory of Molecular Oncology, MSZ Institut für Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, D 97078 Wurzburg, Germany
J Biol Chem 275:10772-8. 2000..The results presented here delineate a novel signaling pathway from HGF to the GTPase Rap1 which depends on the interaction of the adapter protein CRKL with the exchange factor C3G and could be linked to cell migration... - The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteinsW Oehrl
Laboratory of Molecular Oncology, Institute for Medical Radiation and Cell Research MSZ, Bavarian Julius Maximilians University, Wurzburg, Germany
Oncogene 17:1893-901. 1998..Furthermore, c-Crk II and, to a lesser extent, CRKL were substrates for HPK1. These results make it likely that HPK1 and KHS participate in the signal transduction of Crk family adapter proteins in certain cell types... - Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with CrkB Wang
Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
Oncogene 13:1379-85. 1996..These experiments extend the known Arg protein interacting motifs to include SH3 binding sites and suggest that Arg may function as an effector as well as a regulator of Crk activity... - c-Abl kinase regulates the protein binding activity of c-CrkS M Feller
Laboratory of Molecular Oncology, Rockefeller University, New York, NY 10021
EMBO J 13:2341-51. 1994..v-Crk is truncated before c-Crk Y221 and forms constitutive complexes with c-Abl and other proteins. Our results suggest that c-Abl regulates c-Crk function and that it could be involved in v-Crk transformation... - Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinaseP Ling
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 19:1359-68. 1999..Taken together, our findings demonstrate the functional interaction of HPK1 with Crk and CrkL, reveal the downstream pathways of Crk- and CrkL-induced JNK activation, and highlight a potential role of HPK1 in T-cell activation... - Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of CrkB S Knudsen
Laboratory of Molecular Oncology, Rockefeller University, New York, New York 10021
J Biol Chem 269:32781-7. 1994..This unique binding specificity supports the idea that C3G plays an important role in Crk signaling pathways... - Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factorJ Wenzel
Institute for Immunology, Christian Albrechts University, Michaelisstrasse 5, 24105 Kiel, Germany
FEBS Lett 509:255-62. 2001..These results may help to explain the costimulatory capacity of CD95L... - Herpesvirus ateles gene product Tio interacts with nonreceptor protein tyrosine kinasesJ C Albrecht
Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
J Virol 73:4631-9. 1999..In addition, tyrosine-phosphorylated Tio bound to the SH2 domains of Lck, Src, or Fyn. Thus, herpesvirus ateles-encoded Tio may contribute to viral T-cell transformation by influencing the function of Src family kinases... - Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-CrkX Wu
Rockefeller University, New York, NY 10021, USA
Structure 3:215-26. 1995..The presence of a lysine instead of an arginine in the peptides derived from C3G appears to be crucial for this specificity towards c-Crk... - SH2 and SH3 domains as molecular adhesives: the interactions of Crk and AblS M Feller
Rockefeller University, New York, NY 10021
Trends Biochem Sci 19:453-8. 1994..SH2 domains recognize phosphotyrosyl residues in a specific sequence context, while SH3 domains recognize a PxxP motif and additional residues that mediate binding specificity... - Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motilityM Poppe
Junior Research Group, Paul Ehrlich Institute, Langen, Germany
Oncogene 26:3462-72. 2007..pylori infection and pathogenicity. These results implicate c-Abl as a novel molecular target for therapeutic intervention in H. pylori-related gastric diseases...