F Breuckmann

Summary

Country: Germany

Publications

  1. ncbi Fibromatosis of the hand associated with EMO syndrome: a case report
    Carolin Appelhans
    Dept, of Dermatology, Ruhr University Bochum, Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Dermatol 4:17. 2004
  2. ncbi UVA/UVA1 phototherapy and PUVA photochemotherapy in connective tissue diseases and related disorders: a research based review
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    BMC Dermatol 4:11. 2004
  3. ncbi UVA1-induced decrease in dermal neuron-specific enolase (NSE) in acrosclerosis
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 296:182-4. 2004
  4. ncbi Modulation of endothelial dysfunction and apoptosis: UVA1-mediated skin improvement in systemic sclerosis
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 296:235-9. 2004
  5. ncbi Mechanisms of apoptosis: UVA1-induced immediate and UVB-induced delayed apoptosis in human T cells in vitro
    F Breuckmann
    Department of Dermatology, Ruhr University Bochum, Germany
    J Eur Acad Dermatol Venereol 17:418-29. 2003
  6. ncbi Efficacy of ultraviolet A1 phototherapy on the expression of bcl-2 in atopic dermatitis and cutaneous T-cell lymphoma in vivo: a comparison study
    F Breuckmann
    Department of Dermatology, Clinical and Experimental Photodermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Photodermatol Photoimmunol Photomed 18:217-22. 2002
  7. ncbi Apoptosis of human dermal endothelial cells as a potential side effect following therapeutic administration of UVA1 irradiation: preliminary results
    Frank Breuckmann
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 294:303-9. 2002
  8. ncbi Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:12. 2002
  9. ncbi Mononuclear cells in atopic dermatitis in vivo: immunomodulation of the cutaneous infiltrate by medium-dose UVA1 phototherapy
    F Breuckmann
    Department of Dermatology, Ruhr University Bochum, Germany
    Eur J Med Res 7:315-22. 2002
  10. ncbi Immunohistochemical investigations and introduction of new therapeutic strategies in scleromyxoedema: case report
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 4:12. 2004

