Research Topics
Species | Tanja FehmSummaryCountry: Germany Publications
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Publications
Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancerVolkmar Muller
Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20241 Hamburg, Germany
Breast Cancer Res 13:R71. 2011..The aim of the study was to investigate whether serum concentrations of TIMP-1 and CAIX are associated with the detection of CTC in metastatic breast cancer...- Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinomaClaudia Lengerke
University of Tuebingen Medical Center II, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
BMC Cancer 11:42. 2011..In breast cancer, SOX2 expression was reported as a feature of basal-like tumors. In this study, we assessed SOX2 expression in 95 primary tumors of postmenopausal breast cancer patients... - The Brustkrebs-Studien.de website for breast cancer patients: User acceptance of a German internet portal offering information on the disease and treatment options, and a clinical trials matching serviceMarkus Wallwiener
The Heidelberg Breast Centre, Department of Obstetrics and Gynaecology, Heidelberg University Hospital, Voßstr 9, D 69115 Heidelberg, Germany
BMC Cancer 10:663. 2010..We describe the development of BKS and its applications, and report on website statistics and user acceptance... - Prognostic significance of serum HER2 and CA 15-3 at the time of diagnosis of metastatic breast cancerTanja Fehm
Department of Obstetrics and Gynecology, University of Tuebingen, D 72076 Tuebingen, Germany
Anticancer Res 24:1987-92. 2004.... - Bisphosphonate-associated osteonecrosis of the jaw in breast cancer patients: recommendations for prevention and treatmentT Fehm
University Women s Hospital Tübingen, Calwer Strasse 7, 72076 Tubingen, Germany
Breast 18:213-7. 2009..This report summarizes the results and recommendations for the prevention and treatment of ONJ in breast cancer patients receiving BP... - Influence of tumor biological factors on tumor cell dissemination in primary breast cancerT Fehm
Department of Obstetrics and Gynecology University of Tuebingen, Calwerstrasse 7, D 72076 Tuebingen, Germany
Anticancer Res 24:4211-6. 2004..The aim of this study was to identify those features of the primary tumor related to the presence of disseminated tumor cells in the BM... - A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementationTanja Fehm
Department of Obstetrics and Gynecology, University of Tubingen, Tubingen, Germany
Cancer 107:885-92. 2006.... - Detection of disseminated tumor cells in patients with gynecological cancersT Fehm
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, D 72076 Tuebingen, Germany
Gynecol Oncol 103:942-7. 2006..The aim of this study was to evaluate the presence of DTC in the bone marrow (BM) of patients with gynecological cancers and to correlate their presence with established prognostic factors... - Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cellsTanja Fehm
Department of Gynecology and Obstetrics, Calwer Strasse 7, University Hospital of Tuebingen, D 72076 Tuebingen, Germany
Breast Cancer Res 11:R59. 2009.... - Evaluation of ERalpha, PR and ERbeta isoforms in neoadjuvant treated breast cancerMartin Wurster
Department of Obstetrics and Gynecology, University of Tuebingen, D 72076 Tuebingen, Germany
Oncol Rep 24:653-9. 2010..047). Results on ERalpha and PR corroborate findings of previous studies. Our data demonstrate that changes of ERbeta expression occur during PST and that total ERbeta expression and ERbeta2 may have a predictive value for PST... - ERalpha-status of disseminated tumour cells in bone marrow of primary breast cancer patientsTanja Fehm
Department of Obstetrics and Gynecology, University of Tuebingen, Germany
Breast Cancer Res 10:R76. 2008..Of particular interest is their oestrogen-receptor (ER) status because endocrine adjuvant therapy remains a cornerstone of breast cancer treatment... - HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumorNatalia Krawczyk
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
Anticancer Res 29:4019-24. 2009..The aim of this study was to assess HER2 status of persistent DTCs to determine whether the use of HER2-targeted agents might be a therapeutic option in patients with tumor cell persistence... - Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 statusTanja Fehm
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse, D 72076 Tuebingen, Germany
