P Stawowy

Summary

Affiliation: Deutsches Herzzentrum Berlin
Country: Germany

Publications

  1. ncbi LPS regulate ERK1/2-dependent signaling in cardiac fibroblasts via PKC-mediated MKP-1 induction
    Philipp Stawowy
    Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
    Biochem Biophys Res Commun 303:74-80. 2003
  2. ncbi The molecular biology of furin-like proprotein convertases in vascular remodelling
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, D 13353, Berlin, Germany
    Methods Mol Biol 768:191-206. 2011
  3. ncbi Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Circulation 111:2820-7. 2005
  4. ncbi Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Virchows Arch 446:351-9. 2005
  5. ncbi Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Germany
    Biochem Biophys Res Commun 321:531-8. 2004
  6. ncbi Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, D 13353 Berlin, Germany
    Cardiovasc Res 63:87-97. 2004
  7. ncbi Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Circulation 109:770-6. 2004
  8. ncbi Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Histochem Cell Biol 119:239-45. 2003
  9. ncbi PPAR activators inhibit endothelial cell migration by targeting Akt
    Stephan Goetze
    Department of Medicine Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 293:1431-7. 2002
  10. ncbi Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 296:890-6. 2002

Collaborators

Detail Information

Publications31

  1. ncbi LPS regulate ERK1/2-dependent signaling in cardiac fibroblasts via PKC-mediated MKP-1 induction
    Philipp Stawowy
    Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
    Biochem Biophys Res Commun 303:74-80. 2003
    ..This might be relevant with regard to the decreased MAPK activity and increased levels in MKPs reported during chronic heart failure in humans...
  2. ncbi The molecular biology of furin-like proprotein convertases in vascular remodelling
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, D 13353, Berlin, Germany
    Methods Mol Biol 768:191-206. 2011
    ..In conjunction with the development of novel PC inhibitors, this should facilitate the development of new strategies targeting PCs in cardiovascular disease...
  3. ncbi Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Circulation 111:2820-7. 2005
    ..The present study was done to investigate the function of MT1-MMP as well as furin-like PCs in mononuclear inflammatory cells...
  4. ncbi Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Virchows Arch 446:351-9. 2005
    ..In conclusion, our study demonstrates that furin and PC5 are significantly expressed in mononuclear cells in advanced human atherosclerotic lesions, where they regulate alpha(v) endoproteolytic activation...
  5. ncbi Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Germany
    Biochem Biophys Res Commun 321:531-8. 2004
    ..In conclusion, this study demonstrates that targeting furin-like PCs and thus inhibiting IGF-1R activation is a novel target to inhibit IGF-1-mediated signaling and cell functions, such as IGF-1-induced MT1-MMP/MMP-2 in VSMCs...
  6. ncbi Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, D 13353 Berlin, Germany
    Cardiovasc Res 63:87-97. 2004
    ..The present study was done to investigate the contribution of TGF-beta1 and furin to CFBs MMP-activity and motility...
  7. ncbi Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Circulation 109:770-6. 2004
    ..The aim of this study was to investigate the activation of alpha(v) by PCs in VSMCs and its consequences for alpha(v)-dependent cell functions...
  8. ncbi Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Histochem Cell Biol 119:239-45. 2003
    ..Thus, the present study further supports the concept that activation of alphav integrin occurs in the trans-Golgi network in vascular smooth muscle cells and involves PC5...
  9. ncbi PPAR activators inhibit endothelial cell migration by targeting Akt
    Stephan Goetze
    Department of Medicine Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 293:1431-7. 2002
    ..These results provide first evidence for the antimigratory effects of PPAR-activators in EC. By inhibiting EC migration PPAR-activators may protect the vasculature from pathological alterations associated with metabolic disorders...
  10. ncbi Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 296:890-6. 2002
    ..These results demonstrate that hypoxia enhances adhesion of VSMC on extracellular matrix proteins by activating beta(1)-integrin...
  11. ncbi Angiotensin II-augmented migration of VSMCs towards PDGF-BB involves Pyk2 and ERK 1/2 activation
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Medicine/Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Basic Res Cardiol 97:334-42. 2002
    ....
  12. ncbi TNFalpha inhibits insulin's antiapoptotic signaling in vascular smooth muscle cells
    S Goetze
    Department of Medicine Cardiology, German Heart Institute Berlin, Berlin, 13353, Germany
    Biochem Biophys Res Commun 287:662-70. 2001
    ..Thus, TNFalpha selectively interferes with insulin's antiapoptotic signaling in VSMC by inhibiting the association of IRS-1/PI3K and the downstream activation of Akt...
  13. ncbi High resolution magnetic resonance imaging in atherosclerotic mice treated with ezetimibe
    Thore Dietrich
    Department of Internal Medicine, Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, Berlin, Germany
    Int J Cardiovasc Imaging 25:827-36. 2009
    ..001). MRI demonstrates that ezetimibe significantly reduces atherosclerotic disease in apoE ( -/- ). MRI is therefore a useful technique to perform in vivo interventional studies in experimental atherosclerosis...
  14. ncbi Integrin cleavage facilitates cell surface-associated proteolysis required for vascular smooth muscle cell invasion
    Kai Kappert
