Norbert H Hauel

Summary

Affiliation: Boehringer Ingelheim Pharma KG
Country: Germany

Publications

  1. ncbi Structure-based design of novel potent nonpeptide thrombin inhibitors
    Norbert H Hauel
    Boehringer Ingelheim Pharma KG, Research Division, Birkendorfer Strasse 65, D 88397 Biberach Riss, Germany
    J Med Chem 45:1757-66. 2002
  2. ncbi Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives
    Uwe J Ries
    Department of Chemical Research, Boehringer Ingelheim Pharma KG, Birkendorfer Strasse 65, D 88397, Biberach Riss, Germany
    Bioorg Med Chem Lett 13:2291-5. 2003
  3. ncbi Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents
    Uwe J Ries
    Department of Chemical Research, Boehringer Ingelheim Pharma KG, Birkendorfer Strasse 65, D 88397, Biberach Riss, Germany
    Bioorg Med Chem Lett 13:2297-302. 2003

Collaborators

Detail Information

Publications3

  1. ncbi Structure-based design of novel potent nonpeptide thrombin inhibitors
    Norbert H Hauel
    Boehringer Ingelheim Pharma KG, Research Division, Birkendorfer Strasse 65, D 88397 Biberach Riss, Germany
    J Med Chem 45:1757-66. 2002
    ..This zwitterionic molecule was converted into the double-prodrug 31 (BIBR 1048), which showed strong oral activity in different animal species. On the basis of these results, 31 was chosen for clinical development...
  2. ncbi Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives
    Uwe J Ries
    Department of Chemical Research, Boehringer Ingelheim Pharma KG, Birkendorfer Strasse 65, D 88397, Biberach Riss, Germany
    Bioorg Med Chem Lett 13:2291-5. 2003
    ..X-ray analyses of thrombin-bound inhibitors revealed that enzyme inhibition is mainly based on hydrophobic interactions...
  3. ncbi Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents
    Uwe J Ries
    Department of Chemical Research, Boehringer Ingelheim Pharma KG, Birkendorfer Strasse 65, D 88397, Biberach Riss, Germany
    Bioorg Med Chem Lett 13:2297-302. 2003
    ..Quinoxalinone derivatives as prototypes of dual thrombin and factor Xa inhibitors have been discovered. Nanomolar inhibition of both coagulation enzymes resulted in very potent antithrombotic activity in vitro...