Breast Cancer Res 9:R74. 2007..The aim of this study was therefore to determine the HER2 status in serum and corresponding CTCs in patients with metastatic breast cancer whose primary tumors were HER2 negative or of unknown HER2 status... - Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1Hans Neubauer
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse, Germany
Breast Cancer Res 10:R85. 2008..Breast tumors lacking the estrogen receptor-alpha (ER-alpha) have increased incidence of resistance to therapy and poorer clinical prognosis... - Changes in tumour biological markers during primary systemic chemotherapy (PST)Hans Neubauer
Department of Gynaecology and Obstetrics, University of Tubingen, Tubingen, Germany
Anticancer Res 28:1797-804. 2008..The influence of primary systemic therapy (PST) on the expression of relevant therapeutic markers is still under investigation... - Expression and regulation of luteinizing hormone/human chorionic gonadotropin receptors in ovarian cancer and its correlation to human chorionic gonadotropin-doxorubicin sensitivityGerhard Gebauer
Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
Am J Obstet Gynecol 190:1621-8; discussion 1628. 2004..Ovarian cancer cell lines and tissues express gonadotropin receptors. Conjugation of cytostatics to ligands of these receptors may increase the specificity of cytotoxic drugs... - Prediction of axillary lymph node status of breast cancer patients by tumorbiological factors of the primary tumorTanja Fehm
Department of Obstetrics and Gynecology, University of Tuebingen, Germany
Strahlenther Onkol 181:580-6. 2005..By including additional parameters it appears to be feasible to further improve the model in order to avoid axillary lymph node surgery in low-risk women... - Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learnedIngmar Königsrainer
Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
Langenbecks Arch Surg 396:1077-81. 2011..De novo cytoreductive surgery is crucial with the potential to improve prognosis, especially when combined with hyperthermic intraperitoneal chemotherapy (HIPEC)... - HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trialTanja Fehm
Department of Gynecology and Obstetrics, University of Tubingen, Calwer Strasse 7, 72076, Tubingen, Germany
Breast Cancer Res Treat 124:403-12. 2010..Therefore, it will be mandatory to correlate the assay-dependent HER2 status of CTCs to the clinical response on HER2-targeted therapies... - Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trialSabine Riethdorf
Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Clin Cancer Res 16:2634-45. 2010..This study was aimed at detecting and characterizing circulating tumor cells (CTC) before and after neoadjuvant therapy (NT) in the peripheral blood of patients with breast cancer... - Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patientsBahriye Aktas
Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
Breast Cancer Res 11:R46. 2009.... - Her2 expression on disseminated tumor cells from bone marrow of breast cancer patientsSven Becker
Tubingen University Hospital, Department of Gynecology and Obstetrics, Germany
Anticancer Res 25:2171-5. 2005..We studied the her2 expression in the BM of 105 patients with CK-positive cells present and compared it with results from the primary tumor... - Detection of cytokeratin-positive cells in the bone marrow of breast cancer patients undergoing adjuvant therapySven Becker
Department of Gynecology and Obstetrics, University Hospital Tubingen, Tubingen, Germany
Breast Cancer Res Treat 97:91-6. 2006..020). Adjuvant treatment regimens are not able to completely eliminate cytokeratin-positive cells from the bone marrow. Prospective studies need to evaluate, whether these cells could become targets for additional adjuvant therapy... - Comparison of estrogen and progesterone receptor status of circulating tumor cells and the primary tumor in metastatic breast cancer patientsBahriye Aktas
Department of Gynecology and Obstetrics, University of Essen, Hufelandstrase 55, 45122 Essen, Germany
Gynecol Oncol 122:356-60. 2011..It was the purpose of the present study (1) to reevaluate the ER/PR expression by CTCs and (2) to compare the hormone receptor status expression profile of CTCs with the primary tumor... - Disseminated tumor cells in bone marrow may affect prognosis of patients with gynecologic malignanciesMalgorzata Banys
Department of Obstetrics and Gynecology, University of Tuebingen, University of Tuebingen, Liebermeisterstrasse 8, Tuebingen, Germany
