M Huynen

Summary

Affiliation: European Molecular Biology Laboratory
Country: Germany

Publications

  1. ncbi The frequency distribution of gene family sizes in complete genomes
    M A Huynen
    Santa Fe Institute, New Mexico, USA
    Mol Biol Evol 15:583-9. 1998
  2. ncbi Measuring genome evolution
    M A Huynen
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany, and Max Delbrück Centrum for Molecular Medicine, 13122 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 95:5849-56. 1998
  3. ncbi Variation and evolution of the citric-acid cycle: a genomic perspective
    M A Huynen
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Trends Microbiol 7:281-91. 1999
  4. ncbi Exploitation of gene context
    M Huynen
    European Molecular Biology Laboratory, Max Delbrück Centrum for Molecular Medicine, Heidelberg, Berlin Buch, 69117, 13122, Germany
    Curr Opin Struct Biol 10:366-70. 2000
  5. ncbi Predicting protein function by genomic context: quantitative evaluation and qualitative inferences
    M Huynen
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genome Res 10:1204-10. 2000
  6. ncbi Inversions and the dynamics of eukaryotic gene order
    M A Huynen
    EMBL, Biocomputing, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Trends Genet 17:304-6. 2001
  7. ncbi Predicting function: from genes to genomes and back
    P Bork
    European Molecular Biology Laboratory, Meyerhofstr 1, Heidelberg, PF 10 2209, Germany
    J Mol Biol 283:707-25. 1998
  8. ncbi Modularity in the gain and loss of genes: applications for function prediction
    T Ettema
    Biocomputing Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Trends Genet 17:485-7. 2001
  9. ncbi Pathway alignment: application to the comparative analysis of glycolytic enzymes
    T Dandekar
    EMBL, P O Box 102209, D 69012 Heidelberg, Germany
    Biochem J 343:115-24. 1999

Detail Information

Publications9

  1. ncbi The frequency distribution of gene family sizes in complete genomes
    M A Huynen
    Santa Fe Institute, New Mexico, USA
    Mol Biol Evol 15:583-9. 1998
    ..e., the probabilities of duplications of genes within a gene family are not independent of each other. Likewise, the probabilities of deletions of genes within a gene family are not independent of each other...
  2. ncbi Measuring genome evolution
    M A Huynen
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany, and Max Delbrück Centrum for Molecular Medicine, 13122 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 95:5849-56. 1998
    ..Finally, we show that some genomes are more highly organized than others: they show a higher degree of the clustering of genes that have orthologs in other genomes...
  3. ncbi Variation and evolution of the citric-acid cycle: a genomic perspective
    M A Huynen
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Trends Microbiol 7:281-91. 1999
    ..Several distinct, incomplete cycles reflect adaptations to different environments. Their distribution over the phylogenetic tree hints at precursors in the evolution of the citric-acid cycle...
  4. ncbi Exploitation of gene context
    M Huynen
    European Molecular Biology Laboratory, Max Delbrück Centrum for Molecular Medicine, Heidelberg, Berlin Buch, 69117, 13122, Germany
    Curr Opin Struct Biol 10:366-70. 2000
    ..This type of information complements functional features that are predicted by classical homology-based search techniques...
  5. ncbi Predicting protein function by genomic context: quantitative evaluation and qualitative inferences
    M Huynen
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genome Res 10:1204-10. 2000
    ..Using a combination of genomic context and homology searches, new functional features can be predicted for 10% of M. genitalium genes...
  6. ncbi Inversions and the dynamics of eukaryotic gene order
    M A Huynen
    EMBL, Biocomputing, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Trends Genet 17:304-6. 2001
    ..Nevertheless, qualitatively interesting examples of conservation of gene order in eukaryotes can be observed...
  7. ncbi Predicting function: from genes to genomes and back
    P Bork
    European Molecular Biology Laboratory, Meyerhofstr 1, Heidelberg, PF 10 2209, Germany
    J Mol Biol 283:707-25. 1998
    ..The final goal will be to elucidate the mapping between genotype and phenotype...
  8. ncbi Modularity in the gain and loss of genes: applications for function prediction
    T Ettema
    Biocomputing Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Trends Genet 17:485-7. 2001
    ..Hence, this can be used to divide predicted clusters of functionally interacting proteins into sub-clusters, and as such, to refine the prediction of their function and functional interactions...
  9. ncbi Pathway alignment: application to the comparative analysis of glycolytic enzymes
    T Dandekar
    EMBL, P O Box 102209, D 69012 Heidelberg, Germany
    Biochem J 343:115-24. 1999
    ..Archaean, bacterial and parasite specific adaptations are identified and described...