Research Topics
| Anne Claude GavinSummaryAffiliation: Cellzome AG Country: Germany Publications
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Detail Information
Publications
Functional organization of the yeast proteome by systematic analysis of protein complexesAnne Claude Gavin
Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nature 415:141-7. 2002..This higher-order map contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery...- Protein complexes and proteome organization from yeast to manAnne Claude Gavin
Cellzome AG, Meyerhofstrasse 1 69117 Heidelberg, Germany
Curr Opin Chem Biol 7:21-7. 2003..Recent proteome-wide studies provide insight into the properties of cellular protein complexes, their modular nature, their interaction with other complexes and the resulting preliminary organization chart of the proteome... - Proteome survey reveals modularity of the yeast cell machineryAnne-Claude Gavin
Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nature 440:631-6. 2006..This study provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling... - Interaction networks for systems biologySamuel Bader
EMBL, Structural and Computational Biology Unit, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
FEBS Lett 582:1220-4. 2008..The aim of this review is to provide a short overview of the most promising contributions of interaction networks to human biology, structural biology and human genetics... - The social network of a cell: recent advances in interactome mappingSebastian Charbonnier
EMBL, Structural and Computational Biology Unit, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Biotechnol Annu Rev 14:1-28. 2008..The adaptation of these technologies to the large-scale measurement of biomolecular interactions in (semi-)quantitative terms represents an important challenge... - Keystone symposia: proteomics and bioinformatics and systems and biologyAnne-Claude Gavin
Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Expert Rev Proteomics 2:291-3. 2005 - Recent advances in charting protein-protein interaction: mass spectrometry-based approachesAnne Claude Gavin
EMBL, Meyerhofstrasse 1, Heidelberg, Germany
Curr Opin Biotechnol 22:42-9. 2011..In this review, we focus on recent developments in a suite of methods that enable the purification of protein complexes under native conditions and, in conjunction with protein mass spectrometry, identification of their constituents... - Proteome organization in a genome-reduced bacteriumSebastian Kühner
European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Science 326:1235-40. 2009..The data set provides a blueprint of the minimal cellular machinery required for life... - A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathwayTewis Bouwmeester
Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nat Cell Biol 6:97-105. 2004..This systems approach provides significant insight into the logic of the TNF-alpha/NF-kappa B pathway and is generally applicable to other pathways relevant to human disease... - 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factorsPaola Grandi
Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany
Mol Cell 10:105-15. 2002..We conclude that the 40S synthesis machinery predominately associates with the 35S pre-rRNA factors, whereas factors required for 60S subunit synthesis largely bind later, showing an unexpected dichotomy in binding... - Drug target identification using side-effect similarityMonica Campillos
European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Science 321:263-6. 2008..Nine of these were tested and confirmed in cell assays, documenting the feasibility of using phenotypic information to infer molecular interactions and hinting at new uses of marketed drugs... - Meeting report on the 7th World Congress of the Human Proteome Organization (HUPO) in Amsterdam: Proteome BiologyAnne Claude Gavin
European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Mol Cell Proteomics 7:2288-91. 2008..More than 60 nationalities were represented at the meeting... - Structure-based assembly of protein complexes in yeastPatrick Aloy
European Molecular Biology Laboratory, Structural and Computational Biology Programme, 1, 69117 Heidelberg, Germany
Science 303:2026-9. 2004..We also consider interactions between complexes (cross-talk) and use these to construct a structure-based network of molecular machines in the cell... - A complex prediction: three-dimensional model of the yeast exosomePatrick Aloy
EMBL, Meyerhofstrasse, Heidelberg, Germany
EMBO Rep 3:628-35. 2002..The model suggests numerous experiments to probe exosome function, particularly with respect to subunits making direct atomic contacts and conserved, possibly functional residues within the predicted central pore of the complex... - The minimum information required for reporting a molecular interaction experiment (MIMIx)Sandra Orchard
European Molecular Biology Laboratory EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
Nat Biotechnol 25:894-8. 2007.... - New perspectives on an old disease: proteomics in cancer researchOriol Gallego
Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
Genome Biol 8:303. 2007 - Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junctionTatiana Cheusova
Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
Genes Dev 20:1800-16. 2006..This is the first description of a regulatory cross-talk between MuSK and CK2 and of a role for the KI of the receptor tyrosine kinase MuSK for the development of subsynaptic specializations...