Int J Gynecol Cancer 19:948-52. 2009..The aim of our study was to evaluate the incidence of DTC and to assess their prognostic significance in patients with gynecologic malignancies... - Presence of apoptotic and nonapoptotic disseminated tumor cells reflects the response to neoadjuvant systemic therapy in breast cancerTanja Fehm
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, D 72076 Tuebingen, Germany
Breast Cancer Res 8:R60. 2006..The aim of this study was to investigate the incidence of disseminated tumor cells (DTC), including apoptotic DTC, in breast cancer patients after NST, and to investigate the correlation of DTC status with therapy response... - Primary systemic therapy does not eradicate disseminated tumor cells in breast cancer patientsSven Becker
Department of Gynecology and Obstetrics, Tubingen University Hospital, Calwerstr 7, 72076 Tubingen, Germany
Breast Cancer Res Treat 106:239-43. 2007..The aim of this study was to investigate the status of tumor cell dissemination after primary systemic therapy in relation to therapy response... - Evaluation of a RT-PCR based routine screening tool for the detection of disseminated epithelial cells in the bone marrow of breast cancer patientsSven Becker
Department of Gynaecology and Obstetrics, University Hospital Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
Breast Cancer Res Treat 117:227-33. 2009..Immunocytochemistry (ICC) remains the gold standard for their detection. While assays based on RT-PCR are available, they have not been used for routine detection of DTC's... - Symptomatic bone marrow involvement in breast cancer--clinical presentation, treatment, and prognosis: a single institution review of 22 casesHans Georg Kopp
Department of Hematology Oncology, Eberhard Karls University, Otfried Mueller Str 10, D 72076 Tuebingen, Germany
Anticancer Res 31:4025-30. 2011..The objective of this study was to provide our institution's experience with the clinical presentation, prognosis, treatment, and associated complications of marrow involvement in breast cancer... - Fertility conservation in breast cancer patientsBarbara Lawrenz
Department of Obstetrics and Gynaecology, University Hospital for Women, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
Womens Health (Lond Engl) 7:203-12. 2011..Early counseling on fertility-preserving strategies is of utmost importance, so that the fertility-preserving method can be integrated into the oncologic therapy regime... - Clinical utility of serial serum c-erbB-2 determinations in the follow-up of breast cancer patientsTanja Fehm
Department of Obstetrics and Gynecology, University of Erlangen Nuremberg, Erlangen, Germany
Breast Cancer Res Treat 75:97-106. 2002..The serum profiles of c-erbB-2 and CA 15-3 were similar in 17 patients. In summary, our results suggest that serial determinations of serum c-erbB-2 are useful to monitor breast cancer patients... - Influence of platinum-based chemotherapy on disseminated tumor cells in blood and bone marrow of patients with ovarian cancerPauline Wimberger
Department of Gynecology and Obstetrics, University of Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Gynecol Oncol 107:331-8. 2007.... - The influence of removal of primary tumor on incidence and phenotype of circulating tumor cells in primary breast cancerMalgorzata Banys
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
Breast Cancer Res Treat 132:121-9. 2012..Surgery does not significantly influence the tumor cell load in the blood stream. CTC phenotype before and after the surgery generally remains identical but may differ from that of the primary tumor... - A laminin-rich basement membrane matrix influences estrogen receptor beta expression and morphology of MDA-MB-231 breast cancer cellsHans Neubauer
Department of Obstetrics and Gynaecology, University of Tuebingen, 72076 Tuebingen, Germany
Oncol Rep 21:475-81. 2009..A laminin-111-rich microenvironment seems to keep ERbeta1 at very low levels in breast cancer cells... - Pregnancy after breast cancer: case report and review of the literatureBarbara Lawrenz
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
Arch Gynecol Obstet 283:837-43. 2011..The question whether to become pregnant must be discussed individually with the patient, based on tumor characteristics, stage of the disease and patient's wishes... - Predicting resistance to platinum-containing chemotherapy with the ATP tumor chemosensitivity assay in primary ovarian cancerHans Neubauer
Department of Obstetrics and Gynecology, University of Tuebingen, 72076 Tuebingen, Germany
