Research Topics
| F KieferSummaryAffiliation: Central Institute of Mental Health Country: Germany Publications
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Detail Information
Publications
Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapyFalk Kiefer
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J 5, 68159 Mannheim, Germany
Curr Pharm Des 16:2098-102. 2010..To increase the efficacy of this drug, targeted treatment and individualized therapy approaches seem useful and necessary...- Association of leptin with food cue-induced activation in human reward pathwaysMartin Grosshans
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, J5 68159 Mannheim, Germany
Arch Gen Psychiatry 69:529-37. 2012..Whereas the hypothalamic regulation of energy homeostasis by endocrine feedback signals has been widely investigated, its interplay with mesolimbic reward-associated pathways represents a rich field of future research... - Hypothalamic-pituitary-adrenocortical axis activity: a target of pharmacological anticraving treatment?Falk Kiefer
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Biol Psychiatry 60:74-6. 2006..We examined the relationship between efficacy of pharmacological anticraving treatment and HPA axis activity in the relapse prevention treatment of alcoholism... - [Evidence-based treatment of alcoholism]F Kiefer
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg, J5, 68159 Mannheim
Nervenarzt 78:1321-9; quiz 1330-1. 2007.... - Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexoneFalk Kiefer
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Germany
Addict Biol 13:124-9. 2008..It is discussed whether especially these subjects should be targeted for pharmacological relapse prevention treatment with naltrexone... - [Diagnostics and therapy of alcohol addiction]F Kiefer
, , Mannheim, Germany
Fortschr Neurol Psychiatr 75:33-46. 2007 - Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preferenceFalk Kiefer
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
Neurosci Lett 404:103-6. 2006.... - Complete suppression of craving in alcohol-dependent individuals: is it possible?Falk Kiefer
Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim 68159, Germany
CNS Drugs 23:361-7. 2009..Nevertheless, subgroups that carry specific characteristics associated with single receptor dysfunction might benefit from a targeted treatment. Further research is needed to enable clinicians to detect these subgroups... - [What can addiction research contribute towards the understanding of obesity?]F Kiefer
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim, Universitat Heidelberg, J5, 68159, Mannheim, Deutschland
Nervenarzt 80:1040-9. 2009..The relevance of this topic for general psychiatry is reflected by the fact that including obesity in the psychiatric chapters of disease classification systems is currently being discussed... - Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosateF Kiefer
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
Pharmacogenomics J 11:368-74. 2011..These results could help to identify those alcohol-dependent patients who may be at an increased risk of relapse and who may better respond to treatment with acamprosate... - [Neurobiology and genetics of addiction]F Kiefer
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim, Universitat Heidelberg, J5, 68159, Mannheim, Deutschland
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53:284-8. 2010..Genetic factors modulate the individual vulnerability. The challenge of future research will be to generate more efficient and individualized therapies based on the insights from neurobiology and genetics... - [Advances in the treatment of alcohol dependence: pharmacological relapse prevention]M N Smolka
, , Mannheim
MMW Fortschr Med 145:65-9. 2003..The medical treatment, however, is not a replacement for a psychosocial treatment of the alcohol dependence, but should be accompanied by counselling and the attendance in self help groups... - Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memoriesChristoph von der Goltz
Department of Addictive Behaviour and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Psychopharmacology (Berl) 205:389-97. 2009..The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval... - Supervised disulfiram in relapse prevention in alcohol-dependent patients suffering from comorbid borderline personality disorder--a case seriesJochen Mutschler
1Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
Alcohol Alcohol 45:146-50. 2010..We examined the safety and efficacy in relapse prevention of a series of alcoholics with borderline personality disorder (BPD)... - [Pharmacology of disulfiram - an update]J Mutschler
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
Fortschr Neurol Psychiatr 76:225-31. 2008..As an example we demonstrate a case, in which an acute neurological deficit was misjudged as a side effect of Disulfiram. Furthermore, the potential of Disulfiram as a promising treatment in addiction medicine will be discussed... - [Psychosocial treatment plus drug prophylaxis. Fewer recurrences after alcohol withdrawal]M N Smolka
, , , J5, D-68159 Mannheim
MMW Fortschr Med 145:45. 2003 - Disulfiram, an option for the treatment of pathological gambling?Jochen Mutschler
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany
Alcohol Alcohol 45:214-6. 2010..Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling... - Rivastigmine reduces tobacco craving in alcohol-dependent smokersA Diehl
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health Mannheim, University of Heidelberg, Square J 5, Mannheim 68159, Germany
Pharmacopsychiatry 42:89-94. 2009..Although alcohol-dependent smokers represent an important group for applying smoking interventions, a sufficient pharmacotherapy has not been established in this high-risk group so far... - Acamprosate: recent findings and future research directionsKarl Mann
The Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health University of Heidelberg, Mannheim, Germany
Alcohol Clin Exp Res 32:1105-10. 2008..Further research should target the definition of subgroups applying endophenotypic approaches, e.g. by detecting a hyperglutamatergic syndrome using MR spectroscopy... - D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in ratsValentina Vengeliene
Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
Alcohol Alcohol 43:626-9. 2008..The aim of the present study was to examine the influence of partial NMDA receptor agonist d-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour... - An integrated genome research network for studying the genetics of alcohol addictionRainer Spanagel
Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
Addict Biol 15:369-79. 2010.... - [Recent results in relaps prevention of alcoholism with Disulfiram]Jochen Mutschler
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
Neuropsychiatr 22:243-51. 2008..It acts as a psychological deterrence of a possible disulfiram-alcohol reaction. This paper describes the current clinical impact and possible future of disulfiram... - Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptorsJochen Mutschler
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany
Alcohol Alcohol 45:13-6. 2010..We now present first data on alcohol drinking behaviour in mice lacking a functional natriuretic peptide-A (NPR-A) receptor... - [A new pharmacological treatment option for alcohol dependence discovered in transnational study: neurokinin-1 receptor antagonist as a possible therapy for alcoholism?]Jochen Mutschler
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
Neuropsychiatr 22:283-5. 2008..They could demonstrate that either the blockade of the receptor, or the lack of the receptors leds to a decreased alcohol intake as well as reduced alcohol tolerance and craving concomitantly accompanied by improved general well-beeing... - Searching for responders to acamprosate and naltrexone in alcoholism treatment: rationale and design of the PREDICT studyKarl Mann
Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Alcohol Clin Exp Res 33:674-83. 2009..The study follows the assessment methods, treatments, and medications used in the U.S. based COMBINE study, which will allow for a direct comparison between this U.S. study trial and a study performed in Europe... - Orexin and leptin are associated with nicotine craving: a link between smoking, appetite and rewardChristoph von der Goltz
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, Square J5, 68159 Mannheim, Germany
Psychoneuroendocrinology 35:570-7. 2010..The aim of this study was to examine the possible association between orexin and leptin, and nicotine craving in smokers in a clinical case-control study under standardized conditions... - Avoidance of alcohol-related stimuli increases during the early stage of abstinence in alcohol-dependent patientsSabine Vollstädt-Klein
Department of Addictive Behaviour and Addiction Medicine at the University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
Alcohol Alcohol 44:458-63. 2009..Furthermore, we investigated the influence of pre-treatment alcohol consumption and abstinence duration onto alcohol-related attentional bias... - Attentional bias in alcohol-dependent patients: the role of chronicity and executive functioningSabine Loeber
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Addict Biol 14:194-203. 2009..Our results indicate that differences with regard to drinking-related variables as well as cognitive functioning seem to modulate attentional bias and need to be taken into account in models of drinking maintenance... - Drugs for relapse prevention of alcoholism: ten years of progressRainer Spanagel
Department of Psychopharmacology and Department of Addictive Behaviour and Addiction Medicine at the Central Institute of Mental Health, Mannheim, Germany
Trends Pharmacol Sci 29:109-15. 2008..However, the heterogeneity in treatment response makes it necessary to characterize genetic and protein markers and endophenotypes for individualized pharmacotherapy... - Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholismFalk Kiefer
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
J Psychiatr Res 39:545-51. 2005..Moreover, there are hints for an interaction between pharmacological anti-craving treatment, plasma concentration of leptin, and abstinence duration... - New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependenceFalk Kiefer
University of Heidelberg, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, CIMH, J5, D 68159 Mannheim, Germany
Eur J Pharmacol 526:163-71. 2005..New compounds are under investigation. This review discusses the neurobiological basis of alcohol addiction, pharmacological targets for relapse prevention treatment and pre-clinical and clinical results with the most promising drugs... - Pharmacological relapse prevention of alcoholism: clinical predictors of outcomeFalk Kiefer
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Heidelberg, Germany
Eur Addict Res 11:83-91. 2005..The efficacy of pharmacological relapse prevention in alcoholism with acamprosate and naltrexone has been supported by several controlled trials. It remains uncertain whether any differential indication for treatment exists... - The effect of pictorial warnings on cigarette packages on attentional bias of smokersSabine Loeber
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
Pharmacol Biochem Behav 98:292-8. 2011.... - [Illegal purchase of psychotropic drugs from the internet]J Mutschler
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Quadrat J 5, 68159 Mannheim
Nervenarzt 78:818-20. 2007.... - [Treatment outcome after inpatient alcohol withdrawal: impact of motivational interventions: a comparative study]S Loeber
