Thomas Christoph

Summary

Country: Germany

Publications

  1. ncbi Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain
    Thomas Christoph
    Grunenthal GmbH, Global Preclinical Research and Development, Department of Pharmacology, Zieglerstrasse 6, 52078 Aachen, Germany
    Eur J Pharmacol 666:72-9. 2011
  2. ncbi Tapentadol, but not morphine, selectively inhibits disease-related thermal hyperalgesia in a mouse model of diabetic neuropathic pain
    Thomas Christoph
    Global Preclinical Research and Development, Grunenthal GmbH, Aachen, Germany
    Neurosci Lett 470:91-4. 2010
  3. ncbi Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice
    Thomas Christoph
    Preclinical Research and Development, Department of Pharmacology, Grünenthal, Zieglerstrasse 6, 52078 Aachen, Germany
    Mol Cell Neurosci 37:579-89. 2008
  4. ncbi (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties
    Thomas M Tzschentke
    Department of Pharmacology, Grunenthal GmbH, Aachen, Germany
    J Pharmacol Exp Ther 323:265-76. 2007
  5. ncbi Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1
    Thomas Christoph
    Research and Development, Grunenthal GmbH, Zieglerstr 6, 52078 Aachen, Germany
    Neurochem Int 50:281-90. 2007
  6. ncbi The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism
    Thomas Christoph
    Department of Pharmacology, , Zieglerstrasse 6, 52078 Aachen, Germany
    Neuropharmacology 51:12-7. 2006
  7. ncbi Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule
    Thomas M Tzschentke
    Grunenthal GmbH, Aachen, Germany
    Drugs Today (Barc) 45:483-96. 2009
  8. ncbi Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain
    Wolfgang Schroder
    Grunenthal GmbH, Global Preclinical Research and Development, Department of Pharmacology, Aachen, Germany
    Eur J Pain 14:814-21. 2010
  9. ncbi Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models
    Thomas Christoph
    Biomedical Research, Grunenthal GmbH, Aachen, Germany
    Drugs R D 8:51-7. 2007
  10. ncbi Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms
    Thomas Christoph
    Department of Pharmacology, , Zieglerstr. 6, 52078 Aachen, Germany
    Brain Res 1048:218-27. 2005

Detail Information

Publications16

  1. ncbi Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain
    Thomas Christoph
    Grunenthal GmbH, Global Preclinical Research and Development, Department of Pharmacology, Zieglerstrasse 6, 52078 Aachen, Germany
    Eur J Pharmacol 666:72-9. 2011
    ....
  2. ncbi Tapentadol, but not morphine, selectively inhibits disease-related thermal hyperalgesia in a mouse model of diabetic neuropathic pain
    Thomas Christoph
    Global Preclinical Research and Development, Grunenthal GmbH, Aachen, Germany
    Neurosci Lett 470:91-4. 2010
    ..It is hypothesized that this superior efficacy profile of tapentadol is due to simultaneous activation of MOR and inhibition of NA reuptake...
  3. ncbi Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice
    Thomas Christoph
    Preclinical Research and Development, Department of Pharmacology, Grünenthal, Zieglerstrasse 6, 52078 Aachen, Germany
    Mol Cell Neurosci 37:579-89. 2008
    ..The present study provides further evidence for the relevance of TRPV1 in neuropathic pain and characterizes RNA interference as valuable technique for drug target validation in pain research...
  4. ncbi (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties
    Thomas M Tzschentke
    Department of Pharmacology, Grunenthal GmbH, Aachen, Germany
    J Pharmacol Exp Ther 323:265-76. 2007
    ..It is suggested that the broad analgesic profile of tapentadol and its relative resistance to tolerance development may be due to a dual mode of action consisting of both MOR activation and NE reuptake inhibition...
  5. ncbi Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1
    Thomas Christoph
    Research and Development, Grunenthal GmbH, Zieglerstr 6, 52078 Aachen, Germany
    Neurochem Int 50:281-90. 2007
    ....
  6. ncbi The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism
    Thomas Christoph
    Department of Pharmacology, , Zieglerstrasse 6, 52078 Aachen, Germany
    Neuropharmacology 51:12-7. 2006
    ..Development of short-acting NMDA antagonists could represent a strategy for improving their tolerability...
  7. ncbi Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule
    Thomas M Tzschentke
    Grunenthal GmbH, Aachen, Germany
    Drugs Today (Barc) 45:483-96. 2009
    ....
  8. ncbi Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain
    Wolfgang Schroder
    Grunenthal GmbH, Global Preclinical Research and Development, Department of Pharmacology, Aachen, Germany
    Eur J Pain 14:814-21. 2010
    ....
  9. ncbi Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models
    Thomas Christoph
    Biomedical Research, Grunenthal GmbH, Aachen, Germany
    Drugs R D 8:51-7. 2007
    ..The effects of tramadol, an atypically acting analgesic with a combined opioid and monoaminergic mechanism of action, and morphine, a prototypical opioid, were tested in rat models of neuropathic and nociceptive pain...
  10. ncbi Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms
    Thomas Christoph
    Department of Pharmacology, , Zieglerstr. 6, 52078 Aachen, Germany
    Brain Res 1048:218-27. 2005
    ..Thus, peripheral NMDA receptors may substantially contribute to the efficacy of NMDA antagonists in neuropathic pain...
  11. ncbi Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo
    Thomas Christoph
    Research and Development, Grunenthal GmbH, Aachen, Germany
    Biochem Biophys Res Commun 350:238-43. 2006
    ..Our data demonstrate that TRPV1 antagonists, including TRPV1 siRNAs, have potential in the treatment of both, neuropathic and visceral pain...
  12. ncbi The antinociceptive and antihyperalgesic effect of tapentadol is partially retained in OPRM1 (?-opioid receptor) knockout mice
    Babette Kogel
    Grunenthal GmbH, Global Preclinical Research and Development, Department of Pharmacology, Zieglerstrasse 6, 52078 Aachen, Germany
    Neurosci Lett 491:104-7. 2011
    ....
  13. ncbi Semi-mechanistic pharmacokinetic/pharmacodynamic modelling of the antinociceptive response in the presence of competitive antagonism: the interaction between tramadol and its active metabolite on micro-opioid agonism and monoamine reuptake inhibition, in
    Horst Beier
    Department of Pharmacokinetics, Grunenthal GmbH, 52078, Aachen, Germany
    Pharm Res 25:1789-97. 2008
    ....
  14. ncbi Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain
    Thomas Christoph
    Department of Pharmacology, Grünenthal GmbH Research and Development, Zieglerstrasse 6, D 52078 Aachen, Germany
    Eur J Pharmacol 507:87-98. 2005
    ..055 and 0.036 mg/kg i.v. and 0.129 and 0.038 mg/kg i.p., respectively). It is concluded that buprenorphine shows a broad analgesic profile and offers the opportunity to treat different pain conditions, including neuropathic pain...
  15. ncbi Actions of tramadol on micturition in awake, freely moving rats
    Raj Kumar Pandita
    Department of Clinical Pharmacology, Lund University Hospital, Lund, , Aachen, Germany
    Br J Pharmacol 139:741-8. 2003
    ..7 (+/-)-Tramadol effectively inhibits micturition in conscious rats by stimulating micro -opioid receptors. A synergy between opioid receptor stimulation and monoamine reuptake inhibition may contribute to the micturition effects...