Anticancer Res 28:949-55. 2008..Our purpose was to define the optimal calculation method for the adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA) applied to PEOC treated with platinum-containing chemotherapy and to analyze its predictive relevance... - Bone marrow versus sentinel lymph node involvement in breast cancer: a comparison of early hematogenous and early lymphatic tumor spreadAndreas D Hartkopf
Department of Obstetrics and Gynecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany
Breast Cancer Res Treat 131:501-8. 2012..Conversely, a high correlation between nodal status and tumor size, histology, ER-status and lymph vessel invasion was found. Hematogenous and lymphatic tumor spread seem to be because of independent pathways of cancer progression... - Hematogenous and lymphatic tumor cell dissemination may be detected in patients diagnosed with ductal carcinoma in situ of the breastMalgorzata Banys
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076, Tuebingen, Germany
Breast Cancer Res Treat 131:801-8. 2012..The clinical relevance of these cells has to be further evaluated... - Optimal treatment for patients with ectopic pregnancies and a history of fertility-reducing factorsSven Becker
Women s University Hospital, Tubingen University, Calwerstrasse 7, Tubingen, Germany
Arch Gynecol Obstet 283:41-5. 2011..The aim of this study was to evaluate long-term reproductive outcome after salpingotomy versus salpingectomy in patients with and without additional fertility-reducing factors... - Micrometastases in axillary lymph nodes and bone marrow of lymph node-negative breast cancer patients--prognostic relevance after 10 yearsGerhard Gebauer
Department of Obstetrics and Gynecology, Hannover Medical School, Podbielskistrasse 380, D 30659 Hannover, Germany
Anticancer Res 23:4319-24. 2003.... - Number of hysteroscopies and the time interval between hysteroscopy and surgery: influence on peritoneal cytology in patients with endometrial cancerIngolf Juhasz-Böss
Department of Obstetrics and Gynecology, University of Saarland, Kirrbergerstr 100, 66424 Homburg Saar, Germany
Anticancer Res 30:2425-30. 2010..As yet, no data are available showing whether the time interval between hysteroscopy and definitive surgery, or the number of preoperative hysteroscopies, have an influence on the intraperitoneal cytology results... - Mammotome versus ATEC: a comparison of two breast vacuum biopsy techniques under sonographic guidanceMarkus Hahn
Department for Obstetrics and Gynecology, University Hospital of Tuebingen, Calwerstr 7, 72076, Tubingen, Germany
Arch Gynecol Obstet 281:287-92. 2010..The study evaluates the differences between the Mammotome (MT) and ATEC (A) vacuum biopsy (VB) of the breast in terms of diagnostic reliability, biopsy duration and complications... - The PACOVAR-trial: A phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancerMichael Eichbaum
University of Heidelberg Medical School, Department of Gynecology and Obstetrics, Voss Str, 9, 69115 Heidelberg, Germany
BMC Cancer 11:453. 2011..abstract:.. - Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevanceTanja Fehm
Department of Gynecology and Obstetrics, University Tübingen, Tubingen, Germany
Breast Cancer Res 10:S1. 2008..In addition, understanding tumor 'dormancy' and identifying metastatic stem cells might result in the development of new therapeutic concepts... - Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS couplingDino Bullinger
Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, University Hospital Tubingen, Otfried Müller Str, 45, 72076 Tubingen, Germany
BMC Biochem 8:25. 2007.... - Changing levels of circulating tumor cells in monitoring chemotherapy response in patients with metastatic breast cancerAndreas D Hartkopf
Department of Obstetrics and Gynaecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany
Anticancer Res 31:979-84. 2011..The aim of this study was to investigate whether changing CTC levels during the course of chemotherapy treatment would also be useful in monitoring response to treatment... - Image analysis systems for the detection of disseminated breast cancer cells on bone-marrow cytospinsSven Becker
Department of Gynecology and Obstetrics, University of Tubingen, Germany
J Clin Lab Anal 19:115-9. 2005..Using ACIS, we were able to determine the bone marrow status of patients with nonmetastatic breast cancer faster, with greater accuracy, and with greater reproducibility than with the manual technique... - ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereofSarah Schott
Medical School, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, 69115, Germany