Klinik für Abhängiges Verhalten und Suchtmedizin, Lehrstuhl für Suchtforschung, Zentralinstitut fur Seelische Gesundheit, J5, 68159, Mannheim, Deutschland
Nervenarzt 80:1085-92. 2009.... - [Learning and memory in the pathogenesis of addiction]C von der Goltz
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, J5, 68159, Mannheim, Deutschland
Nervenarzt 79:1006-16. 2008..The challenge of future research is to determine which drug-induced adaptations are relevant to the pathophysiology of addiction and to generate more efficient therapies for extinction of addiction-associated cognitions and behavior... - Consultation-liaison psychiatry in general hospitals: improvement in physicians' detection rates of alcohol use disordersAlexander Diehl
Department of Addictive Behavior and Addiction Medicine, Division of Biostatistics, Central Institute of Mental Health, Mannheim, University of Heidelberg, Mannheim, Germany
Psychosomatics 50:599-604. 2009..In the general hospital setting, alcohol-use disorders very commonly remain undetected... - Extended-release intramuscular naltrexone: a viewpoint by Falk KieferFalk Kiefer
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Drugs 66:1752-3. 2006 - [Methylphenidate. Therapy option for adults with ADHD and comorbid substance use disorder?]G Paslakis
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg, J5, 68159, Mannheim
Nervenarzt 81:277-88. 2010.... - Genome-wide association study of alcohol dependenceJens Treutlein
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
Arch Gen Psychiatry 66:773-84. 2009..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder... - Learning and memory in the aetiopathogenesis of addiction: future implications for therapy?Christoph von der Goltz
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
Eur Arch Psychiatry Clin Neurosci 259:S183-7. 2009.... - Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trialHolger Jahn
Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
Arch Gen Psychiatry 61:1235-44. 2004..Inhibitors of steroid synthesis have been reported to exert antidepressive effects, according to preliminary findings... - Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled studyFalk Kiefer
Department of Psychiatry, University Hospital of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
Arch Gen Psychiatry 60:92-9. 2003..Since it remains uncertain whether both substances are equally efficient and whether a combination of both drugs potentiates the efficacy, we conducted the first published controlled study comparing and combining both compounds... - Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyraponeHolger Jahn
Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
Sleep 26:823-9. 2003.... - Combined therapy: what does acamprosate and naltrexone combination tell us?Falk Kiefer
Department of Psychiatry, University Hospital of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
Alcohol Alcohol 39:542-7. 2004..It remains to be answered whether data justify the combination of both drugs in clinical practice... - Suppression of the HPA axis stress-response: implications for relapseByron Adinoff
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
Alcohol Clin Exp Res 29:1351-5. 2005..Alterations in HPA axis responsivity may therefore have a negative impact upon clinical outcome in alcohol-dependent subjects, and disinhibition of the axis with medication may have therapeutic potential... - HPA-axis activity in alcoholism: examples for a gene-environment interactionToni Kim Clarke
Section of Addiction Biology, Institute of Psychiatry, King s College, London, UK
Addict Biol 13:1-14. 2008.... - Alcohol self-administration, craving and HPA-axis activity: an intriguing relationshipFalk Kiefer
Psychopharmacology (Berl) 164:239-40. 2002 - Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyraponeChristian Otte
Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
Biol Psychiatry 60:784-7. 2006..Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD)... - Is withdrawal-induced anxiety in alcoholism based on beta-endorphin deficiency?Falk Kiefer
Department of Psychiatry, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
Psychopharmacology (Berl) 162:433-7. 2002..During alcohol withdrawal, a decreased secretion of beta E with a delayed normalization has been reported, but up to now only few data became available regarding the interaction of plasma beta E and psychopathological parameters... - Characterization of the facial expression of emotions in schizophrenia patients: preliminary findings with a new electromyography methodKarsten Wolf
Department of Psychiatry and Psychotherapy, University Hospital of Hamburg, Germany
Can J Psychiatry 51:335-41. 2006..We investigated facial expression of emotions (FEE) in schizophrenia patients, using an improved and highly selective facial electromyography (EMG) method, and we examined the correlation between FEE and psychopathology... - Measuring alcohol consumption in man--it is time for a changeFalk Kiefer
Addiction 101:1215-6; author reply 1216-7. 2006 - Pharmacotherapy and behavioral intervention for alcohol dependenceFalk Kiefer
JAMA 296:1727-8; author reply 1728-9. 2006 - Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanolFalk Kiefer
Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany
Biol Psychiatry 53:345-51. 2003.... - Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trialBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Arch Intern Med 168:1188-99. 2008..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being... - Adjunctive use of reboxetine in schizophreniaThomas J Raedler
University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martini str 52, 20246 Hamburg, Germany
Eur Psychiatry 19:366-9. 2004..We sought to study the efficacy and tolerability of the adjunctive use of reboxetine in a cohort of schizophrenic patients with prominent depressive or negative symptoms...