Detail Information

Publications18

  1. ncbi Fibromatosis of the hand associated with EMO syndrome: a case report
    Carolin Appelhans
    Dept, of Dermatology, Ruhr University Bochum, Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Dermatol 4:17. 2004
    ..EMO syndrome, defined as a triad including exophthalmus, pretibial myxedema and osteoarthropathia, is a rare condition in patients suffering from hyperthyreosis...
  2. ncbi UVA/UVA1 phototherapy and PUVA photochemotherapy in connective tissue diseases and related disorders: a research based review
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    BMC Dermatol 4:11. 2004
    ..Nevertheless, controlled studies investigating the efficacy of UVA irradiation in connective tissue diseases and related disorders are rare...
  3. ncbi UVA1-induced decrease in dermal neuron-specific enolase (NSE) in acrosclerosis
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 296:182-4. 2004
    ..Even though the origin and the functional mechanisms remain obscure, NSE might be relevant directly within sclerotic skin lesions and may possibly be used as a diagnostic marker at least in SSc-associated acrosclerotic skin...
  4. ncbi Modulation of endothelial dysfunction and apoptosis: UVA1-mediated skin improvement in systemic sclerosis
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 296:235-9. 2004
    ..Our results suggest that UVA1 irradiation exerts its positive effects by a modulation of endothelial regulation/transformation beside the proposed induction of T cell apoptosis and collagenases...
  5. ncbi Mechanisms of apoptosis: UVA1-induced immediate and UVB-induced delayed apoptosis in human T cells in vitro
    F Breuckmann
    Department of Dermatology, Ruhr University Bochum, Germany
    J Eur Acad Dermatol Venereol 17:418-29. 2003
    ..The purpose of our study was to determine the regulating pathway, time course and dose dependence of UVA1- vs. UVB-induced cell death in human T lymphocytes...
  6. ncbi Efficacy of ultraviolet A1 phototherapy on the expression of bcl-2 in atopic dermatitis and cutaneous T-cell lymphoma in vivo: a comparison study
    F Breuckmann
    Department of Dermatology, Clinical and Experimental Photodermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Photodermatol Photoimmunol Photomed 18:217-22. 2002
    ..Furthermore, we investigated whether medium-dose ultraviolet A1 (UVA1) phototherapy is able to modulate the expression of bcl-2 within the dermal inflammatory infiltrate...
  7. ncbi Apoptosis of human dermal endothelial cells as a potential side effect following therapeutic administration of UVA1 irradiation: preliminary results
    Frank Breuckmann
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 294:303-9. 2002
    ..Whereas the p53-positive endothelial cells underwent programmed cell death as demonstrated by M30, ISEL and Hoechst 33342, some fibroblasts seemed to accumulate the p53 antibody, but this did not induce apoptotic cascades...
  8. ncbi Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 2:12. 2002
    ..The purpose of our study was to investigate to what extent UVA1 irradiation is able to modulate the status of protease activity by the use of a monoclonal antibody labeling cathepsin G...
  9. ncbi Mononuclear cells in atopic dermatitis in vivo: immunomodulation of the cutaneous infiltrate by medium-dose UVA1 phototherapy
    F Breuckmann
    Department of Dermatology, Ruhr University Bochum, Germany
    Eur J Med Res 7:315-22. 2002
    ..The purpose of our study was to investigate the extent to which UVA1 irradiation is able to modulate the mononuclear dermal inflammatory infiltrate using different monoclonal antibodies...
  10. ncbi Immunohistochemical investigations and introduction of new therapeutic strategies in scleromyxoedema: case report
    Frank Breuckmann
    Department of Dermatology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Dermatol 4:12. 2004
    ..Even though different casuistic treatment modalities have been described, to date, curing still seems to be impossible...
  11. ncbi Opposing effects of UVA1 phototherapy on the expression of bcl-2 and p53 in atopic dermatitis
    F Breuckmann
    Department of Dermatology, Ruhr-University, Bochum, Germany
    Arch Dermatol Res 293:178-83. 2001
    ..In summary, medium-dose UVA1 irradiation led to a marked modulation of the expression of p53 and bcl-2, and this plays a key role in regulating UVA1-induced apoptosis...
  12. ncbi Unilateral generalized morphea is a rare variant of localized scleroderma
    C Appelhans
    Department of Dermatology, Ruhr-University Bochum, Gudrunstr. 56, D-44791 Bochum, Germany
    Eur J Med Res 11:152-6. 2006
    ..Treatment with combined low-dose methotrexate and pulsed high-dose corticosteroid therapy might represent a promising treatment option for UGM...
  13. ncbi Immunohistochemical investigation of mid-dermal elastolysis
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Clin Exp Dermatol 29:192-5. 2004
    ..Our data may indicate inflammatory processes and an altered balance between MMPs and TIMPs in MDE. Furthermore CD34+ dendritic fibroblasts and/or histiocytes are possibly involved in the pathogenesis of MDE...
  14. ncbi Ultraviolet A1 phototherapy decreases inhibitory SMAD7 gene expression in localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Dermatol Res 298:265-72. 2006
    ..UVA1 phototherapy demonstrated the alteration of SMAD7 gene expression in LS, as SMAD7 mRNA levels normalized after UVA1. The pathogenetic relevance of SMAD7 levels with respect to clinical improvement needs further investigation...
  15. ncbi Low-dose UVA1 phototherapy in systemic sclerosis: effects on acrosclerosis
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany
    J Am Acad Dermatol 50:740-7. 2004
    ..CONCLUSION: Low-dose UVA1 phototherapy is a capable treatment option for acrosclerosis. Its beneficial effect may be mediated by the induction of collagenases and a reduction of collagen deposition and cellular infiltration...
  16. ncbi Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol 141:847-52. 2005
    ..To evaluate the efficacy of pulsed high-dose corticosteroids combined with orally administered low-dose methotrexate therapy in patients with severe localized scleroderma (LS)...
  17. ncbi Medium-dose ultraviolet A1 phototherapy in transient acantholytic dermatosis (Grover's disease)
    Frank Breuckmann
    J Am Acad Dermatol 52:169-70. 2005
  18. ncbi Narrowband UVB phototherapy in skin conditions beyond psoriasis
    Thilo Gambichler
    Department of Dermatology, Oldchurch Hospital, London, United Kingdom
    J Am Acad Dermatol 52:660-70. 2005
    ..However, the role of NB UVB seems to be less clear in the management of skin conditions beyond psoriasis...