Invest New Drugs 29:506-13. 2011.... - Influence of pregnancy on bone density: a risk factor for osteoporosis? Measurements of the calcaneus by ultrasonometryBernhard Kraemer
University Hospital for Women, University of Tuebingen, Calwerstr 7, 72076 Tuebingen, Germany
Arch Gynecol Obstet 285:907-12. 2012..The study aim was to investigate whether there is a significant alteration in maternal bone density during normal pregnancy... - Clinical implications of the detection of circulating tumor cells in breast cancer patientsMalgorzata Banys
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
Biomark Med 6:109-18. 2012..The evaluation of circulating tumor cells may become one of the crucial markers for prediction of survival and therapy monitoring, and its characterization might enable specific targeting of minimal residual, and metastatic disease... - Evaluation of CA125, physical and radiological findings in follow-up of ovarian cancer patientsTanja Fehm
Department of Obstetrics and Gynecology, University of Tuebingen, D - 72076 Tuebingen, Germany
Anticancer Res 25:1551-4. 2005..Imaging techniques did not add clinically relevant information during follow-up and should therefore only be performed prior to surgical or therapeutical intervention... - Lower extremity compartment syndrome after laparoscopic radical hysterectomy: brief report of an unusual complication of laparoscopic positioning requirementsBarbara Lawrenz
Tübingen University Women s Hospital, Tubingen University, Department of Surgery, Tubingen, Germany
J Minim Invasive Gynecol 18:531-3. 2011..We present a case report and review of the existing literature and discuss the main clinical features as well as preventive and therapeutic options... - Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysisChristina S Schuetz
Department of Obstetrics and Gynecology, Microarray Facility, Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
Cancer Res 66:5278-86. 2006.... - Small cell carcinoma of vulva: curative multimodal treatment in face of resistance to initial standard chemotherapyFranziska Eckert
Department of Radiooncology, Eberhard Karls University of Tubingen, Tubingen, Germany
Strahlenther Onkol 186:521-4. 2010..However, of five reported cases of vulvar manifestation only one patient was disease-free at the time of publication with limited follow-up... - Cytotoxic effect of conjugates of doxorubicin and human chorionic gonadotropin (hCG) in breast cancer cellsGerhard Gebauer
Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
Breast Cancer Res Treat 77:125-31. 2003..We conclude that the cytotoxic effect of hCG-doxorubicin conjugates is mediated specifically via the hCG receptor. By using hCG conjugates, the development of more selective cytostatics can be achieved... - The role of smooth muscle in the pathogenesis of pelvic organ prolapse--an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligamentChristl Reisenauer
Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstr 7, 72076 Tuebingen, Germany
Int Urogynecol J Pelvic Floor Dysfunct 19:383-9. 2008..45+/-1.92 microm(2) vs 28.87+/-2.92 microm(2), p<0.05). We conclude that the smooth muscle component of the USL is impaired in POP patients, indicating a possible role of smooth muscle in the pathogenesis of POP... - Oncolytic virotherapy of breast cancerAndreas D Hartkopf
Department of Obstetrics and Gynecology, University Clinic of Tuebingen, Tuebingen, Germany
Gynecol Oncol 123:164-71. 2011.... - Development of a gel-simulation model and generation of standard tables for the complete extirpation of benign breast lesions with vacuum assisted biopsy under ultrasound guidanceUte Krainick-Strobel
Department of Gynaecology and Obstetrics, Breast Centre, University of Tuebingen, Tuebingen, Germany
Ultrasound Med Biol 32:1539-44. 2006..VB is suitable for the removal of benign lesions with a diameter of up to 20 mm... - Fertility preservation in young female lymphoma patients: review of available options and initial experiences with their implementation in clinical routineBarbara Lawrenz
University Women s Hospital, University Hospital Tuebingen, Calwerstrasse 7, Tuebingen, Germany
Onkologie 34:88-93. 2011..Available options are reviewed... - Acute twin-twin transfusion syndrome: a case reportSven Becker
Women s Hospital, Institute of Pathology, Tubingen University, Tubingen, Germany
J Reprod Med 52:953-5. 2007..Antepartum cases of acute TTTS are infrequently described in the literature despite the presence of vascular anastomoses in most monochorionic placentas... - Meconium-stained amniotic fluid--perinatal outcome and obstetrical management in a low-risk suburban populationSven Becker