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, Berlin, Germany
    Int J Biochem Cell Biol 41:1511-7. 2009
    ..Processing of alphav by furin contributes to the recruitment of enzymatic energy to the cell surface, thereby providing focalized proteolysis associated with VSMC invasion...
  15. ncbi ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions
    Thore Dietrich
    Dept of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Basic Res Cardiol 102:298-307. 2007
    ..This study demonstrates that plaque NIRF imaging is feasible with a novel single chain antibody and that ED-B expression is closely associated with inflammation in experimental atherosclerosis...
  16. ncbi Calculation of individual cardiovascular risk in a primary prevention setting shows a high number of patients with a high risk score
    M Neuss
    Deutsches Herzzentrum Berlin, Klinik für Innere Medizin Kardiologie, Augustenburger Platz 1, 13353 Berlin, Germany
    Z Kardiol 93:413-5. 2004
    ..This indicates that patients with a high cardiovascular risk possibly do not take part in unstructured primary screening events...
  17. ncbi IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling
    Vesna Furundzija
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Biochem Biophys Res Commun 394:786-91. 2010
    ..This involves activation of integrins and focal adhesion formation via inside-out PI3-kinase/PKC/p38-dependent signaling, but does not require MMP activation...
  18. ncbi Integrin cleavage regulates bidirectional signalling in vascular smooth muscle cells
    Kai Kappert
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Thromb Haemost 103:556-63. 2010
    ..Furin- dependent integrin processing modulates rapid adaptive integrin/cytoskeleton changes, essential to VSMC motility, which represents a crucial component in atherosclerosis and restenosis...
  19. ncbi Monitoring therapeutical intervention with ezetimibe using targeted near-infrared fluorescence imaging in experimental atherosclerosis
    Kristof Graf
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Mol Imaging 7:68-76. 2008
    ..05), indicating EZE plaque regression. Targeted NIRF imaging showed a correlation to histologic lesion extension during therapeutical intervention in experimental atherosclerosis...
  20. ncbi Images in cardiovascular medicine. Left ventricular cardiac hemangioma presenting with atypical chest pain
    Mattias Roser
    Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Circulation 117:2958-60. 2008
  21. ncbi Statins regulate alpha2beta1-integrin expression and collagen I-dependent functions in human vascular smooth muscle cells
    Kristof Graf
    Deutsches Herzzentrum Berlin, Department of Medicine Cardiology, Berlin, Germany
    J Cardiovasc Pharmacol 41:89-96. 2003
    ..The current study indicates that HMG-CoA reductase inhibitors increase cell-matrix interaction with collagen I via induction of alpha2beta1-integrins and increased adhesion to collagen I...
  22. ncbi Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands
    Stephan Goetze
    Department of Medicine Cardiology, German Heart Institute Berlin, Germany
    Hypertension 40:748-54. 2002
    ..Moreover, inhibition of leptin-directed migration by the PPARgamma-ligands TRO and CIG through inhibition of Akt underscores their potential in the prevention of diabetes-associated complications...
  23. ncbi Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Germany
    Hypertension 39:399-404. 2002
    ..We show that PDGF-induced PC5 expression is PI3-kinase/p70(s6)-kinase dependent. Thus, growth factors regulate the proprotein convertase PC5, which may play an important role during VSMC growth...
  24. ncbi Insulin augments matrix metalloproteinase-9 expression in monocytes
    Arne Fischoeder
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Cardiovasc Res 73:841-8. 2007
    ..The aim of this study was to investigate the regulation of monocyte MMP-9 by insulin...
  25. ncbi Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Cardiovasc Res 67:50-9. 2005
    ..In the present study we investigated the mechanisms involved in AII-increased adhesion of adult rat cardiac fibroblasts (CFBs), obtained from Sprague-Dawley rats, to collagen I mediated by beta1-integrin...
  26. ncbi Increased myocardial expression of osteopontin in patients with advanced heart failure
    Philipp Stawowy
    Department of Medicine/Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, D-13353, Berlin, Germany
    Eur J Heart Fail 4:139-46. 2002
    ..6+/-2.1 microm in group B; P<0.0001). In conclusion, the present study indicates, that factors and/or mechanisms involved in heart failure in patients with dilated cardiomyopathy, lead to induction of OP expression in humans...
  27. ncbi Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation
    Kai Kappert
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, Berlin, Germany
    Hypertension 54:738-43. 2009
    ..Our data show that sufficient serum levels of EXP3179 are present under losartan treatment. PPARgamma activation by AT1R-blockers may translate into synergistic beneficial actions in monocytes...
  28. ncbi Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels
    Philipp Stawowy
    J Mol Med 83:865-75. 2005
    ..Targeting these PCs may provide future anti-atherosclerotic therapies...
  29. ncbi Insulin facilitates monocyte migration: a possible link to tissue inflammation in insulin-resistance
    Kai Kappert
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Hessische Str 3 4, D 10115 Berlin, Germany
    Biochem Biophys Res Commun 365:503-8. 2008
    ....
  30. ncbi Cardiac benefits of mineralocorticoid receptor inhibition in renal failure
    Kristof Graf
    Hypertension 52:209-10. 2008
  31. ncbi Osteopontin: a protective mediator of cardiac fibrosis?
    Kristof Graf
    Hypertension 44:809-10. 2004