Universitätsfrauenklinik Tübingen, Tübingen University Medical Center, Calwerstrasse 7, 72076 Tubingen, Germany
Eur J Obstet Gynecol Reprod Biol 132:46-50. 2007..To determine whether amniotic fluid (MSAF) affects obstetrical interventions and immediate perinatal outcome in a low-risk suburban population... - HER2-Positive DTCs/CTCs in Breast CancerAndreas D Hartkopf
Department of Obstetrics and Gynecology, University of Tuebingen, Calwer Strasse 7, 72076, Tuebingen, Germany
Recent Results Cancer Res 195:203-15. 2012..Phenotyping of CTCs/DTCs will thus help to understand mechanism of resistance to HER2-directed therapy. Moreover, patients that are likely to benefit from HER2-directed therapy despite a HER2-negative primary tumor might be identified. .. - Management of fertility preservation in young breast cancer patients in a large breast cancer centreB Lawrenz
Department of Obstetrics and Gynecology, University of Tuebingen, 72076 Tubingen, Germany
Arch Gynecol Obstet 282:547-51. 2010..We present the fertility-preserving procedures performed after routine counselling for primary breast cancer patients in a large certified breast cancer centre... - Oncolytic virotherapy of gynecologic malignanciesAndreas D Hartkopf
Department of Obstetrics and Gynaecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany
Gynecol Oncol 120:302-10. 2011..Here, we provide an overview of different OVs currently being used for virotherapy of gynecologic cancers and discuss challenges and implications for their future development... - Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignantTanja Fehm
Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Clin Cancer Res 8:2073-84. 2002..The pattern of aneusomy matched a clone in the primary tumor in 10 patients. CONCLUSIONS: We conclude that the vast majority of CECs in breast, kidney, prostate, and colon cancer patients are aneusomic and derived from the primary tumor... - Patterns of aneusomy for three chromosomes in individual cells from breast cancer tumorsTanja Fehm
Cancer Immunobiology Center, UT Southwestern Medical Center, Dallas, TX 75390-8576, USA
Breast Cancer Res Treat 75:227-39. 2002.... - Time is an important factor when processing samples for the detection of disseminated tumor cells in blood/bone marrow by reverse transcription-PCRSven Becker
Clin Chem 50:785-6. 2004 - HER-2 gene amplification can be acquired as breast cancer progressesSongdong Meng
Cancer Immunobiology Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 101:9393-8. 2004..e., 37.5% (95% confidence interval of 18.8-59.4%). Four of the 9 patients were treated with Herceptin-containing therapy. One had a complete response and 2 had a partial response... - Circulating tumor cells in patients with breast cancer dormancySongdong Meng
Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8576, USA
Clin Cancer Res 10:8152-62. 2004..Hence, there appears to be a balance between tumor replication and cell death for as long as 22 years in dormancy candidates. We conclude that this is one mechanism underlying tumor dormancy... - Systemic spread is an early step in breast cancerYves Hüsemann
Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg 93053, Germany
Cancer Cell 13:58-68. 2008..Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis... - Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detectionHans Neubauer
University Women's Hospital, , Germany
Electrophoresis 27:1840-52. 2006..This study demonstrates the potential of ProteoTope and LCM to enable extremely sensitive and precise differential analyses from well-defined primary clinical specimen... - A pooled analysis of bone marrow micrometastasis in breast cancerStephan Braun
Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
N Engl J Med 353:793-802. 2005..We assessed the prognostic significance of the presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis... - Proteomic expression profiling of breast cancerHans Neubauer
Universitats Frauenklinik Tubingen, Germany
Recent Results Cancer Res 176:89-120. 2007.... - Tumor size, axillary lymph node status and steroid receptor expression in breast cancer: prognostic relevance 5 years after surgeryGerhard Gebauer
Sidney Kimmel Cancer Center, San Diego, CA, USA
Breast Cancer Res Treat 75:167-73. 2002..To summarize, prognostic factors obtained at the time of surgery can lose their significance with increasing disease-free survival...